JP2008502683A5 - - Google Patents
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- Publication number
- JP2008502683A5 JP2008502683A5 JP2007516542A JP2007516542A JP2008502683A5 JP 2008502683 A5 JP2008502683 A5 JP 2008502683A5 JP 2007516542 A JP2007516542 A JP 2007516542A JP 2007516542 A JP2007516542 A JP 2007516542A JP 2008502683 A5 JP2008502683 A5 JP 2008502683A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- optionally substituted
- nitrogen
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57936204P | 2004-06-14 | 2004-06-14 | |
| US60/579,362 | 2004-06-14 | ||
| PCT/US2005/019901 WO2005123668A1 (en) | 2004-06-14 | 2005-06-08 | Glucagon receptor antagonists, preparation and therapeutic uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008502683A JP2008502683A (ja) | 2008-01-31 |
| JP2008502683A5 true JP2008502683A5 (enExample) | 2012-05-10 |
| JP5000492B2 JP5000492B2 (ja) | 2012-08-15 |
Family
ID=35219490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007516542A Expired - Lifetime JP5000492B2 (ja) | 2004-06-14 | 2005-06-08 | グルカゴン受容体拮抗物質及びその調製並びに治療的使用 |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US7816557B2 (enExample) |
| EP (2) | EP2159221A1 (enExample) |
| JP (1) | JP5000492B2 (enExample) |
| KR (1) | KR100835496B1 (enExample) |
| CN (1) | CN1968921B (enExample) |
| AT (1) | ATE455756T1 (enExample) |
| AU (2) | AU2005254950B2 (enExample) |
| BR (1) | BRPI0512058A (enExample) |
| CA (1) | CA2569459C (enExample) |
| CY (1) | CY1109787T1 (enExample) |
| DE (1) | DE602005019043D1 (enExample) |
| DK (1) | DK1758853T3 (enExample) |
| EA (1) | EA013003B1 (enExample) |
| EC (1) | ECSP067082A (enExample) |
| ES (1) | ES2337596T3 (enExample) |
| HR (1) | HRP20100148T1 (enExample) |
| IL (1) | IL179599A (enExample) |
| MA (1) | MA28706B1 (enExample) |
| MX (1) | MXPA06014426A (enExample) |
| NO (1) | NO341028B1 (enExample) |
| NZ (1) | NZ551015A (enExample) |
| PL (1) | PL1758853T3 (enExample) |
| PT (1) | PT1758853E (enExample) |
| RS (1) | RS51202B (enExample) |
| SI (1) | SI1758853T1 (enExample) |
| UA (1) | UA86621C2 (enExample) |
| WO (1) | WO2005123668A1 (enExample) |
| ZA (1) | ZA200610298B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1758853E (pt) * | 2004-06-14 | 2010-03-02 | Lilly Co Eli | Antagonistas do receptor de glucagon, sua preparação e usos terapêuticos |
| US7524870B2 (en) * | 2004-12-03 | 2009-04-28 | Hoffmann-La Roche Inc. | Biaryloxymethylarenecarboxylic acids as glycogen synthase activators |
| US8084489B2 (en) | 2005-02-11 | 2011-12-27 | Eli Lilly And Company | Glucagon receptor antagonists, preparation and therapeutic uses |
| US8318760B2 (en) | 2005-03-21 | 2012-11-27 | Merck Sharp & Dohme Corp. | Substituted aryl and heteroaryl derivatives, compositions containing such compounds and methods of use |
| CN101312723B (zh) * | 2005-11-22 | 2012-01-11 | 伊莱利利公司 | 胰高血糖素受体拮抗剂、制备和治疗用途 |
| CA2650619A1 (en) | 2006-05-16 | 2007-11-29 | Merck And Co., Inc. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
| MX2009008534A (es) | 2007-02-09 | 2009-11-23 | Metabasis Therapeutics Inc | Antagonistas novedosos del receptor de glucagon. |
| EP2799428B1 (en) | 2008-08-13 | 2016-11-16 | Metabasis Therapeutics, Inc. | Glucagon antagonists |
