JP2003511415A5 - - Google Patents
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- Publication number
- JP2003511415A5 JP2003511415A5 JP2001529444A JP2001529444A JP2003511415A5 JP 2003511415 A5 JP2003511415 A5 JP 2003511415A5 JP 2001529444 A JP2001529444 A JP 2001529444A JP 2001529444 A JP2001529444 A JP 2001529444A JP 2003511415 A5 JP2003511415 A5 JP 2003511415A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- naphthyl
- substituents
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 description 4
- 229910052794 bromium Inorganic materials 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 125000001624 naphthyl group Chemical group 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 125000001475 halogen functional group Chemical group 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- -1 methylenedioxy Chemical group 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15852999P | 1999-10-08 | 1999-10-08 | |
| US60/158,529 | 1999-10-08 | ||
| PCT/US2000/027591 WO2001026654A1 (en) | 1999-10-08 | 2000-10-06 | Fab i inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003511415A JP2003511415A (ja) | 2003-03-25 |
| JP2003511415A5 true JP2003511415A5 (enExample) | 2012-03-22 |
| JP4961084B2 JP4961084B2 (ja) | 2012-06-27 |
Family
ID=22568552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001529444A Expired - Fee Related JP4961084B2 (ja) | 1999-10-08 | 2000-10-06 | Ｆａｂｉ阻害剤 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1225895B1 (enExample) |
| JP (1) | JP4961084B2 (enExample) |
| AT (1) | ATE294578T1 (enExample) |
| AU (1) | AU1192501A (enExample) |
| CO (1) | CO5251401A1 (enExample) |
| DE (1) | DE60019954T2 (enExample) |
| HK (1) | HK1049610A1 (enExample) |
| WO (1) | WO2001026654A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CO5180550A1 (es) | 1999-04-19 | 2002-07-30 | Smithkline Beecham Corp | Inhibidores de fab i |
| CO5370679A1 (es) | 1999-06-01 | 2004-02-27 | Smithkline Beecham Corp | Inhibidores fab 1 |
| JP4831907B2 (ja) * | 1999-10-08 | 2011-12-07 | アフィニアム・ファーマシューティカルズ・インコーポレイテッド | ＦａｂＩ阻害剤 |
| US6762201B1 (en) | 1999-10-08 | 2004-07-13 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
| US6730684B1 (en) * | 1999-10-08 | 2004-05-04 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
| PE20010635A1 (es) | 1999-10-08 | 2001-08-15 | Smithkline Beecham Corp | Inhibidores de fab i utiles para el tratamiento de infecciones bacterianas |
| US20030055037A1 (en) * | 2000-10-06 | 2003-03-20 | Delombaert Stephane | Benzimidazole and indole derivatives as CRF receptor modulators |
| DK1560584T3 (da) | 2001-04-06 | 2009-05-18 | Affinium Pharm Inc | Fab I inhibitorer |
| AU2003298937A1 (en) * | 2002-12-06 | 2004-06-30 | Affinium Pharmaceuticals, Inc. | Heterocyclic compounds, methods of making them and their use in therapy |
| CA2519429C (en) * | 2003-03-17 | 2013-08-06 | Affinium Pharmaceuticals, Inc. | Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics |
| DK1879877T3 (da) | 2005-05-03 | 2013-04-15 | Ranbaxy Lab Ltd | Antimikrobielle midler |
| CN101203504B (zh) * | 2005-05-03 | 2012-11-14 | 兰贝克赛实验室有限公司 | 抗微生物剂 |
| JP2009533315A (ja) * | 2006-04-10 | 2009-09-17 | ランバクシー ラボラトリーズ リミテッド | 抗菌剤 |
| WO2008009122A1 (en) | 2006-07-20 | 2008-01-24 | Affinium Pharmaceuticals, Inc. | Acrylamide derivatives as fab i inhibitors |
| WO2008098374A1 (en) | 2007-02-16 | 2008-08-21 | Affinium Pharmaceuticals, Inc. | Salts, prodrugs and polymorphs of fab i inhibitors |
| CA2842531C (en) | 2011-08-10 | 2019-07-16 | Janssen R&D Ireland | Antibacterial piperidinyl substituted 3,4-dihydro-1h-[1,8]naphthyridinones |
| EP2742044B1 (en) | 2011-08-10 | 2019-12-04 | Janssen Sciences Ireland Unlimited Company | Antibacterial homopiperidinyl substituted 3,4-dihydro-1h-[1,8]naphthyridinones |
| JO3611B1 (ar) | 2011-08-10 | 2020-08-27 | Janssen Sciences Ireland Uc | سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم |
| NZ702695A (en) | 2012-06-19 | 2015-10-30 | Debiopharm Int Sa | Prodrug derivatives of (e)-n-methyl-n-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide |
| EA201590331A1 (ru) | 2012-08-10 | 2016-05-31 | Янссен Сайенсиз Айрлэнд Юси | Новые антибактериальные соединения |
| CA2879623C (en) | 2012-08-10 | 2021-11-02 | Janssen Sciences Ireland Uc | Fused bicyclic azole heterocycle as inhibitors of the enzyme fabi |
| ES2842443T3 (es) | 2016-02-26 | 2021-07-14 | Debiopharm Int Sa | Medicamento para el tratamiento de infecciones del pie diabético |
| IL285204B2 (en) | 2019-02-14 | 2025-02-01 | Debiopharm Int Sa | Formulation of apavicin, method for its preparation |
| EP3982975A1 (en) | 2019-06-14 | 2022-04-20 | Debiopharm International SA | Afabicin for use for treating bacterial infections involving biofilm |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207679B1 (en) * | 1997-06-19 | 2001-03-27 | Sepracor, Inc. | Antimicrobial agents uses and compositions related thereto |
| US5932743A (en) * | 1997-08-21 | 1999-08-03 | American Home Products Corporation | Methods for the solid phase synthesis of substituted indole compounds |
-
2000
- 2000-10-06 AT AT00973420T patent/ATE294578T1/de not_active IP Right Cessation
- 2000-10-06 HK HK03100340.4A patent/HK1049610A1/zh unknown
- 2000-10-06 EP EP00973420A patent/EP1225895B1/en not_active Expired - Lifetime
- 2000-10-06 CO CO00076101A patent/CO5251401A1/es not_active Application Discontinuation
- 2000-10-06 AU AU11925/01A patent/AU1192501A/en not_active Abandoned
- 2000-10-06 DE DE60019954T patent/DE60019954T2/de not_active Expired - Lifetime
- 2000-10-06 JP JP2001529444A patent/JP4961084B2/ja not_active Expired - Fee Related
- 2000-10-06 WO PCT/US2000/027591 patent/WO2001026654A1/en not_active Ceased
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