ATE541848T1 - Diaryl-purin, azapurine und deazapurine als nichtnukleoside reverse-transkriptase-inhibitoren zur behandlung von hiv - Google Patents

Diaryl-purin, azapurine und deazapurine als nichtnukleoside reverse-transkriptase-inhibitoren zur behandlung von hiv

Info

Publication number
ATE541848T1
ATE541848T1 AT06759292T AT06759292T ATE541848T1 AT E541848 T1 ATE541848 T1 AT E541848T1 AT 06759292 T AT06759292 T AT 06759292T AT 06759292 T AT06759292 T AT 06759292T AT E541848 T1 ATE541848 T1 AT E541848T1
Authority
AT
Austria
Prior art keywords
reverse transcriptase
hiv
transcriptase inhibitors
treatment
nucleoside reverse
Prior art date
Application number
AT06759292T
Other languages
German (de)
English (en)
Inventor
Jean Luc Girardet
Yung-Hyo Koh
Stephanie Shaw
Hong Woo Kim
Original Assignee
Ardea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ardea Biosciences Inc filed Critical Ardea Biosciences Inc
Application granted granted Critical
Publication of ATE541848T1 publication Critical patent/ATE541848T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT06759292T 2005-05-05 2006-05-05 Diaryl-purin, azapurine und deazapurine als nichtnukleoside reverse-transkriptase-inhibitoren zur behandlung von hiv ATE541848T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67866705P 2005-05-05 2005-05-05
PCT/US2006/017677 WO2006122003A2 (en) 2005-05-05 2006-05-05 Diaryl-purine, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitors for treatment of hiv

Publications (1)

Publication Number Publication Date
ATE541848T1 true ATE541848T1 (de) 2012-02-15

Family

ID=37397195

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06759292T ATE541848T1 (de) 2005-05-05 2006-05-05 Diaryl-purin, azapurine und deazapurine als nichtnukleoside reverse-transkriptase-inhibitoren zur behandlung von hiv

Country Status (12)

Country Link
US (2) US8227601B2 (enExample)
EP (1) EP1877411B9 (enExample)
JP (2) JP5138585B2 (enExample)
CN (1) CN101233135B (enExample)
AT (1) ATE541848T1 (enExample)
AU (1) AU2006244195B2 (enExample)
BR (1) BRPI0611455A2 (enExample)
CA (1) CA2607021C (enExample)
ES (1) ES2380951T3 (enExample)
MX (1) MX2007013715A (enExample)
WO (1) WO2006122003A2 (enExample)
ZA (1) ZA200709481B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0414791A (pt) * 2003-09-25 2006-11-21 Janssen Pharmaceutica Nv derivados de purina inibidores da replicação do hiv
ES2380951T3 (es) * 2005-05-05 2012-05-21 Ardea Biosciences, Inc. Diaril-purinas, -azapurinasy - desazapurinas como inhibidores no nucleósidos de la transcriptasa inversa para el tratamiento del VIH
KR20090103897A (ko) * 2006-12-28 2009-10-01 다이쇼 세이야꾸 가부시끼가이샤 피라졸로피리미딘 화합물
WO2009079412A2 (en) 2007-12-14 2009-06-25 Ardea Biosciences Inc. Reverse transcriptase inhibitors
PE20091485A1 (es) 2008-02-06 2009-10-26 Novartis Ag DERIVADOS DE PIRROLO-[2,3-d]-PIRIMIDINA COMO INHIBIDORES DE CINASAS
WO2010111406A2 (en) * 2009-03-24 2010-09-30 Myriad Pharmaceuticals, Inc. Compounds and therapeutic uses thereof
NO3030563T3 (enExample) * 2013-06-27 2018-01-06
CN106232118A (zh) 2014-04-25 2016-12-14 辉瑞大药厂 杂芳族化合物及其作为多巴胺d1配体的用途
EP3256475A4 (en) 2015-02-13 2019-02-13 Dana-Farber Cancer Institute, Inc. LRRK2 INHIBITORS AND METHOD FOR THE PRODUCTION AND USE THEREOF
CN106188060A (zh) * 2015-04-29 2016-12-07 厦门大学 嘧啶并吡咯类化合物、其制备方法、药用组合物及其应用
JP6541871B2 (ja) * 2015-08-13 2019-07-10 北京韓美薬品有限公司 Ｉｒａｋ４阻害剤、及びその応用
CN106117242B (zh) * 2016-06-27 2018-08-03 山东大学 四氢噻喃并嘧啶类衍生物及其制备方法与应用
CN107793417B (zh) * 2016-09-05 2020-06-09 复旦大学 吡咯并[2,3-d]嘧啶类化合物及其盐，及制备方法和药用用途
CN106749266B (zh) * 2016-11-14 2019-01-22 山东大学 吡咯并[2,3-d]嘧啶类化合物的高效制备方法
TW201945003A (zh) 2018-03-01 2019-12-01 愛爾蘭商健生科學愛爾蘭無限公司 ２，４－二胺基喹唑啉衍生物及其醫學用途
CN111499639B (zh) * 2019-01-31 2022-03-04 四川大学华西医院 嘧啶酮衍生物及其在制药中的应用
US20230279006A1 (en) * 2020-07-08 2023-09-07 Klotho Therapeutics, Inc. Novel compounds and methods for increasing klotho gene expression
CN116528869A (zh) * 2020-11-27 2023-08-01 安锐生物医药科技(广州)有限公司 氨基杂芳基激酶抑制剂
WO2024228580A1 (ko) * 2023-05-04 2024-11-07 주식회사 대웅제약 신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물
US20250333424A1 (en) * 2024-03-01 2025-10-30 Gilead Sciences, Inc. Antiviral compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ229453A (en) * 1988-06-10 1991-08-27 Univ Minnesota & Southern Rese A pharmaceutical composition containing purine derivatives with nucleosides such as azt, as antiviral agents
BR9915129A (pt) 1998-11-12 2001-08-07 Neurocrine Biosciences Inc Antagonistas do receptor de crf e processos relacionados aos mesmos
AU2217200A (en) * 1998-12-23 2000-07-12 Neurogen Corporation 2-amino-9-alkylpurines: gaba brain receptor ligands
CZ27399A3 (cs) 1999-01-26 2000-08-16 Ústav Experimentální Botaniky Av Čr Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv
YU25500A (sh) * 1999-05-11 2003-08-29 Pfizer Products Inc. Postupak za sintezu analoga nukleozida
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
CN1747937A (zh) 2003-02-07 2006-03-15 詹森药业有限公司 预防hiv感染的嘧啶衍生物
BRPI0414791A (pt) * 2003-09-25 2006-11-21 Janssen Pharmaceutica Nv derivados de purina inibidores da replicação do hiv
KR20070085286A (ko) 2004-10-29 2007-08-27 티보텍 파마슈티칼즈 리미티드 Ｈｉｖ를 저해하는 바이사이클릭 피리미딘 유도체
ES2380951T3 (es) * 2005-05-05 2012-05-21 Ardea Biosciences, Inc. Diaril-purinas, -azapurinasy - desazapurinas como inhibidores no nucleósidos de la transcriptasa inversa para el tratamiento del VIH

