HRP20100148T1 - Antagonisti glukagonskog receptora, priprema i terapijska primjena - Google Patents
Antagonisti glukagonskog receptora, priprema i terapijska primjena Download PDFInfo
- Publication number
- HRP20100148T1 HRP20100148T1 HR20100148T HRP20100148T HRP20100148T1 HR P20100148 T1 HRP20100148 T1 HR P20100148T1 HR 20100148 T HR20100148 T HR 20100148T HR P20100148 T HRP20100148 T HR P20100148T HR P20100148 T1 HRP20100148 T1 HR P20100148T1
- Authority
- HR
- Croatia
- Prior art keywords
- benzoylamino
- propionic acid
- yloxy
- biphenyl
- butyl
- Prior art date
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- 229940122904 Glucagon receptor antagonist Drugs 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 28
- 150000003839 salts Chemical class 0.000 claims abstract 20
- 102000051325 Glucagon Human genes 0.000 claims abstract 2
- 108060003199 Glucagon Proteins 0.000 claims abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract 2
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims abstract 2
- 229960004666 glucagon Drugs 0.000 claims abstract 2
- 208000030159 metabolic disease Diseases 0.000 claims abstract 2
- 229910052736 halogen Inorganic materials 0.000 claims 52
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 47
- 150000002367 halogens Chemical class 0.000 claims 37
- 229910052757 nitrogen Inorganic materials 0.000 claims 32
- 239000001257 hydrogen Substances 0.000 claims 31
- 229910052739 hydrogen Inorganic materials 0.000 claims 31
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 20
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 19
- -1 1,3-dioxan-2-yl Chemical group 0.000 claims 16
- 125000001424 substituent group Chemical group 0.000 claims 13
- 125000003545 alkoxy group Chemical group 0.000 claims 12
- 125000003342 alkenyl group Chemical group 0.000 claims 11
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 9
- 229910052799 carbon Inorganic materials 0.000 claims 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims 9
- CNEOYRMDNHRHPN-UHFFFAOYSA-N 2-hydroxy-3-[[4-[1-[4-[4-(trifluoromethyl)phenyl]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCC(O)C(O)=O)C=CC=1C(CCCCCC)OC(C=C1)=CC=C1C1=CC=C(C(F)(F)F)C=C1 CNEOYRMDNHRHPN-UHFFFAOYSA-N 0.000 claims 6
- WSPPXWCAPCGQJQ-UHFFFAOYSA-N 3-[[4-[1-(4-tert-butylphenoxy)-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC1=CC=C(C(C)(C)C)C=C1 WSPPXWCAPCGQJQ-UHFFFAOYSA-N 0.000 claims 6
- FIYNEGAABIBBTB-UHFFFAOYSA-N 3-[[4-[1-[(2,2,3,3-tetrafluoro-1,4-benzodioxin-6-yl)oxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C2OC(F)(F)C(F)(F)OC2=CC=1OC(CCCCCC)C1=CC=C(C(=O)NCCC(O)=O)C=C1 FIYNEGAABIBBTB-UHFFFAOYSA-N 0.000 claims 6
- IWGBSYIRRQHWIL-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)-3,5-dimethylphenoxy]-3,3-dimethylbutyl]benzoyl]amino]-2-hydroxypropanoic acid Chemical compound C=1C(C)=C(C=2C=CC(=CC=2)C(C)(C)C)C(C)=CC=1OC(CC(C)(C)C)C1=CC=C(C(=O)NCC(O)C(O)=O)C=C1 IWGBSYIRRQHWIL-UHFFFAOYSA-N 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000001475 halogen functional group Chemical group 0.000 claims 6
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 5
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- ALKVRMGAYOQIGX-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-(4-propan-2-ylphenyl)phenoxy]-2-methylpropyl]benzoyl]amino]-2-hydroxypropanoic acid Chemical compound C=1C=C(C(=O)NCC(O)C(O)=O)C=CC=1C(C(C)C)OC(C=C1C)=CC(C)=C1C1=CC=C(C(C)C)C=C1 ALKVRMGAYOQIGX-UHFFFAOYSA-N 0.000 claims 4
- PRJBNBMSKZJJFV-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-[4-(trifluoromethyl)phenyl]phenoxy]-2-methylpropyl]benzoyl]amino]-2-hydroxypropanoic acid Chemical compound C=1C=C(C(=O)NCC(O)C(O)=O)C=CC=1C(C(C)C)OC(C=C1C)=CC(C)=C1C1=CC=C(C(F)(F)F)C=C1 PRJBNBMSKZJJFV-UHFFFAOYSA-N 0.000 claims 4
- YIRJYWUBDGOMAF-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-[4-(trifluoromethyl)phenyl]phenoxy]-4,4-dimethylpentyl]benzoyl]amino]propanoic acid Chemical compound C=1C(C)=C(C=2C=CC(=CC=2)C(F)(F)F)C(C)=CC=1OC(CCC(C)(C)C)C1=CC=C(C(=O)NCCC(O)=O)C=C1 YIRJYWUBDGOMAF-UHFFFAOYSA-N 0.000 claims 4
- COXXDQWZBMCHRT-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)-3,5-dimethylphenoxy]-2-methylpropyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(C(C)C)OC(C=C1C)=CC(C)=C1C1=CC=C(C(C)(C)C)C=C1 COXXDQWZBMCHRT-UHFFFAOYSA-N 0.000 claims 4
- FASLTMSUPQDLIB-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)-3,5-dimethylphenoxy]-4,4,4-trifluorobutyl]benzoyl]amino]propanoic acid Chemical compound C=1C(C)=C(C=2C=CC(=CC=2)C(C)(C)C)C(C)=CC=1OC(CCC(F)(F)F)C1=CC=C(C(=O)NCCC(O)=O)C=C1 FASLTMSUPQDLIB-UHFFFAOYSA-N 0.000 claims 4
- 125000000439 4-methylpentoxy group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 4
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000004115 pentoxy group Chemical group [*]OC([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 4
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 4
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 3
- HSLOTHSWKXHUIO-UHFFFAOYSA-N 3-[[3-fluoro-4-[1-[3-methyl-4-[4-(trifluoromethyl)phenyl]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=C(F)C=1C(CCCCCC)OC(C=C1C)=CC=C1C1=CC=C(C(F)(F)F)C=C1 HSLOTHSWKXHUIO-UHFFFAOYSA-N 0.000 claims 3
- OHGRKGYWSFIXGP-UHFFFAOYSA-N 3-[[3-fluoro-4-[3-methyl-1-[6-[4-(trifluoromethyl)phenyl]pyridin-3-yl]oxybutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=C(F)C=1C(CC(C)C)OC(C=N1)=CC=C1C1=CC=C(C(F)(F)F)C=C1 OHGRKGYWSFIXGP-UHFFFAOYSA-N 0.000 claims 3
- XUWCKRGDJUUNCD-UHFFFAOYSA-N 3-[[4-[1-(3,5-dimethyl-4-phenylphenoxy)-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1C)=CC(C)=C1C1=CC=CC=C1 XUWCKRGDJUUNCD-UHFFFAOYSA-N 0.000 claims 3
- UOZNCBXVTQLAFF-UHFFFAOYSA-N 3-[[4-[1-(4-phenylmethoxyphenoxy)hexyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCC)OC(C=C1)=CC=C1OCC1=CC=CC=C1 UOZNCBXVTQLAFF-UHFFFAOYSA-N 0.000 claims 3
- KJYDPCNTADRITI-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-(4-propan-2-ylphenyl)phenoxy]-2-methylpropyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(C(C)C)OC(C=C1C)=CC(C)=C1C1=CC=C(C(C)C)C=C1 KJYDPCNTADRITI-UHFFFAOYSA-N 0.000 claims 3
- INPNTERYXTZXCO-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-(4-propan-2-ylphenyl)phenoxy]-4,4,4-trifluorobutyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(C)C)=CC=C1C(C(=C1)C)=C(C)C=C1OC(CCC(F)(F)F)C1=CC=C(C(=O)NCCC(O)=O)C=C1 INPNTERYXTZXCO-UHFFFAOYSA-N 0.000 claims 3
- WJQZKZZBMOZYMN-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-(4-propan-2-ylphenyl)phenoxy]-4,4-dimethylpentyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(C)C)=CC=C1C(C(=C1)C)=C(C)C=C1OC(CCC(C)(C)C)C1=CC=C(C(=O)NCCC(O)=O)C=C1 WJQZKZZBMOZYMN-UHFFFAOYSA-N 0.000 claims 3
- WBYVQJVFAXGBRV-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-(4-propan-2-ylphenyl)phenoxy]-5,5,5-trifluoropentyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(C)C)=CC=C1C(C(=C1)C)=C(C)C=C1OC(CCCC(F)(F)F)C1=CC=C(C(=O)NCCC(O)=O)C=C1 WBYVQJVFAXGBRV-UHFFFAOYSA-N 0.000 claims 3
- FOIKYCSBGDTHPW-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-[4-(trifluoromethoxy)phenyl]phenoxy]-3,3-dimethylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C(C)=C(C=2C=CC(OC(F)(F)F)=CC=2)C(C)=CC=1OC(CC(C)(C)C)C1=CC=C(C(=O)NCCC(O)=O)C=C1 FOIKYCSBGDTHPW-UHFFFAOYSA-N 0.000 claims 3
- DOBLBOPYLZRYFE-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-[4-(trifluoromethoxy)phenyl]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1C)=CC(C)=C1C1=CC=C(OC(F)(F)F)C=C1 DOBLBOPYLZRYFE-UHFFFAOYSA-N 0.000 claims 3
- IKVWDUGWPRTGQC-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-[4-(trifluoromethyl)phenyl]phenoxy]-2-methylpropyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(C(C)C)OC(C=C1C)=CC(C)=C1C1=CC=C(C(F)(F)F)C=C1 IKVWDUGWPRTGQC-UHFFFAOYSA-N 0.000 claims 3
- ACGOWLJCWDDVLQ-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-[4-(trifluoromethyl)phenyl]phenoxy]-3,3-dimethylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C(C)=C(C=2C=CC(=CC=2)C(F)(F)F)C(C)=CC=1OC(CC(C)(C)C)C1=CC=C(C(=O)NCCC(O)=O)C=C1 ACGOWLJCWDDVLQ-UHFFFAOYSA-N 0.000 claims 3
- DRSKYEQDXXYBKN-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-[4-(trifluoromethyl)phenyl]phenoxy]-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1C)=CC(C)=C1C1=CC=C(C(F)(F)F)C=C1 DRSKYEQDXXYBKN-UHFFFAOYSA-N 0.000 claims 3
