JP2008505177A - 目の障害および状態を治療するための組成物および方法 - Google Patents
目の障害および状態を治療するための組成物および方法 Download PDFInfo
- Publication number
- JP2008505177A JP2008505177A JP2007520365A JP2007520365A JP2008505177A JP 2008505177 A JP2008505177 A JP 2008505177A JP 2007520365 A JP2007520365 A JP 2007520365A JP 2007520365 A JP2007520365 A JP 2007520365A JP 2008505177 A JP2008505177 A JP 2008505177A
- Authority
- JP
- Japan
- Prior art keywords
- omega
- composition
- fatty acid
- acid
- eye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 199
- 238000000034 method Methods 0.000 title claims abstract description 42
- 208000030533 eye disease Diseases 0.000 title description 3
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims abstract description 76
- 229940012843 omega-3 fatty acid Drugs 0.000 claims abstract description 70
- 235000020665 omega-6 fatty acid Nutrition 0.000 claims abstract description 70
- 229940033080 omega-6 fatty acid Drugs 0.000 claims abstract description 69
- 239000006014 omega-3 oil Substances 0.000 claims abstract description 29
- 238000011282 treatment Methods 0.000 claims abstract description 18
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims description 58
- 206010013774 Dry eye Diseases 0.000 claims description 58
- 239000004094 surface-active agent Substances 0.000 claims description 48
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims description 36
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims description 32
- 239000000243 solution Substances 0.000 claims description 27
- 239000003889 eye drop Substances 0.000 claims description 25
- 238000002360 preparation method Methods 0.000 claims description 25
- 229940012356 eye drops Drugs 0.000 claims description 23
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims description 19
- 238000002156 mixing Methods 0.000 claims description 19
- 235000021342 arachidonic acid Nutrition 0.000 claims description 18
- 229940114079 arachidonic acid Drugs 0.000 claims description 18
- 206010061218 Inflammation Diseases 0.000 claims description 17
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims description 17
- 230000004054 inflammatory process Effects 0.000 claims description 17
- 235000020778 linoleic acid Nutrition 0.000 claims description 17
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims description 17
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims description 16
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims description 16
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims description 16
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims description 16
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims description 16
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 15
- 235000020664 gamma-linolenic acid Nutrition 0.000 claims description 15
- 239000011780 sodium chloride Substances 0.000 claims description 15
- HOBAELRKJCKHQD-UHFFFAOYSA-N (8Z,11Z,14Z)-8,11,14-eicosatrienoic acid Natural products CCCCCC=CCC=CCC=CCCCCCCC(O)=O HOBAELRKJCKHQD-UHFFFAOYSA-N 0.000 claims description 14
- 235000021298 Dihomo-γ-linolenic acid Nutrition 0.000 claims description 14
- HOBAELRKJCKHQD-QNEBEIHSSA-N dihomo-γ-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HOBAELRKJCKHQD-QNEBEIHSSA-N 0.000 claims description 14
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 claims description 13
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 claims description 13
- 229960002733 gamolenic acid Drugs 0.000 claims description 13
- 238000004519 manufacturing process Methods 0.000 claims description 12
- 238000013268 sustained release Methods 0.000 claims description 11
- 239000012730 sustained-release form Substances 0.000 claims description 11
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims description 10
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims description 9
- 229940090949 docosahexaenoic acid Drugs 0.000 claims description 8
- 230000002757 inflammatory effect Effects 0.000 claims description 7
- 229960004488 linolenic acid Drugs 0.000 claims description 7
- -1 omega-3 fatty acid compound Chemical class 0.000 claims description 7
- 230000000699 topical effect Effects 0.000 claims description 6
- HOVAGTYPODGVJG-UVSYOFPXSA-N (3s,5r)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol Chemical class COC1OC(CO)[C@@H](O)C(O)[C@H]1O HOVAGTYPODGVJG-UVSYOFPXSA-N 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical group FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 claims description 4
- 229920001983 poloxamer Polymers 0.000 claims description 4
- 238000011200 topical administration Methods 0.000 claims description 4
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000007972 injectable composition Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 description 55
- 235000014113 dietary fatty acids Nutrition 0.000 description 50
- 229930195729 fatty acid Natural products 0.000 description 50
- 239000000194 fatty acid Substances 0.000 description 50
- 150000004665 fatty acids Chemical class 0.000 description 50
- 210000001508 eye Anatomy 0.000 description 47
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 36
- 238000010186 staining Methods 0.000 description 36
- 239000003981 vehicle Substances 0.000 description 30
- 239000006196 drop Substances 0.000 description 26
- 241000699670 Mus sp. Species 0.000 description 19
- 239000013543 active substance Substances 0.000 description 18
- 238000012360 testing method Methods 0.000 description 18
- 210000004087 cornea Anatomy 0.000 description 15
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 14
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 description 14
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 14
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 14
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 14
- 229960002646 scopolamine Drugs 0.000 description 14
- 230000001965 increasing effect Effects 0.000 description 13
- 238000003756 stirring Methods 0.000 description 13
- 229910052799 carbon Inorganic materials 0.000 description 12
- 235000002639 sodium chloride Nutrition 0.000 description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
- 150000002632 lipids Chemical class 0.000 description 10
- 230000028327 secretion Effects 0.000 description 9
- 239000004615 ingredient Substances 0.000 description 8
- 239000010410 layer Substances 0.000 description 8
