JP2008507547A5 - - Google Patents
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- Publication number
- JP2008507547A5 JP2008507547A5 JP2007522763A JP2007522763A JP2008507547A5 JP 2008507547 A5 JP2008507547 A5 JP 2008507547A5 JP 2007522763 A JP2007522763 A JP 2007522763A JP 2007522763 A JP2007522763 A JP 2007522763A JP 2008507547 A5 JP2008507547 A5 JP 2008507547A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- purine
- yield
- methyl
- scheme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C1*)OC(*)C(C2*)C12F Chemical compound CC(C1*)OC(*)C(C2*)C12F 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58986604P | 2004-07-21 | 2004-07-21 | |
| US60/589,866 | 2004-07-21 | ||
| US60823004P | 2004-09-09 | 2004-09-09 | |
| US60/608,230 | 2004-09-09 | ||
| PCT/US2005/025916 WO2006012440A2 (en) | 2004-07-21 | 2005-07-21 | Preparation of alkyl-substituted 2-deoxy-2-fluoro-d-ribofuranosyl pyrimidines and purines and their derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011061926A Division JP5351919B2 (ja) | 2004-07-21 | 2011-03-22 | アルキル置換された２−デオキシ−２−フルオロ−ｄ−リボフラノシルピリミジン類及びプリン類及びそれらの誘導体の調製 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2008507547A JP2008507547A (ja) | 2008-03-13 |
| JP2008507547A5 true JP2008507547A5 (https=) | 2011-07-14 |
| JP2008507547A6 JP2008507547A6 (ja) | 2011-09-01 |
| JP5078612B2 JP5078612B2 (ja) | 2012-11-21 |
Family
ID=35786706
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007522763A Expired - Lifetime JP5078612B2 (ja) | 2004-07-21 | 2005-07-21 | アルキル置換された２−デオキシ−２−フルオロ−ｄ−リボフラノシルピリミジン類及びプリン類及びそれらの誘導体の調製 |
| JP2011061926A Expired - Lifetime JP5351919B2 (ja) | 2004-07-21 | 2011-03-22 | アルキル置換された２−デオキシ−２−フルオロ−ｄ−リボフラノシルピリミジン類及びプリン類及びそれらの誘導体の調製 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011061926A Expired - Lifetime JP5351919B2 (ja) | 2004-07-21 | 2011-03-22 | アルキル置換された２−デオキシ−２−フルオロ−ｄ−リボフラノシルピリミジン類及びプリン類及びそれらの誘導体の調製 |
Country Status (16)
| Country | Link |
|---|---|
| EP (2) | EP2348029A1 (https=) |
| JP (2) | JP5078612B2 (https=) |
| KR (2) | KR101236669B1 (https=) |
| CN (1) | CN102199181B (https=) |
| AT (1) | ATE543789T1 (https=) |
| AU (2) | AU2005267051B2 (https=) |
| CA (2) | CA2574651C (https=) |
| DK (1) | DK1773856T3 (https=) |
| ES (1) | ES2386005T3 (https=) |
| IL (2) | IL180832A (https=) |
| MX (1) | MX2007000803A (https=) |
| NZ (1) | NZ552927A (https=) |
| PL (1) | PL1773856T3 (https=) |
| PT (1) | PT1773856E (https=) |
| RU (1) | RU2407747C2 (https=) |
| WO (1) | WO2006012440A2 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| EP1736478B1 (en) | 2000-05-26 | 2015-07-22 | IDENIX Pharmaceuticals, Inc. | Methods and compositions for treating flaviviruses and pestiviruses |
| US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| CN1678326A (zh) | 2002-06-28 | 2005-10-05 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2'－c－甲基－3'－o－l－缬氨酸酯核糖呋喃基胞苷 |
| NZ537662A (en) | 2002-06-28 | 2007-10-26 | Idenix Cayman Ltd | 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| LT1576138T (lt) | 2002-11-15 | 2017-06-26 | Idenix Pharmaceuticals Llc | 2`-šakoti nukleozidai derinyje su interferonu ir flaviviridae mutacija |
| AU2003300901A1 (en) | 2002-12-12 | 2004-06-30 | Idenix (Cayman) Limited | Process for the production of 2'-branched nucleosides |
