CN101233135B - 用作非核苷反转录酶抑制剂治疗人免疫缺陷病毒的二芳基-嘌呤、二芳基-氮杂嘌呤和二芳基-脱氮嘌呤化合物 - Google Patents
用作非核苷反转录酶抑制剂治疗人免疫缺陷病毒的二芳基-嘌呤、二芳基-氮杂嘌呤和二芳基-脱氮嘌呤化合物 Download PDFInfo
- Publication number
- CN101233135B CN101233135B CN2006800243079A CN200680024307A CN101233135B CN 101233135 B CN101233135 B CN 101233135B CN 2006800243079 A CN2006800243079 A CN 2006800243079A CN 200680024307 A CN200680024307 A CN 200680024307A CN 101233135 B CN101233135 B CN 101233135B
- Authority
- CN
- China
- Prior art keywords
- phenyl
- benzyl
- chcn
- cyano
- dimethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C*c1ccc(*)c2c1**C=C2 Chemical compound C*c1ccc(*)c2c1**C=C2 0.000 description 10
- CEOCOEYWBZIJPY-UHFFFAOYSA-N CC(c(cc1C)cc(C)c1Oc(nc(Nc(cc1)ccc1C#N)nc12)c1[nH]cc2Cl)=O Chemical compound CC(c(cc1C)cc(C)c1Oc(nc(Nc(cc1)ccc1C#N)nc12)c1[nH]cc2Cl)=O CEOCOEYWBZIJPY-UHFFFAOYSA-N 0.000 description 1
- QMIPELKRBLEKIP-WOJGMQOQSA-N CN(C)/C=N/C(N(Cc1ccccc1)C1=O)=NC2=C1NCC2 Chemical compound CN(C)/C=N/C(N(Cc1ccccc1)C1=O)=NC2=C1NCC2 QMIPELKRBLEKIP-WOJGMQOQSA-N 0.000 description 1
- PFGKQRWHIVJCSQ-UHFFFAOYSA-N Cc1cc(C#N)cc(C)c1Oc1nc(Nc(cc2)ccc2C#N)nc2c1cc[nH]2 Chemical compound Cc1cc(C#N)cc(C)c1Oc1nc(Nc(cc2)ccc2C#N)nc2c1cc[nH]2 PFGKQRWHIVJCSQ-UHFFFAOYSA-N 0.000 description 1
- AGTHBEGJAMMRCF-UHFFFAOYSA-N Cc1cc(C#N)cc(C)c1Oc1nc(Nc(cc2)ccc2C#N)nc2c1cc[n]2Cc1ccccc1 Chemical compound Cc1cc(C#N)cc(C)c1Oc1nc(Nc(cc2)ccc2C#N)nc2c1cc[n]2Cc1ccccc1 AGTHBEGJAMMRCF-UHFFFAOYSA-N 0.000 description 1
- LOIHNZYZBKERQS-UHFFFAOYSA-N Cc1cc(CN(C)C)cc(C)c1Oc1c2[nH]ccc2nc(Nc(cc2)ccc2C#N)n1 Chemical compound Cc1cc(CN(C)C)cc(C)c1Oc1c2[nH]ccc2nc(Nc(cc2)ccc2C#N)n1 LOIHNZYZBKERQS-UHFFFAOYSA-N 0.000 description 1
- MVTLFDKTYGKJEX-UHFFFAOYSA-N Clc1nc(Cl)nc2c1[nH]cc2 Chemical compound Clc1nc(Cl)nc2c1[nH]cc2 MVTLFDKTYGKJEX-UHFFFAOYSA-N 0.000 description 1
- XOKDXPVXJWTSRM-UHFFFAOYSA-N N#Cc(cc1)ccc1I Chemical compound N#Cc(cc1)ccc1I XOKDXPVXJWTSRM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67866705P | 2005-05-05 | 2005-05-05 | |
| US60/678,667 | 2005-05-05 | ||
| PCT/US2006/017677 WO2006122003A2 (en) | 2005-05-05 | 2006-05-05 | Diaryl-purine, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitors for treatment of hiv |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101233135A CN101233135A (zh) | 2008-07-30 |
| CN101233135B true CN101233135B (zh) | 2012-10-03 |
Family
ID=37397195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2006800243079A Expired - Fee Related CN101233135B (zh) | 2005-05-05 | 2006-05-05 | 用作非核苷反转录酶抑制剂治疗人免疫缺陷病毒的二芳基-嘌呤、二芳基-氮杂嘌呤和二芳基-脱氮嘌呤化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8227601B2 (enExample) |
| EP (1) | EP1877411B9 (enExample) |
