|
SE0104140D0
(sv)
*
|
2001-12-07 |
2001-12-07 |
Astrazeneca Ab |
Novel Compounds
|
|
DK1812440T3
(da)
*
|
2004-11-04 |
2011-01-31 |
Vertex Pharma |
Pyrazolo[1,5-a]pyrimidiner, der kan anvendes som inhibistorer af proteinkinaser
|
|
PL1853588T3
(pl)
*
|
2005-02-16 |
2008-11-28 |
Astrazeneca Ab |
Związki chemiczne
|
|
CA2606017A1
(en)
*
|
2005-05-12 |
2006-11-23 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
JP2008540622A
(ja)
*
|
2005-05-16 |
2008-11-20 |
アストラゼネカ アクチボラグ |
化合物
|
|
WO2007046867A2
(en)
*
|
2005-05-19 |
2007-04-26 |
Xenon Pharmaceuticals Inc. |
Piperidine derivatives and their uses as therapeutic agents
|
|
NZ564065A
(en)
*
|
2005-05-20 |
2011-03-31 |
Vertex Pharma |
Pyrrolopyridines useful as inhibitors of protein kinase
|
|
JP2009513615A
(ja)
*
|
2005-10-28 |
2009-04-02 |
アストラゼネカ アクチボラグ |
癌の治療においてチロシンキナーゼ阻害剤として使用するための４−（３−アミノピラゾール）ピリミジン誘導体
|
|
PT1966202E
(pt)
|
2005-12-13 |
2012-01-03 |
Incyte Corp |
Pirrolo[2,3-b] pirimidinas e pirrolo[2,3-b]piridinas substituídas com heteroarilo como inibidores de janus quinase
|
|
GB0601638D0
(en)
*
|
2006-01-27 |
2006-03-08 |
Merck Sharp & Dohme |
Therapeutic treatment
|
|
US8217177B2
(en)
|
2006-07-14 |
2012-07-10 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
|
PE20121506A1
(es)
|
2006-07-14 |
2012-11-26 |
Amgen Inc |
Compuestos triazolopiridinas como inhibidores de c-met
|
|
US8198448B2
(en)
|
2006-07-14 |
2012-06-12 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
|
WO2008054827A2
(en)
|
2006-11-03 |
2008-05-08 |
Pharmacyclics, Inc. |
Bruton's tyrosine kinase activity probe and method of using
|
|
CN101778825A
(zh)
*
|
2007-03-22 |
2010-07-14 |
沃泰克斯药物股份有限公司 |
适用作詹纳斯激酶抑制剂的n-杂环类化合物
|
|
WO2008129255A1
(en)
*
|
2007-04-18 |
2008-10-30 |
Astrazeneca Ab |
5-aminopyrazol-3-yl-3h-imidazo [4,5-b] pyridine derivatives and their use for the treatment of cancer
|
|
UA99459C2
(en)
*
|
2007-05-04 |
2012-08-27 |
Астразенека Аб |
9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer
|
|
ATE521609T1
(de)
*
|
2007-05-04 |
2011-09-15 |
Astrazeneca Ab |
Aminothiazolylpyrimidinderivate und ihre verwendung bei der behandlung von krebs
|
|
RS53245B2
(sr)
|
2007-06-13 |
2022-10-31 |
Incyte Holdings Corp |
Soli inhibitora janus kinaze (r)-3-(4-(7h-pirolo(2,3-d) pirimidin-4-il)-1h-pirazol-1-il)-3-ciklopentilpropan-nitrila
|
|
EP2206714B1
(en)
*
|
2007-09-28 |
2015-01-21 |
Kyowa Hakko Kirin Co., Ltd. |