- CELZMFIKHZGKKC-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-[4-(trifluoromethyl)phenyl]phenoxy]-4,4,4-trifluorobutyl]benzoyl]amino]propanoic acid Chemical compound C=1C(C)=C(C=2C=CC(=CC=2)C(F)(F)F)C(C)=CC=1OC(CCC(F)(F)F)C1=CC=C(C(=O)NCCC(O)=O)C=C1 CELZMFIKHZGKKC-UHFFFAOYSA-N 0.000 claims 3
- ONAYOXKBQUQBSY-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-[4-(trifluoromethyl)phenyl]phenoxy]-5,5,5-trifluoropentyl]benzoyl]amino]propanoic acid Chemical compound C=1C(C)=C(C=2C=CC(=CC=2)C(F)(F)F)C(C)=CC=1OC(CCCC(F)(F)F)C1=CC=C(C(=O)NCCC(O)=O)C=C1 ONAYOXKBQUQBSY-UHFFFAOYSA-N 0.000 claims 3
- IUAGNFGRIGSELP-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-[4-(trifluoromethyl)phenyl]phenoxy]-5-methylhexyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCC(C)C)OC(C=C1C)=CC(C)=C1C1=CC=C(C(F)(F)F)C=C1 IUAGNFGRIGSELP-UHFFFAOYSA-N 0.000 claims 3
- JQUQVTTYPFUUDO-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-[4-(trifluoromethyl)phenyl]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1C)=CC(C)=C1C1=CC=C(C(F)(F)F)C=C1 JQUQVTTYPFUUDO-UHFFFAOYSA-N 0.000 claims 3
- OSSOGAYWJZEMMA-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-[4-(trifluoromethyl)phenyl]phenyl]sulfanyl-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)SC(C=C1C)=CC(C)=C1C1=CC=C(C(F)(F)F)C=C1 OSSOGAYWJZEMMA-UHFFFAOYSA-N 0.000 claims 3
- UUYKWCRLLJRYBW-UHFFFAOYSA-N 3-[[4-[1-[3-chloro-4-(4-propan-2-ylphenyl)phenoxy]-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1Cl)=CC=C1C1=CC=C(C(C)C)C=C1 UUYKWCRLLJRYBW-UHFFFAOYSA-N 0.000 claims 3
- QESGIFTZFFPZAP-UHFFFAOYSA-N 3-[[4-[1-[3-chloro-4-[4-(trifluoromethyl)phenyl]phenoxy]-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1Cl)=CC=C1C1=CC=C(C(F)(F)F)C=C1 QESGIFTZFFPZAP-UHFFFAOYSA-N 0.000 claims 3
- QLXBXPSZLACKEE-UHFFFAOYSA-N 3-[[4-[1-[3-cyano-4-(4-propan-2-ylphenyl)phenoxy]-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1C#N)=CC=C1C1=CC=C(C(C)C)C=C1 QLXBXPSZLACKEE-UHFFFAOYSA-N 0.000 claims 3
- GNGZNTXDUXYVPR-UHFFFAOYSA-N 3-[[4-[1-[3-ethyl-4-[4-(trifluoromethyl)phenyl]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1CC)=CC=C1C1=CC=C(C(F)(F)F)C=C1 GNGZNTXDUXYVPR-UHFFFAOYSA-N 0.000 claims 3
- CIBYLWSSHSAOKM-UHFFFAOYSA-N 3-[[4-[1-[3-methoxy-4-(4-propan-2-ylphenyl)phenoxy]-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C(C)C)C(OC)=CC=1OC(CC(C)C)C1=CC=C(C(=O)NCCC(O)=O)C=C1 CIBYLWSSHSAOKM-UHFFFAOYSA-N 0.000 claims 3
- RWXIIIVHWMSEMC-UHFFFAOYSA-N 3-[[4-[1-[3-methyl-4-(4-propan-2-ylphenyl)phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1C)=CC=C1C1=CC=C(C(C)C)C=C1 RWXIIIVHWMSEMC-UHFFFAOYSA-N 0.000 claims 3
- NQIVCQWYJWFRIW-UHFFFAOYSA-N 3-[[4-[1-[3-methyl-4-[4-(trifluoromethyl)phenyl]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1C)=CC=C1C1=CC=C(C(F)(F)F)C=C1 NQIVCQWYJWFRIW-UHFFFAOYSA-N 0.000 claims 3
- DKQGAAXKMWPUBH-UHFFFAOYSA-N 3-[[4-[1-[4-(2-phenylpropan-2-yl)phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1)=CC=C1C(C)(C)C1=CC=CC=C1 DKQGAAXKMWPUBH-UHFFFAOYSA-N 0.000 claims 3
- HIJGMXCQYWWMSJ-UHFFFAOYSA-N 3-[[4-[1-[4-(4-chlorophenyl)-3,5-dimethylphenoxy]-4,4-dimethylpentyl]benzoyl]amino]propanoic acid Chemical compound C=1C(C)=C(C=2C=CC(Cl)=CC=2)C(C)=CC=1OC(CCC(C)(C)C)C1=CC=C(C(=O)NCCC(O)=O)C=C1 HIJGMXCQYWWMSJ-UHFFFAOYSA-N 0.000 claims 3
- MXWCPKQOLRUIKE-UHFFFAOYSA-N 3-[[4-[1-[4-(4-ethylphenyl)-3,5-dimethylphenoxy]-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(CC)=CC=C1C(C(=C1)C)=C(C)C=C1OC(CC(C)C)C1=CC=C(C(=O)NCCC(O)=O)C=C1 MXWCPKQOLRUIKE-UHFFFAOYSA-N 0.000 claims 3
- DDQPFKRDXSKRFY-UHFFFAOYSA-N 3-[[4-[1-[4-(4-ethylphenyl)phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1)=CC=C1C1=CC=C(CC)C=C1 DDQPFKRDXSKRFY-UHFFFAOYSA-N 0.000 claims 3
- OTWHWDRCEMPYSX-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)-3,5-dimethylphenoxy]-3,3-dimethylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C(C)=C(C=2C=CC(=CC=2)C(C)(C)C)C(C)=CC=1OC(CC(C)(C)C)C1=CC=C(C(=O)NCCC(O)=O)C=C1 OTWHWDRCEMPYSX-UHFFFAOYSA-N 0.000 claims 3
- YXCNSMPUDZMRHG-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)-3,5-dimethylphenoxy]-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1C)=CC(C)=C1C1=CC=C(C(C)(C)C)C=C1 YXCNSMPUDZMRHG-UHFFFAOYSA-N 0.000 claims 3
- KSTCJQKMQHKIHW-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)-3,5-dimethylphenoxy]-5,5,5-trifluoropentyl]benzoyl]amino]propanoic acid Chemical compound C=1C(C)=C(C=2C=CC(=CC=2)C(C)(C)C)C(C)=CC=1OC(CCCC(F)(F)F)C1=CC=C(C(=O)NCCC(O)=O)C=C1 KSTCJQKMQHKIHW-UHFFFAOYSA-N 0.000 claims 3
- HWFPEDDQCGOTCV-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)-3,5-dimethylphenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1C)=CC(C)=C1C1=CC=C(C(C)(C)C)C=C1 HWFPEDDQCGOTCV-UHFFFAOYSA-N 0.000 claims 3
- LERSGUCLTVBKFU-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)-3,5-dimethylphenyl]sulfanyl-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)SC(C=C1C)=CC(C)=C1C1=CC=C(C(C)(C)C)C=C1 LERSGUCLTVBKFU-UHFFFAOYSA-N 0.000 claims 3
- MDRIPIUBQOIOAU-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)-3,5-dimethylphenyl]sulfanyl-4,4,4-trifluorobutyl]benzoyl]amino]propanoic acid Chemical compound C=1C(C)=C(C=2C=CC(=CC=2)C(C)(C)C)C(C)=CC=1SC(CCC(F)(F)F)C1=CC=C(C(=O)NCCC(O)=O)C=C1 MDRIPIUBQOIOAU-UHFFFAOYSA-N 0.000 claims 3
- ABJCPKIFFABSJV-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)-3-(trifluoromethyl)phenoxy]-2-methylpropyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(C(C)C)OC(C=C1C(F)(F)F)=CC=C1C1=CC=C(C(C)(C)C)C=C1 ABJCPKIFFABSJV-UHFFFAOYSA-N 0.000 claims 3
- YNLUKPGPKVSPME-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)-3-(trifluoromethyl)phenoxy]-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1C(F)(F)F)=CC=C1C1=CC=C(C(C)(C)C)C=C1 YNLUKPGPKVSPME-UHFFFAOYSA-N 0.000 claims 3
- KPQXLEDGTXHZSK-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)-3-(trifluoromethyl)phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1C(F)(F)F)=CC=C1C1=CC=C(C(C)(C)C)C=C1 KPQXLEDGTXHZSK-UHFFFAOYSA-N 0.000 claims 3
- TYTKVKWIGOKBNL-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)-3-(trifluoromethyl)phenoxy]pentyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCC)OC(C=C1C(F)(F)F)=CC=C1C1=CC=C(C(C)(C)C)C=C1 TYTKVKWIGOKBNL-UHFFFAOYSA-N 0.000 claims 3
- CURWQRPSQJEVFG-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)-3-methylphenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1C)=CC=C1C1=CC=C(C(C)(C)C)C=C1 CURWQRPSQJEVFG-UHFFFAOYSA-N 0.000 claims 3
- LCQODXISZIEPIJ-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)phenoxy]-3-methylbutyl]-3-fluorobenzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=C(F)C=1C(CC(C)C)OC(C=C1)=CC=C1C1=CC=C(C(C)(C)C)C=C1 LCQODXISZIEPIJ-UHFFFAOYSA-N 0.000 claims 3
- ZTUNIZPAWRAKFQ-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)phenoxy]-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1)=CC=C1C1=CC=C(C(C)(C)C)C=C1 ZTUNIZPAWRAKFQ-UHFFFAOYSA-N 0.000 claims 3
- RGCXBKFOWNYUHZ-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)phenoxy]-4,4,4-trifluorobutyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(C)(C)C)=CC=C1C(C=C1)=CC=C1OC(CCC(F)(F)F)C1=CC=C(C(=O)NCCC(O)=O)C=C1 RGCXBKFOWNYUHZ-UHFFFAOYSA-N 0.000 claims 3
- GDCYCTGVCQJKPW-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)phenoxy]-5,5,5-trifluoropentyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(C)(C)C)=CC=C1C(C=C1)=CC=C1OC(CCCC(F)(F)F)C1=CC=C(C(=O)NCCC(O)=O)C=C1 GDCYCTGVCQJKPW-UHFFFAOYSA-N 0.000 claims 3
- AWNGCPZBQKAEIN-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)phenoxy]butyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCC)OC(C=C1)=CC=C1C1=CC=C(C(C)(C)C)C=C1 AWNGCPZBQKAEIN-UHFFFAOYSA-N 0.000 claims 3
- QNYCDPWHSVGLPR-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)phenoxy]heptyl]-3-fluorobenzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=C(F)C=1C(CCCCCC)OC(C=C1)=CC=C1C1=CC=C(C(C)(C)C)C=C1 QNYCDPWHSVGLPR-UHFFFAOYSA-N 0.000 claims 3
- QUZPFKQOPXCRBE-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1)=CC=C1C1=CC=C(C(C)(C)C)C=C1 QUZPFKQOPXCRBE-UHFFFAOYSA-N 0.000 claims 3
- IVFLFFPRMYSUFU-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)phenoxy]hexyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCC)OC(C=C1)=CC=C1C1=CC=C(C(C)(C)C)C=C1 IVFLFFPRMYSUFU-UHFFFAOYSA-N 0.000 claims 3
- IELFAHBBOBEISU-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)phenoxy]pentyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCC)OC(C=C1)=CC=C1C1=CC=C(C(C)(C)C)C=C1 IELFAHBBOBEISU-UHFFFAOYSA-N 0.000 claims 3
- WOJVUYQOVGOLRN-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)phenoxy]propyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC)OC(C=C1)=CC=C1C1=CC=C(C(C)(C)C)C=C1 WOJVUYQOVGOLRN-UHFFFAOYSA-N 0.000 claims 3