| JP (2) | JP5138585B2 (enExample) |
| CN (1) | CN101233135B (enExample) |
| AT (1) | ATE541848T1 (enExample) |
| AU (1) | AU2006244195B2 (enExample) |
| BR (1) | BRPI0611455A2 (enExample) |
| CA (1) | CA2607021C (enExample) |
| ES (1) | ES2380951T3 (enExample) |
| MX (1) | MX2007013715A (enExample) |
| WO (1) | WO2006122003A2 (enExample) |
| ZA (1) | ZA200709481B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0414791A (pt) * | 2003-09-25 | 2006-11-21 | Janssen Pharmaceutica Nv | derivados de purina inibidores da replicação do hiv |
| ES2380951T3 (es) * | 2005-05-05 | 2012-05-21 | Ardea Biosciences, Inc. | Diaril-purinas, -azapurinasy - desazapurinas como inhibidores no nucleósidos de la transcriptasa inversa para el tratamiento del VIH |
| KR20090103897A (ko) * | 2006-12-28 | 2009-10-01 | 다이쇼 세이야꾸 가부시끼가이샤 | 피라졸로피리미딘 화합물 |
| WO2009079412A2 (en) | 2007-12-14 | 2009-06-25 | Ardea Biosciences Inc. | Reverse transcriptase inhibitors |
| PE20091485A1 (es) | 2008-02-06 | 2009-10-26 | Novartis Ag | DERIVADOS DE PIRROLO-[2,3-d]-PIRIMIDINA COMO INHIBIDORES DE CINASAS |
| WO2010111406A2 (en) * | 2009-03-24 | 2010-09-30 | Myriad Pharmaceuticals, Inc. | Compounds and therapeutic uses thereof |
| NO3030563T3 (enExample) * | 2013-06-27 | 2018-01-06 | ||
| CN106232118A (zh) | 2014-04-25 | 2016-12-14 | 辉瑞大药厂 | 杂芳族化合物及其作为多巴胺d1配体的用途 |
| EP3256475A4 (en) | 2015-02-13 | 2019-02-13 | Dana-Farber Cancer Institute, Inc. | LRRK2 INHIBITORS AND METHOD FOR THE PRODUCTION AND USE THEREOF |
| CN106188060A (zh) * | 2015-04-29 | 2016-12-07 | 厦门大学 | 嘧啶并吡咯类化合物、其制备方法、药用组合物及其应用 |
| JP6541871B2 (ja) * | 2015-08-13 | 2019-07-10 | 北京韓美薬品有限公司 | Ｉｒａｋ４阻害剤、及びその応用 |
| CN106117242B (zh) * | 2016-06-27 | 2018-08-03 | 山东大学 | 四氢噻喃并嘧啶类衍生物及其制备方法与应用 |
| CN107793417B (zh) * | 2016-09-05 | 2020-06-09 | 复旦大学 | 吡咯并[2,3-d]嘧啶类化合物及其盐，及制备方法和药用用途 |
| CN106749266B (zh) * | 2016-11-14 | 2019-01-22 | 山东大学 | 吡咯并[2,3-d]嘧啶类化合物的高效制备方法 |
| TW201945003A (zh) | 2018-03-01 | 2019-12-01 | 愛爾蘭商健生科學愛爾蘭無限公司 | ２，４－二胺基喹唑啉衍生物及其醫學用途 |
| CN111499639B (zh) * | 2019-01-31 | 2022-03-04 | 四川大学华西医院 | 嘧啶酮衍生物及其在制药中的应用 |
| US20230279006A1 (en) * | 2020-07-08 | 2023-09-07 | Klotho Therapeutics, Inc. | Novel compounds and methods for increasing klotho gene expression |
| CN116528869A (zh) * | 2020-11-27 | 2023-08-01 | 安锐生物医药科技(广州)有限公司 | 氨基杂芳基激酶抑制剂 |
| WO2024228580A1 (ko) * | 2023-05-04 | 2024-11-07 | 주식회사 대웅제약 | 신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물 |