- 230000000770 proinflammatory effect Effects 0.000 description 8
- 230000002829 reductive effect Effects 0.000 description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 7
- 229930003427 Vitamin E Natural products 0.000 description 7
- 239000002253 acid Substances 0.000 description 7
- 208000035475 disorder Diseases 0.000 description 7
- 150000002066 eicosanoids Chemical class 0.000 description 7
- 239000000839 emulsion Substances 0.000 description 7
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 7
- 239000002502 liposome Substances 0.000 description 7
- 235000019165 vitamin E Nutrition 0.000 description 7
- 229940046009 vitamin E Drugs 0.000 description 7
- 239000011709 vitamin E Substances 0.000 description 7
- 239000011159 matrix material Substances 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000004372 Polyvinyl alcohol Substances 0.000 description 5
- 150000001721 carbon Chemical group 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 235000004626 essential fatty acids Nutrition 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000002480 mineral oil Substances 0.000 description 5
- 235000010446 mineral oil Nutrition 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 description 5
- 230000004489 tear production Effects 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 102000003777 Interleukin-1 beta Human genes 0.000 description 4
- 108090000193 Interleukin-1 beta Proteins 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 208000021386 Sjogren Syndrome Diseases 0.000 description 4
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 4
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 4
- 235000006708 antioxidants Nutrition 0.000 description 4
- 230000037396 body weight Effects 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 210000000795 conjunctiva Anatomy 0.000 description 4
- 230000003247 decreasing effect Effects 0.000 description 4
- 239000002274 desiccant Substances 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 210000004969 inflammatory cell Anatomy 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 4
- 238000007127 saponification reaction Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 description 3
- 206010010071 Coma Diseases 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 3
- 102000004127 Cytokines Human genes 0.000 description 3
- 108090000695 Cytokines Proteins 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 description 3
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 description 3
- 210000001744 T-lymphocyte Anatomy 0.000 description 3
- 125000001931 aliphatic group Chemical group 0.000 description 3
- 229960000711 alprostadil Drugs 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 239000003550 marker Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 239000004530 micro-emulsion Substances 0.000 description 3
- 239000004005 microsphere Substances 0.000 description 3
- 210000000440 neutrophil Anatomy 0.000 description 3
- 231100000252 nontoxic Toxicity 0.000 description 3
- 230000003000 nontoxic effect Effects 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 3
- 229920000053 polysorbate 80 Polymers 0.000 description 3
- GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 210000003786 sclera Anatomy 0.000 description 3
- 230000004488 tear evaporation Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 description 2
- LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 description 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 2
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 description 2
- 102100034544 Acyl-CoA 6-desaturase Human genes 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- 206010015943 Eye inflammation Diseases 0.000 description 2
- 102000004889 Interleukin-6 Human genes 0.000 description 2
- 108090001005 Interleukin-6 Proteins 0.000 description 2
- 206010023644 Lacrimation increased Diseases 0.000 description 2
- 108010037138 Linoleoyl-CoA Desaturase Proteins 0.000 description 2
- 102000003820 Lipoxygenases Human genes 0.000 description 2
- 108090000128 Lipoxygenases Proteins 0.000 description 2
- 208000029549 Muscle injury Diseases 0.000 description 2
- 208000028389 Nerve injury Diseases 0.000 description 2
- 229920002732 Polyanhydride Polymers 0.000 description 2
- 229920000954 Polyglycolide Polymers 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 208000010217 blepharitis Diseases 0.000 description 2
- 239000003618 borate buffered saline Substances 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000000744 eyelid Anatomy 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000008595 infiltration Effects 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- 229940100601 interleukin-6 Drugs 0.000 description 2
- 230000002262 irrigation Effects 0.000 description 2
- 238000003973 irrigation Methods 0.000 description 2
- 229940113601 irrigation solution Drugs 0.000 description 2
- 206010023332 keratitis Diseases 0.000 description 2
- 201000010666 keratoconjunctivitis Diseases 0.000 description 2
- 230000004317 lacrimation Effects 0.000 description 2
- VNYSSYRCGWBHLG-AMOLWHMGSA-N leukotriene B4 Chemical group CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O VNYSSYRCGWBHLG-AMOLWHMGSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000002540 macrophage Anatomy 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 210000001616 monocyte Anatomy 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000008764 nerve damage Effects 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 2
- 235000019271 petrolatum Nutrition 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 229920000747 poly(lactic acid) Polymers 0.000 description 2
- 229920001610 polycaprolactone Polymers 0.000 description 2
- 239000004632 polycaprolactone Substances 0.000 description 2
- 229920001451 polypropylene glycol Polymers 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 150000003180 prostaglandins Chemical class 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 230000007928 solubilization Effects 0.000 description 2
- 238000005063 solubilization Methods 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 2
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 208000030507 AIDS Diseases 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 102100027211 Albumin Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 241000024188 Andala Species 0.000 description 1
