ATE543789T1 - Herstellung von alkylsubstituierten 2-desoxy-2- fluor-d-ribofuranosylpyrimidinen und -purinen und derivaten davon - Google Patents
Herstellung von alkylsubstituierten 2-desoxy-2- fluor-d-ribofuranosylpyrimidinen und -purinen und derivaten davonInfo
- Publication number
- ATE543789T1 ATE543789T1 AT05775359T AT05775359T ATE543789T1 AT E543789 T1 ATE543789 T1 AT E543789T1 AT 05775359 T AT05775359 T AT 05775359T AT 05775359 T AT05775359 T AT 05775359T AT E543789 T1 ATE543789 T1 AT E543789T1
- Authority
- AT
- Austria
- Prior art keywords
- ribofuranosylpyrimidines
- fluorod
- desoxy
- purines
- derivatives
- Prior art date
Links
- 150000003212 purines Chemical class 0.000 title 1
- 239000002777 nucleoside Substances 0.000 abstract 3
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58986604P | 2004-07-21 | 2004-07-21 | |
| US60823004P | 2004-09-09 | 2004-09-09 | |
| PCT/US2005/025916 WO2006012440A2 (en) | 2004-07-21 | 2005-07-21 | Preparation of alkyl-substituted 2-deoxy-2-fluoro-d-ribofuranosyl pyrimidines and purines and their derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE543789T1 true ATE543789T1 (de) | 2012-02-15 |
Family
ID=35786706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05775359T ATE543789T1 (de) | 2004-07-21 | 2005-07-21 | Herstellung von alkylsubstituierten 2-desoxy-2- fluor-d-ribofuranosylpyrimidinen und -purinen und derivaten davon |
Country Status (16)
| Country | Link |
|---|---|
| EP (2) | EP1773856B1 (de) |
| JP (2) | JP5078612B2 (de) |
| KR (2) | KR101235548B1 (de) |
| CN (1) | CN102199181B (de) |
| AT (1) | ATE543789T1 (de) |
| AU (2) | AU2005267051B2 (de) |
| CA (2) | CA2574651C (de) |
| DK (1) | DK1773856T3 (de) |
| ES (1) | ES2386005T3 (de) |
| IL (2) | IL180832A (de) |
| MX (1) | MX2007000803A (de) |
| NZ (1) | NZ552927A (de) |
| PL (1) | PL1773856T3 (de) |
| PT (1) | PT1773856E (de) |
| RU (1) | RU2407747C2 (de) |
| WO (1) | WO2006012440A2 (de) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| PL359169A1 (en) | 2000-05-26 | 2004-08-23 | Idenix (Cayman) Limited | Methods and compositions for treating flaviviruses and pestiviruses |
| KR20050035194A (ko) | 2002-06-28 | 2005-04-15 | 이데닉스 (케이만) 리미티드 | 플라비비리다에 감염 치료용 2'-ｃ-메틸-3'-ｏ-ｌ-발린에스테르 리보푸라노실 사이티딘 |
| CN101172993A (zh) | 2002-06-28 | 2008-05-07 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷 |
| US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| AU2003298658A1 (en) | 2002-11-15 | 2004-06-15 | Idenix (Cayman) Limited | 2'-branched nucleosides and flaviviridae mutation |
| US7598373B2 (en) | 2002-12-12 | 2009-10-06 | Idenix Pharmaceuticals, Inc. | Process for the production of 2-C-methyl-D-ribonolactone |
| RU2358979C2 (ru) | 2003-05-30 | 2009-06-20 | Фармассет, Инк. | Модифицированные фторированные аналоги нуклеозида |
| CN101023094B (zh) | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
| ES2725457T3 (es) * | 2004-09-14 | 2019-09-24 | Gilead Pharmasset Llc | Preparación de ribofuranosil pirimidinas y purinas 2'fluoro-2'-alquil-sustituidas u otras opcionalmente sustituidas y sus derivados |
| WO2008045419A1 (en) * | 2006-10-10 | 2008-04-17 | Pharmasset, Inc. | Preparation of nucleosides ribofuranosyl pyrimidines |
| CN101573349B (zh) * | 2006-12-18 | 2013-07-10 | 弗·哈夫曼-拉罗切有限公司 | 制备3,5-二-o-酰基-2-氟-2-C-甲基-D-核糖酸-γ-内酯的方法 |
| US7951789B2 (en) | 2006-12-28 | 2011-05-31 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
| WO2008090046A1 (en) * | 2007-01-23 | 2008-07-31 | F. Hoffmann-La Roche Ag | Alternate process for preparing 3,5-di-omicron-acyl-2-fluoro-2-c-methyl-d-ribono-gamma-lactone |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| MX2011006890A (es) | 2008-12-23 | 2011-07-20 | Pharmasset Inc | Analogos de nucleosidos. |
| AR074897A1 (es) | 2008-12-23 | 2011-02-23 | Pharmasset Inc | Fosforamidatos de nucleosidos |