| US20250333424A1 (en) * | 2024-03-01 | 2025-10-30 | Gilead Sciences, Inc. | Antiviral compounds |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005028479A2 (en) * | 2003-09-25 | 2005-03-31 | Janssen Pharmaceutica N.V. | Hiv replication inhibiting purine derivatives |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ229453A (en) * | 1988-06-10 | 1991-08-27 | Univ Minnesota & Southern Rese | A pharmaceutical composition containing purine derivatives with nucleosides such as azt, as antiviral agents |
| BR9915129A (pt) | 1998-11-12 | 2001-08-07 | Neurocrine Biosciences Inc | Antagonistas do receptor de crf e processos relacionados aos mesmos |
| AU2217200A (en) * | 1998-12-23 | 2000-07-12 | Neurogen Corporation | 2-amino-9-alkylpurines: gaba brain receptor ligands |
| CZ27399A3 (cs) | 1999-01-26 | 2000-08-16 | Ústav Experimentální Botaniky Av Čr | Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv |
| YU25500A (sh) * | 1999-05-11 | 2003-08-29 | Pfizer Products Inc. | Postupak za sintezu analoga nukleozida |
| JO3429B1 (ar) | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
| CN1747937A (zh) | 2003-02-07 | 2006-03-15 | 詹森药业有限公司 | 预防hiv感染的嘧啶衍生物 |
| KR20070085286A (ko) | 2004-10-29 | 2007-08-27 | 티보텍 파마슈티칼즈 리미티드 | Ｈｉｖ를 저해하는 바이사이클릭 피리미딘 유도체 |
| ES2380951T3 (es) * | 2005-05-05 | 2012-05-21 | Ardea Biosciences, Inc. | Diaril-purinas, -azapurinasy - desazapurinas como inhibidores no nucleósidos de la transcriptasa inversa para el tratamiento del VIH |
-
2006
- 2006-05-05 ES ES06759292T patent/ES2380951T3/es active Active
- 2006-05-05 CA CA2607021A patent/CA2607021C/en not_active Expired - Fee Related
- 2006-05-05 AT AT06759292T patent/ATE541848T1/de active
- 2006-05-05 WO PCT/US2006/017677 patent/WO2006122003A2/en not_active Ceased
- 2006-05-05 EP EP06759292A patent/EP1877411B9/en not_active Not-in-force
- 2006-05-05 AU AU2006244195A patent/AU2006244195B2/en not_active Ceased
- 2006-05-05 BR BRPI0611455-5A patent/BRPI0611455A2/pt not_active Application Discontinuation
- 2006-05-05 MX MX2007013715A patent/MX2007013715A/es active IP Right Grant
- 2006-05-05 JP JP2008510307A patent/JP5138585B2/ja not_active Expired - Fee Related
- 2006-05-05 US US11/919,786 patent/US8227601B2/en not_active Expired - Fee Related
- 2006-05-05 CN CN2006800243079A patent/CN101233135B/zh not_active Expired - Fee Related
-
2007
- 2007-11-02 ZA ZA200709481A patent/ZA200709481B/xx unknown
-
2012
- 2012-05-11 US US13/470,116 patent/US8354532B2/en not_active Expired - Fee Related
- 2012-06-26 JP JP2012143245A patent/JP2012188454A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005028479A2 (en) * | 2003-09-25 | 2005-03-31 | Janssen Pharmaceutica N.V. | Hiv replication inhibiting purine derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1877411A4 (en) | 2008-10-22 |
| CN101233135A (zh) | 2008-07-30 |
| EP1877411A2 (en) | 2008-01-16 |