- 206010003591 Ataxia Diseases 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 240000002791 Brassica napus Species 0.000 description 1
- 235000006008 Brassica napus var napus Nutrition 0.000 description 1
- 101150013553 CD40 gene Proteins 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 description 1
- 206010011026 Corneal lesion Diseases 0.000 description 1
- 206010048843 Cytomegalovirus chorioretinitis Diseases 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 208000001730 Familial dysautonomia Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 description 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102100022338 Integrin alpha-M Human genes 0.000 description 1
- STECJAGHUSJQJN-USLFZFAMSA-N LSM-4015 Chemical compound C1([C@@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-USLFZFAMSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 235000004431 Linum usitatissimum Nutrition 0.000 description 1
- 240000006240 Linum usitatissimum Species 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 206010065062 Meibomian gland dysfunction Diseases 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 206010029315 Neuromuscular blockade Diseases 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 241000721454 Pemphigus Species 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 244000234609 Portulaca oleracea Species 0.000 description 1
- 235000001855 Portulaca oleracea Nutrition 0.000 description 1
- 206010036346 Posterior capsule opacification Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 238000010240 RT-PCR analysis Methods 0.000 description 1
- 240000001890 Ribes hudsonianum Species 0.000 description 1
- 235000016954 Ribes hudsonianum Nutrition 0.000 description 1
- 235000001466 Ribes nigrum Nutrition 0.000 description 1
- 201000001638 Riley-Day syndrome Diseases 0.000 description 1
- 235000012377 Salvia columbariae var. columbariae Nutrition 0.000 description 1
- 240000005481 Salvia hispanica Species 0.000 description 1
- 235000001498 Salvia hispanica Nutrition 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 206010042033 Stevens-Johnson syndrome Diseases 0.000 description 1
- 231100000168 Stevens-Johnson syndrome Toxicity 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 description 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 1
- 238000001793 Wilcoxon signed-rank test Methods 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 238000004378 air conditioning Methods 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 150000001298 alcohols Chemical group 0.000 description 1
- 208000002205 allergic conjunctivitis Diseases 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000000607 artificial tear Substances 0.000 description 1
- 208000024998 atopic conjunctivitis Diseases 0.000 description 1
- 206010069664 atopic keratoconjunctivitis Diseases 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 229920000249 biocompatible polymer Polymers 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 description 1
- 235000019577 caloric intake Nutrition 0.000 description 1
- 229940096529 carboxypolymethylene Drugs 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000002771 cell marker Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000014167 chia Nutrition 0.000 description 1
- 238000004581 coalescence Methods 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 208000035623 congenital anemia Diseases 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 208000001763 cytomegalovirus retinitis Diseases 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000018823 dietary intake Nutrition 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 229960002986 dinoprostone Drugs 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000008157 edible vegetable oil Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 230000009144 enzymatic modification Effects 0.000 description 1
- 230000008378 epithelial damage Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000005038 ethylene vinyl acetate Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 229960002963 ganciclovir Drugs 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 230000000762 glandular Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 125000001183 hydrocarbyl group Chemical group 0.000 description 1
- 229920013746 hydrophilic polyethylene oxide Polymers 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000011532 immunohistochemical staining Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 208000033065 inborn errors of immunity Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 210000004561 lacrimal apparatus Anatomy 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 150000002617 leukotrienes Chemical class 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- 238000010841 mRNA extraction Methods 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000037353 metabolic pathway Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- HOVAGTYPODGVJG-UHFFFAOYSA-N methyl beta-galactoside Natural products COC1OC(CO)C(O)C(O)C1O HOVAGTYPODGVJG-UHFFFAOYSA-N 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 230000008450 motivation Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000002232 neuromuscular Effects 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 125000006353 oxyethylene group Chemical group 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 238000007427 paired t-test Methods 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 229940021222 peritoneal dialysis isotonic solution Drugs 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 239000003209 petroleum derivative Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 208000028529 primary immunodeficiency disease Diseases 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- JJICLMJFIKGAAU-UHFFFAOYSA-M sodium;2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)purin-6-olate Chemical compound [Na+].NC1=NC([O-])=C2N=CN(COC(CO)CO)C2=N1 JJICLMJFIKGAAU-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 description 1
- 150000003595 thromboxanes Chemical class 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 230000004393 visual impairment Effects 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Nutrition Science (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58451404P | 2004-07-01 | 2004-07-01 | |