| CL2009002206A1 (es) * | 2008-12-23 | 2011-08-26 | Gilead Pharmasset Llc | Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales. |
| TWI576352B (zh) | 2009-05-20 | 2017-04-01 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| AP2012006535A0 (en) | 2010-03-31 | 2012-10-31 | Gilead Pharmasset Llc | Stereoselective synthesis of phosphorous containing actives |
| JP5716500B2 (ja) | 2010-06-03 | 2015-05-13 | セントラル硝子株式会社 | （２Ｒ）−２−フルオロ−２−Ｃ−メチル−Ｄ−リボノ−γ−ラクトン類前駆体の製造方法 |
| ES2716158T3 (es) | 2010-11-30 | 2019-06-10 | Gilead Pharmasset Llc | 2'-spiro-nucleótidos para el tratamiento de hepatitis C |
| US9243025B2 (en) | 2011-03-31 | 2016-01-26 | Idenix Pharmaceuticals, Llc | Compounds and pharmaceutical compositions for the treatment of viral infections |
| EP2697241B1 (de) | 2011-04-13 | 2019-06-12 | Gilead Sciences, Inc. | 1'-substituierte pyrimidin-nukleosidanaloga für antivirale behandlung |
| HRP20180237T4 (hr) | 2011-09-16 | 2020-12-11 | Gilead Pharmasset Llc | Metode za liječenje hcv-a |
| US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
| EP2950786B1 (de) | 2013-01-31 | 2019-11-27 | Gilead Pharmasset LLC | Kombinationsformulierung zweier antiviraler verbindungen |
| CN105026382B (zh) * | 2013-02-28 | 2016-10-19 | 中央硝子株式会社 | (2R)-2-氟-2-C-甲基-D-核糖酸-γ-内酯的制造方法 |
| JP6476591B2 (ja) * | 2013-06-05 | 2019-03-06 | セントラル硝子株式会社 | （２Ｒ）−２−フルオロ−２−Ｃ−メチル−Ｄ−リボノ−γ−ラクトン類の製造方法 |
| EA201690473A1 (ru) | 2013-08-27 | 2017-03-31 | ГАЙЛИД ФАРМАССЕТ ЭлЭлСи | Комбинированный состав двух противовирусных соединений |
| WO2015097605A1 (en) * | 2013-12-23 | 2015-07-02 | Mylan Laboratories Ltd. | Process for the preparation of sofosbuvir |
| WO2016035006A1 (en) * | 2014-09-01 | 2016-03-10 | Dr. Reddy’S Laboratories Limited | Novel nucleotide analogs, process for the preparation of sofosbuvir and its analogs, novel forms of sofosbuvir and solid dispersion of sofosbuvir |
| WO2016042576A1 (en) | 2014-09-16 | 2016-03-24 | Cadila Healthcare Limited | Co-crystal of sofosbuvir and amino acid and process for preparation thereof |
| CN104327138B (zh) * | 2014-10-21 | 2017-05-10 | 齐鲁制药有限公司 | Psi‑7977中间体化合物的制备方法 |
| USD791845S1 (en) | 2015-09-22 | 2017-07-11 | Samsung Electronics Co., Ltd. | Door guard for refrigerator |
| USD791200S1 (en) | 2015-09-24 | 2017-07-04 | Samsung Electronics Co., Ltd. | Door guard for refrigerator |
| US10239910B2 (en) | 2016-07-20 | 2019-03-26 | Optimus Drugs (P) Limited | Process for the preparation of sofosbuvir |
| CN109422710B (zh) * | 2017-08-28 | 2022-06-21 | 常州制药厂有限公司 | 一种索非布韦氟内酯中间体的制备方法 |
| CN111362989B (zh) * | 2020-03-19 | 2022-03-08 | 江苏工程职业技术学院 | 一种索非布韦关键中间体的制备方法 |
| WO2021202669A2 (en) | 2020-04-01 | 2021-10-07 | Reyoung Corporation | Nucleoside and nucleotide conjugate compounds and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5A (en) * | 1836-08-10 | Thomas Blanchard | Machine for mortising solid wooden shells of ships' tackle-blocks | |
| US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
| YU25500A (sh) * | 1999-05-11 | 2003-08-29 | Pfizer Products Inc. | Postupak za sintezu analoga nukleozida |
| US6462191B1 (en) * | 2000-07-13 | 2002-10-08 | Air Products And Chemicals, Inc. | Synthesis of 2-deoxy-2-fluoro-arabinose derivatives |
| MXPA03006514A (es) * | 2001-01-22 | 2004-12-02 | Merck & Co Inc | Derivados de nucleosidos como inhibidores de polimerasa de acido ribonucleico viral dependiente de acido ribonucleico. |
| EP1556399A4 (de) * | 2002-07-16 | 2007-09-26 | Merck & Co Inc | Nukleosidderivate als inhibitoren von rna-abhängiger viraler rna-polymerase |
| RU2358979C2 (ru) * | 2003-05-30 | 2009-06-20 | Фармассет, Инк. | Модифицированные фторированные аналоги нуклеозида |
-
2005
- 2005-07-21 ES ES05775359T patent/ES2386005T3/es not_active Expired - Lifetime
