JP2003511415A5 - - Google Patents
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- Publication number
- JP2003511415A5 JP2003511415A5 JP2001529444A JP2001529444A JP2003511415A5 JP 2003511415 A5 JP2003511415 A5 JP 2003511415A5 JP 2001529444 A JP2001529444 A JP 2001529444A JP 2001529444 A JP2001529444 A JP 2001529444A JP 2003511415 A5 JP2003511415 A5 JP 2003511415A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- naphthyl
- substituents
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 description 4
- 229910052794 bromium Inorganic materials 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 125000001624 naphthyl group Chemical group 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 125000001475 halogen functional group Chemical group 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- -1 methylenedioxy Chemical group 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15852999P | 1999-10-08 | 1999-10-08 | |
| US60/158,529 | 1999-10-08 | ||
| PCT/US2000/027591 WO2001026654A1 (en) | 1999-10-08 | 2000-10-06 | Fab i inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003511415A JP2003511415A (ja) | 2003-03-25 |
| JP2003511415A5 true JP2003511415A5 (enExample) | 2012-03-22 |
| JP4961084B2 JP4961084B2 (ja) | 2012-06-27 |
Family
ID=22568552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001529444A Expired - Fee Related JP4961084B2 (ja) | 1999-10-08 | 2000-10-06 | Ｆａｂｉ阻害剤 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1225895B1 (enExample) |
| JP (1) | JP4961084B2 (enExample) |
| AT (1) | ATE294578T1 (enExample) |
| AU (1) | AU1192501A (enExample) |
| CO (1) | CO5251401A1 (enExample) |
| DE (1) | DE60019954T2 (enExample) |
| HK (1) | HK1049610A1 (enExample) |
| WO (1) | WO2001026654A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CO5180550A1 (es) | 1999-04-19 | 2002-07-30 | Smithkline Beecham Corp | Inhibidores de fab i |
| CO5370679A1 (es) | 1999-06-01 | 2004-02-27 | Smithkline Beecham Corp | Inhibidores fab 1 |
| US6730684B1 (en) * | 1999-10-08 | 2004-05-04 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
| DE60029235T2 (de) * | 1999-10-08 | 2007-06-14 | Affinium Pharmaceuticals, Inc., Toronto | Fab-i-hemmer |
| ECSP003699A (es) | 1999-10-08 | 2002-04-23 | Smithkline Beecham Corp | Inhibidores de fab i |
| US6762201B1 (en) | 1999-10-08 | 2004-07-13 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
| MXPA03003039A (es) * | 2000-10-06 | 2003-10-15 | Neurogen Corp | Derivados de indola y bencimidazola como moduladores del receptor crf. |
| DE60230934D1 (de) | 2001-04-06 | 2009-03-05 | Affinium Pharm Inc | Fab-i-inhibitoren |
| EP1575951B1 (en) * | 2002-12-06 | 2014-06-25 | Debiopharm International SA | Heterocyclic compounds, methods of making them and their use in therapy |
| WO2004082586A2 (en) * | 2003-03-17 | 2004-09-30 | Affinium Pharmaceuticals, Inc. | Phamaceutical compositions comprising inhibitors of fab i and further antibiotics |
| CN101203504B (zh) * | 2005-05-03 | 2012-11-14 | 兰贝克赛实验室有限公司 | 抗微生物剂 |
| US8076370B2 (en) | 2005-05-03 | 2011-12-13 | Ranbaxy Laboratories Limited | Antimicrobial agents |
| JP2009533315A (ja) * | 2006-04-10 | 2009-09-17 | ランバクシー ラボラトリーズ リミテッド | 抗菌剤 |
| EP2687533B1 (en) | 2006-07-20 | 2017-07-19 | Debiopharm International SA | Acrylamide derivatives as FAB I inhibitors |
| WO2008098374A1 (en) | 2007-02-16 | 2008-08-21 | Affinium Pharmaceuticals, Inc. | Salts, prodrugs and polymorphs of fab i inhibitors |
| CN104039782A (zh) | 2011-08-10 | 2014-09-10 | 爱尔兰詹森研发公司 | 抗菌的高哌啶基取代的3,4二氢1h[1,8]萘啶酮类 |
| JO3611B1 (ar) | 2011-08-10 | 2020-08-27 | Janssen Sciences Ireland Uc | سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم |
| BR112014002958B1 (pt) | 2011-08-10 | 2020-10-06 | Janssen Sciences Ireland Uc | 3,4-dihidro-1h-[1,8]naftiridinonas substituídas com piperidinila antibacterianas, composição farmacêutica compreendendo os referidos compostos, processos para preparação destes e uso |
| KR101720885B1 (ko) | 2012-06-19 | 2017-03-28 | 데비오팜 인터네셔날 에스 에이 | (e)-n-메틸-n-((3-메틸벤조푸란-2-일)메틸)-3-(7-옥소-5,6,7,8-테트라히드로-1,8-나프티리딘-3-일)아크릴아미드의전구약물 유도체 |
| JP6250668B2 (ja) | 2012-08-10 | 2017-12-20 | ヤンセン・サイエンシズ・アイルランド・ユーシー | 新しい抗菌化合物 |
| EA201590339A1 (ru) | 2012-08-10 | 2015-06-30 | Янссен Сайенсиз Айрлэнд Юси | Новые антибактериальные соединения |
| RS61312B1 (sr) | 2016-02-26 | 2021-02-26 | Debiopharm Int Sa | Lek za lečenje infekcija dijabetskog stopala |
| MY203711A (en) | 2019-02-14 | 2024-07-15 | Debiopharm Int Sa | Afabicin formulation, method for making the same and uses thereof |
| JP7418475B2 (ja) | 2019-06-14 | 2024-01-19 | デバイオファーム インターナショナル エス．エー． | バイオフィルムが関与する細菌感染症を治療するための医薬及びその使用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207679B1 (en) * | 1997-06-19 | 2001-03-27 | Sepracor, Inc. | Antimicrobial agents uses and compositions related thereto |
| US5932743A (en) * | 1997-08-21 | 1999-08-03 | American Home Products Corporation | Methods for the solid phase synthesis of substituted indole compounds |
-
2000
- 2000-10-06 DE DE60019954T patent/DE60019954T2/de not_active Expired - Lifetime
- 2000-10-06 HK HK03100340.4A patent/HK1049610A1/zh unknown
- 2000-10-06 JP JP2001529444A patent/JP4961084B2/ja not_active Expired - Fee Related
- 2000-10-06 CO CO00076101A patent/CO5251401A1/es not_active Application Discontinuation
- 2000-10-06 WO PCT/US2000/027591 patent/WO2001026654A1/en not_active Ceased
- 2000-10-06 EP EP00973420A patent/EP1225895B1/en not_active Expired - Lifetime
- 2000-10-06 AT AT00973420T patent/ATE294578T1/de not_active IP Right Cessation
- 2000-10-06 AU AU11925/01A patent/AU1192501A/en not_active Abandoned
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