- VSDWYNZZCAQBMP-UHFFFAOYSA-N 3-[[4-[1-[4-[4-(trifluoromethyl)phenoxy]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1)=CC=C1OC1=CC=C(C(F)(F)F)C=C1 VSDWYNZZCAQBMP-UHFFFAOYSA-N 0.000 claims 3
- MJHPKPASKRCFIQ-UHFFFAOYSA-N 3-[[4-[1-[4-[4-(trifluoromethyl)phenyl]phenoxy]butyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCC)OC(C=C1)=CC=C1C1=CC=C(C(F)(F)F)C=C1 MJHPKPASKRCFIQ-UHFFFAOYSA-N 0.000 claims 3
- CGSXJYZTNRHKGD-UHFFFAOYSA-N 3-[[4-[1-[4-[4-(trifluoromethyl)phenyl]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1)=CC=C1C1=CC=C(C(F)(F)F)C=C1 CGSXJYZTNRHKGD-UHFFFAOYSA-N 0.000 claims 3
- FXPOAKWHMWZYBQ-UHFFFAOYSA-N 3-[[4-[1-[4-[4-(trifluoromethyl)phenyl]phenoxy]hexyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCC)OC(C=C1)=CC=C1C1=CC=C(C(F)(F)F)C=C1 FXPOAKWHMWZYBQ-UHFFFAOYSA-N 0.000 claims 3
- DKLSRPMMGWIUNK-UHFFFAOYSA-N 3-[[4-[1-[4-[4-(trifluoromethyl)phenyl]phenoxy]nonyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCCCC)OC(C=C1)=CC=C1C1=CC=C(C(F)(F)F)C=C1 DKLSRPMMGWIUNK-UHFFFAOYSA-N 0.000 claims 3
- FDRUCLWJOXILLM-UHFFFAOYSA-N 3-[[4-[1-[4-[4-(trifluoromethyl)phenyl]phenoxy]pentyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCC)OC(C=C1)=CC=C1C1=CC=C(C(F)(F)F)C=C1 FDRUCLWJOXILLM-UHFFFAOYSA-N 0.000 claims 3
- LWEWOQRMSZEKEG-UHFFFAOYSA-N 3-[[4-[1-[4-[4-(trifluoromethyl)phenyl]phenoxy]propyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC)OC(C=C1)=CC=C1C1=CC=C(C(F)(F)F)C=C1 LWEWOQRMSZEKEG-UHFFFAOYSA-N 0.000 claims 3
- RPZRSVXFJCWLFU-UHFFFAOYSA-N 3-[[4-[1-[4-[4-(trifluoromethyl)phenyl]phenyl]sulfanylheptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)SC(C=C1)=CC=C1C1=CC=C(C(F)(F)F)C=C1 RPZRSVXFJCWLFU-UHFFFAOYSA-N 0.000 claims 3
- ZETXYZGLMGUTJH-UHFFFAOYSA-N 3-[[4-[1-[6-(4-tert-butylphenyl)pyridin-3-yl]oxy-4,4,4-trifluorobutyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(C)(C)C)=CC=C1C(N=C1)=CC=C1OC(CCC(F)(F)F)C1=CC=C(C(=O)NCCC(O)=O)C=C1 ZETXYZGLMGUTJH-UHFFFAOYSA-N 0.000 claims 3
- XHGOIDVSPHIYNL-UHFFFAOYSA-N 3-[[4-[1-[6-(4-tert-butylphenyl)pyridin-3-yl]oxy-5-methylhexyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCC(C)C)OC(C=N1)=CC=C1C1=CC=C(C(C)(C)C)C=C1 XHGOIDVSPHIYNL-UHFFFAOYSA-N 0.000 claims 3
- WRNIHDZHAXIBEQ-UHFFFAOYSA-N 3-[[4-[1-[6-[4-(trifluoromethyl)phenyl]pyridin-3-yl]oxyheptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=N1)=CC=C1C1=CC=C(C(F)(F)F)C=C1 WRNIHDZHAXIBEQ-UHFFFAOYSA-N 0.000 claims 3
- OBQLWFKMHHRMSV-UHFFFAOYSA-N 3-[[4-[1-[6-[4-(trifluoromethyl)phenyl]pyridin-3-yl]oxypentyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCC)OC(C=N1)=CC=C1C1=CC=C(C(F)(F)F)C=C1 OBQLWFKMHHRMSV-UHFFFAOYSA-N 0.000 claims 3
- SZYNDWGNTAMRBF-UHFFFAOYSA-N 3-[[4-[2-methyl-1-[3-methyl-4-[4-(trifluoromethyl)phenyl]phenoxy]propyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(C(C)C)OC(C=C1C)=CC=C1C1=CC=C(C(F)(F)F)C=C1 SZYNDWGNTAMRBF-UHFFFAOYSA-N 0.000 claims 3
- VLRYCPJEKYSWGO-UHFFFAOYSA-N 3-[[4-[2-methyl-1-[4-[4-(trifluoromethyl)phenyl]phenoxy]propyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(C(C)C)OC(C=C1)=CC=C1C1=CC=C(C(F)(F)F)C=C1 VLRYCPJEKYSWGO-UHFFFAOYSA-N 0.000 claims 3
- LNOCEPXFUSPVPQ-UHFFFAOYSA-N 3-[[4-[3-methyl-1-[3-methyl-4-(4-propan-2-ylphenyl)phenoxy]butyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1C)=CC=C1C1=CC=C(C(C)C)C=C1 LNOCEPXFUSPVPQ-UHFFFAOYSA-N 0.000 claims 3
- CGXMXHJCUOGLIT-UHFFFAOYSA-N 3-[[4-[3-methyl-1-[4-[5-(trifluoromethyl)pyridin-2-yl]phenoxy]butyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1)=CC=C1C1=CC=C(C(F)(F)F)C=N1 CGXMXHJCUOGLIT-UHFFFAOYSA-N 0.000 claims 3
- ULRCQLQEOGGTKV-UHFFFAOYSA-N 3-[[4-[3-methyl-1-[4-[6-(trifluoromethyl)pyridin-3-yl]phenoxy]butyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1)=CC=C1C1=CC=C(C(F)(F)F)N=C1 ULRCQLQEOGGTKV-UHFFFAOYSA-N 0.000 claims 3
- MLLJABZIDYCYAI-UHFFFAOYSA-N 3-[[4-[3-methyl-1-[5-methyl-6-(4-propan-2-ylphenyl)pyridin-3-yl]oxybutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1C)=CN=C1C1=CC=C(C(C)C)C=C1 MLLJABZIDYCYAI-UHFFFAOYSA-N 0.000 claims 3
- KCNFWUROXNHKKB-UHFFFAOYSA-N 3-[[4-[3-methyl-1-[5-methyl-6-[4-(trifluoromethyl)phenyl]pyridin-3-yl]oxybutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1C)=CN=C1C1=CC=C(C(F)(F)F)C=C1 KCNFWUROXNHKKB-UHFFFAOYSA-N 0.000 claims 3
- QHYKBQUUDBQJBW-UHFFFAOYSA-N 3-[[4-[4,4,4-trifluoro-1-[4-[4-(trifluoromethyl)phenyl]phenoxy]butyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(=O)NCCC(=O)O)=CC=C1C(CCC(F)(F)F)OC1=CC=C(C=2C=CC(=CC=2)C(F)(F)F)C=C1 QHYKBQUUDBQJBW-UHFFFAOYSA-N 0.000 claims 3
- SSDDUKTYNVZKEK-UHFFFAOYSA-N 3-[[4-[4,4,4-trifluoro-1-[6-[4-(trifluoromethyl)phenyl]pyridin-3-yl]oxybutyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(=O)NCCC(=O)O)=CC=C1C(CCC(F)(F)F)OC1=CC=C(C=2C=CC(=CC=2)C(F)(F)F)N=C1 SSDDUKTYNVZKEK-UHFFFAOYSA-N 0.000 claims 3
- MHUAHZSMEDSRLE-UHFFFAOYSA-N 3-[[4-[4,4-dimethyl-1-[4-[4-(trifluoromethyl)phenyl]phenoxy]pentyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCC(C)(C)C)OC(C=C1)=CC=C1C1=CC=C(C(F)(F)F)C=C1 MHUAHZSMEDSRLE-UHFFFAOYSA-N 0.000 claims 3
- BMTRKUBQCQJDTL-UHFFFAOYSA-N 3-[[4-[5,5,5-trifluoro-1-[4-(4-propan-2-ylphenyl)phenoxy]pentyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(C)C)=CC=C1C(C=C1)=CC=C1OC(CCCC(F)(F)F)C1=CC=C(C(=O)NCCC(O)=O)C=C1 BMTRKUBQCQJDTL-UHFFFAOYSA-N 0.000 claims 3
- KKEHRXCIOKTICI-UHFFFAOYSA-N 3-[[4-[5,5,5-trifluoro-1-[4-[4-(trifluoromethyl)phenyl]phenoxy]pentyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(=O)NCCC(=O)O)=CC=C1C(CCCC(F)(F)F)OC1=CC=C(C=2C=CC(=CC=2)C(F)(F)F)C=C1 KKEHRXCIOKTICI-UHFFFAOYSA-N 0.000 claims 3
- PDOXOYNDORRESQ-UHFFFAOYSA-N 3-[[4-[5,5,5-trifluoro-1-[5-methyl-6-[4-(trifluoromethyl)phenyl]pyridin-3-yl]oxypentyl]benzoyl]amino]propanoic acid Chemical compound C=1N=C(C=2C=CC(=CC=2)C(F)(F)F)C(C)=CC=1OC(CCCC(F)(F)F)C1=CC=C(C(=O)NCCC(O)=O)C=C1 PDOXOYNDORRESQ-UHFFFAOYSA-N 0.000 claims 3
- PLWSFHKKEUETGX-UHFFFAOYSA-N 3-[[4-[5-methyl-1-[4-[4-(trifluoromethyl)phenyl]phenoxy]hexyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCC(C)C)OC(C=C1)=CC=C1C1=CC=C(C(F)(F)F)C=C1 PLWSFHKKEUETGX-UHFFFAOYSA-N 0.000 claims 3
- FCJLQPPOORVTIP-UHFFFAOYSA-N 3-[[4-[cyclohexyl-[4-[4-(trifluoromethyl)phenyl]phenoxy]methyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(=O)NCCC(=O)O)=CC=C1C(C1CCCCC1)OC1=CC=C(C=2C=CC(=CC=2)C(F)(F)F)C=C1 FCJLQPPOORVTIP-UHFFFAOYSA-N 0.000 claims 3
- VLSLVIDWWHRHOT-UHFFFAOYSA-N 3-[[4-[cyclopropyl-[4-[4-(trifluoromethyl)phenyl]phenoxy]methyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(=O)NCCC(=O)O)=CC=C1C(C1CC1)OC1=CC=C(C=2C=CC(=CC=2)C(F)(F)F)C=C1 VLSLVIDWWHRHOT-UHFFFAOYSA-N 0.000 claims 3
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- QNVKUZCYKVLYFG-UHFFFAOYSA-N 3-[[4-[1-(4-bromo-3,5-dimethylphenyl)sulfanyl-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)SC1=CC(C)=C(Br)C(C)=C1 QNVKUZCYKVLYFG-UHFFFAOYSA-N 0.000 claims 2
- TZMBAAOTXXIBMA-UHFFFAOYSA-N 3-[[4-[1-(4-bromo-3,5-dimethylphenyl)sulfanyl-4,4,4-trifluorobutyl]benzoyl]amino]propanoic acid Chemical compound CC1=C(Br)C(C)=CC(SC(CCC(F)(F)F)C=2C=CC(=CC=2)C(=O)NCCC(O)=O)=C1 TZMBAAOTXXIBMA-UHFFFAOYSA-N 0.000 claims 2
- SYQCOSNUILKHCI-UHFFFAOYSA-N 3-[[4-[1-(4-pentylphenoxy)heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC1=CC=C(CCCCC)C=C1 SYQCOSNUILKHCI-UHFFFAOYSA-N 0.000 claims 2
- PYALZTPVPPLSBC-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-(4-propan-2-ylphenyl)phenoxy]-3,3-dimethylbutyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(C)C)=CC=C1C(C(=C1)C)=C(C)C=C1OC(CC(C)(C)C)C1=CC=C(C(=O)NCCC(O)=O)C=C1 PYALZTPVPPLSBC-UHFFFAOYSA-N 0.000 claims 2
- UQQRJSRQSUIPNF-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-[4-(trifluoromethyl)phenyl]phenoxy]-3,3-dimethylbutyl]benzoyl]amino]-2-hydroxypropanoic acid Chemical compound C=1C(C)=C(C=2C=CC(=CC=2)C(F)(F)F)C(C)=CC=1OC(CC(C)(C)C)C1=CC=C(C(=O)NCC(O)C(O)=O)C=C1 UQQRJSRQSUIPNF-UHFFFAOYSA-N 0.000 claims 2
- ZEISKDBZKMNDHL-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-[4-(trifluoromethyl)phenyl]phenoxy]-3-methylbutyl]benzoyl]amino]-2-hydroxypropanoic acid Chemical compound C=1C=C(C(=O)NCC(O)C(O)=O)C=CC=1C(CC(C)C)OC(C=C1C)=CC(C)=C1C1=CC=C(C(F)(F)F)C=C1 ZEISKDBZKMNDHL-UHFFFAOYSA-N 0.000 claims 2
- TYLGMIXJGSNRMC-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-[4-(trifluoromethyl)phenyl]phenyl]sulfanyl-5,5,5-trifluoropentyl]benzoyl]amino]propanoic acid Chemical compound C=1C(C)=C(C=2C=CC(=CC=2)C(F)(F)F)C(C)=CC=1SC(CCCC(F)(F)F)C1=CC=C(C(=O)NCCC(O)=O)C=C1 TYLGMIXJGSNRMC-UHFFFAOYSA-N 0.000 claims 2
