JP2008530102A5 - - Google Patents
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- Publication number
- JP2008530102A5 JP2008530102A5 JP2007555195A JP2007555195A JP2008530102A5 JP 2008530102 A5 JP2008530102 A5 JP 2008530102A5 JP 2007555195 A JP2007555195 A JP 2007555195A JP 2007555195 A JP2007555195 A JP 2007555195A JP 2008530102 A5 JP2008530102 A5 JP 2008530102A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- hydrogen
- nitrogen
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 63
- 229910052739 hydrogen Inorganic materials 0.000 claims description 40
- 239000001257 hydrogen Substances 0.000 claims description 40
- 229910052757 nitrogen Inorganic materials 0.000 claims description 37
- 229910052736 halogen Inorganic materials 0.000 claims description 22
- 125000003545 alkoxy group Chemical group 0.000 claims description 21
- 150000002367 halogens Chemical class 0.000 claims description 14
- 125000003342 alkenyl group Chemical group 0.000 claims description 11
- 150000001875 compounds Chemical class 0.000 claims description 11
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 11
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 10
- 229910052799 carbon Inorganic materials 0.000 claims description 10
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 10
- 125000001475 halogen functional group Chemical group 0.000 claims description 8
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 125000004429 atom Chemical group 0.000 claims description 6
- 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims description 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 3
- IPWGCHBBVBSTMX-UHFFFAOYSA-N 3-[[5-[1-[4-(4-tert-butylphenyl)-3,5-dimethylphenyl]sulfanyl-2,2-dimethylpropyl]thiophene-2-carbonyl]amino]propanoic acid Chemical compound C=1C(C)=C(C=2C=CC(=CC=2)C(C)(C)C)C(C)=CC=1SC(C(C)(C)C)C1=CC=C(C(=O)NCCC(O)=O)S1 IPWGCHBBVBSTMX-UHFFFAOYSA-N 0.000 claims description 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 4
- -1 - nitro Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 description 4
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 description 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65249205P | 2005-02-11 | 2005-02-11 | |
| US60/652,492 | 2005-02-11 | ||
| PCT/US2006/004461 WO2006086488A2 (en) | 2005-02-11 | 2006-02-09 | Substituted thiophene derivatives as glucagon receptor antagonists, preparation and therapeutic uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008530102A JP2008530102A (ja) | 2008-08-07 |
| JP2008530102A5 true JP2008530102A5 (enExample) | 2009-03-26 |
| JP4988604B2 JP4988604B2 (ja) | 2012-08-01 |
Family
ID=36694345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007555195A Expired - Fee Related JP4988604B2 (ja) | 2005-02-11 | 2006-02-09 | グルカゴン受容体アンタゴニストとしての置換チオフェン誘導体、その調製及び治療への使用 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8084489B2 (enExample) |
| EP (1) | EP1856090B1 (enExample) |
| JP (1) | JP4988604B2 (enExample) |
| KR (1) | KR20070104409A (enExample) |
| CN (1) | CN101115735B (enExample) |
| AT (1) | ATE445609T1 (enExample) |
| AU (1) | AU2006213894B2 (enExample) |
| BR (1) | BRPI0607015A2 (enExample) |
| CA (1) | CA2597073C (enExample) |
| CR (1) | CR9304A (enExample) |
| CY (1) | CY1109624T1 (enExample) |
| DE (1) | DE602006009773D1 (enExample) |
| DK (1) | DK1856090T3 (enExample) |
| EA (1) | EA200701705A1 (enExample) |
| ES (1) | ES2332470T3 (enExample) |
| IL (1) | IL184932A0 (enExample) |
| MA (1) | MA29432B1 (enExample) |
| MX (1) | MX2007009661A (enExample) |
| NO (1) | NO20074567L (enExample) |
| PL (1) | PL1856090T3 (enExample) |
| PT (1) | PT1856090E (enExample) |
| SI (1) | SI1856090T1 (enExample) |
| TN (1) | TNSN07313A1 (enExample) |
| WO (1) | WO2006086488A2 (enExample) |
| ZA (1) | ZA200706354B (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE455756T1 (de) * | 2004-06-14 | 2010-02-15 | Lilly Co Eli | Glucagonrezeptorantagonisten, deren herstellung und therapeutische verwendung |
