NO20161808A1 - Sammensetninger omfattende ornitin og fenylacetat eller fenylbutyrat for å behandle hepatisk encefalopati - Google Patents
Sammensetninger omfattende ornitin og fenylacetat eller fenylbutyrat for å behandle hepatisk encefalopatiInfo
- Publication number
- NO20161808A1 NO20161808A1 NO20161808A NO20161808A NO20161808A1 NO 20161808 A1 NO20161808 A1 NO 20161808A1 NO 20161808 A NO20161808 A NO 20161808A NO 20161808 A NO20161808 A NO 20161808A NO 20161808 A1 NO20161808 A1 NO 20161808A1
- Authority
- NO
- Norway
- Prior art keywords
- phenylbutyrate
- phenylacetate
- ornithine
- compositions
- treatment
- Prior art date
Links
- OBKXEAXTFZPCHS-UHFFFAOYSA-N 4-phenylbutyric acid Chemical compound OC(=O)CCCC1=CC=CC=C1 OBKXEAXTFZPCHS-UHFFFAOYSA-N 0.000 title abstract 3
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 title abstract 3
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 title abstract 3
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 title abstract 3
- IPBVNPXQWQGGJP-UHFFFAOYSA-N acetic acid phenyl ester Natural products CC(=O)OC1=CC=CC=C1 IPBVNPXQWQGGJP-UHFFFAOYSA-N 0.000 title abstract 3
- 229960003104 ornithine Drugs 0.000 title abstract 3
- 229940049953 phenylacetate Drugs 0.000 title abstract 3
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 title abstract 3
- 229950009215 phenylbutanoic acid Drugs 0.000 title abstract 3
- 208000007386 hepatic encephalopathy Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 206010020575 Hyperammonaemia Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0426141A GB0426141D0 (en) | 2004-11-26 | 2004-11-26 | Treatment |
GB0426142A GB0426142D0 (en) | 2004-11-26 | 2004-11-26 | Formulation |
PCT/GB2005/004539 WO2006056794A1 (en) | 2004-11-26 | 2005-11-28 | Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20161808A1 true NO20161808A1 (no) | 2016-11-16 |
NO341491B1 NO341491B1 (no) | 2017-11-27 |
Family
ID=35559327
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20073254A NO342198B1 (no) | 2004-11-26 | 2007-06-25 | Sammensetninger omfattende ornitin og fenylacetat eller fenylbutyrat for å behandle hepatisk encefalopati |
NO20161808A NO341491B1 (no) | 2004-11-26 | 2016-11-16 | Sammensetninger omfattende ornitin og fenylacetat eller fenylbutyrat for å behandle hepatisk encefalopati |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20073254A NO342198B1 (no) | 2004-11-26 | 2007-06-25 | Sammensetninger omfattende ornitin og fenylacetat eller fenylbutyrat for å behandle hepatisk encefalopati |
Country Status (23)
Country | Link |
---|---|
US (3) | US8389576B2 (no) |
EP (3) | EP1824563B1 (no) |
JP (2) | JP5116479B2 (no) |
KR (1) | KR101380446B1 (no) |
CN (1) | CN102512408B (no) |
AT (1) | ATE457187T1 (no) |
AU (1) | AU2005308622B2 (no) |
CA (1) | CA2589261C (no) |
CY (3) | CY1112259T1 (no) |
DE (1) | DE602005019319D1 (no) |
DK (3) | DK1824563T3 (no) |
EA (2) | EA018007B1 (no) |
ES (3) | ES2341120T3 (no) |
HK (1) | HK1141471A1 (no) |
IL (1) | IL183401A (no) |
MX (1) | MX2007006171A (no) |
NO (2) | NO342198B1 (no) |
NZ (1) | NZ555870A (no) |
PL (3) | PL1824563T3 (no) |
PT (3) | PT2153870E (no) |
SG (1) | SG158073A1 (no) |
SI (3) | SI1824563T1 (no) |
WO (1) | WO2006056794A1 (no) |
