JP2008515798A5 - - Google Patents
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- Publication number
- JP2008515798A5 JP2008515798A5 JP2007534851A JP2007534851A JP2008515798A5 JP 2008515798 A5 JP2008515798 A5 JP 2008515798A5 JP 2007534851 A JP2007534851 A JP 2007534851A JP 2007534851 A JP2007534851 A JP 2007534851A JP 2008515798 A5 JP2008515798 A5 JP 2008515798A5
- Authority
- JP
- Japan
- Prior art keywords
- aliphatic
- optionally substituted
- independently
- ring
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *Cc(c(S=C)c1)ccc1[Rh] Chemical compound *Cc(c(S=C)c1)ccc1[Rh] 0.000 description 1
- UWRWHOKKUJISAM-UHFFFAOYSA-N CC(C)c(cccc1)c1SC Chemical compound CC(C)c(cccc1)c1SC UWRWHOKKUJISAM-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61576104P | 2004-10-04 | 2004-10-04 | |
| US60/615,761 | 2004-10-04 | ||
| PCT/US2005/035458 WO2006041773A2 (en) | 2004-10-04 | 2005-10-03 | Lactam compounds useful as protein kinase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012019746A Division JP2012092143A (ja) | 2004-10-04 | 2012-02-01 | タンパク質キナーゼインヒビターとして有用なラクタム化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008515798A JP2008515798A (ja) | 2008-05-15 |
| JP2008515798A5 true JP2008515798A5 (enExample) | 2008-11-20 |
| JP5002460B2 JP5002460B2 (ja) | 2012-08-15 |
Family
ID=35789256
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007534851A Expired - Fee Related JP5002460B2 (ja) | 2004-10-04 | 2005-10-03 | タンパク質キナーゼインヒビターとして有用なラクタム化合物 |
| JP2012019746A Withdrawn JP2012092143A (ja) | 2004-10-04 | 2012-02-01 | タンパク質キナーゼインヒビターとして有用なラクタム化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012019746A Withdrawn JP2012092143A (ja) | 2004-10-04 | 2012-02-01 | タンパク質キナーゼインヒビターとして有用なラクタム化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US7459448B2 (enExample) |
| EP (2) | EP1799684B1 (enExample) |
| JP (2) | JP5002460B2 (enExample) |
| CN (2) | CN102766142A (enExample) |
| AU (1) | AU2005294575B2 (enExample) |
| CA (1) | CA2582235A1 (enExample) |
| WO (1) | WO2006041773A2 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1799684B1 (en) * | 2004-10-04 | 2014-12-03 | Millennium Pharmaceuticals, Inc. | Lactam compounds useful as protein kinase inhibitors |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| PE20080145A1 (es) | 2006-03-21 | 2008-02-11 | Janssen Pharmaceutica Nv | Tetrahidro-pirimidoazepinas como moduladores de trpv1 |
| US7985745B2 (en) | 2006-10-02 | 2011-07-26 | Abbott Laboratories | Method for pain treatment |
| US8735411B2 (en) | 2006-10-02 | 2014-05-27 | Abbvie Inc. | Macrocyclic benzofused pyrimidine derivatives |
| JP2010505962A (ja) | 2006-10-09 | 2010-02-25 | 武田薬品工業株式会社 | キナーゼ阻害剤 |
| AU2008287339A1 (en) | 2007-08-15 | 2009-02-19 | Vertex Pharmaceuticals Incorporated | 4-(9-(3, 3-difluorocyclopentyl) -5, 7, 7-trimethyl-6-oxo-6, 7, 8, 9-tetrahydro-5H-pyrimido [4, 5-b][1, 4] diazepin-2-ylamino)-3-methoxybenzamide Derivatives as Inhibitors of the Human Protein Kinases PLK1 to PLK4 for the Treatment of Proliferative Diseases |
| CN101878216B (zh) * | 2007-09-28 | 2013-07-10 | 西克拉塞尔有限公司 | 作为蛋白激酶抑制剂的嘧啶衍生物 |