- IPYRFSITBNNVLJ-UHFFFAOYSA-N 3-[[4-[1-[3-chloro-4-(2,4-dichlorophenyl)phenoxy]-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1Cl)=CC=C1C1=CC=C(Cl)C=C1Cl IPYRFSITBNNVLJ-UHFFFAOYSA-N 0.000 claims 2
- POGVUXMKUUSCKD-UHFFFAOYSA-N 3-[[4-[1-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC1=CC=C(C(C)(C)CC(C)(C)C)C=C1 POGVUXMKUUSCKD-UHFFFAOYSA-N 0.000 claims 2
- PAOZBRUYJCCRNA-UHFFFAOYSA-N 3-[[4-[1-[4-(3,5-dichlorophenyl)phenoxy]butyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCC)OC(C=C1)=CC=C1C1=CC(Cl)=CC(Cl)=C1 PAOZBRUYJCCRNA-UHFFFAOYSA-N 0.000 claims 2
- BLSPWGNEOOPLDC-UHFFFAOYSA-N 3-[[4-[1-[4-(4-ethylphenyl)-3-methylphenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1C)=CC=C1C1=CC=C(CC)C=C1 BLSPWGNEOOPLDC-UHFFFAOYSA-N 0.000 claims 2
- SVBQFTLVCNHVTP-UHFFFAOYSA-N 3-[[4-[1-[4-(4-fluorophenyl)-3-methylphenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1C)=CC=C1C1=CC=C(F)C=C1 SVBQFTLVCNHVTP-UHFFFAOYSA-N 0.000 claims 2
- GNGNGQFAWZUWOW-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)-3-methylphenoxy]-3-methylbutyl]-3-fluorobenzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=C(F)C=1C(CC(C)C)OC(C=C1C)=CC=C1C1=CC=C(C(C)(C)C)C=C1 GNGNGQFAWZUWOW-UHFFFAOYSA-N 0.000 claims 2
- MYZUFCORAKGKIG-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)phenoxy]-2-methylpropyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(C(C)C)OC(C=C1)=CC=C1C1=CC=C(C(C)(C)C)C=C1 MYZUFCORAKGKIG-UHFFFAOYSA-N 0.000 claims 2
- WWBALOFZYQSVEB-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)phenoxy]-3-methylbutyl]benzoyl]amino]-2-hydroxypropanoic acid Chemical compound C=1C=C(C(=O)NCC(O)C(O)=O)C=CC=1C(CC(C)C)OC(C=C1)=CC=C1C1=CC=C(C(C)(C)C)C=C1 WWBALOFZYQSVEB-UHFFFAOYSA-N 0.000 claims 2
- UHAYYLBMJJBVBJ-UHFFFAOYSA-N 3-[[4-[1-[4-[3,5-bis(trifluoromethyl)phenyl]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1)=CC=C1C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 UHAYYLBMJJBVBJ-UHFFFAOYSA-N 0.000 claims 2
- CQEKRBPMWCGVSX-UHFFFAOYSA-N 3-[[4-[1-[4-[4-(2-fluoropropan-2-yl)phenyl]phenyl]sulfanyl-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)SC(C=C1)=CC=C1C1=CC=C(C(C)(C)F)C=C1 CQEKRBPMWCGVSX-UHFFFAOYSA-N 0.000 claims 2
- ZKPDHCPHRBCINE-UHFFFAOYSA-N 3-[[4-[1-[4-[4-(trifluoromethoxy)phenyl]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1)=CC=C1C1=CC=C(OC(F)(F)F)C=C1 ZKPDHCPHRBCINE-UHFFFAOYSA-N 0.000 claims 2
- SSZANYZSCVMDPS-UHFFFAOYSA-N 3-[[4-[1-[6-(4-tert-butylphenyl)pyridin-3-yl]oxy-4,4-dimethylpentyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCC(C)(C)C)OC(C=N1)=CC=C1C1=CC=C(C(C)(C)C)C=C1 SSZANYZSCVMDPS-UHFFFAOYSA-N 0.000 claims 2
- XGZTYLPEIFJNOF-UHFFFAOYSA-N 3-[[4-[1-[6-(4-tert-butylphenyl)pyridin-3-yl]oxy-5,5,5-trifluoropentyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(C)(C)C)=CC=C1C(N=C1)=CC=C1OC(CCCC(F)(F)F)C1=CC=C(C(=O)NCCC(O)=O)C=C1 XGZTYLPEIFJNOF-UHFFFAOYSA-N 0.000 claims 2
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- DZAPAPSYNXKNBU-UHFFFAOYSA-N 3-[[4-[2-methyl-1-[3-methyl-4-[4-(trifluoromethoxy)phenyl]phenoxy]propyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(C(C)C)OC(C=C1C)=CC=C1C1=CC=C(OC(F)(F)F)C=C1 DZAPAPSYNXKNBU-UHFFFAOYSA-N 0.000 claims 2
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- WOURGEDULKUVQF-UHFFFAOYSA-N 3-[[4-[[4-(4-tert-butylphenyl)-3,5-dimethylphenoxy]methyl]benzoyl]amino]propanoic acid Chemical compound C=1C(C)=C(C=2C=CC(=CC=2)C(C)(C)C)C(C)=CC=1OCC1=CC=C(C(=O)NCCC(O)=O)C=C1 WOURGEDULKUVQF-UHFFFAOYSA-N 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 229910052740 iodine Inorganic materials 0.000 claims 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 2
- WWBALOFZYQSVEB-QXPUDEPPSA-N (2r)-3-[[4-[1-[4-(4-tert-butylphenyl)phenoxy]-3-methylbutyl]benzoyl]amino]-2-hydroxypropanoic acid Chemical compound C=1C=C(C(=O)NC[C@@H](O)C(O)=O)C=CC=1C(CC(C)C)OC(C=C1)=CC=C1C1=CC=C(C(C)(C)C)C=C1 WWBALOFZYQSVEB-QXPUDEPPSA-N 0.000 claims 1
- WWBALOFZYQSVEB-MBMZGMDYSA-N (2s)-3-[[4-[1-[4-(4-tert-butylphenyl)phenoxy]-3-methylbutyl]benzoyl]amino]-2-hydroxypropanoic acid Chemical compound C=1C=C(C(=O)NC[C@H](O)C(O)=O)C=CC=1C(CC(C)C)OC(C=C1)=CC=C1C1=CC=C(C(C)(C)C)C=C1 WWBALOFZYQSVEB-MBMZGMDYSA-N 0.000 claims 1
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- KDLFARVPZQGALH-UHFFFAOYSA-N 3-[[4-[1-(3,5-dimethylphenoxy)-5,5,5-trifluoropentyl]benzoyl]amino]propanoic acid Chemical compound CC1=CC(C)=CC(OC(CCCC(F)(F)F)C=2C=CC(=CC=2)C(=O)NCCC(O)=O)=C1 KDLFARVPZQGALH-UHFFFAOYSA-N 0.000 claims 1
- OVFHXNHVPNOYFD-UHFFFAOYSA-N 3-[[4-[1-(3-chloro-4-methylphenoxy)-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC1=CC=C(C)C(Cl)=C1 OVFHXNHVPNOYFD-UHFFFAOYSA-N 0.000 claims 1
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- MSUJUQBALMJDFI-UHFFFAOYSA-N 3-[[4-[1-(4-bromo-3,5-dimethylphenyl)sulfanyl-5,5,5-trifluoropentyl]benzoyl]amino]propanoic acid Chemical compound CC1=C(Br)C(C)=CC(SC(CCCC(F)(F)F)C=2C=CC(=CC=2)C(=O)NCCC(O)=O)=C1 MSUJUQBALMJDFI-UHFFFAOYSA-N 0.000 claims 1
- GBYRAAGJBBHMRA-UHFFFAOYSA-N 3-[[4-[1-(4-bromophenoxy)-5,5,5-trifluoropentyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(=O)NCCC(=O)O)=CC=C1C(CCCC(F)(F)F)OC1=CC=C(Br)C=C1 GBYRAAGJBBHMRA-UHFFFAOYSA-N 0.000 claims 1
- AFUCYKHHOFWDTQ-UHFFFAOYSA-N 3-[[4-[1-(4-cyclohexylphenoxy)hexyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCC)OC(C=C1)=CC=C1C1CCCCC1 AFUCYKHHOFWDTQ-UHFFFAOYSA-N 0.000 claims 1
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- MGVLXIBGTVHBLI-UHFFFAOYSA-N 3-[[4-[1-(4-hydroxyphenoxy)heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC1=CC=C(O)C=C1 MGVLXIBGTVHBLI-UHFFFAOYSA-N 0.000 claims 1
- LYMSWYYRHDBEDT-UHFFFAOYSA-N 3-[[4-[1-(4-pentoxyphenoxy)heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC1=CC=C(OCCCCC)C=C1 LYMSWYYRHDBEDT-UHFFFAOYSA-N 0.000 claims 1
- FSDIXLPRCIYLHG-UHFFFAOYSA-N 3-[[4-[1-(6-chloropyridin-3-yl)oxy-4,4,4-trifluorobutyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(=O)NCCC(=O)O)=CC=C1C(CCC(F)(F)F)OC1=CC=C(Cl)N=C1 FSDIXLPRCIYLHG-UHFFFAOYSA-N 0.000 claims 1
- OGCIQWIOSUXCET-UHFFFAOYSA-N 3-[[4-[1-(6-chloropyridin-3-yl)oxy-5-methylhexyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCC(C)C)OC1=CC=C(Cl)N=C1 OGCIQWIOSUXCET-UHFFFAOYSA-N 0.000 claims 1
- YQNDZZHMCSBCMW-UHFFFAOYSA-N 3-[[4-[1-[2,6-dimethyl-4-[4-(trifluoromethyl)phenyl]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C(=C1)C)=C(C)C=C1C1=CC=C(C(F)(F)F)C=C1 YQNDZZHMCSBCMW-UHFFFAOYSA-N 0.000 claims 1
- YHAQSWNDFRLZJZ-UHFFFAOYSA-N 3-[[4-[1-[3,5-difluoro-4-(4-propan-2-ylphenyl)phenoxy]-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1F)=CC(F)=C1C1=CC=C(C(C)C)C=C1 YHAQSWNDFRLZJZ-UHFFFAOYSA-N 0.000 claims 1
- CZDHVNSLRYMWLO-UHFFFAOYSA-N 3-[[4-[1-[3,5-difluoro-4-[4-(trifluoromethyl)phenyl]phenoxy]-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1F)=CC(F)=C1C1=CC=C(C(F)(F)F)C=C1 CZDHVNSLRYMWLO-UHFFFAOYSA-N 0.000 claims 1
- UFJBQCFCCCNZHU-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-(4-propan-2-ylphenyl)phenoxy]-3,3-dimethylbutyl]benzoyl]amino]-2-hydroxypropanoic acid Chemical compound C1=CC(C(C)C)=CC=C1C(C(=C1)C)=C(C)C=C1OC(CC(C)(C)C)C1=CC=C(C(=O)NCC(O)C(O)=O)C=C1 UFJBQCFCCCNZHU-UHFFFAOYSA-N 0.000 claims 1
- AKOSUTGNWSCMRH-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-(4-propan-2-ylphenyl)phenoxy]-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1C)=CC(C)=C1C1=CC=C(C(C)C)C=C1 AKOSUTGNWSCMRH-UHFFFAOYSA-N 0.000 claims 1
- VMVYXTHWQQUOPC-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-(4-propan-2-ylphenyl)phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1C)=CC(C)=C1C1=CC=C(C(C)C)C=C1 VMVYXTHWQQUOPC-UHFFFAOYSA-N 0.000 claims 1
- IZXFUNIKQAOYQG-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-[4-(trifluoromethoxy)phenyl]phenoxy]-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1C)=CC(C)=C1C1=CC=C(OC(F)(F)F)C=C1 IZXFUNIKQAOYQG-UHFFFAOYSA-N 0.000 claims 1
- PQJIGAAJZBRKRT-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-[4-(trifluoromethyl)phenyl]phenoxy]ethyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(C)OC(C=C1C)=CC(C)=C1C1=CC=C(C(F)(F)F)C=C1 PQJIGAAJZBRKRT-UHFFFAOYSA-N 0.000 claims 1
- MIDGESQDAOXHOT-UHFFFAOYSA-N 3-[[4-[1-[3,5-dimethyl-4-[4-(trifluoromethyl)phenyl]phenyl]sulfanyl-4,4,4-trifluorobutyl]benzoyl]amino]propanoic acid Chemical compound C=1C(C)=C(C=2C=CC(=CC=2)C(F)(F)F)C(C)=CC=1SC(CCC(F)(F)F)C1=CC=C(C(=O)NCCC(O)=O)C=C1 MIDGESQDAOXHOT-UHFFFAOYSA-N 0.000 claims 1