| PT2129654E (pt) | 2007-02-09 | 2014-09-04 | Metabasis Therapeutics Inc | Antagonistas do receptor de glucagina |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| MX2011001708A (es) | 2008-08-13 | 2011-04-26 | Metabasis Therapeutics Inc | Antagonistas de glucagon. |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| WO2012085745A1 (en) | 2010-12-23 | 2012-06-28 | Pfizer Inc. | Glucagon receptor modulators |
| PT2673260T (pt) | 2011-02-08 | 2016-10-24 | Pfizer | Modulador do recetor de glucagon |
| US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| JP5647379B2 (ja) | 2011-07-22 | 2014-12-24 | ファイザー・インク | キノリニルグルカゴン受容体モジュレーター |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| TW201427658A (zh) | 2012-12-10 | 2014-07-16 | Merck Sharp & Dohme | 藉由投予升糖素受體拮抗劑及膽固醇吸收抑制劑治療糖尿病之方法 |
| US9649294B2 (en) | 2013-11-04 | 2017-05-16 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
| JP2017519000A (ja) | 2014-06-12 | 2017-07-13 | リガンド・ファーマシューティカルズ・インコーポレイテッド | グルカゴンアンタゴニスト |
| EP3350200A4 (en) | 2015-09-18 | 2019-03-27 | Wake Forest University Health Services | ANGIOTENSIN (1 7) ANALOGUE AND ASSOCIATED PROCEDURES |
| US20180289859A1 (en) | 2015-10-05 | 2018-10-11 | Hettwer Holding Aps | Compositions and methods for treatment of bone defects |
| CA2914601A1 (en) * | 2015-12-11 | 2017-06-11 | Wake Forest University Health Sciences | Angiotensin-(1-7) analogs and methods relating thereto |
| KR102708864B1 (ko) | 2016-08-30 | 2024-09-25 | 리제너론 파마슈티칼스 인코포레이티드 | 글루카곤 수용체 신호전달을 간섭함에 의한 중증 인슐린 저항성의 치료 방법 |
| US20190248888A1 (en) | 2016-10-20 | 2019-08-15 | Regeneron Pharmaceuticals, Inc. | Methods of lowering blood glucose levels |
| JP7781519B2 (ja) | 2017-08-22 | 2025-12-08 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | グルカゴン受容体シグナル伝達に干渉することによって尿素サイクル異常症を治療する方法 |
| JP2021513564A (ja) | 2018-02-13 | 2021-05-27 | リガンド・ファーマシューティカルズ・インコーポレイテッド | グルカゴン受容体拮抗薬 |
| CN118496197A (zh) | 2019-12-20 | 2024-08-16 | 拜耳公司 | 取代的噻吩甲酰胺、噻吩甲酸及其衍生物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1463715A1 (en) * | 2001-12-03 | 2004-10-06 | Novo Nordisk A/S | Novel glucagon antagonists |
| AU2003233780A1 (en) * | 2002-06-27 | 2004-01-19 | Novo Nordisk A/S | Novel glucagon antagonists/inverse agonists |
| WO2005118542A1 (en) * | 2004-05-28 | 2005-12-15 | Eli Lilly And Company | Glucagon receptor antagonists, preparation and therapeutic uses |
| ATE455756T1 (de) | 2004-06-14 | 2010-02-15 | Lilly Co Eli | Glucagonrezeptorantagonisten, deren herstellung und therapeutische verwendung |
-
2006
- 2006-02-09 US US11/815,987 patent/US8084489B2/en not_active Expired - Fee Related
- 2006-02-09 ES ES06720513T patent/ES2332470T3/es not_active Expired - Lifetime
- 2006-02-09 AT AT06720513T patent/ATE445609T1/de active
- 2006-02-09 AU AU2006213894A patent/AU2006213894B2/en not_active Ceased
- 2006-02-09 BR BRPI0607015-9A patent/BRPI0607015A2/pt not_active IP Right Cessation
- 2006-02-09 PL PL06720513T patent/PL1856090T3/pl unknown
- 2006-02-09 CN CN2006800046189A patent/CN101115735B/zh not_active Expired - Fee Related
- 2006-02-09 SI SI200630534T patent/SI1856090T1/sl unknown
- 2006-02-09 JP JP2007555195A patent/JP4988604B2/ja not_active Expired - Fee Related
- 2006-02-09 MX MX2007009661A patent/MX2007009661A/es active IP Right Grant
- 2006-02-09 PT PT06720513T patent/PT1856090E/pt unknown
- 2006-02-09 DK DK06720513T patent/DK1856090T3/da active
- 2006-02-09 CA CA2597073A patent/CA2597073C/en not_active Expired - Fee Related
- 2006-02-09 EP EP06720513A patent/EP1856090B1/en not_active Expired - Lifetime
- 2006-02-09 KR KR1020077018437A patent/KR20070104409A/ko not_active Ceased
- 2006-02-09 EA EA200701705A patent/EA200701705A1/ru unknown
- 2006-02-09 DE DE602006009773T patent/DE602006009773D1/de not_active Expired - Lifetime
- 2006-02-09 WO PCT/US2006/004461 patent/WO2006086488A2/en not_active Ceased
-
2007
- 2007-07-30 IL IL184932A patent/IL184932A0/en unknown
- 2007-07-31 ZA ZA200706354A patent/ZA200706354B/xx unknown
- 2007-08-10 CR CR9304A patent/CR9304A/es not_active Application Discontinuation
- 2007-08-10 TN TNP2007000313A patent/TNSN07313A1/en unknown
- 2007-09-10 NO NO20074567A patent/NO20074567L/no not_active Application Discontinuation
- 2007-09-11 MA MA30221A patent/MA29432B1/fr unknown
-
2009
- 2009-11-12 CY CY20091101192T patent/CY1109624T1/el unknown
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