| JP5562865B2 (ja) | 2007-12-17 | 2014-07-30 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｔｒｐｖ１のイミダゾロ−、オキサゾロ−、及びチアゾロピリミジン・モジュレーター |
| WO2009081222A1 (en) | 2007-12-21 | 2009-07-02 | Glenmark Pharmaceuticals, S.A. | Substituted tricyclic pyridine or pyrimidine vanilloid receptor ligands |
| GB0800383D0 (en) * | 2008-01-10 | 2008-02-20 | Univ Strathclyde | Weight reducing compounds |
| EP2100894A1 (en) | 2008-03-12 | 2009-09-16 | 4Sc Ag | Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors |
| US7998952B2 (en) * | 2008-12-05 | 2011-08-16 | Millennium Pharmaceuticals, Inc. | Thiolactams and uses thereof |
| GEP20207129B (en) | 2009-06-17 | 2020-07-10 | Vertex Pharma | Inhibitors of influenza viruses replication |
| RU2013132681A (ru) | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы репликации вирусов гриппа |
| EP2668177B1 (en) | 2011-01-28 | 2014-10-22 | Boehringer Ingelheim International GmbH | Substituted pyridinyl-pyrimidines and their use as medicaments |
| CN102174016A (zh) * | 2011-03-02 | 2011-09-07 | 宁波人健药业集团有限公司 | 一种制备7-氯-2,3,4,5-四氢-1h-1-苯并氮杂卓-2,5-二酮的方法 |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| WO2013033093A1 (en) * | 2011-08-29 | 2013-03-07 | Biocryst Pharmaceuticals, Inc. | Heterocyclic compounds as janus kinase inhibitors |
| MX364895B (es) | 2013-03-13 | 2019-05-10 | Forma Therapeutics Inc | Nuevos compuestos y composiciones para la inhibicion de fasn. |
| HUE038820T2 (hu) | 2013-11-13 | 2018-11-28 | Vertex Pharma | Eljárás influenzavírusok replikációjának inhibitorai elõállítására |
| PT3068776T (pt) | 2013-11-13 | 2019-08-26 | Vertex Pharma | Inibidores da replicação de vírus da gripe |
| CN103601678B (zh) * | 2013-11-21 | 2015-02-11 | 爱斯特（成都）医药技术有限公司 | 7-氯-1,2,3,4-四氢苯并[b]氮杂卓-5-酮的合成方法 |
| KR102061390B1 (ko) | 2014-04-17 | 2019-12-31 | 이뮤노메트테라퓨틱스 인코포레이티드 | 구아니딘 화합물 및 그의 용도 |
| WO2016183120A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| EP3294717B1 (en) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Methods of preparing inhibitors of influenza viruses replication |
| WO2017070235A1 (en) * | 2015-10-19 | 2017-04-27 | Attenua, Inc. | Antitussive compositions and methods |
| RS63116B1 (sr) | 2016-05-06 | 2022-05-31 | Shanghai De Novo Pharmatech Co Ltd | Derivat benzazepina, postupak za dobijanje, farmaceutska kompozicija i njegova upotreba |
| CN113382633A (zh) | 2018-10-29 | 2021-09-10 | 福马治疗股份有限公司 | (4-(2-氟-4-(1-甲基-1H-苯并[d]咪唑-5-基)苯甲酰基)哌嗪-1-基)(1-羟基环丙基)甲酮的固体形式 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06172355A (ja) | 1992-04-14 | 1994-06-21 | Mect Corp | ピリミジン誘導体およびそれを有効成分とする血小板凝集阻止剤 |
| DE4332168A1 (de) | 1993-02-22 | 1995-03-23 | Thomae Gmbh Dr K | Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US5686445A (en) * | 1993-07-29 | 1997-11-11 | American Cyanamid Company | Pyridobenzoxazepine and pyridobenzothiazepine vasopressin antagonists |
| US5428040A (en) | 1993-08-31 | 1995-06-27 | The Du Pont Merck Pharmaceutical Company | Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents |
| WO1997047601A1 (en) | 1996-06-11 | 1997-12-18 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused heterocyclic compounds and medicinal uses thereof |
