CA2584407C - Method for the isolation of haptoglobin - Google Patents

Method for the isolation of haptoglobin Download PDF

Info

Publication number
CA2584407C
CA2584407C CA2584407A CA2584407A CA2584407C CA 2584407 C CA2584407 C CA 2584407C CA 2584407 A CA2584407 A CA 2584407A CA 2584407 A CA2584407 A CA 2584407A CA 2584407 C CA2584407 C CA 2584407C
Authority
CA
Canada
Prior art keywords
human
substrate
chromatography
anion exchange
elution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2584407A
Other languages
English (en)
French (fr)
Other versions
CA2584407A1 (en
Inventor
Joan Dalton
Adrian Podmore
Peter Kumpalume
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bio Products Laboratory Ltd
Original Assignee
Bio Products Laboratory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Products Laboratory Ltd filed Critical Bio Products Laboratory Ltd
Publication of CA2584407A1 publication Critical patent/CA2584407A1/en
Application granted granted Critical
Publication of CA2584407C publication Critical patent/CA2584407C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1722—Plasma globulins, lactoglobulins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4717—Plasma globulins, lactoglobulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Semiconductor Lasers (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2584407A 2004-10-19 2005-10-19 Method for the isolation of haptoglobin Expired - Lifetime CA2584407C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0423196.5A GB0423196D0 (en) 2004-10-19 2004-10-19 Method
GB0423196.5 2004-10-19
PCT/GB2005/004037 WO2006043062A1 (en) 2004-10-19 2005-10-19 Method for the isolation of haptoglobin

Publications (2)

Publication Number Publication Date
CA2584407A1 CA2584407A1 (en) 2006-04-27
CA2584407C true CA2584407C (en) 2015-02-03

Family

ID=33484812

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2584407A Expired - Lifetime CA2584407C (en) 2004-10-19 2005-10-19 Method for the isolation of haptoglobin

Country Status (13)

Country Link
US (1) US9145448B2 (enExample)
EP (1) EP1802654B1 (enExample)
JP (1) JP4950053B2 (enExample)
AT (1) ATE539085T1 (enExample)
AU (1) AU2005297061B2 (enExample)
BR (1) BRPI0516933B8 (enExample)
CA (1) CA2584407C (enExample)
ES (1) ES2379157T3 (enExample)
GB (1) GB0423196D0 (enExample)
IL (1) IL182340A (enExample)
MX (1) MX2007004244A (enExample)
PL (1) PL1802654T3 (enExample)
WO (1) WO2006043062A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0423196D0 (en) 2004-10-19 2004-11-24 Nat Blood Authority Method
US9534029B2 (en) 2012-10-03 2017-01-03 Csl Behring Ag Method of purifying proteins
HK1212995A1 (zh) * 2012-10-03 2016-06-24 Csl Behring Ag 一种纯化蛋白质的方法
EP3917943A4 (en) * 2019-02-01 2022-12-07 Ohio State Innovation Foundation PROTEINS PURIFICATION PROCEDURES
US20220218834A1 (en) * 2019-05-20 2022-07-14 Ohio State Innovation Foundation Apohemoglobin-haptoglobin complexes and methods of using thereof
US20240034749A1 (en) * 2021-02-04 2024-02-01 Green Cross Corporation Method for purification of hemopexin and haptoglobin
CN115531921B (zh) * 2022-08-26 2024-07-16 大连依利特分析仪器有限公司 一种制备型液相色谱馏分收集装置及方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4061735A (en) * 1973-11-15 1977-12-06 The Green Cross Corporation Haptoglobin in aqueous solution and process for preparing the same
GB1426039A (en) 1973-11-15 1976-02-25 Green Cross Corp Haptoglobin in aqueous solution and process for tits preparation
US4137307A (en) * 1973-11-15 1979-01-30 The Green Cross Corporation Process for preparing haptoglobin aqueous solution using strong anion exchanger
JPS5337406B2 (enExample) * 1973-11-15 1978-10-09
JPS52128205A (en) * 1976-04-16 1977-10-27 Green Cross Corp:The Prophylactic and therapeutic drugs for cerebro-vascular contraction
US4540573A (en) 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
US5094960A (en) * 1988-10-07 1992-03-10 New York Blood Center, Inc. Removal of process chemicals from labile biological mixtures by hydrophobic interaction chromatography
JP3554796B2 (ja) * 1988-10-31 2004-08-18 三菱ウェルファーマ株式会社 アルブミン製剤及びその製造方法
JP3825061B2 (ja) * 1994-09-28 2006-09-20 三菱ウェルファーマ株式会社 ハプトグロビンの製造方法
DE19960500A1 (de) * 1999-12-15 2001-07-12 Giesing Michael Antikörper und Verfahren zu ihrer Herstellung, deren Verwendung sowie Immunisierungscocktails, Immunoassay-Sets und Peptide
PT1328297E (pt) * 2000-10-16 2010-01-04 Cytoguide Aps Função de um receptor de haptoglobina-hemoglobina e suas utilizações
US20030113830A1 (en) 2001-07-11 2003-06-19 Rappaport Family Institute For Research In The Medical Sciences Novel antioxidant, nucleic acid constructs encoding same, pharmaceutical compositions containing same and use of same for reducing oxidative-stress
JP2004244348A (ja) * 2003-02-13 2004-09-02 Nihon Pharmaceutical Co Ltd パプトグロビンの精製法
GB0423196D0 (en) 2004-10-19 2004-11-24 Nat Blood Authority Method
WO2006107708A1 (en) 2005-04-04 2006-10-12 Alexion Pharmaceuticals, Inc. Treatment of disease caused by excess free hemoglobin