Agent for prevention and/or treatment of skin diseases
|
|
WO2009064835A1
(en)
*
|
2007-11-16 |
2009-05-22 |
Incyte Corporation |
4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors
|
|
KR20100108390A
(ko)
|
2007-12-19 |
2010-10-06 |
버텍스 파마슈티칼스 인코포레이티드 |
ＪＡＫ２ 억제제로서 유용한 피라졸로［１，５－ａ］피리미딘
|
|
CA2710194C
(en)
*
|
2007-12-19 |
2014-04-22 |
Amgen Inc. |
Inhibitors of p13 kinase
|
|
CA2718403A1
(en)
|
2008-03-13 |
2009-09-17 |
The General Hospital Corporation |
Inhibitors of the bmp signaling pathway
|
|
AR072085A1
(es)
*
|
2008-06-11 |
2010-08-04 |
Astrazeneca Ab |
Compuestos triciclicos, metodos para su preparacion, composicion farma-ceutica que los comprende y su uso en el tratamiento de enfermedades me-diadas por la actividad de las proteinas quinasas
|
|
US8394802B2
(en)
*
|
2008-09-19 |
2013-03-12 |
Nerviano Medical Sciences S.R.L. |
3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-one derivatives for the modulation of the activity of protein kinases
|
|
US8450322B2
(en)
|
2008-09-22 |
2013-05-28 |
Array Biopharma Inc. |
Substituted imidazo[1,2b]pyridazine compounds as Trk kinase inhibitors
|
|
TW201018693A
(en)
*
|
2008-09-30 |
2010-05-16 |
Astrazeneca Ab |
Chemical compounds 496-1p
|
|
JP5769199B2
(ja)
*
|
2008-10-31 |
2015-08-26 |
ジェネンテック， インコーポレイテッド |
ピラゾロピリミジンｊａｋ阻害剤化合物と方法
|
|
GB0821913D0
(en)
|
2008-12-02 |
2009-01-07 |
Price & Co |
Antibacterial compounds
|
|
TW201100429A
(en)
|
2009-05-22 |
2011-01-01 |
Incyte Corp |
N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
PL2432472T3
(pl)
|
2009-05-22 |
2020-03-31 |
Incyte Holdings Corporation |
3-[4-(7H-Pirolo[2,3-d]pirymidyn-4-ylo)-1H-pirazol-1-ilo]oktano- lub heptano-nitryle jako inhibitory JAK
|
|
CN102448969A
(zh)
*
|
2009-05-28 |
2012-05-09 |
沃泰克斯药物股份有限公司 |
C-met蛋白激酶抑制剂
|
|
KR101903354B1
(ko)
|
2009-06-17 |
2018-10-04 |
버텍스 파마슈티칼스 인코포레이티드 |
인플루엔자 바이러스 복제의 억제제
|
|
UA110324C2
(en)
|
2009-07-02 |
2015-12-25 |
Genentech Inc |
Jak inhibitory compounds based on pyrazolo pyrimidine
|
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
|
TW201113285A
(en)
|
2009-09-01 |
2011-04-16 |
Incyte Corp |
Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
US8785440B2
(en)
|
2009-09-04 |
2014-07-22 |
Biogen Idec Ma, Inc. |
Bruton's tyrosine kinase inhibitors
|
|
MX354212B
(es)
|
2010-03-10 |
2018-02-19 |
Incyte Corp |
Derivados de piperidin-4-il azetidina como inhibidores de janus cinasa 1 (jak1).