| PCT/US2005/023113 WO2006007510A1 (en) | 2004-07-01 | 2005-06-30 | Compositions and methods for treating eye disorders and conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008505177A true JP2008505177A (ja) | 2008-02-21 |
| JP2008505177A5 JP2008505177A5 (https=) | 2008-12-04 |
Family
ID=35784207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007520365A Pending JP2008505177A (ja) | 2004-07-01 | 2005-06-30 | 目の障害および状態を治療するための組成物および方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20060009522A1 (https=) |
| EP (1) | EP1781278B2 (https=) |
| JP (1) | JP2008505177A (https=) |
| KR (1) | KR20070040381A (https=) |
| CN (1) | CN101043884A (https=) |
| AU (1) | AU2005262392A1 (https=) |
| BR (1) | BRPI0512864B8 (https=) |
| CA (1) | CA2572344A1 (https=) |
| IL (1) | IL180342A0 (https=) |
| MX (1) | MX2007000208A (https=) |
| NO (1) | NO20070561L (https=) |
| NZ (1) | NZ552481A (https=) |
| RU (1) | RU2007103835A (https=) |
| WO (1) | WO2006007510A1 (https=) |
| ZA (1) | ZA200700918B (https=) |
Cited By (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2012067224A1 (ja) * | 2010-11-19 | 2014-05-19 | 日本水産株式会社 | 角膜上皮障害及び／又は結膜上皮障害の治療又は予防剤 |
| JP2014518261A (ja) * | 2011-06-30 | 2014-07-28 | ジョンソン・アンド・ジョンソン・ビジョン・ケア・インコーポレイテッド | 眼の炎症状態を治療するためのエステル |
| KR20150054997A (ko) * | 2012-09-12 | 2015-05-20 | 노바리크 게엠베하 | 부분불소화 알칸 조성물 |
| JP2015526515A (ja) * | 2012-08-31 | 2015-09-10 | ボシュ・アンド・ロム・インコーポレイテッドＢａｕｓｃｈ ＆ Ｌｏｍｂ Ｉｎｃｏｒｐｏｒａｔｅｄ | オメガ３脂肪酸を有する眼用組成物 |
| JP2015531344A (ja) * | 2012-09-12 | 2015-11-02 | ノバリック ゲーエムベーハー | 半フッ化アルカンの混合物を含む組成物 |
| JP2016512245A (ja) * | 2013-03-12 | 2016-04-25 | フィジシャンズ レコメンデッド ニュートリシューティカルズ エルエルシーＰｈｙｓｉｃｉａｎｓ Ｒｅｃｏｍｍｅｎｄｅｄ Ｎｕｔｒｉｃｅｕｔｉｃａｌｓ，Ｌｌｃ | マイボーム腺を標的とする栄養補給剤 |
| US10064944B2 (en) | 2010-11-11 | 2018-09-04 | Novaliq Gmbh | Liquid pharmaceutical composition for the treatment of a posterior eye disease |
| US10273298B2 (en) | 2013-07-23 | 2019-04-30 | Novaliq Gmbh | Stabilized antibody compositions |
| US10507132B2 (en) | 2016-06-23 | 2019-12-17 | Novaliq Gmbh | Topical administration method |
| US10555953B2 (en) | 2010-03-17 | 2020-02-11 | Novaliq Gmbh | Pharmaceutical composition for treatment of increased intraocular pressure |
| US10682315B2 (en) | 2015-09-30 | 2020-06-16 | Novaliq Gmbh | Semifluorinated compounds and their compositions |
| US10813976B2 (en) | 2016-09-23 | 2020-10-27 | Novaliq Gmbh | Ophthalmic compositions comprising ciclosporin |
| US11154513B2 (en) | 2015-09-30 | 2021-10-26 | Novaliq Gmbh | Semifluorinated compounds |
| JP2021529167A (ja) * | 2018-06-19 | 2021-10-28 | エーパックス ノルウェー アクスイェ セルスカプ | ドライアイ疾患及び瞼板腺炎の治療のための組成物 |
| US11160865B2 (en) | 2010-10-20 | 2021-11-02 | Novaliq Gmbh | Liquid pharmaceutical composition for the delivery of active ingredients |
| US11273174B2 (en) | 2017-04-21 | 2022-03-15 | Novaliq Gmbh | Iodine compositions |
| US11278503B2 (en) | 2017-05-12 | 2022-03-22 | Novaliq Gmbh | Pharmaceutical compositions comprising semifluorinated alkanes for the treatment of contact lense-related conditions |
| US11684589B2 (en) | 2016-09-22 | 2023-06-27 | Novaliq Gmbh | Pharmaceutical compositions for use in the therapy of blepharitis |
| US11723861B2 (en) | 2017-09-27 | 2023-08-15 | Novaliq Gmbh | Ophthalmic compositions comprising latanoprost for use in the treatment of ocular diseases |
| US11896559B2 (en) | 2017-10-04 | 2024-02-13 | Novaliq Gmbh | Opthalmic compositions comprising F6H8 |
| JP2024511994A (ja) * | 2021-03-18 | 2024-03-18 | ジェニヴィジョン インク． | 眼疾患を処置するための方法および組成物 |
| US12496326B2 (en) | 2016-12-23 | 2025-12-16 | Novaliq Gmbh | Ophthalmic composition for treatment of dry eye disease |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060251685A1 (en) * | 2003-03-18 | 2006-11-09 | Zhi-Jian Yu | Stable ophthalmic oil-in-water emulsions with Omega-3 fatty acids for alleviating dry eye |
| AU2005296212A1 (en) * | 2004-10-19 | 2006-04-27 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Topical treatment with NGF and DHA in damaged corneas |
| US20070293410A1 (en) * | 2006-06-15 | 2007-12-20 | Surowiak Richard J | Contact lens and method for preventing contact lens intolerance |
| US8343753B2 (en) | 2007-11-01 | 2013-01-01 | Wake Forest University School Of Medicine | Compositions, methods, and kits for polyunsaturated fatty acids from microalgae |
| CA2704371A1 (en) * | 2007-11-01 | 2009-05-07 | Wake Forest University School Of Medicine | Compositions and methods for prevention and treatment of mammalian diseases |
| IT1393419B1 (it) * | 2009-03-19 | 2012-04-20 | Medivis S R L | Composizioni oftalmiche a base di acidi grassi polinsaturi omega-3 e omega-6. |
| GB0907413D0 (en) | 2009-04-29 | 2009-06-10 | Equateq Ltd | Novel methods |
| MX358504B (es) | 2009-06-05 | 2018-08-21 | Allergan Inc | Lagrimas artificiales y usos terapeuticos. |
| US20110206741A1 (en) * | 2010-02-18 | 2011-08-25 | Martek Biosciences Corporation | DHA Triglyceride Emulsions |
| US20110200644A1 (en) * | 2010-02-18 | 2011-08-18 | Martek Biosciences Corporation | DHA Ester Emulsions |
| US20110200645A1 (en) * | 2010-02-18 | 2011-08-18 | Martek Biosciences Corporation | DHA Free Fatty Acid Emulsions |
| DE102010050570A1 (de) * | 2010-11-05 | 2012-05-10 | F. Holzer Gmbh | Zusammensetzung und Arzneimittel enthaltend ω-3-Fettsäuren sowie einen Inhibitor des NF-κB-Transkriptionsfaktors |
| WO2012145119A2 (en) * | 2011-04-17 | 2012-10-26 | Michael Gurin | Low inflammatory blended oils |
| DK2714010T3 (en) | 2011-05-25 | 2017-06-12 | Novaliq Gmbh | TOPICAL PHARMACEUTICAL COMPOSITION BASED ON SEMIFLUORED ALKANES |
| JP6023181B2 (ja) | 2011-05-25 | 2016-11-09 | ノバリック ゲーエムベーハー | 爪に投与するための医薬組成物 |
| US20160310456A1 (en) * | 2013-03-12 | 2016-10-27 | Physicians Recommended Nutriceuticals, Llc | Compositions and methods for using same for reducing levels of arachidonic acid in tissue having undergone an invasive procedure |
| WO2013037794A1 (en) * | 2011-09-12 | 2013-03-21 | Georgiou Tassos | Use of omega fatty acids for treating disease |
| US8957048B2 (en) * | 2011-10-06 | 2015-02-17 | Allergan, Inc. | Compositions for the treatment of dry eye |
| US8293790B2 (en) | 2011-10-19 | 2012-10-23 | Dignity Sciences Limited | Pharmaceutical compositions comprising DGLA and benzoyl peroxide and methods of use thereof |
| KR101989648B1 (ko) | 2012-01-23 | 2019-06-14 | 노바리크 게엠베하 | 부분불소화 알칸에 기초한 안정화된 단백질 조성물 |