| US8809579B2 (en) | 2009-02-13 | 2014-08-19 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
| US8039495B2 (en) * | 2009-11-16 | 2011-10-18 | Hoffman-La Roche Inc. | Biphenyl carboxylic acids and bioisosteres as glycogen synthase activators |
| AU2011346670B2 (en) * | 2010-12-23 | 2015-05-07 | Pfizer Inc. | Glucagon receptor modulators |
| PH12013501557A1 (en) | 2011-02-08 | 2019-06-03 | Pfizer | Glucagon receptor modulator |
| RU2013157388A (ru) | 2011-07-22 | 2015-08-27 | Пфайзер Инк. | Хинолинильные модуляторы глюкагонового рецептора |
| JP2015505828A (ja) | 2011-12-02 | 2015-02-26 | イーライ リリー アンド カンパニー | 抗グルカゴン抗体およびその使用 |
| US20140210770A1 (en) * | 2012-10-04 | 2014-07-31 | Corning Incorporated | Pressure sensing touch systems and methods |
| TW201427658A (zh) | 2012-12-10 | 2014-07-16 | Merck Sharp & Dohme | 藉由投予升糖素受體拮抗劑及膽固醇吸收抑制劑治療糖尿病之方法 |
| EP3065736B1 (en) | 2013-11-04 | 2018-11-14 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions thereof, and methods of use |
| WO2015191900A1 (en) | 2014-06-12 | 2015-12-17 | Ligand Pharmaceuticals, Inc. | Glucagon antagonists |
| BR112018010316A2 (pt) | 2015-12-01 | 2018-12-04 | Basf Se | compostos de fórmula, composição, utilização de um composto de fórmula, método para o combate de fungos fitopatogênicos e semente |
| EP3383848B1 (en) | 2015-12-01 | 2020-01-08 | Basf Se | Pyridine compounds as fungicides |
| UA126679C2 (uk) | 2017-05-30 | 2023-01-11 | Басф Се | Піридинові та піразинові сполуки |
| JP2021513564A (ja) | 2018-02-13 | 2021-05-27 | リガンド・ファーマシューティカルズ・インコーポレイテッド | グルカゴン受容体拮抗薬 |
| CN111184706B (zh) * | 2020-03-05 | 2020-11-17 | 牡丹江医学院 | 一种防治胆囊炎的活性药物及其用途 |
| KR102606541B1 (ko) * | 2021-04-23 | 2023-11-29 | 가천대학교 산학협력단 | 바이페닐설폰아마이드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 글루카곤 수용체 활성 관련 질환의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4973731A (en) | 1987-04-23 | 1990-11-27 | Riker Laboratories, Inc. | Di-t-butylphenyl alkyl and benzyl ether nitriles |
| GB9420557D0 (en) | 1994-10-12 | 1994-11-30 | Zeneca Ltd | Aromatic compounds |
| WO1999050249A2 (en) * | 1998-04-01 | 1999-10-07 | Du Pont Pharmaceuticals Company | Pyrimidines and triazines as integrin antagonists |
| AU4537900A (en) * | 1999-05-17 | 2000-12-05 | Agouron Pharmaceuticals, Inc. | Glucagon antagonists/inverse agonists |
| KR20030029061A (ko) * | 2000-06-23 | 2003-04-11 | 노보 노르디스크 에이/에스 | 글루카곤 길항제/역작용제 |
| US6706744B2 (en) | 2000-11-17 | 2004-03-16 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| AU2002365622A1 (en) * | 2001-12-03 | 2003-06-17 | Novo Nordisk A/S | Novel glucagon antagonists |
| JP2006500325A (ja) * | 2002-06-27 | 2006-01-05 | ノボ ノルディスク アクティーゼルスカブ | 新規なグルカゴンアンタゴニスト |
| WO2004056763A2 (en) | 2002-12-20 | 2004-07-08 | Novo Nordisk A/S | Novel glucagon antagonists |
| WO2005102067A1 (en) | 2004-04-26 | 2005-11-03 | Ipn Ip B.V. | Packaged flowable ice product, such as a milk shake |
| US7989457B2 (en) | 2004-05-28 | 2011-08-02 | Eli Lilly And Company | Glucagon receptor antagonists, preparation and therapeutic uses |
| PT1758853E (pt) * | 2004-06-14 | 2010-03-02 | Lilly Co Eli | Antagonistas do receptor de glucagon, sua preparação e usos terapêuticos |
