ATE294578T1 - Fab i hemmer - Google Patents

Fab i hemmer

Info

Publication number
ATE294578T1
ATE294578T1 AT00973420T AT00973420T ATE294578T1 AT E294578 T1 ATE294578 T1 AT E294578T1 AT 00973420 T AT00973420 T AT 00973420T AT 00973420 T AT00973420 T AT 00973420T AT E294578 T1 ATE294578 T1 AT E294578T1
Authority
AT
Austria
Prior art keywords
4alkyl
het
fab
hemmer
6alkyl
Prior art date
Application number
AT00973420T
Other languages
German (de)
English (en)
Inventor
William H Miller
Kenneth A Newlander
Mark A Seefeld
Original Assignee
Affinium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affinium Pharm Inc filed Critical Affinium Pharm Inc
Application granted granted Critical
Publication of ATE294578T1 publication Critical patent/ATE294578T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Semiconductor Lasers (AREA)
AT00973420T 1999-10-08 2000-10-06 Fab i hemmer ATE294578T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15852999P 1999-10-08 1999-10-08
PCT/US2000/027591 WO2001026654A1 (en) 1999-10-08 2000-10-06 Fab i inhibitors

Publications (1)

Publication Number Publication Date
ATE294578T1 true ATE294578T1 (de) 2005-05-15

Family

ID=22568552

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00973420T ATE294578T1 (de) 1999-10-08 2000-10-06 Fab i hemmer

Country Status (8)

Country Link
EP (1) EP1225895B1 (enExample)
JP (1) JP4961084B2 (enExample)
AT (1) ATE294578T1 (enExample)
AU (1) AU1192501A (enExample)
CO (1) CO5251401A1 (enExample)
DE (1) DE60019954T2 (enExample)
HK (1) HK1049610A1 (enExample)
WO (1) WO2001026654A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5180550A1 (es) 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
AR024158A1 (es) 1999-06-01 2002-09-04 Smithkline Beecham Corp Compuestos antibacterianos
HK1049656A1 (zh) 1999-10-08 2003-05-23 Smithkline Beecham Corporation Fab i抑制剂
AU7866300A (en) * 1999-10-08 2001-04-23 Smithkline Beecham Corporation Fab i inhibitors
US6730684B1 (en) * 1999-10-08 2004-05-04 Affinium Pharmaceuticals, Inc. Fab I inhibitors
US6762201B1 (en) 1999-10-08 2004-07-13 Affinium Pharmaceuticals, Inc. Fab I inhibitors
CA2425185A1 (en) * 2000-10-06 2002-04-11 Stephane De Lombaert Benzimidazole and indole derivatives as crf receptor modulators
DE60230934D1 (de) 2001-04-06 2009-03-05 Affinium Pharm Inc Fab-i-inhibitoren
CA2508792C (en) * 2002-12-06 2013-02-05 Affinium Pharmaceuticals, Inc. Heterocyclic compounds, methods of making them and their use in therapy
JP4880448B2 (ja) * 2003-03-17 2012-02-22 アフィナム ファーマシューティカルズ，インコーポレーテッド 複数の抗生物質を含む組成物、及びそれを用いる方法
CN101203504B (zh) * 2005-05-03 2012-11-14 兰贝克赛实验室有限公司 抗微生物剂
NZ563186A (en) 2005-05-03 2011-09-30 Ranbaxy Lab Ltd Antimicrobial agents
JP2009533315A (ja) * 2006-04-10 2009-09-17 ランバクシー ラボラトリーズ リミテッド 抗菌剤
JP5468899B2 (ja) 2006-07-20 2014-04-09 アフィニウム ファーマシューティカルズ， インク． Ｆａｂｉインヒビターとしてのアクリルアミド誘導体
EP2125802A4 (en) 2007-02-16 2014-08-20 Debiopharm Int Sa SALTS, PRODRUGS AND POLYMORPHES OF FAB I INHIBITORS
JO3611B1 (ar) 2011-08-10 2020-08-27 Janssen Sciences Ireland Uc سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم
AU2012293619B2 (en) 2011-08-10 2017-05-04 Janssen Sciences Ireland Uc Antibacterial piperidinyl substituted 3,4-dihydro-1h-[1,8]naphthyridinones
US9394295B2 (en) 2011-08-10 2016-07-19 Janssen Sciences Ireland Uc Antibacterial homopiperidinyl substituted 3,4-dihydro-1H-[1,8]naphthyridinones
SMT201900411T1 (it) 2012-06-19 2019-09-09 Debiopharm Int Sa Derivati di profaramci di (e)-n-metil-n-((3-metilbenzofuran-2-il)metil -3-(7-osso-5,6,7,8-tetraidro-1,8-naftiridin-3-il)acrilammide
WO2014023815A1 (en) 2012-08-10 2014-02-13 Janssen R&D Ireland New antibacterial compounds
KR102323873B1 (ko) 2012-08-10 2021-11-09 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 신규한 항균성 화합물
HUE052140T2 (hu) 2016-02-26 2021-04-28 Debiopharm Int Sa Diabéteszes lábfertõzések kezelésére szolgáló gyógyszer
JP7383715B2 (ja) 2019-02-14 2023-11-20 デバイオファーム インターナショナル エス．エー． アファビシン製剤、その作製方法及びその使用
EA202290048A1 (ru) 2019-06-14 2022-03-10 Дебиофарм Интернэшнл C.A. Лекарственное средство и его применение для лечения бактериальных инфекций, связанных с биопленкой

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207679B1 (en) * 1997-06-19 2001-03-27 Sepracor, Inc. Antimicrobial agents uses and compositions related thereto
US5932743A (en) * 1997-08-21 1999-08-03 American Home Products Corporation Methods for the solid phase synthesis of substituted indole compounds

Also Published As

Publication number Publication date
DE60019954T2 (de) 2006-02-23
EP1225895B1 (en) 2005-05-04
EP1225895A1 (en) 2002-07-31
CO5251401A1 (es) 2003-02-28
DE60019954D1 (en) 2005-06-09
HK1049610A1 (zh) 2003-05-23
JP4961084B2 (ja) 2012-06-27
JP2003511415A (ja) 2003-03-25
WO2001026654A1 (en) 2001-04-19
EP1225895A4 (en) 2002-11-13
AU1192501A (en) 2001-04-23

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Legal Events

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