JP2008540454A5 - - Google Patents
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- Publication number
- JP2008540454A5 JP2008540454A5 JP2008510307A JP2008510307A JP2008540454A5 JP 2008540454 A5 JP2008540454 A5 JP 2008540454A5 JP 2008510307 A JP2008510307 A JP 2008510307A JP 2008510307 A JP2008510307 A JP 2008510307A JP 2008540454 A5 JP2008540454 A5 JP 2008540454A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- compound
- cyclopropyl
- chcn
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 30
- 229910052801 chlorine Inorganic materials 0.000 claims 27
- -1 CH 2 CF 3 Chemical group 0.000 claims 22
- 229910052731 fluorine Inorganic materials 0.000 claims 19
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 19
- 229910052794 bromium Inorganic materials 0.000 claims 17
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 15
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 14
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 9
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- 229910052740 iodine Inorganic materials 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 3
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 3
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical group 0.000 claims 2
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 claims 2
- 125000006413 ring segment Chemical group 0.000 claims 2
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 230000037361 pathway Effects 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67866705P | 2005-05-05 | 2005-05-05 | |
| US60/678,667 | 2005-05-05 | ||
| PCT/US2006/017677 WO2006122003A2 (en) | 2005-05-05 | 2006-05-05 | Diaryl-purine, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitors for treatment of hiv |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012143245A Division JP2012188454A (ja) | 2005-05-05 | 2012-06-26 | Ｈｉｖの処置のための非ヌクレオシド逆転写酵素インヒビターとしてのジアリル−プリン、−アザプリンおよび−デアザプリン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008540454A JP2008540454A (ja) | 2008-11-20 |
| JP2008540454A5 true JP2008540454A5 (enExample) | 2010-05-06 |
| JP5138585B2 JP5138585B2 (ja) | 2013-02-06 |
Family
ID=37397195
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008510307A Expired - Fee Related JP5138585B2 (ja) | 2005-05-05 | 2006-05-05 | Ｈｉｖの処置のための非ヌクレオシド逆転写酵素インヒビターとしてのジアリル−プリン、−アザプリンおよび−デアザプリン |
| JP2012143245A Pending JP2012188454A (ja) | 2005-05-05 | 2012-06-26 | Ｈｉｖの処置のための非ヌクレオシド逆転写酵素インヒビターとしてのジアリル−プリン、−アザプリンおよび−デアザプリン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012143245A Pending JP2012188454A (ja) | 2005-05-05 | 2012-06-26 | Ｈｉｖの処置のための非ヌクレオシド逆転写酵素インヒビターとしてのジアリル−プリン、−アザプリンおよび−デアザプリン |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8227601B2 (enExample) |
| EP (1) | EP1877411B9 (enExample) |
| JP (2) | JP5138585B2 (enExample) |
| CN (1) | CN101233135B (enExample) |
| AT (1) | ATE541848T1 (enExample) |
| AU (1) | AU2006244195B2 (enExample) |
| BR (1) | BRPI0611455A2 (enExample) |
| CA (1) | CA2607021C (enExample) |
| ES (1) | ES2380951T3 (enExample) |
| MX (1) | MX2007013715A (enExample) |
| WO (1) | WO2006122003A2 (enExample) |
| ZA (1) | ZA200709481B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0414791A (pt) * | 2003-09-25 | 2006-11-21 | Janssen Pharmaceutica Nv | derivados de purina inibidores da replicação do hiv |
| ES2380951T3 (es) * | 2005-05-05 | 2012-05-21 | Ardea Biosciences, Inc. | Diaril-purinas, -azapurinasy - desazapurinas como inhibidores no nucleósidos de la transcriptasa inversa para el tratamiento del VIH |
| KR20090103897A (ko) * | 2006-12-28 | 2009-10-01 | 다이쇼 세이야꾸 가부시끼가이샤 | 피라졸로피리미딘 화합물 |
| WO2009079412A2 (en) | 2007-12-14 | 2009-06-25 | Ardea Biosciences Inc. | Reverse transcriptase inhibitors |
| PE20091485A1 (es) | 2008-02-06 | 2009-10-26 | Novartis Ag | DERIVADOS DE PIRROLO-[2,3-d]-PIRIMIDINA COMO INHIBIDORES DE CINASAS |