- MXYSKYLHXBGDDM-UHFFFAOYSA-N 3-[[4-[1-[3-(1,3-dioxan-2-yl)-4-(4-propan-2-ylphenyl)phenoxy]-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1C2OCCCO2)=CC=C1C1=CC=C(C(C)C)C=C1 MXYSKYLHXBGDDM-UHFFFAOYSA-N 0.000 claims 1
- NFODFMRQQSTPRP-UHFFFAOYSA-N 3-[[4-[1-[3-(4-tert-butylphenyl)-4-methylphenoxy]-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=1)=CC=C(C)C=1C1=CC=C(C(C)(C)C)C=C1 NFODFMRQQSTPRP-UHFFFAOYSA-N 0.000 claims 1
- FSXSAMJCILXVNK-UHFFFAOYSA-N 3-[[4-[1-[3-(4-tert-butylphenyl)phenoxy]-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=1)=CC=CC=1C1=CC=C(C(C)(C)C)C=C1 FSXSAMJCILXVNK-UHFFFAOYSA-N 0.000 claims 1
- ZLYLTQQBXFIPTR-UHFFFAOYSA-N 3-[[4-[1-[3-(hydroxymethyl)-4-(4-propan-2-ylphenyl)phenoxy]-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1CO)=CC=C1C1=CC=C(C(C)C)C=C1 ZLYLTQQBXFIPTR-UHFFFAOYSA-N 0.000 claims 1
- FVHSFLKLLBIJOO-UHFFFAOYSA-N 3-[[4-[1-[3-chloro-4-[4-(trifluoromethyl)phenyl]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1Cl)=CC=C1C1=CC=C(C(F)(F)F)C=C1 FVHSFLKLLBIJOO-UHFFFAOYSA-N 0.000 claims 1
- HBGSXAIOXKRWPL-UHFFFAOYSA-N 3-[[4-[1-[3-formyl-4-(4-propan-2-ylphenyl)phenoxy]-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1C=O)=CC=C1C1=CC=C(C(C)C)C=C1 HBGSXAIOXKRWPL-UHFFFAOYSA-N 0.000 claims 1
- MTBKDJNRJHHVPI-UHFFFAOYSA-N 3-[[4-[1-[3-hydroxy-4-(4-propan-2-ylphenyl)phenoxy]-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1O)=CC=C1C1=CC=C(C(C)C)C=C1 MTBKDJNRJHHVPI-UHFFFAOYSA-N 0.000 claims 1
- IWDRHEYABDPRBE-UHFFFAOYSA-N 3-[[4-[1-[3-methyl-4-[4-(trifluoromethoxy)phenyl]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1C)=CC=C1C1=CC=C(OC(F)(F)F)C=C1 IWDRHEYABDPRBE-UHFFFAOYSA-N 0.000 claims 1
- WTISSISDZLSPAV-UHFFFAOYSA-N 3-[[4-[1-[4-(2,3,4-trifluorophenyl)phenoxy]butyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCC)OC(C=C1)=CC=C1C1=CC=C(F)C(F)=C1F WTISSISDZLSPAV-UHFFFAOYSA-N 0.000 claims 1
- RBEXAEJFLZBHCM-UHFFFAOYSA-N 3-[[4-[1-[4-(2,3-dimethylphenyl)phenyl]sulfanylheptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)SC(C=C1)=CC=C1C1=CC=CC(C)=C1C RBEXAEJFLZBHCM-UHFFFAOYSA-N 0.000 claims 1
- JJRRVRMZEPVOOO-UHFFFAOYSA-N 3-[[4-[1-[4-(2,4,6-trimethylphenyl)phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1)=CC=C1C1=C(C)C=C(C)C=C1C JJRRVRMZEPVOOO-UHFFFAOYSA-N 0.000 claims 1
- LTQIIHTUZFNRDV-UHFFFAOYSA-N 3-[[4-[1-[4-(2,4-dimethoxyphenyl)phenoxy]butyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCC)OC(C=C1)=CC=C1C1=CC=C(OC)C=C1OC LTQIIHTUZFNRDV-UHFFFAOYSA-N 0.000 claims 1
- GLQSHAZYLJSUQU-UHFFFAOYSA-N 3-[[4-[1-[4-(2,6-dimethylphenyl)phenyl]sulfanylheptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)SC(C=C1)=CC=C1C1=C(C)C=CC=C1C GLQSHAZYLJSUQU-UHFFFAOYSA-N 0.000 claims 1
- GQSLKSSTHUALIB-UHFFFAOYSA-N 3-[[4-[1-[4-(3,4-dimethylphenyl)phenyl]sulfanyl-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)SC(C=C1)=CC=C1C1=CC=C(C)C(C)=C1 GQSLKSSTHUALIB-UHFFFAOYSA-N 0.000 claims 1
- HUDOVIFINRSGKH-UHFFFAOYSA-N 3-[[4-[1-[4-(3,4-dimethylphenyl)phenyl]sulfanylheptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)SC(C=C1)=CC=C1C1=CC=C(C)C(C)=C1 HUDOVIFINRSGKH-UHFFFAOYSA-N 0.000 claims 1
- HVRWSODVFYFCEO-UHFFFAOYSA-N 3-[[4-[1-[4-(3-acetylphenyl)phenyl]sulfanylheptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)SC(C=C1)=CC=C1C1=CC=CC(C(C)=O)=C1 HVRWSODVFYFCEO-UHFFFAOYSA-N 0.000 claims 1
- IVIVGORLNXPDEM-UHFFFAOYSA-N 3-[[4-[1-[4-(3-propan-2-ylphenyl)phenyl]sulfanylheptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)SC(C=C1)=CC=C1C1=CC=CC(C(C)C)=C1 IVIVGORLNXPDEM-UHFFFAOYSA-N 0.000 claims 1
- HDZOQCNGBQELOB-UHFFFAOYSA-N 3-[[4-[1-[4-(4-acetylphenyl)-3,5-dimethylphenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1C)=CC(C)=C1C1=CC=C(C(C)=O)C=C1 HDZOQCNGBQELOB-UHFFFAOYSA-N 0.000 claims 1
- UXUGPCFZRIPJHB-UHFFFAOYSA-N 3-[[4-[1-[4-(4-acetylphenyl)-3-methylphenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1C)=CC=C1C1=CC=C(C(C)=O)C=C1 UXUGPCFZRIPJHB-UHFFFAOYSA-N 0.000 claims 1
- VYXZQXBBROCOJY-UHFFFAOYSA-N 3-[[4-[1-[4-(4-acetylphenyl)phenoxy]butyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCC)OC(C=C1)=CC=C1C1=CC=C(C(C)=O)C=C1 VYXZQXBBROCOJY-UHFFFAOYSA-N 0.000 claims 1
- RLSBQTJHAPFEMH-UHFFFAOYSA-N 3-[[4-[1-[4-(4-acetylphenyl)phenyl]sulfanylheptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)SC(C=C1)=CC=C1C1=CC=C(C(C)=O)C=C1 RLSBQTJHAPFEMH-UHFFFAOYSA-N 0.000 claims 1
- WCEFMYWZBITPGX-UHFFFAOYSA-N 3-[[4-[1-[4-(4-chlorophenyl)-2,6-dimethylphenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C(=C1)C)=C(C)C=C1C1=CC=C(Cl)C=C1 WCEFMYWZBITPGX-UHFFFAOYSA-N 0.000 claims 1
- PJMBEKUCFILVFZ-UHFFFAOYSA-N 3-[[4-[1-[4-(4-chlorophenyl)-2-methylphenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C(=C1)C)=CC=C1C1=CC=C(Cl)C=C1 PJMBEKUCFILVFZ-UHFFFAOYSA-N 0.000 claims 1
- INTLHCRDSOODCG-UHFFFAOYSA-N 3-[[4-[1-[4-(4-chlorophenyl)-3,5-dimethylphenoxy]-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1C)=CC(C)=C1C1=CC=C(Cl)C=C1 INTLHCRDSOODCG-UHFFFAOYSA-N 0.000 claims 1
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- SNOUPZOYUZQTPX-UHFFFAOYSA-N 3-[[4-[1-[4-(4-cyanophenyl)phenyl]sulfanyl-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)SC(C=C1)=CC=C1C1=CC=C(C#N)C=C1 SNOUPZOYUZQTPX-UHFFFAOYSA-N 0.000 claims 1
- YAOZYTRKIOLLSW-UHFFFAOYSA-N 3-[[4-[1-[4-(4-cyclohexylphenyl)phenyl]sulfanylheptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)SC(C=C1)=CC=C1C(C=C1)=CC=C1C1CCCCC1 YAOZYTRKIOLLSW-UHFFFAOYSA-N 0.000 claims 1
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- NWXMTMFMGKTAAA-UHFFFAOYSA-N 3-[[4-[1-[4-(4-fluoro-2-methylphenyl)phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1)=CC=C1C1=CC=C(F)C=C1C NWXMTMFMGKTAAA-UHFFFAOYSA-N 0.000 claims 1
- PEDVHVQIIZHKJZ-UHFFFAOYSA-N 3-[[4-[1-[4-(4-fluorophenyl)-3,5-dimethylphenoxy]-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=C1C)=CC(C)=C1C1=CC=C(F)C=C1 PEDVHVQIIZHKJZ-UHFFFAOYSA-N 0.000 claims 1
- XHLXLHIMCCBTMZ-UHFFFAOYSA-N 3-[[4-[1-[4-(4-fluorophenyl)phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1)=CC=C1C1=CC=C(F)C=C1 XHLXLHIMCCBTMZ-UHFFFAOYSA-N 0.000 claims 1
- GOKUZEASLNWATR-UHFFFAOYSA-N 3-[[4-[1-[4-(4-methylpentoxy)phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC1=CC=C(OCCCC(C)C)C=C1 GOKUZEASLNWATR-UHFFFAOYSA-N 0.000 claims 1
- KDKZLBJRVQJBPE-UHFFFAOYSA-N 3-[[4-[1-[4-(4-methylsulfonylphenyl)phenyl]sulfanylheptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)SC(C=C1)=CC=C1C1=CC=C(S(C)(=O)=O)C=C1 KDKZLBJRVQJBPE-UHFFFAOYSA-N 0.000 claims 1
- MWVNWODAOABXKL-UHFFFAOYSA-N 3-[[4-[1-[4-(4-pentylphenyl)phenoxy]butyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(CCCCC)=CC=C1C(C=C1)=CC=C1OC(CCC)C1=CC=C(C(=O)NCCC(O)=O)C=C1 MWVNWODAOABXKL-UHFFFAOYSA-N 0.000 claims 1
- RRVIYPUYMQQECZ-UHFFFAOYSA-N 3-[[4-[1-[4-(4-pentylphenyl)phenyl]sulfanylheptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)SC(C=C1)=CC=C1C1=CC=C(CCCCC)C=C1 RRVIYPUYMQQECZ-UHFFFAOYSA-N 0.000 claims 1
- FZLRTMAYVMDJHU-UHFFFAOYSA-N 3-[[4-[1-[4-(4-propan-2-ylphenyl)-3-(trifluoromethyl)phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1C(F)(F)F)=CC=C1C1=CC=C(C(C)C)C=C1 FZLRTMAYVMDJHU-UHFFFAOYSA-N 0.000 claims 1
- BVECIJGLVZNUFA-UHFFFAOYSA-N 3-[[4-[1-[4-(4-propan-2-ylphenyl)phenyl]sulfanylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCC)SC(C=C1)=CC=C1C1=CC=C(C(C)C)C=C1 BVECIJGLVZNUFA-UHFFFAOYSA-N 0.000 claims 1
- LUFLZOXJYOTZMN-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)-3,5-dimethylphenoxy]ethyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(C)OC(C=C1C)=CC(C)=C1C1=CC=C(C(C)(C)C)C=C1 LUFLZOXJYOTZMN-UHFFFAOYSA-N 0.000 claims 1
- RIIOFYLNJOASDG-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)-3,5-dimethylphenyl]sulfanyl-5,5,5-trifluoropentyl]benzoyl]amino]propanoic acid Chemical compound C=1C(C)=C(C=2C=CC(=CC=2)C(C)(C)C)C(C)=CC=1SC(CCCC(F)(F)F)C1=CC=C(C(=O)NCCC(O)=O)C=C1 RIIOFYLNJOASDG-UHFFFAOYSA-N 0.000 claims 1
- SCSFYEZTWGPPNE-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)-3-chlorophenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1Cl)=CC=C1C1=CC=C(C(C)(C)C)C=C1 SCSFYEZTWGPPNE-UHFFFAOYSA-N 0.000 claims 1
- USCYPIVBBRGAMD-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)phenoxy]-4,4-dimethylpentyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCC(C)(C)C)OC(C=C1)=CC=C1C1=CC=C(C(C)(C)C)C=C1 USCYPIVBBRGAMD-UHFFFAOYSA-N 0.000 claims 1
- JKTIMSMYDIUSJQ-UHFFFAOYSA-N 3-[[4-[1-[4-(4-tert-butylphenyl)phenoxy]-5-methylhexyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCC(C)C)OC(C=C1)=CC=C1C1=CC=C(C(C)(C)C)C=C1 JKTIMSMYDIUSJQ-UHFFFAOYSA-N 0.000 claims 1
- STOGGVRPNFBULU-UHFFFAOYSA-N 3-[[4-[1-[4-(6-methoxypyridin-3-yl)phenyl]sulfanyl-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C1=NC(OC)=CC=C1C(C=C1)=CC=C1SC(CC(C)C)C1=CC=C(C(=O)NCCC(O)=O)C=C1 STOGGVRPNFBULU-UHFFFAOYSA-N 0.000 claims 1
- ZCAKTCXRYMXNHM-UHFFFAOYSA-N 3-[[4-[1-[4-[(3,4-dimethylphenyl)methoxy]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1)=CC=C1OCC1=CC=C(C)C(C)=C1 ZCAKTCXRYMXNHM-UHFFFAOYSA-N 0.000 claims 1
- HDBMACOBKNPOHM-UHFFFAOYSA-N 3-[[4-[1-[4-[(3-chlorophenyl)methoxy]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1)=CC=C1OCC1=CC=CC(Cl)=C1 HDBMACOBKNPOHM-UHFFFAOYSA-N 0.000 claims 1
- RQNNZARUEYJIKX-UHFFFAOYSA-N 3-[[4-[1-[4-[(4-bromophenyl)methoxy]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1)=CC=C1OCC1=CC=C(Br)C=C1 RQNNZARUEYJIKX-UHFFFAOYSA-N 0.000 claims 1
- OQRLYBFQMYXQJD-UHFFFAOYSA-N 3-[[4-[1-[4-[(4-chlorophenyl)methoxy]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1)=CC=C1OCC1=CC=C(Cl)C=C1 OQRLYBFQMYXQJD-UHFFFAOYSA-N 0.000 claims 1
- IVNLBUMFCAOKKZ-UHFFFAOYSA-N 3-[[4-[1-[4-[(4-ethylphenyl)methoxy]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1)=CC=C1OCC1=CC=C(CC)C=C1 IVNLBUMFCAOKKZ-UHFFFAOYSA-N 0.000 claims 1
- WTUUDOASCWBWJC-UHFFFAOYSA-N 3-[[4-[1-[4-[(4-fluorophenyl)methoxy]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1)=CC=C1OCC1=CC=C(F)C=C1 WTUUDOASCWBWJC-UHFFFAOYSA-N 0.000 claims 1
- HRNWPMZTZKIFIQ-UHFFFAOYSA-N 3-[[4-[1-[4-[(4-phenylphenyl)methoxy]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1)=CC=C1OCC(C=C1)=CC=C1C1=CC=CC=C1 HRNWPMZTZKIFIQ-UHFFFAOYSA-N 0.000 claims 1
- GKTIFOPYEVIOFO-UHFFFAOYSA-N 3-[[4-[1-[4-[(4-propan-2-ylphenyl)methoxy]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1)=CC=C1OCC1=CC=C(C(C)C)C=C1 GKTIFOPYEVIOFO-UHFFFAOYSA-N 0.000 claims 1
- FKRFJCQJOPVQPH-UHFFFAOYSA-N 3-[[4-[1-[4-[(4-tert-butylphenyl)methoxy]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1)=CC=C1OCC1=CC=C(C(C)(C)C)C=C1 FKRFJCQJOPVQPH-UHFFFAOYSA-N 0.000 claims 1
- HEHYOJBGQKEKCC-UHFFFAOYSA-N 3-[[4-[1-[4-[2,4-bis(trifluoromethyl)phenyl]-3-chlorophenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1Cl)=CC=C1C1=CC=C(C(F)(F)F)C=C1C(F)(F)F HEHYOJBGQKEKCC-UHFFFAOYSA-N 0.000 claims 1
- QQTKQARDQWZQIM-UHFFFAOYSA-N 3-[[4-[1-[4-[3-(trifluoromethyl)phenyl]phenyl]sulfanylheptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)SC(C=C1)=CC=C1C1=CC=CC(C(F)(F)F)=C1 QQTKQARDQWZQIM-UHFFFAOYSA-N 0.000 claims 1
- ADCVFNYILFHTQH-UHFFFAOYSA-N 3-[[4-[1-[4-[4-(2-methylpropyl)phenyl]phenoxy]butyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCC)OC(C=C1)=CC=C1C1=CC=C(CC(C)C)C=C1 ADCVFNYILFHTQH-UHFFFAOYSA-N 0.000 claims 1
- KXQVDGBNLDYZNE-UHFFFAOYSA-N 3-[[4-[1-[4-[4-(trifluoromethoxy)phenyl]phenoxy]hexyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCC)OC(C=C1)=CC=C1C1=CC=C(OC(F)(F)F)C=C1 KXQVDGBNLDYZNE-UHFFFAOYSA-N 0.000 claims 1
- DQLAKVPTMALBQV-UHFFFAOYSA-N 3-[[4-[1-[4-[[3,5-bis(trifluoromethyl)phenyl]methoxy]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1)=CC=C1OCC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 DQLAKVPTMALBQV-UHFFFAOYSA-N 0.000 claims 1
- CVPOALVIVYOGME-UHFFFAOYSA-N 3-[[4-[1-[4-[[4-(trifluoromethyl)phenyl]methoxy]phenoxy]heptyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCCCC)OC(C=C1)=CC=C1OCC1=CC=C(C(F)(F)F)C=C1 CVPOALVIVYOGME-UHFFFAOYSA-N 0.000 claims 1
- MBNZTMWWENMYLS-UHFFFAOYSA-N 3-[[4-[1-[4-bromo-3-(1,3-dioxan-2-yl)phenoxy]-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=1)=CC=C(Br)C=1C1OCCCO1 MBNZTMWWENMYLS-UHFFFAOYSA-N 0.000 claims 1
- HYUARFFZIMRSIR-UHFFFAOYSA-N 3-[[4-[1-[4-chloro-3-(trifluoromethyl)phenoxy]heptyl]benzoyl]amino]-2-hydroxypropanoic acid Chemical compound C=1C=C(C(=O)NCC(O)C(O)=O)C=CC=1C(CCCCCC)OC1=CC=C(Cl)C(C(F)(F)F)=C1 HYUARFFZIMRSIR-UHFFFAOYSA-N 0.000 claims 1
- GCYZPAGJCPRDKP-UHFFFAOYSA-N 3-[[4-[1-[6-(4-tert-butylphenyl)pyridin-3-yl]oxy-3-methylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=N1)=CC=C1C1=CC=C(C(C)(C)C)C=C1 GCYZPAGJCPRDKP-UHFFFAOYSA-N 0.000 claims 1
- AREUABAZAWIIIU-UHFFFAOYSA-N 3-[[4-[1-[6-[4-(2-methylpropyl)phenyl]pyridin-3-yl]oxybutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCC)OC(C=N1)=CC=C1C1=CC=C(CC(C)C)C=C1 AREUABAZAWIIIU-UHFFFAOYSA-N 0.000 claims 1
- FVCJNQVBCUCIFX-UHFFFAOYSA-N 3-[[4-[1-[6-[4-(trifluoromethyl)phenyl]pyridin-3-yl]butoxy]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C=2C=CC(=CC=2)C(F)(F)F)N=CC=1C(CCC)OC1=CC=C(C(=O)NCCC(O)=O)C=C1 FVCJNQVBCUCIFX-UHFFFAOYSA-N 0.000 claims 1
- SSLGXDRBOGQNRR-UHFFFAOYSA-N 3-[[4-[2-methyl-1-[3-methyl-4-(4-propan-2-ylphenyl)phenoxy]propyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(C(C)C)OC(C=C1C)=CC=C1C1=CC=C(C(C)C)C=C1 SSLGXDRBOGQNRR-UHFFFAOYSA-N 0.000 claims 1
- ZWBQWVUPRRRSGF-UHFFFAOYSA-N 3-[[4-[2-methyl-1-[4-[6-(trifluoromethyl)pyridin-3-yl]phenoxy]propyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(C(C)C)OC(C=C1)=CC=C1C1=CC=C(C(F)(F)F)N=C1 ZWBQWVUPRRRSGF-UHFFFAOYSA-N 0.000 claims 1
- QRGYAYCZQLFSFZ-UHFFFAOYSA-N 3-[[4-[3-methyl-1-[3-(4-propan-2-ylphenyl)phenoxy]butyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=1)=CC=CC=1C1=CC=C(C(C)C)C=C1 QRGYAYCZQLFSFZ-UHFFFAOYSA-N 0.000 claims 1
- HAKHWGFXWQIUOJ-UHFFFAOYSA-N 3-[[4-[3-methyl-1-[3-(morpholin-4-ylmethyl)-4-(4-propan-2-ylphenyl)phenoxy]butyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=1)=CC=C(C=2C=CC(=CC=2)C(C)C)C=1CN1CCOCC1 HAKHWGFXWQIUOJ-UHFFFAOYSA-N 0.000 claims 1
- GRDJPRRZSOPVOB-UHFFFAOYSA-N 3-[[4-[3-methyl-1-[3-[4-(trifluoromethoxy)phenyl]phenoxy]butyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=1)=CC=CC=1C1=CC=C(OC(F)(F)F)C=C1 GRDJPRRZSOPVOB-UHFFFAOYSA-N 0.000 claims 1
- NPLBHNZZYSHKIL-UHFFFAOYSA-N 3-[[4-[3-methyl-1-[3-[4-(trifluoromethyl)phenyl]phenoxy]butyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=1)=CC=CC=1C1=CC=C(C(F)(F)F)C=C1 NPLBHNZZYSHKIL-UHFFFAOYSA-N 0.000 claims 1
- PZZSELYPURUIEC-UHFFFAOYSA-N 3-[[4-[3-methyl-1-[4-[4-(2-methylpropyl)phenyl]phenyl]sulfanylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)SC(C=C1)=CC=C1C1=CC=C(CC(C)C)C=C1 PZZSELYPURUIEC-UHFFFAOYSA-N 0.000 claims 1
- HDSYLSRMIZVVKJ-UHFFFAOYSA-N 3-[[4-[3-methyl-1-[4-[4-(trifluoromethoxy)phenyl]phenyl]sulfanylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)SC(C=C1)=CC=C1C1=CC=C(OC(F)(F)F)C=C1 HDSYLSRMIZVVKJ-UHFFFAOYSA-N 0.000 claims 1
- YZQKSXAWPACRMR-UHFFFAOYSA-N 3-[[4-[3-methyl-1-[4-[4-(trifluoromethyl)phenyl]phenyl]sulfanylbutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)SC(C=C1)=CC=C1C1=CC=C(C(F)(F)F)C=C1 YZQKSXAWPACRMR-UHFFFAOYSA-N 0.000 claims 1
- VIAVYRUYEQMYSU-UHFFFAOYSA-N 3-[[4-[3-methyl-1-[4-methyl-3-[4-(trifluoromethyl)phenyl]phenoxy]butyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=1)=CC=C(C)C=1C1=CC=C(C(F)(F)F)C=C1 VIAVYRUYEQMYSU-UHFFFAOYSA-N 0.000 claims 1
- DUSMKNIBGJHCQA-UHFFFAOYSA-N 3-[[4-[3-methyl-1-[6-[4-(trifluoromethyl)phenyl]pyridin-3-yl]oxybutyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CC(C)C)OC(C=N1)=CC=C1C1=CC=C(C(F)(F)F)C=C1 DUSMKNIBGJHCQA-UHFFFAOYSA-N 0.000 claims 1
- GXEBEZLLOMPJSE-UHFFFAOYSA-N 3-[[4-[4,4,4-trifluoro-1-[5-methyl-6-[4-(trifluoromethyl)phenyl]pyridin-3-yl]oxybutyl]benzoyl]amino]propanoic acid Chemical compound C=1N=C(C=2C=CC(=CC=2)C(F)(F)F)C(C)=CC=1OC(CCC(F)(F)F)C1=CC=C(C(=O)NCCC(O)=O)C=C1 GXEBEZLLOMPJSE-UHFFFAOYSA-N 0.000 claims 1
- QZYOKYQTCDICPH-UHFFFAOYSA-N 3-[[4-[4,4,4-trifluoro-1-[6-(4-propan-2-ylphenyl)pyridin-3-yl]oxybutyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(C)C)=CC=C1C(N=C1)=CC=C1OC(CCC(F)(F)F)C1=CC=C(C(=O)NCCC(O)=O)C=C1 QZYOKYQTCDICPH-UHFFFAOYSA-N 0.000 claims 1
- BCKRDEAWLBJXHY-UHFFFAOYSA-N 3-[[4-[4,4-dimethyl-1-[5-methyl-6-(4-propan-2-ylphenyl)pyridin-3-yl]oxypentyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(C)C)=CC=C1C(C(=C1)C)=NC=C1OC(CCC(C)(C)C)C1=CC=C(C(=O)NCCC(O)=O)C=C1 BCKRDEAWLBJXHY-UHFFFAOYSA-N 0.000 claims 1
- JTPNGWNNXBIWSD-UHFFFAOYSA-N 3-[[4-[4,4-dimethyl-1-[5-methyl-6-[4-(trifluoromethoxy)phenyl]pyridin-3-yl]oxypentyl]benzoyl]amino]propanoic acid Chemical compound C=1N=C(C=2C=CC(OC(F)(F)F)=CC=2)C(C)=CC=1OC(CCC(C)(C)C)C1=CC=C(C(=O)NCCC(O)=O)C=C1 JTPNGWNNXBIWSD-UHFFFAOYSA-N 0.000 claims 1
- UVJYJGMJTBKPCD-UHFFFAOYSA-N 3-[[4-[4,4-dimethyl-1-[6-[4-(trifluoromethyl)phenyl]pyridin-3-yl]oxypentyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCC(C)(C)C)OC(C=N1)=CC=C1C1=CC=C(C(F)(F)F)C=C1 UVJYJGMJTBKPCD-UHFFFAOYSA-N 0.000 claims 1