| HUE029877T2 (en) | 2003-05-30 | 2017-04-28 | Gilead Pharmasset Llc | Modified fluorinated nucleoside analogues |
| CN101023094B (zh) | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
| US8492539B2 (en) * | 2004-09-14 | 2013-07-23 | Gilead Pharmasset Llc | Preparation of 2′-fluoro-2′-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives |
| KR101057239B1 (ko) * | 2006-10-10 | 2011-08-16 | 에프. 호프만-라 로슈 아게 | 뉴클레오사이드 리보푸라노실 피리미딘의 제조 |
| ATE542810T1 (de) * | 2006-12-18 | 2012-02-15 | Hoffmann La Roche | Verfahren zur herstellung von 3,5-di-omikron-acyl-2-fluor-2-c-methyl-d-ribono gamma-lacton |
| US20080261913A1 (en) | 2006-12-28 | 2008-10-23 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of liver disorders |
| WO2008090046A1 (en) * | 2007-01-23 | 2008-07-31 | F. Hoffmann-La Roche Ag | Alternate process for preparing 3,5-di-omicron-acyl-2-fluoro-2-c-methyl-d-ribono-gamma-lactone |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| PA8855601A1 (es) | 2008-12-23 | 2010-07-27 | Forformidatos de nucleósidos | |
| NZ593649A (en) | 2008-12-23 | 2013-11-29 | Gilead Pharmasset Llc | Nucleoside analogs |
| AU2009329872B2 (en) * | 2008-12-23 | 2016-07-07 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| TWI583692B (zh) | 2009-05-20 | 2017-05-21 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| SG184324A1 (en) | 2010-03-31 | 2012-11-29 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| JP5716500B2 (ja) | 2010-06-03 | 2015-05-13 | セントラル硝子株式会社 | （２Ｒ）−２−フルオロ−２−Ｃ−メチル−Ｄ−リボノ−γ−ラクトン類前駆体の製造方法 |
| CA2818853A1 (en) | 2010-11-30 | 2012-06-07 | Gilead Pharmasset Llc | 2'-spirocyclo-nucleosides for use in therapy of hcv or dengue virus |
| US9243025B2 (en) | 2011-03-31 | 2016-01-26 | Idenix Pharmaceuticals, Llc | Compounds and pharmaceutical compositions for the treatment of viral infections |
| US8877733B2 (en) | 2011-04-13 | 2014-11-04 | Gilead Sciences, Inc. | 1′-substituted pyrimidine N-nucleoside analogs for antiviral treatment |
| EP2709613B2 (en) | 2011-09-16 | 2020-08-12 | Gilead Pharmasset LLC | Methods for treating hcv |
| US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
| EP2950786B1 (en) | 2013-01-31 | 2019-11-27 | Gilead Pharmasset LLC | Combination formulation of two antiviral compounds |
| JP6394588B2 (ja) * | 2013-02-28 | 2018-09-26 | セントラル硝子株式会社 | （２Ｒ）−２−フルオロ−２−Ｃ−メチル−Ｄ−リボノ−γ−ラクトンの製造方法 |
| JP6476591B2 (ja) * | 2013-06-05 | 2019-03-06 | セントラル硝子株式会社 | （２Ｒ）−２−フルオロ−２−Ｃ−メチル−Ｄ−リボノ−γ−ラクトン類の製造方法 |
| PT3038601T (pt) | 2013-08-27 | 2020-06-30 | Gilead Pharmasset Llc | Formulação combinada de dois compostos antivirais |
| WO2015097605A1 (en) * | 2013-12-23 | 2015-07-02 | Mylan Laboratories Ltd. | Process for the preparation of sofosbuvir |
| WO2016035006A1 (en) * | 2014-09-01 | 2016-03-10 | Dr. Reddy’S Laboratories Limited | Novel nucleotide analogs, process for the preparation of sofosbuvir and its analogs, novel forms of sofosbuvir and solid dispersion of sofosbuvir |
| WO2016042576A1 (en) | 2014-09-16 | 2016-03-24 | Cadila Healthcare Limited | Co-crystal of sofosbuvir and amino acid and process for preparation thereof |
| CN104327138B (zh) * | 2014-10-21 | 2017-05-10 | 齐鲁制药有限公司 | Psi‑7977中间体化合物的制备方法 |
| USD791845S1 (en) | 2015-09-22 | 2017-07-11 | Samsung Electronics Co., Ltd. | Door guard for refrigerator |
| USD791200S1 (en) | 2015-09-24 | 2017-07-04 | Samsung Electronics Co., Ltd. | Door guard for refrigerator |
| US10239910B2 (en) | 2016-07-20 | 2019-03-26 | Optimus Drugs (P) Limited | Process for the preparation of sofosbuvir |
| CN109422710B (zh) * | 2017-08-28 | 2022-06-21 | 常州制药厂有限公司 | 一种索非布韦氟内酯中间体的制备方法 |
| CN111362989B (zh) * | 2020-03-19 | 2022-03-08 | 江苏工程职业技术学院 | 一种索非布韦关键中间体的制备方法 |
| WO2021202669A2 (en) | 2020-04-01 | 2021-10-07 | Reyoung Corporation | Nucleoside and nucleotide conjugate compounds and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5A (en) * | 1836-08-10 | Thomas Blanchard | Machine for mortising solid wooden shells of ships' tackle-blocks | |
| US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
| YU25500A (sh) * | 1999-05-11 | 2003-08-29 | Pfizer Products Inc. | Postupak za sintezu analoga nukleozida |
| US6462191B1 (en) * | 2000-07-13 | 2002-10-08 | Air Products And Chemicals, Inc. | Synthesis of 2-deoxy-2-fluoro-arabinose derivatives |
| SK286630B6 (sk) * | 2001-01-22 | 2009-02-05 | Merck & Co., Inc. | Nukleozidové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie |
| EP1556399A4 (en) * | 2002-07-16 | 2007-09-26 | Merck & Co Inc | Nucleoside derivatives as inhibitors of RNA-dependent viral RNA polymerase |
| HUE029877T2 (en) * | 2003-05-30 | 2017-04-28 | Gilead Pharmasset Llc | Modified fluorinated nucleoside analogues |
-
2005
- 2005-07-21 EP EP11159814A patent/EP2348029A1/en not_active Withdrawn
- 2005-07-21 CN CN201110079046.3A patent/CN102199181B/zh not_active Expired - Lifetime
- 2005-07-21 KR KR1020077003980A patent/KR101236669B1/ko not_active Expired - Lifetime
- 2005-07-21 WO PCT/US2005/025916 patent/WO2006012440A2/en not_active Ceased
- 2005-07-21 DK DK05775359.2T patent/DK1773856T3/da active
- 2005-07-21 NZ NZ552927A patent/NZ552927A/en not_active IP Right Cessation
- 2005-07-21 ES ES05775359T patent/ES2386005T3/es not_active Expired - Lifetime
- 2005-07-21 JP JP2007522763A patent/JP5078612B2/ja not_active Expired - Lifetime
- 2005-07-21 PL PL05775359T patent/PL1773856T3/pl unknown
- 2005-07-21 AT AT05775359T patent/ATE543789T1/de active
- 2005-07-21 EP EP05775359A patent/EP1773856B1/en not_active Expired - Lifetime
- 2005-07-21 CA CA2574651A patent/CA2574651C/en not_active Expired - Lifetime
- 2005-07-21 CA CA2735079A patent/CA2735079C/en not_active Expired - Lifetime
- 2005-07-21 KR KR1020117006244A patent/KR101235548B1/ko not_active Expired - Lifetime
- 2005-07-21 RU RU2007106574/04A patent/RU2407747C2/ru not_active IP Right Cessation
- 2005-07-21 MX MX2007000803A patent/MX2007000803A/es active IP Right Grant
- 2005-07-21 AU AU2005267051A patent/AU2005267051B2/en not_active Expired
- 2005-07-21 PT PT05775359T patent/PT1773856E/pt unknown
-
2007
- 2007-01-21 IL IL180832A patent/IL180832A/en not_active IP Right Cessation
-
2011
- 2011-03-03 AU AU2011200941A patent/AU2011200941C1/en not_active Expired
- 2011-03-07 IL IL211606A patent/IL211606A0/en not_active IP Right Cessation
- 2011-03-22 JP JP2011061926A patent/JP5351919B2/ja not_active Expired - Lifetime
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