| US9480651B2 (en) | 2012-03-30 | 2016-11-01 | Sancilio & Company, Inc. | Omega-3 fatty acid ester compositions unitary pharmaceutical dosage forms |
| JP6359517B2 (ja) | 2012-03-30 | 2018-07-18 | サンシリオ アンド カンパニー, インコーポレイテッドSancilio & Company, Inc. | ω−３脂肪酸エステル組成物 |
| US20160228397A1 (en) | 2012-03-30 | 2016-08-11 | Sancilio & Company, Inc. | Omega-3 fatty acid ester compositions |
| US10898458B2 (en) | 2012-03-30 | 2021-01-26 | Micelle Biopharma, Inc. | Self-micellizing fatty acids and fatty acid ester compositions and their use in the treatment of disease states |
| EP2664330A1 (de) | 2012-05-15 | 2013-11-20 | F. Holzer GmbH | Zusammensetzung und Arzneimittel enthaltend Omega-3-Fettsäuren sowie einen Glucosaminoglucan |
| US8673325B1 (en) * | 2012-09-06 | 2014-03-18 | Dignity Sciences Limited | Cosmetic compositions comprising EPA and salicylic acid and methods of making and using same |
| GB201301626D0 (en) | 2013-01-30 | 2013-03-13 | Dignity Sciences Ltd | Composition comprising 15-OHEPA and methods of using the same |
| WO2014132162A1 (en) | 2013-02-26 | 2014-09-04 | Belkin Laser Ltd. | System for glaucoma treatment |
| WO2015042442A1 (en) * | 2013-09-19 | 2015-03-26 | Dignity Sciences Limited | Pharmaceutical compositions comprising dha, epa, and/or gla and an antibiotic agent and methods of use thereof |
| US9682055B2 (en) | 2014-06-04 | 2017-06-20 | Dignity Sciences Limted | Pharmaceutical compositions comprising DGLA and use of same |
| JP6768653B2 (ja) | 2014-11-25 | 2020-10-14 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | 安定したオメガ−３眼科用組成物 |
| US20180228811A1 (en) * | 2014-12-12 | 2018-08-16 | The Schepens Eye Research Institute, Inc. | Gdnf induction for the treatment of retinal disorders |
| MA47141A (fr) | 2015-05-13 | 2019-11-06 | Ds Biopharma Ltd | Compositions comprenant du15-oxo-epa ou du 15-oxo-dgla et leurs procédés de préparation et d'utilisation |
| ES2851525T3 (es) | 2015-07-21 | 2021-09-07 | Afimmune Ltd | Composiciones que comprenden 15(S)-HEPE para su uso en la sensibilización de las células cancerosas a la radioterapia |
| CA3129008A1 (en) | 2015-12-18 | 2017-06-22 | Afimmune Limited | Compositions comprising 15-hepe and methods of using the same |
| CN106963728A (zh) * | 2016-01-13 | 2017-07-21 | 汤欣 | 一种二十二碳六烯酸结膜下注射液的制备方法及其应用 |
| KR20200128407A (ko) | 2018-03-02 | 2020-11-12 | 노바리크 게엠베하 | 네비볼롤을 포함하는 약제학적 조성물 |
| SG11202007860XA (en) | 2018-03-28 | 2020-09-29 | Novaliq Gmbh | Pharmaceutical composition comprising timolol |
| CN112153970A (zh) | 2018-04-27 | 2020-12-29 | 诺瓦利克有限责任公司 | 用于治疗青光眼的包含他氟前列素的眼用组合物 |
| SG11202102820VA (en) | 2018-10-12 | 2021-04-29 | Novaliq Gmbh | Ophthalmic composition for treatment of dry eye disease |
| EP3923907B1 (en) | 2019-02-13 | 2024-09-25 | Novaliq GmbH | Compositions and methods for the treatment of ocular neovascularization |
| ES2982698T3 (es) * | 2020-01-23 | 2024-10-17 | Visufarma S P A | Composición oftálmica para el tratamiento de la enfermedad del ojo seco |
| US20210315851A1 (en) | 2020-04-03 | 2021-10-14 | Afimmune Limited | Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63297323A (ja) * | 1987-05-07 | 1988-12-05 | ソシエテ・ド・コンセイユ・ド・ルシエルシエ・エ・ダアツ プリカーシヨン・シヤンテイフイツク・（エス．セー．エール．アー．エス） | 眼科薬 |
| JPH06122627A (ja) * | 1992-10-13 | 1994-05-06 | Sagami Chem Res Center | 抗アレルギー点眼液 |
| WO2003018049A2 (en) * | 2001-08-23 | 2003-03-06 | Westgate Biological Limited | Use of milk serum apoproteins in the prophylaxis or treatment of microbial or viral infection |
| JP2003512312A (ja) * | 1999-10-20 | 2003-04-02 | ヴェジファクト・アクチェンゲゼルシャフト | マイクロエマルジョン予備濃縮物、マイクロエマルジョンおよび組成物の使用 |
| WO2004004599A2 (en) * | 2002-07-08 | 2004-01-15 | Advanced Vision Research | Epa and dha enriched omega-3 supplement for the treatment of dry eye, meibomianitis and xerostomia |
| JP2005008570A (ja) * | 2003-06-19 | 2005-01-13 | Santen Pharmaceut Co Ltd | 角膜疾患治療剤 |
| JP2006526579A (ja) * | 2003-03-18 | 2006-11-24 | アドバンスト メディカル オプティクス， インコーポレーテッド | 自己乳化組成物、その使用および製造方法 |
Family Cites Families (106)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US437014A (en) * | 1890-09-23 | Swing | ||
| US3572913A (en) * | 1969-02-03 | 1971-03-30 | Boylston Res Ass | Comprehensive support for ophthalmic examination apparatus and instruments |
| US3957362A (en) * | 1972-10-02 | 1976-05-18 | Corneal Sciences, Inc. | Hydrogels and articles made therefrom |
| US4401372A (en) * | 1972-10-02 | 1983-08-30 | Syntex (U.S.A.) Inc. | Contact lens |
| US4180308A (en) * | 1972-10-02 | 1979-12-25 | Syntex (Usa) Inc. | Contact lens |
| US4056496A (en) * | 1972-10-02 | 1977-11-01 | Corneal Sciences, Inc. | Hydrogels and articles made therefrom |
| DE2309440A1 (de) * | 1973-02-26 | 1974-09-05 | Katz | Verfahren zum isolieren von lysozym |
| US3991759A (en) | 1975-10-28 | 1976-11-16 | Alza Corporation | Method and therapeutic system for treating aqueous deficient dry eye |
| US4313355A (en) * | 1978-02-06 | 1982-02-02 | Syntex (U.S.A.) Inc. | Method and apparatus for manufacturing plastic lenses |
| US4202226A (en) * | 1978-02-06 | 1980-05-13 | SyntexLaboratories, Inc. | Method and apparatus for manufacturing plastic lenses |
| US4267295A (en) * | 1979-02-09 | 1981-05-12 | Syntex (U.S.A.) Inc. | Polymeric compositions and hydrogels formed therefrom |
| US4338419A (en) * | 1979-02-09 | 1982-07-06 | Syntex (U.S.A.) Inc. | Process for treatment of hydrogel lens with thiols |
| US4379864A (en) * | 1979-02-09 | 1983-04-12 | Syntex (U.S.A.) Inc. | Polymeric compositions and hydrogels formed therefrom |
| US4543371A (en) * | 1981-03-05 | 1985-09-24 | Syntex (U.S.A.) Inc. | Polymeric compositions and hydrogels formed therefrom |
| US5145686A (en) * | 1982-02-03 | 1992-09-08 | Efamol Limited | Topical pharmaceutical compositions |
| EP0092076B1 (fr) | 1982-04-16 | 1986-12-17 | Societe Des Produits Nestle S.A. | Composition lipidique destinée à l'alimentation orale, entérale ou parentérale |
| US4421748A (en) * | 1982-07-13 | 1983-12-20 | Trager Seymour F | Artificial tear aid |
| US4678698A (en) * | 1983-04-12 | 1987-07-07 | Minnesota Mining And Manufacturing Company | Contact lens cleaning article |
| US4533399A (en) * | 1983-04-12 | 1985-08-06 | Minnesota Mining And Manufacturing Company | Contact lens cleaning method |
| US4622258A (en) * | 1983-04-12 | 1986-11-11 | Minnesota Mining And Manufacturing Company | Contact lens cleaning article |
| JPS6158539A (ja) * | 1984-08-29 | 1986-03-25 | Nisshin Oil Mills Ltd:The | スナツク様菓子の製造法 |