| WO2006122003A2 (en) | 2006-11-16 |
| MX2007013715A (es) | 2008-01-28 |
| CA2607021A1 (en) | 2006-11-16 |
| EP1877411B9 (en) | 2012-08-29 |
| US8227601B2 (en) | 2012-07-24 |
| BRPI0611455A2 (pt) | 2010-09-08 |
| JP2008540454A (ja) | 2008-11-20 |
| JP2012188454A (ja) | 2012-10-04 |
| ES2380951T3 (es) | 2012-05-21 |
| JP5138585B2 (ja) | 2013-02-06 |
| ES2380951T9 (es) | 2012-12-21 |
| US8354532B2 (en) | 2013-01-15 |
| AU2006244195B2 (en) | 2012-03-15 |
| ZA200709481B (en) | 2008-11-26 |
| WO2006122003A3 (en) | 2007-01-04 |
| US20120226037A1 (en) | 2012-09-06 |
| EP1877411B1 (en) | 2012-01-18 |
| ATE541848T1 (de) | 2012-02-15 |
| CA2607021C (en) | 2013-10-29 |
| AU2006244195A1 (en) | 2006-11-16 |
| US20090124802A1 (en) | 2009-05-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101233135B (zh) | 用作非核苷反转录酶抑制剂治疗人免疫缺陷病毒的二芳基-嘌呤、二芳基-氮杂嘌呤和二芳基-脱氮嘌呤化合物 | |
| TWI227235B (en) | Bicyclic nitrogen heterocycles | |
| JP2815617B2 (ja) | 縮合ピリミジン誘導体およびその製造方法 | |
| JP5046942B2 (ja) | Ｈｃｖ阻害性の二環式ピリミジン類 | |
| US7439240B2 (en) | Purine-or pyrrolol[2,3-d]pyrimidine-2-carbonitiles for treating diseases associated with cysteine protease activity | |
| TWI598343B (zh) | 非核苷反轉錄酶抑制劑 | |
| KR100571339B1 (ko) | 세포증식 억제제로서의 7-옥소 피리도피리미딘 | |
| AU2016370743B2 (en) | Bipyrazolyl derivatives useful for the treatment of autoimmune diseases | |
| AU2003267098A1 (en) | Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors | |
| JP2006521398A (ja) | ＴＧＦβの二−環式ピリミジン阻害剤 | |
| CN101443318A (zh) | 作为激酶抑制剂的杂二环甲酰胺 | |
| EP1940846B9 (en) | Pyrimidin-4-yl-3,4-dihydro-2h-pyrrolo[1,2a]pyrazin-1-one compounds | |
| US6387912B1 (en) | Utilization of pyrimidine derivatives for preventing and treating cerebral ischaemia | |
| EP1636235A1 (en) | Pyridinylpyrazolopyrimidinone derivatives as pde 7 inhibitors | |
| Gatta et al. | New [f]‐fused xanthines: Synthesis of 1, 3‐dipropyl‐1H, 3H‐pyrazino, pyrido, pyrimido and pyrrolo [2, 1‐f] purine‐2, 4‐diones | |
| EP2905024A1 (en) | Pyrido[2,3-d]pyrimidine-7(8H)-one derivatives for the treatment of infections caused by Flaviviridae | |
| JPH0559056A (ja) | キサンチン誘導体 | |
| TW202246261A (zh) | 作為抗癌劑的化合物 | |
| AU2012203082A1 (en) | Diaryl-purine, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitors for treatment of HIV | |
| CN120192323A (zh) | 含有吡咯酮的化合物 | |
| CN119462663A (zh) | 含有吡咯酮的化合物 | |
| MX2007002450A (es) | Pirimidinas biciclicas inhibidoras del virus de la hepatitis c. | |
| HK1197678A (en) | Purine derivatives for the treatment of viral infections |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121003 Termination date: 20210505 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |