KR101236669B1 - 알킬-치환된 2-데옥시-2-플루오로-ｄ-리보퓨라노실피리미딘 및 퓨린 및 그 유도체의 제조 - Google Patents

알킬-치환된 2-데옥시-2-플루오로-ｄ-리보퓨라노실피리미딘 및 퓨린 및 그 유도체의 제조 Download PDF

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Publication number
KR101236669B1
KR101236669B1 KR1020077003980A KR20077003980A KR101236669B1 KR 101236669 B1 KR101236669 B1 KR 101236669B1 KR 1020077003980 A KR1020077003980 A KR 1020077003980A KR 20077003980 A KR20077003980 A KR 20077003980A KR 101236669 B1 KR101236669 B1 KR 101236669B1
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alkyl
formula
trityl
independently
benzyl
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KR20070114344A (ko
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페이유안 왕
우즈시에취 스텍
천병권
중싱 쉬
진파 두
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길리어드 파마셋 엘엘씨
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Assigned to 길리애드 사이언시즈, 인코포레이티드 reassignment 길리애드 사이언시즈, 인코포레이티드 권리의 전부이전등록 Assignors: 길리어드 파마셋 엘엘씨
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020077003980A 2004-07-21 2005-07-21 알킬-치환된 2-데옥시-2-플루오로-ｄ-리보퓨라노실피리미딘 및 퓨린 및 그 유도체의 제조 Expired - Lifetime KR101236669B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US58986604P 2004-07-21 2004-07-21
US60/589,866 2004-07-21
US60823004P 2004-09-09 2004-09-09
US60/608,320 2004-09-09
PCT/US2005/025916 WO2006012440A2 (en) 2004-07-21 2005-07-21 Preparation of alkyl-substituted 2-deoxy-2-fluoro-d-ribofuranosyl pyrimidines and purines and their derivatives

Related Child Applications (1)

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KR1020117006244A Division KR101235548B1 (ko) 2004-07-21 2005-07-21 2'-데옥시-2'-플루오로-2'-Ｃ-메틸-β-Ｄ-리보퓨라노실 뉴클레오사이드의 제조 방법

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KR20070114344A KR20070114344A (ko) 2007-12-03
KR101236669B1 true KR101236669B1 (ko) 2013-02-22

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KR1020117006244A Expired - Lifetime KR101235548B1 (ko) 2004-07-21 2005-07-21 2'-데옥시-2'-플루오로-2'-Ｃ-메틸-β-Ｄ-리보퓨라노실 뉴클레오사이드의 제조 방법

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EP (2) EP1773856B1 (https=)
JP (2) JP5078612B2 (https=)
KR (2) KR101236669B1 (https=)
CN (1) CN102199181B (https=)
AT (1) ATE543789T1 (https=)
AU (2) AU2005267051B2 (https=)
CA (2) CA2574651C (https=)
DK (1) DK1773856T3 (https=)
ES (1) ES2386005T3 (https=)
IL (2) IL180832A (https=)
MX (1) MX2007000803A (https=)
NZ (1) NZ552927A (https=)
PL (1) PL1773856T3 (https=)
PT (1) PT1773856E (https=)
RU (1) RU2407747C2 (https=)
WO (1) WO2006012440A2 (https=)

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IL180832A0 (en) 2007-06-03
WO2006012440A3 (en) 2006-07-27
JP5351919B2 (ja) 2013-11-27
CN102199181A (zh) 2011-09-28
ES2386005T3 (es) 2012-08-07
MX2007000803A (es) 2007-04-02
EP2348029A1 (en) 2011-07-27
HK1106249A1 (en) 2008-03-07
NZ552927A (en) 2010-05-28
KR20070114344A (ko) 2007-12-03
JP2008507547A (ja) 2008-03-13
CA2574651C (en) 2013-05-21
RU2407747C2 (ru) 2010-12-27
AU2011200941B2 (en) 2011-11-24
CA2735079C (en) 2013-11-05
JP5078612B2 (ja) 2012-11-21
EP1773856A2 (en) 2007-04-18
DK1773856T3 (da) 2012-05-21
IL180832A (en) 2011-07-31
RU2007106574A (ru) 2008-08-27
CN102199181B (zh) 2014-09-17
WO2006012440A2 (en) 2006-02-02
JP2011148817A (ja) 2011-08-04
WO2006012440A8 (en) 2011-06-16
ATE543789T1 (de) 2012-02-15
PL1773856T3 (pl) 2013-01-31
PT1773856E (pt) 2012-05-14
AU2005267051B2 (en) 2011-07-14
CA2735079A1 (en) 2006-02-02
AU2011200941C1 (en) 2012-05-10
CA2574651A1 (en) 2006-02-02
AU2005267051A1 (en) 2006-02-02
KR20110034699A (ko) 2011-04-05
IL211606A0 (en) 2011-05-31
AU2011200941A1 (en) 2011-03-24
EP1773856A4 (en) 2010-10-13
KR101235548B1 (ko) 2013-02-21
EP1773856B1 (en) 2012-02-01

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