| US4613380A (en) * | 1985-04-01 | 1986-09-23 | Dow Corning Corporation | Method for removing lipid deposits from contact lenses |
| US5484432A (en) * | 1985-09-27 | 1996-01-16 | Laser Biotech, Inc. | Collagen treatment apparatus |
| GB8524275D0 (en) * | 1985-10-02 | 1985-11-06 | Efamol Ltd | Pharmaceutical & dietary compositions |
| US5039520A (en) * | 1986-05-15 | 1991-08-13 | Emory University | Plasma extender |
| US5080894A (en) * | 1986-05-15 | 1992-01-14 | Emory University | Method and composition for reducing tissue damage |
| US5032394A (en) * | 1986-05-15 | 1991-07-16 | Emory University | Method of treating burns |
| US4937070A (en) * | 1986-05-15 | 1990-06-26 | Emory University | Methods and compositions for treatment of pathological hydrophobic interactions in biological fluids |
| US4897263A (en) * | 1986-05-15 | 1990-01-30 | Emory University | Methods and compositions for treatment of pathological hydrophobic interactions in biological fluids |
| US5078995A (en) * | 1986-05-15 | 1992-01-07 | Emory University | Fibrionolytic composition |
| US5047236A (en) * | 1986-05-15 | 1991-09-10 | Emory University | Method of treating stroke |
| US5028599A (en) * | 1986-05-15 | 1991-07-02 | Emory University | Method of treating mycardial damage |
| US5198211A (en) * | 1986-05-15 | 1993-03-30 | Emory University | Method of treating myocardial damage |
| US4801452A (en) * | 1986-05-15 | 1989-01-31 | Hunter Robert L | Fibrinolytic composition |
| US4837014A (en) * | 1986-05-15 | 1989-06-06 | Emory University | An improved method of treating sickle cell anemia |
| US5071649A (en) * | 1986-05-15 | 1991-12-10 | Emory University | Method of preventing blockage in catheters |
| US5250294A (en) * | 1986-05-15 | 1993-10-05 | Emory University | Improved perfusion medium for transplantation of organs |
| US4997644A (en) * | 1986-05-15 | 1991-03-05 | Emory University | Method of treating adult respiratory distress syndrome |
| US5064643A (en) * | 1986-05-15 | 1991-11-12 | Emory University | Method for treating sickle cell disease |
| US5017370A (en) * | 1986-05-15 | 1991-05-21 | Emory University | Improved method of performing angioplasty procedures |
| US5030448A (en) * | 1986-05-15 | 1991-07-09 | Emory University | Method of delivering drugs to damaged or diseased tissue |
| US5240701A (en) * | 1986-05-15 | 1993-08-31 | Emory University | Method of performing angioplasty procedures |
| US5648071A (en) * | 1986-05-15 | 1997-07-15 | Emory University | Method of treating tumors |
| US5182106A (en) * | 1986-05-15 | 1993-01-26 | Emory University | Method for treating hypothermia |
| US5089260A (en) * | 1986-05-15 | 1992-02-18 | Emory University | Method of treating ischemic tissue |
| US5240702A (en) * | 1986-05-15 | 1993-08-31 | Emory University | Method of treating stroke |
| US5041288A (en) * | 1986-05-15 | 1991-08-20 | Emory University | Method of treating tissue damaged by reperfusion injury |
| US4879109A (en) * | 1986-05-15 | 1989-11-07 | Emory University | Method for treating burns |
| US4914088A (en) * | 1987-04-02 | 1990-04-03 | Thomas Glonek | Dry eye treatment solution and method |
| US5278151A (en) * | 1987-04-02 | 1994-01-11 | Ocular Research Of Boston, Inc. | Dry eye treatment solution |
| US5252333A (en) * | 1987-04-27 | 1993-10-12 | Scotia Holdings Plc | Lithium salt-containing pharmaceutical compositions |
| CA1263270A (en) * | 1987-08-19 | 1989-11-28 | Bruce J. Holub | Animal feed supplement |
| US5225374A (en) * | 1988-05-13 | 1993-07-06 | The United States Of America As Represented By The Secretary Of The Navy | Method of fabricating a receptor-based sensor |
| US5111221A (en) * | 1988-05-13 | 1992-05-05 | United States Of America As Represented By The Secretary Of The Navy | Receptor-based sensor |
| US4923700A (en) * | 1988-06-03 | 1990-05-08 | Kaufman Herbert E | Artificial tear suspension |
| US4959048A (en) * | 1989-01-17 | 1990-09-25 | Helix Medical, Inc. | Lacrimal duct occluder |
| US5182258A (en) * | 1989-03-20 | 1993-01-26 | Orbon Corporation | Systemic delivery of polypeptides through the eye |
| US5278142A (en) * | 1989-03-20 | 1994-01-11 | Orbon Corporation | Systemic delivery of polypeptides through the eye |
| US5174988A (en) * | 1989-07-27 | 1992-12-29 | Scientific Development & Research, Inc. | Phospholipid delivery system |
| US5206298A (en) * | 1989-12-19 | 1993-04-27 | Tomei Sangyo Kabushiki Kaisha | Graft copolymer, solution containing the graft copolymer for treating contact lens, and method of treating contact lens with the solution and making hydrophilic lens surface |
| ZA912797B (en) * | 1990-05-29 | 1992-12-30 | Boston Ocular Res | Dry eye treatment process and solution |
| EP0459148B1 (en) * | 1990-05-29 | 1996-01-03 | Ocular Research Of Boston Inc. | Dry eye treatment composition |
| US5167323A (en) * | 1990-08-09 | 1992-12-01 | Tomei Sangyo Co., Ltd. | Lens treating device for treating contact lens |
| US5181604A (en) * | 1990-09-14 | 1993-01-26 | Tomei Sangyo Co., Ltd. | Contact lens holder and treating device |
| US5203337A (en) * | 1991-05-08 | 1993-04-20 | Brigham And Women's Hospital, Inc. | Coronary artery imaging system |
| ZA927277B (en) * | 1991-10-02 | 1993-05-19 | Boston Ocular Res | Dry eye treatment process and solution. |
| US5469867A (en) * | 1992-09-02 | 1995-11-28 | Landec Corporation | Cast-in place thermoplastic channel occluder |
| PH30249A (en) * | 1992-09-16 | 1997-02-05 | Zhejiang Provincial Hospital O | Neutral lipids from endosperm of job's tears |
| US5378488A (en) * | 1993-06-10 | 1995-01-03 | Abbott Laboratories | Aseptic processing of infant formula |
| AU1520095A (en) * | 1993-12-29 | 1995-07-17 | Bausch & Lomb Incorporated | Carbohydrate composition and method for cleaning and disinfecting contact lenses |
| US6060644A (en) * | 1994-03-24 | 2000-05-09 | Iowa State University Research Foundation, Inc. | Isolation and use of cuticular lipid genes |
| US5474979A (en) | 1994-05-17 | 1995-12-12 | Allergan, Inc. | Nonirritating emulsions for sensitive tissue |
| US5861148A (en) * | 1995-01-23 | 1999-01-19 | Smith; Stewart Gregory | Ophthalmic compositions and process of using |
| US6113894A (en) * | 1995-01-23 | 2000-09-05 | Smith; S. Gregory | Ophthalmic compositions and process of using |
| DE69629230D1 (de) * | 1995-03-24 | 2003-09-04 | Ocular Res Of Bonton Inc | Hydrogellinse mit Lipid-Vorbeschichtigung |
