JP2008517046A5 - - Google Patents
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- Publication number
- JP2008517046A5 JP2008517046A5 JP2007537377A JP2007537377A JP2008517046A5 JP 2008517046 A5 JP2008517046 A5 JP 2008517046A5 JP 2007537377 A JP2007537377 A JP 2007537377A JP 2007537377 A JP2007537377 A JP 2007537377A JP 2008517046 A5 JP2008517046 A5 JP 2008517046A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- buffer
- anion exchange
- substrate
- fraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 38
- 239000000758 substrate Substances 0.000 claims 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 9
- 240000008042 Zea mays Species 0.000 claims 9
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 9
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 9
- 235000005822 corn Nutrition 0.000 claims 9
- 238000005349 anion exchange Methods 0.000 claims 8
- 239000000872 buffer Substances 0.000 claims 8
- 238000005406 washing Methods 0.000 claims 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 6
- 241000700605 Viruses Species 0.000 claims 6
- 238000010828 elution Methods 0.000 claims 5
- 102000001708 Protein Isoforms Human genes 0.000 claims 4
- 108010029485 Protein Isoforms Proteins 0.000 claims 4
- 238000005571 anion exchange chromatography Methods 0.000 claims 4
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims 3
- 239000012535 impurity Substances 0.000 claims 3
- 230000002779 inactivation Effects 0.000 claims 3
- 239000001632 sodium acetate Substances 0.000 claims 3
- 235000017281 sodium acetate Nutrition 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical group CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 claims 2
- 229920000936 Agarose Polymers 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 2
- 108010088751 Albumins Proteins 0.000 claims 2
- 101001078385 Homo sapiens Haptoglobin Proteins 0.000 claims 2
- 239000012149 elution buffer Substances 0.000 claims 2
- 102000050796 human HP Human genes 0.000 claims 2
- 239000000047 product Substances 0.000 claims 2
- 238000000746 purification Methods 0.000 claims 2
- 239000011534 wash buffer Substances 0.000 claims 2
- 239000007853 buffer solution Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 239000012467 final product Substances 0.000 claims 1
- 238000004191 hydrophobic interaction chromatography Methods 0.000 claims 1
- 238000010348 incorporation Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000011100 viral filtration Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0423196.5A GB0423196D0 (en) | 2004-10-19 | 2004-10-19 | Method |
| GB0423196.5 | 2004-10-19 | ||
| PCT/GB2005/004037 WO2006043062A1 (en) | 2004-10-19 | 2005-10-19 | Method for the isolation of haptoglobin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008517046A JP2008517046A (ja) | 2008-05-22 |
| JP2008517046A5 true JP2008517046A5 (enExample) | 2008-11-27 |
| JP4950053B2 JP4950053B2 (ja) | 2012-06-13 |
Family
ID=33484812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007537377A Expired - Lifetime JP4950053B2 (ja) | 2004-10-19 | 2005-10-19 | ハプトグロビンの単離方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9145448B2 (enExample) |
| EP (1) | EP1802654B1 (enExample) |
| JP (1) | JP4950053B2 (enExample) |
| AT (1) | ATE539085T1 (enExample) |
| AU (1) | AU2005297061B2 (enExample) |
| BR (1) | BRPI0516933B8 (enExample) |
| CA (1) | CA2584407C (enExample) |
| ES (1) | ES2379157T3 (enExample) |
| GB (1) | GB0423196D0 (enExample) |
| IL (1) | IL182340A (enExample) |
| MX (1) | MX2007004244A (enExample) |
| PL (1) | PL1802654T3 (enExample) |
| WO (1) | WO2006043062A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0423196D0 (en) | 2004-10-19 | 2004-11-24 | Nat Blood Authority | Method |