- ONIOCCUQOUWFOB-UHFFFAOYSA-N 3-[[4-[5,5,5-trifluoro-1-(2,3,4,5,6-pentamethylphenoxy)pentyl]benzoyl]amino]propanoic acid Chemical compound CC1=C(C)C(C)=C(C)C(C)=C1OC(CCCC(F)(F)F)C1=CC=C(C(=O)NCCC(O)=O)C=C1 ONIOCCUQOUWFOB-UHFFFAOYSA-N 0.000 claims 1
- VENCGBJGFCLCDM-UHFFFAOYSA-N 3-[[4-[5,5,5-trifluoro-1-[2,4,6-tri(propan-2-yl)phenoxy]pentyl]benzoyl]amino]propanoic acid Chemical compound CC(C)C1=CC(C(C)C)=CC(C(C)C)=C1OC(CCCC(F)(F)F)C1=CC=C(C(=O)NCCC(O)=O)C=C1 VENCGBJGFCLCDM-UHFFFAOYSA-N 0.000 claims 1
- GHMFUGAPLAZDCD-UHFFFAOYSA-N 3-[[4-[5,5,5-trifluoro-1-[4-[3-fluoro-4-(trifluoromethyl)phenyl]phenoxy]pentyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(=O)NCCC(=O)O)=CC=C1C(CCCC(F)(F)F)OC1=CC=C(C=2C=C(F)C(=CC=2)C(F)(F)F)C=C1 GHMFUGAPLAZDCD-UHFFFAOYSA-N 0.000 claims 1
- NLPUVYDZFPEQHO-UHFFFAOYSA-N 3-[[4-[5,5,5-trifluoro-1-[6-(4-propan-2-ylphenyl)pyridin-3-yl]oxypentyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(C)C)=CC=C1C(N=C1)=CC=C1OC(CCCC(F)(F)F)C1=CC=C(C(=O)NCCC(O)=O)C=C1 NLPUVYDZFPEQHO-UHFFFAOYSA-N 0.000 claims 1
- WLMMHIKPPIDITF-UHFFFAOYSA-N 3-[[4-[5,5,5-trifluoro-1-[6-[4-(trifluoromethyl)phenyl]pyridin-3-yl]oxypentyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(=O)NCCC(=O)O)=CC=C1C(CCCC(F)(F)F)OC1=CC=C(C=2C=CC(=CC=2)C(F)(F)F)N=C1 WLMMHIKPPIDITF-UHFFFAOYSA-N 0.000 claims 1
- FYBAVDHCIGWHNI-UHFFFAOYSA-N 3-[[4-[5-methyl-1-[6-[4-(trifluoromethyl)phenyl]pyridin-3-yl]oxyhexyl]benzoyl]amino]propanoic acid Chemical compound C=1C=C(C(=O)NCCC(O)=O)C=CC=1C(CCCC(C)C)OC(C=N1)=CC=C1C1=CC=C(C(F)(F)F)C=C1 FYBAVDHCIGWHNI-UHFFFAOYSA-N 0.000 claims 1
- JZBNLXCTSZQOGV-UHFFFAOYSA-N 3-[[4-[[4-(4-tert-butylphenyl)-3,5-dimethylphenoxy]-cyclohexylmethyl]benzoyl]amino]propanoic acid Chemical compound C=1C(C)=C(C=2C=CC(=CC=2)C(C)(C)C)C(C)=CC=1OC(C=1C=CC(=CC=1)C(=O)NCCC(O)=O)C1CCCCC1 JZBNLXCTSZQOGV-UHFFFAOYSA-N 0.000 claims 1
- DGYHJQOAPFGKIL-UHFFFAOYSA-N 3-[[4-[[4-(4-tert-butylphenyl)phenoxy]-cyclohexylmethyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(C)(C)C)=CC=C1C(C=C1)=CC=C1OC(C=1C=CC(=CC=1)C(=O)NCCC(O)=O)C1CCCCC1 DGYHJQOAPFGKIL-UHFFFAOYSA-N 0.000 claims 1
- YLKKRAUGZCBWOE-UHFFFAOYSA-N 3-[[4-[[6-(4-tert-butylphenyl)pyridin-3-yl]oxy-cyclohexylmethyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(C)(C)C)=CC=C1C(N=C1)=CC=C1OC(C=1C=CC(=CC=1)C(=O)NCCC(O)=O)C1CCCCC1 YLKKRAUGZCBWOE-UHFFFAOYSA-N 0.000 claims 1
- OMYNTJCMDVPXLH-UHFFFAOYSA-N 3-[[4-[cyclohexyl-[3,5-dimethyl-4-(4-propan-2-ylphenyl)phenoxy]methyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(C)C)=CC=C1C(C(=C1)C)=C(C)C=C1OC(C=1C=CC(=CC=1)C(=O)NCCC(O)=O)C1CCCCC1 OMYNTJCMDVPXLH-UHFFFAOYSA-N 0.000 claims 1
- POAVHKPQBMVIAU-UHFFFAOYSA-N 3-[[4-[cyclohexyl-[6-(4-propan-2-ylphenyl)pyridin-3-yl]oxymethyl]benzoyl]amino]propanoic acid Chemical compound C1=CC(C(C)C)=CC=C1C(N=C1)=CC=C1OC(C=1C=CC(=CC=1)C(=O)NCCC(O)=O)C1CCCCC1 POAVHKPQBMVIAU-UHFFFAOYSA-N 0.000 claims 1
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 125000005336 allyloxy group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- BIZGMTWBKDPTLH-UHFFFAOYSA-N propan-2-yl hypochlorite Chemical compound CC(C)OCl BIZGMTWBKDPTLH-UHFFFAOYSA-N 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract 1
- 229940125425 inverse agonist Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000002469 receptor inverse agonist Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract
Spoj predstavljen strukturnom Formulom I (I) ili njegova farmaceutski prihvatljiva sol, naznačen time što: Y je -O- ili -S-;Q, D, X i T neovisno predstavljaju ugljik (supstituiran s vodikom ili izbornim supstituentima kako je naznačeno ovdje), ili dušik (izborno supstituiran s kisikom), pod uvjetom da najviše 2 od Q, D, X i T su dušici; R1 je -H, -OH, ili -halogen; R2 je -H ili -(C1-C3) alkil (izborno supstituiran s 1 do 3 halogena); R3 i R4 su neovisno- H, -halogen, -CN, -OH, -(C1-C7) alkoksi, -(C1-C7)alkil (izborno supstituiran s 1 do 3 halogena), ili -(C2-C7) alkenil; R5 se izabire od- H, -(C1-C12)alkila (izborno supstituiranog s 1 do 3 halogena), -(C3-C12)cikloalkila, -fenila, -fenil-fenil-(C1-C12)alkila, - arila, -aril-(C1-C12)alkila, -heteroarila, -heteroaril-(C1-C12)alkila, -(C2-C12)alkenila, - (C3-C12)cikloalkenila, -heterocikloalkila, -aril-(C2-C10)alkenila, - heteroaril-(C2-C10)alkenila, -(C2-C12)alkinila, -(C3-C12)cikloalkinila, - aril-(C2-C12)alkinila i -heteroaril-(C2-C12)alkinila, a pri čemu -(C1-C12)alkil, -(C3-C12)cikloalkil, -fenil, -fenil-fenil-(C1-C12)alkil, -aril, -aril-(C1-C12)alkil, -heteroaril, -heteroaril-(C1-C12)alkil, -heterocikloalkil, -(C2-C12)alkenil, -(C3-C12)cikloalkenil, -aril-(C2-C10)alkenil, -heteroaril-(C2-C10) alkenil, -(C2-C12) alkinil, -(C3-C12)cikloalkinil, -aril-(C2-C12)alkinil, -heteroaril-(C2-C12)alkinil je svaki izborno supstituiran s od 1 do 3 supstituenata od kojih se svaki neovisno izabire od -vodika, -hidroksi, -ciano, nitro, -halo, -okso, -(C1-C7)alkil (izborno supstituiran s 1 do 3 halogena), -(C1-C7) alkil-C(O) OR12, (C1-C7)alkoksi, -(C3-C7)cikloalkila, -C(O)R12, -C(O)OR12, -OC(O)R12, -OS(O)2R12, -N(R12)2, i- NR12C(O)R12, -NR12SO2R12, -SR12, -S(O)R12, -S(O)2R12 i -S(O)2N(R12)2;R6 i R7 se neovisno na svakom pojavljivanju izabire od- H, -halogena, -hidroksi, -CN, -(C1-C7)alkoksi, -(C2-C7)alkenila, -(C1-C10)alkila (izborno supstituiranog s 1 do 3 halogena), -(C3-C12)cikloalkila, terc-butoksiiminmetila, 1,3-dioksan-2-ila, hidroksimetila, formila, hidroksi-iminmetila, morfilino-4-il-metila, 4-metilpentiloksi i pentiloksi; međutim pod uvjetom da kada D je dušik, tada R6 ili R7 nisu vezani na D, i pod uvjetom da kada T je dušik, tada R6 ili R7 nisu vezani na T, i pod uvjetom da kada Q je dušik, tada R6 ili R7 nisu vezani na Q, i pod uvjetom da kada X je dušik, tada R6 ili R7 nisu vezani na X; pri čemu R6 i R7 mogu izborno tvoriti 6-člani prsten s atomima na koje su vezani, a tako formiran prsten može izborno sadržavati do najviše 2 kisika, i osim toga tako formiran prsten može izborno biti supstituiran s do najviše 4 halogena; R8 i R9 se neovisno na svakom pojavljivanju izabire od- vodika, -hidroksi, -CN, -nitro, -halo, -(C1-C7)alkila (izborno supstituiranog s 1 do 3 halogena), -(C1-C7) alkoksi, -(C3-C7)cikloalkila, arila, -aril-(C1-C7)alkila, -heteroarila, -heteroaril-(C1-C7)alkila, -ariloksi, -C(O)R12, -COOR12, -OC(O)R12, -OS(O)2R12, -N(R12)2, -NR12C(O)R12, -NR12SO2R12, -SR12, -S(O)R12, -S(O)2R12, -O
Claims (19)
1. Spoj predstavljen strukturnom Formulom I
[image]
(I)
ili njegova farmaceutski prihvatljiva sol,
naznačen time što:
Y je -O- ili -S-;
Q, D, X i T neovisno predstavljaju ugljik (supstituiran s vodikom ili izbornim supstituentima kako je naznačeno ovdje), ili dušik (izborno supstituiran s kisikom), pod uvjetom da najviše 2 od Q, D, X i T su dušici;
R1 je -H, -OH, ili -halogen;
R2 je -H ili -(C1-C3) alkil (izborno supstituiran s 1 do 3 halogena);
R3 i R4 su neovisno
- H, -halogen, -CN, -OH, -(C1-C7) alkoksi, -(C1-C7)alkil (izborno supstituiran s 1 do 3 halogena), ili -(C2-C7) alkenil;
R5 se izabire od
- H, -(C1-C12)alkila (izborno supstituiranog s 1 do 3 halogena), -(C3-C12)cikloalkila, -fenila, -fenil-fenil-(C1-C12)alkila,
- arila, -aril-(C1-C12)alkila, -heteroarila, -heteroaril-(C1-C12)alkila, -(C2-C12)alkenila,
- (C3-C12)cikloalkenila, -heterocikloalkila, -aril-(C2-C10)alkenila,
- heteroaril-(C2-C10)alkenila, -(C2-C12)alkinila, -(C3-C12)cikloalkinila,
- aril-(C2-C12)alkinila i -heteroaril-(C2-C12)alkinila, a pri čemu -(C1-C12)alkil, -(C3-C12)cikloalkil, -fenil, -fenil-fenil-(C1-C12)alkil, -aril, -aril-(C1-C12)alkil, -heteroaril, -heteroaril-(C1-C12)alkil, heterocikloalkil, -(C2-C12)alkenil, -(C3-C12)cikloalkenil, -aril-(C2-C10)alkenil, -heteroaril-(C2-C10) alkenil, -(C2-C12) alkinil, -(C3-C12)cikloalkinil, -aril-(C2-C12)alkinil, -heteroaril-(C2-C12)alkinil je svaki izborno supstituiran s od 1 do 3 supstituenata od kojih se svaki neovisno izabire od -vodika, -hidroksi, ciano, nitro, -halo, -okso, -(C1-C7)alkil (izborno supstituiran s 1 do 3 halogena), -(C1-C7) alkil-C(O) OR12, (C1-C7)alkoksi, -(C3-C7)cikloalkila, -C(O)R12, -C(O)OR12, -OC(O)R12, OS(O)2R12, -N(R12)2, i
- NR12C(O)R12, -NR12SO2R12, -SR12, -S(O)R12, -S(O)2R12 i -S(O)2N(R12)2;
R6 i R7 se neovisno na svakom pojavljivanju izabire od
- H, -halogena, -hidroksi, -CN, -(C1-C7)alkoksi, -(C2-C7)alkenila, -(C1-C10)alkila (izborno supstituiranog s 1 do 3 halogena), -(C3-C12)cikloalkila, terc-butoksiiminmetila, 1,3-dioksan-2-ila, hidroksimetila, formila, hidroksi-iminmetila, morfilino-4-il-metila, 4-metilpentiloksi i pentiloksi;