| US5738856A (en) * | 1995-11-03 | 1998-04-14 | Ocular Research Of Boston, Inc. | Skin care preparation and method |
| WO1997020578A1 (en) * | 1995-12-04 | 1997-06-12 | University Of Miami | Non-preserved topical corticosteroid for treatment of dry eye, filamentary keratitis, and delayed tear clearance |
| AU3692097A (en) * | 1996-08-02 | 1998-02-25 | Plum Kemi Produktion A/S | An oil-in-water emulsion for use on human skin for cleansing, preserving or improving the condition of the skin |
| KR19990071477A (ko) * | 1996-09-20 | 1999-09-27 | 아테로제닉스, 인코포레이티드 | 염증성질환의진단방법및매개체 |
| US6475789B1 (en) * | 1996-10-01 | 2002-11-05 | University Technology Corporation | Human telomerase catalytic subunit: diagnostic and therapeutic methods |
| JPH10218760A (ja) | 1997-02-04 | 1998-08-18 | Nobel Igaku Kenkyusho:Kk | ドライアイ治療用の微量油添加目薬 |
| WO1998039025A2 (en) * | 1997-03-03 | 1998-09-11 | Adcock Ingram Limited | A composition comprising a carrier and a purified mycobacterial lipid cell-wall component and its use in the prevention, treatment and diagnosis of disease |
| US6107365A (en) * | 1997-09-03 | 2000-08-22 | The Regents Of The University Of California | Biomimetic hydrogel materials |
| US6475784B1 (en) * | 1997-11-14 | 2002-11-05 | Valentis, Inc. | Inhibition of angiogenesis by delivery of nucleic acids encoding anti-angiogenic polypeptides |
| US5981607A (en) * | 1998-01-20 | 1999-11-09 | Allergan | Emulsion eye drop for alleviation of dry eye related symptoms in dry eye patients and/or contact lens wearers |
| EP1082966A4 (en) | 1998-05-15 | 2004-07-21 | Wakamoto Pharma Co Ltd | ANTI-INFLAMMATORY EYE DROPS |
| US6346594B1 (en) * | 1998-09-21 | 2002-02-12 | Menicon Co., Ltd. | Ocular lens material and process for producing same |
| EP1156809B1 (en) * | 1999-03-01 | 2005-12-07 | Vista Scientific LLC | Mucin containing ophthalmic preparations |
| US6429194B1 (en) * | 1999-03-01 | 2002-08-06 | Vista Scientific Llc | Mucin containing ophthalmic preparation |
| US6428502B1 (en) * | 1999-06-25 | 2002-08-06 | Alcon Manufacturing, Ltd. | Punctal cannula |
| TWI225398B (en) * | 1999-07-14 | 2004-12-21 | R Tech Ueno Ltd | Composition for treatment of external secretion disorders |
| AUPQ228199A0 (en) | 1999-08-18 | 1999-09-09 | Sly, Anthony William | Ophthalmic fluid |
| US6286955B1 (en) * | 1999-12-15 | 2001-09-11 | Tetsuya Sakai | Biocompatible lens, and method of producing the same |
| US6344047B1 (en) * | 2000-02-02 | 2002-02-05 | Eagle Vision | Instrument for inserting a punctum plug and method for manufacturing the instrument |
| US6533415B2 (en) * | 2000-03-21 | 2003-03-18 | Menicon Co., Ltd. | Ocular lens material having hydrophilic surface and process for preparing the same |
| GB0012597D0 (en) * | 2000-05-25 | 2000-07-12 | Astrazeneca Ab | Formulation |
| WO2002009803A1 (en) * | 2000-08-01 | 2002-02-07 | Ocular Research Of Boston, Inc. | Visual discomfort relief |
| US6506412B2 (en) | 2000-11-29 | 2003-01-14 | Sciencebased Health | Treatment of dry eye syndrome |
| US6667047B2 (en) * | 2001-07-27 | 2003-12-23 | International Flute Technologies Ltd | Ultra-stable composition comprising moringa oil and its derivatives and uses thereof |
| US20040076691A1 (en) | 2002-01-16 | 2004-04-22 | David Haines | Anti-inflammatory formulations |
| US20040048926A1 (en) * | 2002-03-15 | 2004-03-11 | Hoffman Dennis Robert | Use of docosahexaenoic acid and arachidonic acid to enhance the visual development of term infants breast-fed up to the age of six months |
| JP2005529945A (ja) * | 2002-06-17 | 2005-10-06 | リソルヴィックス ファーマシューティカルズ | オメガ−３ｐｕｆａ由来の脂質メディエーターの類似体及び使用方法 |
| AU2003259145A1 (en) | 2002-07-17 | 2004-02-02 | Spencer P. Thornton | Treatment for dry eye syndrome |
| US20060251685A1 (en) * | 2003-03-18 | 2006-11-09 | Zhi-Jian Yu | Stable ophthalmic oil-in-water emulsions with Omega-3 fatty acids for alleviating dry eye |
| US20050255144A1 (en) * | 2003-04-09 | 2005-11-17 | Directcontact Llc | Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases |
| US20050202097A1 (en) * | 2004-03-12 | 2005-09-15 | Melbj Holdings, Llc, Florida | Lubricant for the ocular surface |
-
2005
- 2005-06-30 AU AU2005262392A patent/AU2005262392A1/en not_active Abandoned
- 2005-06-30 RU RU2007103835/15A patent/RU2007103835A/ru not_active Application Discontinuation
- 2005-06-30 CN CNA2005800287299A patent/CN101043884A/zh active Pending
- 2005-06-30 US US11/171,815 patent/US20060009522A1/en not_active Abandoned
- 2005-06-30 NZ NZ552481A patent/NZ552481A/en unknown
- 2005-06-30 MX MX2007000208A patent/MX2007000208A/es not_active Application Discontinuation
- 2005-06-30 WO PCT/US2005/023113 patent/WO2006007510A1/en not_active Ceased
- 2005-06-30 JP JP2007520365A patent/JP2008505177A/ja active Pending
- 2005-06-30 KR KR1020077002456A patent/KR20070040381A/ko not_active Withdrawn
- 2005-06-30 CA CA002572344A patent/CA2572344A1/en not_active Abandoned
- 2005-06-30 EP EP05767809.6A patent/EP1781278B2/en not_active Expired - Lifetime
- 2005-06-30 BR BRPI0512864A patent/BRPI0512864B8/pt not_active IP Right Cessation
-
2006
- 2006-12-26 IL IL180342A patent/IL180342A0/en unknown
-
2007
- 2007-01-30 NO NO20070561A patent/NO20070561L/no not_active Application Discontinuation
- 2007-01-31 ZA ZA200700918A patent/ZA200700918B/xx unknown
- 2007-10-17 US US11/873,478 patent/US20080153909A1/en not_active Abandoned
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63297323A (ja) * | 1987-05-07 | 1988-12-05 | ソシエテ・ド・コンセイユ・ド・ルシエルシエ・エ・ダアツ プリカーシヨン・シヤンテイフイツク・（エス．セー．エール．アー．エス） | 眼科薬 |
| JPH06122627A (ja) * | 1992-10-13 | 1994-05-06 | Sagami Chem Res Center | 抗アレルギー点眼液 |
| JP2003512312A (ja) * | 1999-10-20 | 2003-04-02 | ヴェジファクト・アクチェンゲゼルシャフト | マイクロエマルジョン予備濃縮物、マイクロエマルジョンおよび組成物の使用 |
| WO2003018049A2 (en) * | 2001-08-23 | 2003-03-06 | Westgate Biological Limited | Use of milk serum apoproteins in the prophylaxis or treatment of microbial or viral infection |
| WO2004004599A2 (en) * | 2002-07-08 | 2004-01-15 | Advanced Vision Research | Epa and dha enriched omega-3 supplement for the treatment of dry eye, meibomianitis and xerostomia |
| JP2006526579A (ja) * | 2003-03-18 | 2006-11-24 | アドバンスト メディカル オプティクス， インコーポレーテッド | 自己乳化組成物、その使用および製造方法 |
| JP2005008570A (ja) * | 2003-06-19 | 2005-01-13 | Santen Pharmaceut Co Ltd | 角膜疾患治療剤 |
Cited By (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11324757B2 (en) | 2010-03-17 | 2022-05-10 | Novaliq Gmbh | Pharmaceutical composition for treatment of increased intraocular pressure |
