JP5078612B2 - アルキル置換された２−デオキシ−２−フルオロ−ｄ−リボフラノシルピリミジン類及びプリン類及びそれらの誘導体の調製 - Google Patents

アルキル置換された２−デオキシ−２−フルオロ−ｄ−リボフラノシルピリミジン類及びプリン類及びそれらの誘導体の調製 Download PDF

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JP5078612B2
JP5078612B2 JP2007522763A JP2007522763A JP5078612B2 JP 5078612 B2 JP5078612 B2 JP 5078612B2 JP 2007522763 A JP2007522763 A JP 2007522763A JP 2007522763 A JP2007522763 A JP 2007522763A JP 5078612 B2 JP5078612 B2 JP 5078612B2
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compound
alkyl
substituted
independently
benzyl
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JP2008507547A5 (https=
JP2008507547A (ja
JP2008507547A6 (ja
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ペイユアン ワン，
ヴォイチェハ ステック，
ビョン−クォン チュン，
ジュンジング シ，
ジンファ デュ，
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ギリアド ファーマセット エルエルシー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2007522763A 2004-07-21 2005-07-21 アルキル置換された２−デオキシ−２−フルオロ−ｄ−リボフラノシルピリミジン類及びプリン類及びそれらの誘導体の調製 Expired - Lifetime JP5078612B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US58986604P 2004-07-21 2004-07-21
US60/589,866 2004-07-21
US60823004P 2004-09-09 2004-09-09
US60/608,230 2004-09-09
PCT/US2005/025916 WO2006012440A2 (en) 2004-07-21 2005-07-21 Preparation of alkyl-substituted 2-deoxy-2-fluoro-d-ribofuranosyl pyrimidines and purines and their derivatives

Related Child Applications (1)

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JP2011061926A Division JP5351919B2 (ja) 2004-07-21 2011-03-22 アルキル置換された２−デオキシ−２−フルオロ−ｄ−リボフラノシルピリミジン類及びプリン類及びそれらの誘導体の調製

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JP2008507547A JP2008507547A (ja) 2008-03-13
JP2008507547A5 JP2008507547A5 (https=) 2011-07-14
JP2008507547A6 JP2008507547A6 (ja) 2011-09-01
JP5078612B2 true JP5078612B2 (ja) 2012-11-21

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JP2011061926A Expired - Lifetime JP5351919B2 (ja) 2004-07-21 2011-03-22 アルキル置換された２−デオキシ−２−フルオロ−ｄ−リボフラノシルピリミジン類及びプリン類及びそれらの誘導体の調製

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EP (2) EP1773856B1 (https=)
JP (2) JP5078612B2 (https=)
KR (2) KR101236669B1 (https=)
CN (1) CN102199181B (https=)
AT (1) ATE543789T1 (https=)
AU (2) AU2005267051B2 (https=)
CA (2) CA2574651C (https=)
DK (1) DK1773856T3 (https=)
ES (1) ES2386005T3 (https=)
IL (2) IL180832A (https=)
MX (1) MX2007000803A (https=)
NZ (1) NZ552927A (https=)
PL (1) PL1773856T3 (https=)
PT (1) PT1773856E (https=)
RU (1) RU2407747C2 (https=)
WO (1) WO2006012440A2 (https=)

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Publication number Publication date
IL180832A0 (en) 2007-06-03
WO2006012440A3 (en) 2006-07-27
JP5351919B2 (ja) 2013-11-27
CN102199181A (zh) 2011-09-28
ES2386005T3 (es) 2012-08-07
MX2007000803A (es) 2007-04-02
EP2348029A1 (en) 2011-07-27
HK1106249A1 (en) 2008-03-07
NZ552927A (en) 2010-05-28
KR20070114344A (ko) 2007-12-03
JP2008507547A (ja) 2008-03-13
CA2574651C (en) 2013-05-21
RU2407747C2 (ru) 2010-12-27
AU2011200941B2 (en) 2011-11-24
CA2735079C (en) 2013-11-05
EP1773856A2 (en) 2007-04-18
DK1773856T3 (da) 2012-05-21
IL180832A (en) 2011-07-31
RU2007106574A (ru) 2008-08-27
CN102199181B (zh) 2014-09-17
WO2006012440A2 (en) 2006-02-02
JP2011148817A (ja) 2011-08-04
WO2006012440A8 (en) 2011-06-16
ATE543789T1 (de) 2012-02-15
PL1773856T3 (pl) 2013-01-31
PT1773856E (pt) 2012-05-14
AU2005267051B2 (en) 2011-07-14
CA2735079A1 (en) 2006-02-02
AU2011200941C1 (en) 2012-05-10
KR101236669B1 (ko) 2013-02-22
CA2574651A1 (en) 2006-02-02
AU2005267051A1 (en) 2006-02-02
KR20110034699A (ko) 2011-04-05
IL211606A0 (en) 2011-05-31
AU2011200941A1 (en) 2011-03-24
EP1773856A4 (en) 2010-10-13
KR101235548B1 (ko) 2013-02-21
EP1773856B1 (en) 2012-02-01

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