|
|
WO2011130515A1
(en)
*
|
2010-04-14 |
2011-10-20 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Arylthiazolyl piperidines and related compounds as modulators of survival motor neuron (smn) protein production
|
|
CA2798080C
(en)
|
2010-05-17 |
2020-08-25 |
Incozen Therapeutics Pvt. Ltd. |
3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of protein kinases
|
|
ES2628418T3
(es)
|
2010-05-20 |
2017-08-02 |
Array Biopharma, Inc. |
Compuestos macrocíclicos como inhibidores de la TRK cinasa
|
|
EA202091303A3
(ru)
|
2010-05-21 |
2021-05-31 |
Инсайт Холдингс Корпорейшн |
Композиция ингибитора jak для местного применения
|
|
SI2575968T1
(sl)
|
2010-06-01 |
2016-06-30 |
Summit Therapeutics Plc |
Spojine za zdravljenje bolezni, ki je povezana s clostridium difficile
|
|
GB2480814A
(en)
*
|
2010-06-01 |
2011-12-07 |
Summit Corp Plc |
Compounds for the treatment of clostridium difficile-associated disease
|
|
CA2818542A1
(en)
|
2010-11-19 |
2012-05-24 |
Incyte Corporation |
Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
|
|
WO2012068440A1
(en)
|
2010-11-19 |
2012-05-24 |
Incyte Corporation |
Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
|
|
EP2651940A1
(en)
*
|
2010-12-16 |
2013-10-23 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of influenza viruses replication
|
|
KR101880966B1
(ko)
*
|
2011-06-10 |
2018-07-23 |
메르크 파텐트 게엠베하 |
Btk 억제 활성을 갖는 피리미딘 및 피리딘 화합물의 조성물 및 제조방법
|
|
CN103797010B
(zh)
|
2011-06-20 |
2016-02-24 |
因塞特控股公司 |
作为jak抑制剂的氮杂环丁烷基苯基、吡啶基或吡嗪基甲酰胺衍生物
|
|
JP2014517079A
(ja)
|
2011-06-22 |
2014-07-17 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Ａｔｒキナーゼ阻害剤として有用な化合物
|
|
UA118010C2
(uk)
|
2011-08-01 |
2018-11-12 |
Вертекс Фармасьютікалз Інкорпорейтед |
Інгібітори реплікації вірусів грипу
|
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
|
|
US9096605B2
(en)
*
|
2011-08-24 |
2015-08-04 |
Glaxosmithkline Llc |
Pyrazolopyrimidine derivatives as PI3 kinase inhibitors
|
|
UA111854C2
(uk)
|
2011-09-07 |
2016-06-24 |
Інсайт Холдінгс Корпорейшн |
Способи і проміжні сполуки для отримання інгібіторів jak
|
|
AP3908A
(en)
|
2012-03-30 |
2016-11-24 |
Rhizen Pharmaceuticals Sa |
Novel 3,5-disubstituted-3H-imidazo[4,5-B]pyridine and 3,5-disubstituted-3H-[1,2,3]triazolo [4,5-B] pyridine compounds as modulators of C-met protein kinases
|
|
US9193733B2
(en)
|
2012-05-18 |
2015-11-24 |
Incyte Holdings Corporation |
Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
|
|
AR091273A1
(es)
|
2012-06-08 |
2015-01-21 |
Biogen Idec Inc |
Inhibidores de pirimidinil tirosina quinasa
|
|
CA2882132C
(en)
*
|
2012-08-16 |
2021-07-06 |
The Scripps Research Institute |
Kappa opioid ligands
|
|
NZ708157A
(en)
|
2012-11-15 |
2019-07-26 |
Incyte Holdings Corp |
Sustained-release dosage forms of ruxolitinib
|
|
WO2014081996A1
(en)
*
|
2012-11-23 |
2014-05-30 |
Glaxosmithkline Llc |
Novel compounds as diacylglycerol acyltransferase inhibitors
|
|
SMT202000713T1
(it)
|
2012-12-07 |
2021-03-15 |
Vertex Pharma |
Pirazolo [1,5-a] pirimidine utili come inibitori dell'atr chinasi per il trattamento di malattie del cancro
|
|
TW201501713A
(zh)
*
|
2013-03-01 |
2015-01-16 |
Kyowa Hakko Kirin Co Ltd |
眼炎症性疾病之預防及／或治療劑
|
|
TWI634121B
(zh)
|
2013-03-06 |
2018-09-01 |
英塞特控股公司 |
用於製備ｊａｋ抑制劑之方法及中間物
|
|
JP6542192B2
(ja)
|
2013-03-14 |
2019-07-10 |
ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． |
Ｂｍｐ阻害剤およびその使用方法
|
|
US9663519B2
(en)
|
2013-03-15 |
2017-05-30 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
EP2970289A1
(en)
|
2013-03-15 |
2016-01-20 |
Vertex Pharmaceuticals Inc. |
Compounds useful as inhibitors of atr kinase
|
|
US8969360B2
(en)
|
2013-03-15 |
2015-03-03 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
WO2014175370A1
(ja)
*
|
2013-04-25 |
2014-10-30 |
塩野義製薬株式会社 |
ピロリジン誘導体およびそれらを含有する医薬組成物
|
|
MX394928B
(es)
|
2013-08-07 |
2025-03-24 |
Incyte Holdings Corp |
Formas de dosificacion de liberacion prolongada para un inhibidor de jak 1 (cinasa de janus 1).