| WO2010111406A2 (en) * | 2009-03-24 | 2010-09-30 | Myriad Pharmaceuticals, Inc. | Compounds and therapeutic uses thereof |
| NO3030563T3 (enExample) * | 2013-06-27 | 2018-01-06 | ||
| CN106232118A (zh) | 2014-04-25 | 2016-12-14 | 辉瑞大药厂 | 杂芳族化合物及其作为多巴胺d1配体的用途 |
| EP3256475A4 (en) | 2015-02-13 | 2019-02-13 | Dana-Farber Cancer Institute, Inc. | LRRK2 INHIBITORS AND METHOD FOR THE PRODUCTION AND USE THEREOF |
| CN106188060A (zh) * | 2015-04-29 | 2016-12-07 | 厦门大学 | 嘧啶并吡咯类化合物、其制备方法、药用组合物及其应用 |
| JP6541871B2 (ja) * | 2015-08-13 | 2019-07-10 | 北京韓美薬品有限公司 | Ｉｒａｋ４阻害剤、及びその応用 |
| CN106117242B (zh) * | 2016-06-27 | 2018-08-03 | 山东大学 | 四氢噻喃并嘧啶类衍生物及其制备方法与应用 |
| CN107793417B (zh) * | 2016-09-05 | 2020-06-09 | 复旦大学 | 吡咯并[2,3-d]嘧啶类化合物及其盐，及制备方法和药用用途 |
| CN106749266B (zh) * | 2016-11-14 | 2019-01-22 | 山东大学 | 吡咯并[2,3-d]嘧啶类化合物的高效制备方法 |
| TW201945003A (zh) | 2018-03-01 | 2019-12-01 | 愛爾蘭商健生科學愛爾蘭無限公司 | ２，４－二胺基喹唑啉衍生物及其醫學用途 |
| CN111499639B (zh) * | 2019-01-31 | 2022-03-04 | 四川大学华西医院 | 嘧啶酮衍生物及其在制药中的应用 |
| US20230279006A1 (en) * | 2020-07-08 | 2023-09-07 | Klotho Therapeutics, Inc. | Novel compounds and methods for increasing klotho gene expression |
| CN116528869A (zh) * | 2020-11-27 | 2023-08-01 | 安锐生物医药科技(广州)有限公司 | 氨基杂芳基激酶抑制剂 |
| WO2024228580A1 (ko) * | 2023-05-04 | 2024-11-07 | 주식회사 대웅제약 | 신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물 |
| US20250333424A1 (en) * | 2024-03-01 | 2025-10-30 | Gilead Sciences, Inc. | Antiviral compounds |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ229453A (en) * | 1988-06-10 | 1991-08-27 | Univ Minnesota & Southern Rese | A pharmaceutical composition containing purine derivatives with nucleosides such as azt, as antiviral agents |
| BR9915129A (pt) | 1998-11-12 | 2001-08-07 | Neurocrine Biosciences Inc | Antagonistas do receptor de crf e processos relacionados aos mesmos |
| AU2217200A (en) * | 1998-12-23 | 2000-07-12 | Neurogen Corporation | 2-amino-9-alkylpurines: gaba brain receptor ligands |
| CZ27399A3 (cs) | 1999-01-26 | 2000-08-16 | Ústav Experimentální Botaniky Av Čr | Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv |
| YU25500A (sh) * | 1999-05-11 | 2003-08-29 | Pfizer Products Inc. | Postupak za sintezu analoga nukleozida |
| JO3429B1 (ar) | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
| CN1747937A (zh) | 2003-02-07 | 2006-03-15 | 詹森药业有限公司 | 预防hiv感染的嘧啶衍生物 |
| BRPI0414791A (pt) * | 2003-09-25 | 2006-11-21 | Janssen Pharmaceutica Nv | derivados de purina inibidores da replicação do hiv |
| KR20070085286A (ko) | 2004-10-29 | 2007-08-27 | 티보텍 파마슈티칼즈 리미티드 | Ｈｉｖ를 저해하는 바이사이클릭 피리미딘 유도체 |
| ES2380951T3 (es) * | 2005-05-05 | 2012-05-21 | Ardea Biosciences, Inc. | Diaril-purinas, -azapurinasy - desazapurinas como inhibidores no nucleósidos de la transcriptasa inversa para el tratamiento del VIH |
-
2006
- 2006-05-05 ES ES06759292T patent/ES2380951T3/es active Active
- 2006-05-05 CA CA2607021A patent/CA2607021C/en not_active Expired - Fee Related
- 2006-05-05 AT AT06759292T patent/ATE541848T1/de active
- 2006-05-05 WO PCT/US2006/017677 patent/WO2006122003A2/en not_active Ceased
- 2006-05-05 EP EP06759292A patent/EP1877411B9/en not_active Not-in-force
- 2006-05-05 AU AU2006244195A patent/AU2006244195B2/en not_active Ceased
- 2006-05-05 BR BRPI0611455-5A patent/BRPI0611455A2/pt not_active Application Discontinuation
- 2006-05-05 MX MX2007013715A patent/MX2007013715A/es active IP Right Grant
- 2006-05-05 JP JP2008510307A patent/JP5138585B2/ja not_active Expired - Fee Related
- 2006-05-05 US US11/919,786 patent/US8227601B2/en not_active Expired - Fee Related
- 2006-05-05 CN CN2006800243079A patent/CN101233135B/zh not_active Expired - Fee Related
-
2007
- 2007-11-02 ZA ZA200709481A patent/ZA200709481B/xx unknown
-
2012
- 2012-05-11 US US13/470,116 patent/US8354532B2/en not_active Expired - Fee Related
- 2012-06-26 JP JP2012143245A patent/JP2012188454A/ja active Pending
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