- 2005-07-21 KR KR1020117006244A patent/KR101235548B1/ko not_active Expired - Lifetime
- 2005-07-21 WO PCT/US2005/025916 patent/WO2006012440A2/en not_active Ceased
- 2005-07-21 EP EP05775359A patent/EP1773856B1/de not_active Expired - Lifetime
- 2005-07-21 DK DK05775359.2T patent/DK1773856T3/da active
- 2005-07-21 CA CA2574651A patent/CA2574651C/en not_active Expired - Lifetime
- 2005-07-21 AT AT05775359T patent/ATE543789T1/de active
- 2005-07-21 CN CN201110079046.3A patent/CN102199181B/zh not_active Expired - Lifetime
- 2005-07-21 JP JP2007522763A patent/JP5078612B2/ja not_active Expired - Lifetime
- 2005-07-21 RU RU2007106574/04A patent/RU2407747C2/ru not_active IP Right Cessation
- 2005-07-21 MX MX2007000803A patent/MX2007000803A/es active IP Right Grant
- 2005-07-21 EP EP11159814A patent/EP2348029A1/de not_active Withdrawn
- 2005-07-21 PL PL05775359T patent/PL1773856T3/pl unknown
- 2005-07-21 PT PT05775359T patent/PT1773856E/pt unknown
- 2005-07-21 CA CA2735079A patent/CA2735079C/en not_active Expired - Lifetime
- 2005-07-21 AU AU2005267051A patent/AU2005267051B2/en not_active Expired
- 2005-07-21 KR KR1020077003980A patent/KR101236669B1/ko not_active Expired - Lifetime
- 2005-07-21 NZ NZ552927A patent/NZ552927A/en not_active IP Right Cessation
-
2007
- 2007-01-21 IL IL180832A patent/IL180832A/en not_active IP Right Cessation
-
2011
- 2011-03-03 AU AU2011200941A patent/AU2011200941C1/en not_active Expired
- 2011-03-07 IL IL211606A patent/IL211606A0/en not_active IP Right Cessation
- 2011-03-22 JP JP2011061926A patent/JP5351919B2/ja not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1773856T3 (da) | Fremstilling af alkylsubstituerede 2-desoxy-2-fluor-D-ribofuranosylpyrimidiner og -puriner og derivater deraf | |
| DK1343782T3 (da) | Pyrimidinaminer som angiogenesemodulatorer | |
| ATE490788T1 (de) | Antivirale phosphonate analoge | |
| UY27143A1 (es) | Inhibidores de sulfonamida lactama de fxa y método | |
| DE60321662D1 (de) | Für die zementierung von bohrlöchern | |
| EP1638993A4 (de) | Immunmodulierende zusammensetzungen, anwendungen davon und verfahren zu deren herstellung | |
| MXPA03010134A (es) | Derivados de ciclohexan-1-4-diamina sustituidos. | |
| ATE551345T1 (de) | Polymorphe formen des phosphatsalzes von 8-fluor- 2-ä4-ä(methylamino)methylüphenylü-1,3,4,5- tetrahydro-6h-azepinoä5,4,3-cdüindol-6-on | |
| ATE335755T1 (de) | Antivirale nukleosidderivate | |
| NO20052058D0 (no) | Behandling av influensa. | |
| DK1656372T3 (da) | 2,4-pyrimidindiaminforbindelser til anvendelse til behandling eller forebyggelse af autoimmunsygdomme | |
| NO20073055L (no) | Forbindelser til behandling av tilstander i de ovre luftveier | |
| NO20021559L (no) | Fremgangsmåte til gjenvinning av ammoniakk | |
| DE10393276D2 (de) | Mehrachsiger monolithischer Beschleunigungssensor | |
| DE60108042D1 (de) | Prozesse zur Herstellung von pulverförmigen Schlagzäh-Modifizierern | |
| NO20062062L (no) | Procsesser for preparering av forskjellige former for (S)-(+)-clopidogrel bisulfat | |
| MA25927A1 (fr) | Procedes de production de substitues sulfanomide imidacotriazinones | |
| ATE433466T1 (de) | Herstellung von homopolymeren, copolymeren und terpolymeren aus substituierten styrolen | |
| NO20040665L (no) | Produksjon av hydrokarboner. | |
| PL372533A1 (pl) | Sposób wytwarzania miedzi konwertorowej | |
| DK1881830T3 (da) | 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin-derivater til behandling af infertilitet | |
| NO20053205D0 (no) | Forbedret fremgangsmate for produksjon av vitamin B12. | |
| CY1105275T1 (el) | Ενωσεις υποκατεστημενης γ-λακτονης ως ανταγωνισται - νμda | |
| EP1212353A4 (de) | Kleine, zyklische analoge des neurotrophen faktor des gehirns (bdnf) | |
| DK1450786T3 (da) | Isoflavonkoncentrater samt fremgangsmåde til fremstilling deraf |