| US10555953B2 (en) | 2010-03-17 | 2020-02-11 | Novaliq Gmbh | Pharmaceutical composition for treatment of increased intraocular pressure |
| US11160865B2 (en) | 2010-10-20 | 2021-11-02 | Novaliq Gmbh | Liquid pharmaceutical composition for the delivery of active ingredients |
| US10064944B2 (en) | 2010-11-11 | 2018-09-04 | Novaliq Gmbh | Liquid pharmaceutical composition for the treatment of a posterior eye disease |
| JPWO2012067224A1 (ja) * | 2010-11-19 | 2014-05-19 | 日本水産株式会社 | 角膜上皮障害及び／又は結膜上皮障害の治療又は予防剤 |
| US12364679B2 (en) | 2011-06-30 | 2025-07-22 | Johnson & Johnson Vision Care, Inc. | Esters for treatment of ocular inflammatory conditions |
| JP2014518261A (ja) * | 2011-06-30 | 2014-07-28 | ジョンソン・アンド・ジョンソン・ビジョン・ケア・インコーポレイテッド | 眼の炎症状態を治療するためのエステル |
| JP2015526515A (ja) * | 2012-08-31 | 2015-09-10 | ボシュ・アンド・ロム・インコーポレイテッドＢａｕｓｃｈ ＆ Ｌｏｍｂ Ｉｎｃｏｒｐｏｒａｔｅｄ | オメガ３脂肪酸を有する眼用組成物 |
| US10369117B2 (en) | 2012-09-12 | 2019-08-06 | Novaliq Gmbh | Compositions comprising mixtures of semifluorinated alkanes |
| US10449164B2 (en) | 2012-09-12 | 2019-10-22 | Novaliq Gmbh | Methods of treating ocular disorders using semifluorinated alkanes |
| KR20180101640A (ko) * | 2012-09-12 | 2018-09-12 | 노바리크 게엠베하 | 부분불소화 알칸 조성물 |
| KR20150054997A (ko) * | 2012-09-12 | 2015-05-20 | 노바리크 게엠베하 | 부분불소화 알칸 조성물 |
| KR102115111B1 (ko) | 2012-09-12 | 2020-05-26 | 노바리크 게엠베하 | 부분불소화 알칸 조성물 |
| US12005033B2 (en) | 2012-09-12 | 2024-06-11 | Novaliq Gmbh | Compositions comprising mixtures of semifluorinated alkanes |
| US11583513B2 (en) | 2012-09-12 | 2023-02-21 | Novaliq Gmbh | Semifluorinated alkane compositions |
| KR102171897B1 (ko) | 2012-09-12 | 2020-11-02 | 노바리크 게엠베하 | 부분불소화 알칸 조성물 |
| JP2015531344A (ja) * | 2012-09-12 | 2015-11-02 | ノバリック ゲーエムベーハー | 半フッ化アルカンの混合物を含む組成物 |
| JP2016512245A (ja) * | 2013-03-12 | 2016-04-25 | フィジシャンズ レコメンデッド ニュートリシューティカルズ エルエルシーＰｈｙｓｉｃｉａｎｓ Ｒｅｃｏｍｍｅｎｄｅｄ Ｎｕｔｒｉｃｅｕｔｉｃａｌｓ，Ｌｌｃ | マイボーム腺を標的とする栄養補給剤 |
| US10273298B2 (en) | 2013-07-23 | 2019-04-30 | Novaliq Gmbh | Stabilized antibody compositions |
| US11154513B2 (en) | 2015-09-30 | 2021-10-26 | Novaliq Gmbh | Semifluorinated compounds |
| US10682315B2 (en) | 2015-09-30 | 2020-06-16 | Novaliq Gmbh | Semifluorinated compounds and their compositions |
| US11357738B2 (en) | 2015-09-30 | 2022-06-14 | Novaliq Gmbh | Semifluorinated compounds and their compositions |
| USRE50060E1 (en) | 2016-06-23 | 2024-07-30 | Novaliq Gmbh | Topical administration method |
| US10507132B2 (en) | 2016-06-23 | 2019-12-17 | Novaliq Gmbh | Topical administration method |
| US11684589B2 (en) | 2016-09-22 | 2023-06-27 | Novaliq Gmbh | Pharmaceutical compositions for use in the therapy of blepharitis |
| US11400132B2 (en) | 2016-09-23 | 2022-08-02 | Novaliq Gmbh | Ophthalmic compositions comprising ciclosporin |
| US10813976B2 (en) | 2016-09-23 | 2020-10-27 | Novaliq Gmbh | Ophthalmic compositions comprising ciclosporin |
| US12496326B2 (en) | 2016-12-23 | 2025-12-16 | Novaliq Gmbh | Ophthalmic composition for treatment of dry eye disease |
| US11273174B2 (en) | 2017-04-21 | 2022-03-15 | Novaliq Gmbh | Iodine compositions |
| US11278503B2 (en) | 2017-05-12 | 2022-03-22 | Novaliq Gmbh | Pharmaceutical compositions comprising semifluorinated alkanes for the treatment of contact lense-related conditions |
| US11723861B2 (en) | 2017-09-27 | 2023-08-15 | Novaliq Gmbh | Ophthalmic compositions comprising latanoprost for use in the treatment of ocular diseases |
| US11896559B2 (en) | 2017-10-04 | 2024-02-13 | Novaliq Gmbh | Opthalmic compositions comprising F6H8 |
| US12569452B2 (en) | 2017-10-04 | 2026-03-10 | Novaliq Gmbh | Ophthalmic compositions comprising F6H8 |
| JP2021529167A (ja) * | 2018-06-19 | 2021-10-28 | エーパックス ノルウェー アクスイェ セルスカプ | ドライアイ疾患及び瞼板腺炎の治療のための組成物 |
| JP2024511994A (ja) * | 2021-03-18 | 2024-03-18 | ジェニヴィジョン インク． | 眼疾患を処置するための方法および組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2572344A1 (en) | 2006-01-19 |
| BRPI0512864A (pt) | 2008-04-08 |
| CN101043884A (zh) | 2007-09-26 |
| KR20070040381A (ko) | 2007-04-16 |
| MX2007000208A (es) | 2007-08-07 |
| NZ552481A (en) | 2008-12-24 |
| EP1781278A4 (en) | 2009-09-02 |
| EP1781278B2 (en) | 2019-10-16 |
| IL180342A0 (en) | 2007-07-04 |
| NO20070561L (no) | 2007-03-30 |
| AU2005262392A1 (en) | 2006-01-19 |
| EP1781278A1 (en) | 2007-05-09 |
| RU2007103835A (ru) | 2008-08-10 |
| US20060009522A1 (en) | 2006-01-12 |
| WO2006007510A1 (en) | 2006-01-19 |
| EP1781278B1 (en) | 2016-08-10 |
| ZA200700918B (en) | 2008-10-29 |
| BRPI0512864B1 (pt) | 2021-04-27 |
| US20080153909A1 (en) | 2008-06-26 |
| BRPI0512864B8 (pt) | 2021-05-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1781278B2 (en) | Compositions and methods for treating eye disorders and conditions | |
| US20070265341A1 (en) | Compositions and methods for treating eye disorders and conditions | |
| KR101677308B1 (ko) | 오메가-3 및 오메가-6 다가 불포화 지방산계 안과용 조성물 | |
| CN103533962B (zh) | 一种眼用组合物 | |
| JP6675361B2 (ja) | 眼の炎症状態を治療するためのエステル | |
| JPH0899867A (ja) | 眼科用ビヒクルとして有用な水中油型ナノエマルジョンおよびその調製法 | |
| US6410006B2 (en) | Composition for prophylaxis and/or treatment of dry eye syndrome comprising vitamin D | |
| JP2022506684A (ja) | 人工涙液 | |
| EP3280395B1 (en) | Ophthalmic compositions based on polyunsaturated fatty acids and triacylglycerols | |
| WO2023055321A1 (en) | Anti-inflammatory microemulsion eye formulations derived from nigella sativa oil | |
| HK1166714B (en) | Ophthalmic compositions based on polyunsaturated omega-3 and omega-6 fatty acids | |
| HK40066479A (zh) | 人工泪液 | |
| Ellingson | Biopharmaceutic considerations in the development of a topical ocular prodrug of ibuprofen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080625 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20081017 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110809 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20110905 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20111108 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20111115 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20111208 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20111215 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20111215 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20111222 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120209 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20120531 |