| US8084489B2 (en) * | 2005-02-11 | 2011-12-27 | Eli Lilly And Company | Glucagon receptor antagonists, preparation and therapeutic uses |
| US8318760B2 (en) | 2005-03-21 | 2012-11-27 | Merck Sharp & Dohme Corp. | Substituted aryl and heteroaryl derivatives, compositions containing such compounds and methods of use |
| CN101312940B (zh) | 2005-11-17 | 2012-11-14 | 伊莱利利公司 | 胰高血糖素受体拮抗剂、制备和治疗用途 |
| ES2391109T3 (es) | 2005-11-17 | 2012-11-21 | Eli Lilly And Company | Antagonistas del receptor de glucagón, preparación y usos terapéuticos |
| AU2006341392B2 (en) | 2005-11-18 | 2012-05-17 | Eli Lilly And Company | Glucagon receptor antagonists, preparation and therapeutic uses |
| CN101312723B (zh) | 2005-11-22 | 2012-01-11 | 伊莱利利公司 | 胰高血糖素受体拮抗剂、制备和治疗用途 |
| EP1957484B1 (en) | 2005-11-23 | 2010-03-03 | Eli Lilly & Company | Glucagon receptor antagonists, preparation and therapeutic uses |
-
2005
- 2005-06-08 PT PT05757998T patent/PT1758853E/pt unknown
- 2005-06-08 BR BRPI0512058-6A patent/BRPI0512058A/pt not_active IP Right Cessation
- 2005-06-08 RS RSP-2010/0134A patent/RS51202B/sr unknown
- 2005-06-08 CN CN2005800194966A patent/CN1968921B/zh not_active Expired - Lifetime
- 2005-06-08 EP EP08170258A patent/EP2159221A1/en not_active Withdrawn
- 2005-06-08 CA CA2569459A patent/CA2569459C/en not_active Expired - Fee Related
- 2005-06-08 EA EA200700027A patent/EA013003B1/ru not_active IP Right Cessation
- 2005-06-08 KR KR1020067026229A patent/KR100835496B1/ko not_active Expired - Fee Related
- 2005-06-08 PL PL05757998T patent/PL1758853T3/pl unknown
- 2005-06-08 AU AU2005254950A patent/AU2005254950B2/en not_active Ceased
- 2005-06-08 DK DK05757998.9T patent/DK1758853T3/da active
- 2005-06-08 DE DE602005019043T patent/DE602005019043D1/de not_active Expired - Lifetime
- 2005-06-08 HR HR20100148T patent/HRP20100148T1/hr unknown
- 2005-06-08 WO PCT/US2005/019901 patent/WO2005123668A1/en not_active Ceased
- 2005-06-08 EP EP05757998A patent/EP1758853B1/en not_active Expired - Lifetime
- 2005-06-08 AT AT05757998T patent/ATE455756T1/de active
- 2005-06-08 US US11/570,449 patent/US7816557B2/en active Active
- 2005-06-08 SI SI200530975T patent/SI1758853T1/sl unknown
- 2005-06-08 MX MXPA06014426A patent/MXPA06014426A/es active IP Right Grant
- 2005-06-08 NZ NZ551015A patent/NZ551015A/en not_active IP Right Cessation
- 2005-06-08 JP JP2007516542A patent/JP5000492B2/ja not_active Expired - Lifetime
- 2005-06-08 UA UAA200612965A patent/UA86621C2/ru unknown
- 2005-06-08 ES ES05757998T patent/ES2337596T3/es not_active Expired - Lifetime
-
2006
- 2006-11-27 IL IL179599A patent/IL179599A/en not_active IP Right Cessation
- 2006-12-08 ZA ZA200610298A patent/ZA200610298B/en unknown
- 2006-12-13 EC EC2006007082A patent/ECSP067082A/es unknown
- 2006-12-29 MA MA29594A patent/MA28706B1/fr unknown
-
2007
- 2007-01-12 NO NO20070213A patent/NO341028B1/no not_active IP Right Cessation
-
2010
- 2010-02-11 CY CY20101100144T patent/CY1109787T1/el unknown
- 2010-08-26 US US12/868,773 patent/US20100324140A1/en not_active Abandoned
- 2010-11-19 AU AU2010246329A patent/AU2010246329A1/en not_active Abandoned
-
2011
- 2011-01-25 US US13/013,280 patent/US8609892B2/en active Active