Also Published As

Publication number Publication date
EP1877411A4 (en) 2008-10-22
CN101233135A (zh) 2008-07-30
EP1877411A2 (en) 2008-01-16
CN101233135B (zh) 2012-10-03
WO2006122003A2 (en) 2006-11-16
MX2007013715A (es) 2008-01-28
CA2607021A1 (en) 2006-11-16
EP1877411B9 (en) 2012-08-29
US8227601B2 (en) 2012-07-24
BRPI0611455A2 (pt) 2010-09-08
JP2008540454A (ja) 2008-11-20
JP2012188454A (ja) 2012-10-04
ES2380951T3 (es) 2012-05-21
JP5138585B2 (ja) 2013-02-06
ES2380951T9 (es) 2012-12-21
US8354532B2 (en) 2013-01-15
AU2006244195B2 (en) 2012-03-15
ZA200709481B (en) 2008-11-26
WO2006122003A3 (en) 2007-01-04
US20120226037A1 (en) 2012-09-06
EP1877411B1 (en) 2012-01-18
CA2607021C (en) 2013-10-29
AU2006244195A1 (en) 2006-11-16
US20090124802A1 (en) 2009-05-14

Similar Documents

Publication Publication Date Title
ZA200709481B (en) Diaryl-purine, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitors for treatment of HIV
EA200901490A1 (ru) Химические соединения
EA201000777A1 (ru) Ингибиторы репликации вируса иммунодефицита человека
EA201070247A1 (ru) Ингибиторы протеасом
EA200900959A1 (ru) Ингибиторы мек
UA89220C2 (ru) Способ лечения вич/спида путем приема без пищи или в условиях голодания твердого фармацевтического дозированного состава ингибитора вич-протеазы
EA201390609A1 (ru) ПРОИЗВОДНЫЕ ГИДАНТОИНА, ПОЛЕЗНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ Kv3-КАНАЛОВ
SG161310A1 (en) Modulators of indoleamine 2,3-dioxygenase and methods of using the same
MX2009009290A (es) Compuestos activos en ppar.
EA201070238A1 (ru) Соединения пиримидина
ATE526991T1 (de) Zusammensetzungen und ihre verwendungen für die gentherapeutische behandlung von knochenerkrankungen
MX2009005009A (es) Compuestos heterociclicos biciclicos 4-cianofenilamino sustituidos como inhibidores del virus de inmunodeficiencia humana.
NO20055130L (no) Aminocykloheksyleter-forbindelser og deres anvendelse
DE60330161D1 (de) Rifalazil zur behandlung von infektionen mit clostridium difficile
EA201991073A1 (ru) Ингибиторы magl
DK1776349T3 (da) 2-amino-puinazolin derivater anvendelige som inhibitorer af beta-sekretase (BACE)
PH12023500023A1 (en) Cdk2 degraders and uses thereof
EA200700717A1 (ru) Сульфонамиды
MX2022000811A (es) Inhibidores de enzimas.
EP1858520A4 (en) CALCIUM CHANNEL ANTAGONISTS TYPE CHINAZOLINONE T
EA201000494A1 (ru) Новые гидрокси-8-гетероарилфенантридины и их применение в качестве ингибиторов pde4
NO20055741L (no) Nye kjemiske forbindelser
DE60326069D1 (de) 4-(heterocyclyl)-benzenesulfoximin verbindungen zur behandlung entzündlicher erkrankungenen
EA200602281A1 (ru) Гетероарилсульфоны и сульфонамиды и их терапевтические применения
EA201000063A1 (ru) Новые соединения, обладающие функцией ингибиторов тромбина, и фармацевтические композиции на их основе