| AU3296497A (en) | 1996-06-13 | 1998-01-07 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| AU5330698A (en) * | 1996-12-23 | 1998-07-17 | Celltech Therapeutics Limited | Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors |
| US6723498B1 (en) | 1999-06-30 | 2004-04-20 | Millennium Pharmaceuticals, Inc. | Chk1 and uses thereof |
| FR2804959B1 (fr) * | 2000-02-15 | 2006-04-28 | Centre Nat Rech Scient | Utilisation de derives de paullones pour la fabrication de medicaments |
| US6369222B1 (en) | 2000-07-18 | 2002-04-09 | Hoffmann-La Roche Inc. | mGluR antagonists and a method for their synthesis |
| US6610677B2 (en) * | 2000-09-15 | 2003-08-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| WO2002088079A2 (en) | 2001-05-01 | 2002-11-07 | Bristol-Myers Squibb Company | Dual inhibitors of pde 7 and pde 4 |
| US7105667B2 (en) | 2001-05-01 | 2006-09-12 | Bristol-Myers Squibb Co. | Fused heterocyclic compounds and use thereof |
| US6686352B2 (en) * | 2001-05-18 | 2004-02-03 | Hoffmann-La Roche Inc. | Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives |
| AU2003242252A1 (en) | 2002-06-07 | 2003-12-22 | Kyowa Hakko Kogyo Co., Ltd. | Bicyclic pyrimidine derivatives |
| PL378116A1 (pl) * | 2003-02-27 | 2006-03-06 | Abbott Laboratories | Heterocykliczne inhibitory kinazy |
| ES2331245T3 (es) | 2003-07-21 | 2009-12-28 | Pfizer Products Inc. | Compuestos azapoliciclicos condensados con heteroarilo que reducen la adiccion a la nicotina. |
| CN1897950A (zh) | 2003-10-14 | 2007-01-17 | 惠氏公司 | 稠合芳基和杂芳基衍生物及其使用方法 |
| KR101792651B1 (ko) * | 2004-05-14 | 2017-11-20 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 아우로라 키나아제의 억제에 의해 유사분열 진행을 억제하기 위한 화합물 및 그 화합물을 포함하는 약학적 조성물 |
| EP1799684B1 (en) | 2004-10-04 | 2014-12-03 | Millennium Pharmaceuticals, Inc. | Lactam compounds useful as protein kinase inhibitors |
| PE20070171A1 (es) | 2005-06-30 | 2007-03-08 | Boehringer Ingelheim Int | GLICINAMIDAS SUSTITUIDAS CON EFECTO ANTITROMBOTICO E INHIBIDOR DEL FACTOR Xa |
| US7998952B2 (en) * | 2008-12-05 | 2011-08-16 | Millennium Pharmaceuticals, Inc. | Thiolactams and uses thereof |
-
2005
- 2005-10-03 EP EP05812472.8A patent/EP1799684B1/en not_active Expired - Lifetime
- 2005-10-03 CN CN2012102393383A patent/CN102766142A/zh active Pending
- 2005-10-03 AU AU2005294575A patent/AU2005294575B2/en not_active Ceased
- 2005-10-03 US US11/242,413 patent/US7459448B2/en not_active Expired - Lifetime
- 2005-10-03 JP JP2007534851A patent/JP5002460B2/ja not_active Expired - Fee Related
- 2005-10-03 EP EP11182921A patent/EP2439207A1/en not_active Withdrawn
- 2005-10-03 CA CA002582235A patent/CA2582235A1/en not_active Abandoned
- 2005-10-03 WO PCT/US2005/035458 patent/WO2006041773A2/en not_active Ceased
- 2005-10-03 CN CN2005800414294A patent/CN101068815B/zh not_active Expired - Fee Related
-
2008
- 2008-09-04 US US12/231,661 patent/US7935694B2/en not_active Expired - Lifetime
-
2010
- 2010-10-13 US US12/903,370 patent/US20110039820A1/en not_active Abandoned
-
2012
- 2012-02-01 JP JP2012019746A patent/JP2012092143A/ja not_active Withdrawn
- 2012-03-14 US US13/419,663 patent/US20120178739A1/en not_active Abandoned
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