|
|
ES2684755T3
(es)
|
2013-11-13 |
2018-10-04 |
Vertex Pharmaceuticals Incorporated |
Métodos para preparar inhibidores de la replicación de virus de la gripe
|
|
DK3068776T3
(da)
|
2013-11-13 |
2019-07-29 |
Vertex Pharma |
Inhibitorer af replikation af influenzavira
|
|
WO2015073267A1
(en)
*
|
2013-11-15 |
2015-05-21 |
Calitor Sciences, Llc |
Substituted heteroaryl compounds and methods of use
|
|
CN104650092B
(zh)
*
|
2013-11-16 |
2017-11-10 |
广东东阳光药业有限公司 |
取代的杂芳基化合物及其组合物和用途
|
|
ES2768678T3
(es)
|
2013-12-06 |
2020-06-23 |
Vertex Pharma |
Compuesto de 2-amino-6-fluoro-N-[5-fluoro-piridin-3-il]pirazolo[1,5-a]pirimidin-3-carboxamida útil como inhibidor de la ATR quinasa, su preparación, diferentes formas sólidas y derivados radiomarcados de las mismas
|
|
UA121658C2
(uk)
|
2014-05-23 |
2020-07-10 |
Ф. Хоффманн-Ля Рош Аг |
Сполуки 5-хлордифторметоксифенілпіразолопіримідину як інгібітори янус-кінази
|
|
US9498467B2
(en)
|
2014-05-30 |
2016-11-22 |
Incyte Corporation |
Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1
|
|
SG10201902206QA
(en)
|
2014-06-05 |
2019-04-29 |
Vertex Pharma |
Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof
|
|
AU2015277212B2
(en)
|
2014-06-17 |
2020-07-02 |
Vertex Pharmaceuticals Incorporated |
Method for treating cancer using a combination of Chk1 and ATR inhibitors
|
|
WO2016011019A1
(en)
|
2014-07-15 |
2016-01-21 |
The Brigham And Women's Hospital, Inc. |
Compositions and methods for inhibiting bmp
|
|
PT3699181T
(pt)
|
2014-11-16 |
2023-04-05 |
Array Biopharma Inc |
Forma cristalina de hidrogenossulfato de (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida
|
|
WO2016183120A1
(en)
|
2015-05-13 |
2016-11-17 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of influenza viruses replication
|
|
WO2016183116A1
(en)
|
2015-05-13 |
2016-11-17 |
Vertex Pharmaceuticals Incorporated |
Methods of preparing inhibitors of influenza viruses replication
|
|
RU2768621C1
(ru)
|
2015-09-30 |
2022-03-24 |
Вертекс Фармасьютикалз Инкорпорейтед |
Способ лечения рака с использованием комбинации повреждающих днк средств и ингибиторов atr
|
|
TN2018000138A1
(en)
|
2015-10-26 |
2019-10-04 |
Array Biopharma Inc |
Point mutations in trk inhibitor-resistant cancer and methods relating to the same
|
|
US10045991B2
(en)
|
2016-04-04 |
2018-08-14 |
Loxo Oncology, Inc. |
Methods of treating pediatric cancers
|
|
CN109414442B
(zh)
|
2016-04-04 |
2024-03-29 |
洛克索肿瘤学股份有限公司 |
一种化合物的液体制剂
|
|
DK3800189T3
(da)
|
2016-05-18 |
2023-07-31 |
Loxo Oncology Inc |
Fremstilling af (s)-n-(5-((r)-2-(2,5-difluorphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidin-1-carboxamid
|
|
MX385289B
(es)
*
|
2016-07-18 |
2025-03-18 |
Univ Health Network |
Formas sólidas del inhibidor de la tirosina treonina cinasa (ttk).