Also Published As

Publication number Publication date
BRPI0516933B8 (pt) 2021-05-25
JP4950053B2 (ja) 2012-06-13
BRPI0516933A (pt) 2008-09-23
ES2379157T3 (es) 2012-04-23
IL182340A0 (en) 2007-07-24
EP1802654B1 (en) 2011-12-28
AU2005297061A1 (en) 2006-04-27
EP1802654A1 (en) 2007-07-04
MX2007004244A (es) 2007-09-07
JP2008517046A (ja) 2008-05-22
AU2005297061B2 (en) 2011-09-01
US20090281282A1 (en) 2009-11-12
IL182340A (en) 2012-06-28
BRPI0516933B1 (pt) 2021-02-09
CA2584407A1 (en) 2006-04-27
GB0423196D0 (en) 2004-11-24
WO2006043062A1 (en) 2006-04-27
ATE539085T1 (de) 2012-01-15
US9145448B2 (en) 2015-09-29
PL1802654T3 (pl) 2012-05-31

Similar Documents

Publication Publication Date Title
JP6876655B2 (ja) タンパク質の精製方法
US6921808B2 (en) Purification process for large scale production of Gc-globulin, the Gc-globulin produced hereby, a use of Gc-globulin and a Gc-globulin medicinal product
JP2005500265A (ja) 治療的使用のためのヒト免疫グロブリン濃縮物の調製方法
JP2002517516A (ja) 静脈投与用免疫グロブリン及び他の免疫グロブリン生成物の製造法
AU2013203930A1 (en) A method of purifying proteins
JP2965623B2 (ja) 精製されたアルブミン溶液の製造方法
CA2584407C (en) Method for the isolation of haptoglobin
EP1419177B1 (en) A purification process for large scale production of gc-globulin, product obtained thereby and their use in medicine
US8580931B2 (en) Method for the purification of alpha-1-antitrypsin
HK40050028A (en) A method of purifying proteins
HU200345B (en) Process for producing immunoglobin and albumin by combination of 2-ethoxy-6,9-diaminoacridine and chromatography

Legal Events

Date Code Title Description
EEER Examination request