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CN102512408B (zh) | 2004-11-26 | 2015-11-25 | Ucl商业有限公司 | 用于治疗肝性脑病的含有鸟氨酸和苯基乙酸或苯基丁酸的组合物 |
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BRPI0920465A2 (pt) | 2008-10-02 | 2018-03-20 | Salix Pharmaceuticals, Inc. | metodo de tratamento de encefalopatia hepática |
US20110035232A1 (en) | 2008-10-02 | 2011-02-10 | Salix Pharmaceuticals, Ltd. | Methods of treating hepatic encephalopathy |
US7928115B2 (en) | 2008-10-02 | 2011-04-19 | Salix Pharmaceuticals, Ltd. | Methods of treating travelers diarrhea and hepatic encephalopathy |
EP2413924B1 (en) | 2009-04-03 | 2017-09-27 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
CN102625699B (zh) | 2009-06-08 | 2014-08-20 | Ucl商业有限公司 | 使用l-鸟氨酸苯乙酸盐治疗门静脉高压和恢复肝功能 |
EP2397458A1 (en) * | 2010-06-21 | 2011-12-21 | Lunamed AG | Organic salts and co-crystals of phenylbutyric acid |
EP2625162B1 (en) * | 2010-10-06 | 2019-03-13 | Ocera Therapeutics, Inc. | Methods of making l-ornithine phenyl acetate |
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KR20150086510A (ko) | 2012-11-21 | 2015-07-28 | 하이페리온 쎄라퓨틱스, 인크. | 간성뇌증의 치료를 위한 질소 소거 약물을 투여 및 평가하는 방법 |
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WO2015048818A1 (en) * | 2013-09-30 | 2015-04-02 | Hyperion Therapeutics, Inc. | Diagnosing, grading, monitoring, and treating hepatic encephalopathy |
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CN113633777A (zh) * | 2014-11-24 | 2021-11-12 | Ucl商业有限公司 | 使用降氨疗法治疗与肝星状细胞激活相关的疾病 |
TWI748936B (zh) | 2015-01-12 | 2021-12-11 | 瑞典商優鎂奎認知Ab公司 | 新穎化合物 |
EP4205735A1 (en) * | 2015-04-20 | 2023-07-05 | Ocera Therapeutics, Inc. | Formulations of l-ornithine phenylacetate |
CA2995823A1 (en) | 2015-08-18 | 2017-02-23 | Ocera Therapeutics, Inc. | Treatment and prevention of muscle loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
US20200206174A1 (en) * | 2015-09-25 | 2020-07-02 | Ocera Therapeutics, Inc. | Treatment and prevention of neuronal cell loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
US11219611B2 (en) | 2015-11-13 | 2022-01-11 | Ocera Therapeutics, Inc. | Formulations of L-ornithine phenylacetate |
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US9914692B2 (en) | 2016-05-25 | 2018-03-13 | Horizon Therapeutics, Llc | Procedure for the preparation of 4-phenyl butyrate and uses thereof |
JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
JP7126520B2 (ja) | 2017-05-11 | 2022-08-26 | オセラ セラピューティクス, インコーポレイテッド | L-オルニチンフェニルアセテートを製造する方法 |
WO2018225482A1 (ja) | 2017-06-07 | 2018-12-13 | 花王株式会社 | アンモニア代謝促進剤 |
WO2018225167A1 (ja) | 2017-06-07 | 2018-12-13 | 花王株式会社 | アンモニア代謝促進剤 |
WO2019036471A1 (en) | 2017-08-14 | 2019-02-21 | Axcella Health Inc. | AMINO ACIDS BRANCHED FOR THE TREATMENT OF LIVER DISEASE |
US10668040B2 (en) | 2017-09-11 | 2020-06-02 | Horizon Therapeutics, Llc | Treatment of urea cycle disorders in neonates and infants |
AR115585A1 (es) | 2018-06-20 | 2021-02-03 | Axcella Health Inc | Composiciones y métodos para el tratamiento de la infiltración de grasa en músculo |
JP7197340B2 (ja) * | 2018-12-06 | 2022-12-27 | 花王株式会社 | 認知機能改善剤 |
CN113713817B (zh) * | 2020-05-26 | 2023-06-27 | 中国科学院大连化学物理研究所 | 一种采用镍基催化剂催化丙醛加氢制正丙醇的方法 |
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