| US9534029B2 (en) | 2012-10-03 | 2017-01-03 | Csl Behring Ag | Method of purifying proteins |
| HK1212995A1 (zh) * | 2012-10-03 | 2016-06-24 | Csl Behring Ag | 一种纯化蛋白质的方法 |
| EP3917943A4 (en) * | 2019-02-01 | 2022-12-07 | Ohio State Innovation Foundation | PROTEINS PURIFICATION PROCEDURES |
| US20220218834A1 (en) * | 2019-05-20 | 2022-07-14 | Ohio State Innovation Foundation | Apohemoglobin-haptoglobin complexes and methods of using thereof |
| US20240034749A1 (en) * | 2021-02-04 | 2024-02-01 | Green Cross Corporation | Method for purification of hemopexin and haptoglobin |
| CN115531921B (zh) * | 2022-08-26 | 2024-07-16 | 大连依利特分析仪器有限公司 | 一种制备型液相色谱馏分收集装置及方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4061735A (en) * | 1973-11-15 | 1977-12-06 | The Green Cross Corporation | Haptoglobin in aqueous solution and process for preparing the same |
| GB1426039A (en) | 1973-11-15 | 1976-02-25 | Green Cross Corp | Haptoglobin in aqueous solution and process for tits preparation |
| US4137307A (en) * | 1973-11-15 | 1979-01-30 | The Green Cross Corporation | Process for preparing haptoglobin aqueous solution using strong anion exchanger |
| JPS5337406B2 (enExample) * | 1973-11-15 | 1978-10-09 | ||
| JPS52128205A (en) * | 1976-04-16 | 1977-10-27 | Green Cross Corp:The | Prophylactic and therapeutic drugs for cerebro-vascular contraction |
| US4540573A (en) | 1983-07-14 | 1985-09-10 | New York Blood Center, Inc. | Undenatured virus-free biologically active protein derivatives |
| US5094960A (en) * | 1988-10-07 | 1992-03-10 | New York Blood Center, Inc. | Removal of process chemicals from labile biological mixtures by hydrophobic interaction chromatography |
| JP3554796B2 (ja) * | 1988-10-31 | 2004-08-18 | 三菱ウェルファーマ株式会社 | アルブミン製剤及びその製造方法 |
| JP3825061B2 (ja) * | 1994-09-28 | 2006-09-20 | 三菱ウェルファーマ株式会社 | ハプトグロビンの製造方法 |
| DE19960500A1 (de) * | 1999-12-15 | 2001-07-12 | Giesing Michael | Antikörper und Verfahren zu ihrer Herstellung, deren Verwendung sowie Immunisierungscocktails, Immunoassay-Sets und Peptide |
| PT1328297E (pt) * | 2000-10-16 | 2010-01-04 | Cytoguide Aps | Função de um receptor de haptoglobina-hemoglobina e suas utilizações |
| US20030113830A1 (en) | 2001-07-11 | 2003-06-19 | Rappaport Family Institute For Research In The Medical Sciences | Novel antioxidant, nucleic acid constructs encoding same, pharmaceutical compositions containing same and use of same for reducing oxidative-stress |
| JP2004244348A (ja) * | 2003-02-13 | 2004-09-02 | Nihon Pharmaceutical Co Ltd | パプトグロビンの精製法 |
| GB0423196D0 (en) | 2004-10-19 | 2004-11-24 | Nat Blood Authority | Method |
| WO2006107708A1 (en) | 2005-04-04 | 2006-10-12 | Alexion Pharmaceuticals, Inc. | Treatment of disease caused by excess free hemoglobin |
-
2004
- 2004-10-19 GB GBGB0423196.5A patent/GB0423196D0/en not_active Ceased
-
2005
- 2005-10-19 US US11/577,478 patent/US9145448B2/en active Active
- 2005-10-19 CA CA2584407A patent/CA2584407C/en not_active Expired - Lifetime
- 2005-10-19 ES ES05794729T patent/ES2379157T3/es not_active Expired - Lifetime
- 2005-10-19 BR BRPI0516933A patent/BRPI0516933B8/pt active IP Right Grant
- 2005-10-19 AU AU2005297061A patent/AU2005297061B2/en not_active Ceased
- 2005-10-19 MX MX2007004244A patent/MX2007004244A/es active IP Right Grant
- 2005-10-19 WO PCT/GB2005/004037 patent/WO2006043062A1/en not_active Ceased
- 2005-10-19 EP EP05794729A patent/EP1802654B1/en not_active Expired - Lifetime
- 2005-10-19 JP JP2007537377A patent/JP4950053B2/ja not_active Expired - Lifetime
- 2005-10-19 AT AT05794729T patent/ATE539085T1/de active
- 2005-10-19 PL PL05794729T patent/PL1802654T3/pl unknown
-
2007
- 2007-03-29 IL IL182340A patent/IL182340A/en active IP Right Grant
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