|
|
CN110049976A
(zh)
|
2016-07-21 |
2019-07-23 |
比奥根Ma公司 |
布鲁顿氏酪氨酸激酶抑制剂的琥珀酸盐形式和组合物
|
|
JOP20190092A1
(ar)
|
2016-10-26 |
2019-04-25 |
Array Biopharma Inc |
عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
|
|
JOP20190213A1
(ar)
|
2017-03-16 |
2019-09-16 |
Array Biopharma Inc |
مركبات حلقية ضخمة كمثبطات لكيناز ros1
|
|
JP7175917B2
(ja)
*
|
2017-04-27 |
2022-11-21 |
ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド |
新規のａｌｋ２阻害剤及びｂｍｐシグナル伝達の阻害方法
|
|
PL233595B1
(pl)
*
|
2017-05-12 |
2019-11-29 |
Celon Pharma Spolka Akcyjna |
Pochodne pirazolo[1,5-a]pirymidyny jako inhibitory kinazy JAK
|
|
KR20200010390A
(ko)
|
2017-05-22 |
2020-01-30 |
에프. 호프만-라 로슈 아게 |
치료 화합물 및 조성물, 및 이의 사용 방법
|
|
AR113922A1
(es)
|
2017-12-08 |
2020-07-01 |
Incyte Corp |
Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas
|
|
CN111918651B
(zh)
*
|
2018-01-29 |
2024-01-30 |
默克专利股份有限公司 |
Gcn2抑制剂及其用途
|
|
EP3746071A4
(en)
|
2018-01-29 |
2021-09-01 |
Merck Patent GmbH |
GCN2 INHIBITORS AND THEIR USES
|
|
WO2019152374A1
(en)
|
2018-01-30 |
2019-08-08 |
Incyte Corporation |
Processes for preparing (1 -(3-fluoro-2-(trifluoromethyl)isonicotinyl)piperidine-4-one)
|
|
HUE067471T2
(hu)
|
2018-03-30 |
2024-10-28 |
Incyte Corp |
Gennyes verejtékmirigy-gyulladás kezelése jak inhibitorok alkalmazásával
|
|
EP3870181B1
(en)
*
|
2018-10-26 |
2024-08-14 |
Keros Therapeutics, Inc. |
Crystal forms of an alk2 inhibitor
|
|
MX2021007426A
(es)
|
2018-12-20 |
2021-09-08 |
Incyte Corp |
Compuestos de imidazopiridazina e imidazopiridina como inhibidores de cinasa-2 de tipo receptor de activina.
|
|
US11833155B2
(en)
|
2020-06-03 |
2023-12-05 |
Incyte Corporation |
Combination therapy for treatment of myeloproliferative neoplasms
|
|
WO2022098812A1
(en)
|
2020-11-04 |
2022-05-12 |
Keros Therapeutics, Inc. |
Methods of treating iron overload
|
|
EP4392418A4
(en)
*
|
2021-08-24 |
2025-06-18 |
The Johns Hopkins University |
Compositions and methods for treating proteotoxicity-associated diseases
|
|
CN116987083A
(zh)
*
|
2022-04-25 |
2023-11-03 |
杭州健崃生物科技有限公司 |
吡唑并[1,5-a]嘧啶衍生物及其制备方法和用途
|
|
KR20240155634A
(ko)
|
2023-04-20 |
2024-10-29 |
한국화학연구원 |
신규한 헤테로고리 화합물 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 포함하는 바이러스성 질환의 예방 또는 치료용 약학적 조성물
|