međutim pod uvjetom da kada D je dušik, tada R6 ili R7 nisu vezani na D, i pod uvjetom da kada T je dušik, tada R6 ili R7 nisu vezani na T, i pod uvjetom da kada Q je dušik, tada R6 ili R7 nisu vezani na Q, i pod uvjetom da kada X je dušik, tada R6 ili R7 nisu vezani na X;
pri čemu R6 i R7 mogu izborno tvoriti 6-člani prsten s atomima na koje su vezani, a tako formiran prsten može izborno sadržavati do najviše 2 kisika, i osim toga tako formiran prsten može izborno biti supstituiran s do najviše 4 halogena;
R8 i R9 se neovisno na svakom pojavljivanju izabire od
- vodika, -hidroksi, -CN, -nitro, -halo, -(C1-C7)alkila (izborno supstituiranog s 1 do 3 halogena), -(C1-C7) alkoksi, -(C3-C7)cikloalkila, arila, -aril-(C1-C7)alkila, -heteroarila, -heteroaril-(C1-C7)alkila, -ariloksi, -C(O)R12, -COOR12, -OC(O)R12, -OS(O)2R12, -N(R12)2, -NR12C(O)R12, -NR12SO2R12, -SR12, -S(O)R12, -S(O)2R12, -O(C2-C7)alkenila i -S(O)2N(R12)2; a pri čemu -(C1-C7)alkil, -(C1-C7)alkoksi, -(C3-C7) cikloalkil, -aril, -aril-(C1-C7)alkil, -heteroaril, -heteroaril-(C1-C7)alkil, -ariloksi i -O(C2-C7)alkenil je svaki izborno supstituiran s od 1 do 3 supstituenata neovisno izabiranih od -vodika, -hidroksi, -ciano, -nitro, -halo, -okso, -(C1-C7)alkila, -(C1-C7)alkil-C(O)OR12, -(C1-C7)alkoksi, -(C3-C7)cikloalkila,
- heterocikloalkila, -C(O)R12, -COOR12, -OC(O)R12, OS(O)2R12, -N(R12)2, i
- NR12C(O)R12, -NR12SO2R12, -SR12, -S(O)R12, -S(O)2R12 i -S(O)2N(R12)2,
R10 se izabire od
- H, halogena, -(C1-C12)alkila (izborno supstituiranog s 1 do 3 halogena), -cikloalkila, -arila, -aril-(C1-C7) alkila, -heteroarila, -(C1-C7)alkila, -(C2-C12)alkenila,
- (C3-C12)cikloalkenila, -aril-(C2-C10)alkenila, -heteroaril-(C2-C10)alkenila,
- (C2-C12)alkinil, -(C3-C12)cikloalkinil, -aril-(C2-C12)alkinil, i
- heteroaril-(C2-C12)alkinila;
R11 se neovisno na svakom pojavljivanju izabire od
- H, -halogena, i
[image]
,
gdje cik-cak oznaka pokazuje točku vezanja na matičnu molekulu, pri čemu A, G i E neovisno predstavlja ugljik (supstituiran s vodikom ili izbornim supstituentima kako je naznačeno ovdje) ili dušik, pod uvjetom da najviše 2 od A, G i E su dušici;
međutim pod uvjetom da kada A je dušik, tada R8, R9 i R14 nisu vezani na A, i pod uvjetom da kada G je dušik, tada R8, R9 i R14 nisu vezani na G, i pod uvjetom da kada E je dušik, tada R8, R9 i R14 nisu vezani na E
[image]
,
gdje cik-cak oznaka pokazuje točku vezanja na matičnu molekulu, pri čemu m je cijeli broj od 0, 1, 2, ili 3, a kada m je 0, tada (CH2)m je veza, i
[image]
,
gdje cik-cak oznaka pokazuje točku vezanja na matičnu molekulu,
međutim pod uvjetom da kada D je dušik, tada R11 nije vezan na D, i pod uvjetom da kada T je dušik, tada R11 nije vezan na T, i pod uvjetom da kada Q je dušik, tada R11 nije vezan na Q, i pod uvjetom da kada X je dušik, tada R11 nije vezan na X;
R12 se neovisno na svakom pojavljivanju izabire od
- vodika, -(C1-C7) alkila (izborno supstituiranog s 1 do 3 halogena) i -arila;
R13 se neovisno na svakom pojavljivanju izabire od
- vodika, -halogena, -{C1-C7) alkila (izborno supstituiranog s 1 do 3 halogena), fenila i -(C2-C7)alkenila; i
R14 je neovisno na svakom pojavljivanju -H, halogen, ili -(C1-C7) alkil (izborno supstituiran s 1 do 3 halogena).
2. Spoj Formule I, kako je tražena zaštita u patentnom zahtjevu 1, ili njegova farmaceutski prihvatljiva sol, naznačen time što:
Y je -O- ili -S-;
Q, D, X i T neovisno predstavljaju ugljik (supstituiran s vodikom ili izbornim supstituentima kako je naznačeno ovdje), ili dušik, pod uvjetom da najviše 2 od Q, D, X i T su dušici;
R1 je -H, -OH, ili -halogen;
R2 je -H ili -(C1-C3) alkil (izborno supstituiran s 1 do 3 halogena);
R3 i R4 su neovisno
- H, -halogen, -CN, -(C1-C7) alkoksi, -(C1-C7) alkil (izborno supstituiran s 1 do 3 halogena), ili -(C2-C7) alkenil;
R5 se izabire od
- (C1-C12) alkila (izborno supstituiranog s 1 do 3 halogena), -(C3-C12)cikloalkila, -fenila, -fenil-fenil-(C1-C12)alkila, -(C2-C12)alkenila,
- (C3-C12)cikloalkenila, -heterocikloalkila, -(C2-C12)akinila i -(C3-C12)cikloalkinila, a pri čemu -(C1-C12) alkil, -(C3-C12)cikloalkil, -fenil, -fenil-fenil-(C1-C12)alkil, -heterocikloalkil, -(C2-C12)alkenil, -(C3-C12) cikloalkenil, -(C2-C12)alkinil i -(C3-C12)cikloalkinil je svaki izborno supstituiran s od 1 do 3 supstituenata od kojih se svaki neovisno izabire od -vodika, -hidroksi, -ciano, -nitro, -halo, -okso, i
- (C1-C7) alkila (izborno supstituiranog s 1 do 3 halogena);
R6 i R7 se neovisno na svakom pojavljivanju izabire od
- H, -halogena, -hidroksi, -CN, -(C1-C7)alkoksi, -(C2-C7)alkenila, -(C1-C10)alkila (izborno supstituiranog s 1 do 3 halogena), -(C3-C12)cikloalkila, terc-butoksiiminmetila, 1,3-dioksan-2-ila, hidroksimetila, formila, hidroksi-iminmetila, morfilino-4-il-metila, 4-metilpentiloksi i pentiloksi;
međutim pod uvjetom da kada D je dušik, tada R6 ili R7 nisu vezani na D, i pod uvjetom da kada T je dušik, tada R6 ili R7 nisu vezani na T, i pod uvjetom da kada Q je dušik, tada R6 ili R7 nisu vezani na Q, i pod uvjetom da kada X je dušik, tada R6 ili R7 nisu vezani na X;
pri čemu R6 i R7 mogu izborno tvoriti 6-člani prsten s atomima na koje su vezani, a tako formiran prsten može izborno sadržavati do najviše 2 kisika, i osim toga tako formiran prsten može izborno biti supstituiran s do najviše 4 halogena;
R8 i R9 se neovisno na svakom pojavljivanju izabire od
- vodika, -hidroksi, -CN, -nitro, -halo, -(C1-C7)alkila (izborno supstituiranog s 1 do 3 halogena), -(C1-C7) alkoksi, -(C3-C7)cikloalkila, -C(O)R12, -C(O)OR12, -OC(O)R12, -OS(O)2R12, -N(R12)2, -NR12C(O) R12, NR12SO2R12, -SR12, -S(O)R12, -S(O)2R12, -O(C2-C7)alkenila i -S(O)2N(R12)2; a pri čemu -(C1-C7) alkil, -(C1-C7)alkoksi, -(C3-C7)cikloalkil i -O(C2-C7)alkenil je svaki izborno supstituiran s od 1 do 3 supstituenata neovisno izabiranih od -vodika, -hidroksi, -ciano, -nitro, -halo, -okso i -(C1-C7)alkila;
R10 se izabire od
- H, halogena i -(C1-C12)alkila (izborno supstituiranog s 1 do 3 halogena);
R11 se neovisno na svakom pojavljivanju izabire od
- H, -halogena, i
[image]
,
gdje cik-cak oznaka pokazuje točku vezanja na matičnu molekulu, pri čemu A, G i E neovisno predstavlja ugljik (supstituiran s vodikom ili izbornim supstituentima kako je naznačeno ovdje) ili dušik, pod uvjetom da najviše 2 od A, G i E su dušici;
međutim pod uvjetom da kada A je dušik, tada R8, R9 i R14 nisu vezani na A, i pod uvjetom da kada G je dušik, tada R8, R9 i R14 nisu vezani na G, i pod uvjetom da kada E je dušik, tada R8, R9 i R14 nisu vezani na E
[image]
,
gdje cik-cak oznaka pokazuje točku vezanja na matičnu molekulu, pri čemu m je cijeli broj od 0, 1, 2, ili 3, a kada m je 0, tada (CH2)m je veza, i
[image]
,
gdje cik-cak oznaka pokazuje točku vezanja na matičnu molekulu, međutim pod uvjetom da kada D je dušik, tada R11 nije vezan na D, i pod uvjetom da kada T je dušik, tada R11 nije vezan na T, i pod uvjetom da kada Q je dušik, tada R11 nije vezan na Q, i pod uvjetom da kada X je dušik, tada R11 nije vezan na X;
R12 se neovisno na svakom pojavljivanju izabire od
- vodika i -{C1-C7)alkila (izborno supstituiranog s 1 do 3 halogena);
R13 se neovisno na svakom pojavljivanju izabire od
- vodika, -halogena, -(C1-C7)alkila (izborno supstituiranog s 1 do 3 halogena), fenila i -(C2-C7)alkenila;
R14 je neovisno na svakom pojavljivanju -H, halogen, ili -(C1-C7) alkil (izborno supstituiran s 1 do 3 halogena).
3. Spoj Formule I, kako je tražena zaštita u patentnom zahtjevu 1 ili 2, ili njegova farmaceutski prihvatljiva sol, naznačen time što:
Y je -O-, ili -S-;
Q, D, X i T neovisno predstavljaju ugljik (supstituiran s vodikom ili izbornim supstituentima kako je naznačeno ovdje);
R1 je -H, -OH, ili -halogen;
R2 je-H;
R3 i R4 su neovisno -H, -halogen, ili -{C1-C7) alkil (izborno supstituiran s 1 do 3 halogena);
R5 se izabire od
- (C1-C12) alkila (izborno supstituiranog s 1 do 3 halogena), i
- (C3-C12)cikloalkila (izborno supstituiranog s 1 do 3 halogena);
R6 i R7 se neovisno na svakom pojavljivanju izabire od
- H, -halogena, -hidroksi, -CN, -(C2-C7)alkoksi, -(C2-C7)alkenila, -(C1-C10)alkila (izborno supstituiranog s 1 do 3 halogena), -(C3-C12)cikloalkila, terc-butoksiiminmetila, 1,3-dioksan-2-ila, hidroksimetila, formila, hidroksi-iminmetila, morfilino-4-il-metila, 4-metilpentiloksi i pentiloksi;
međutim pod uvjetom da kada D je dušik, tada R6 ili R7 nisu vezani na D, i pod uvjetom da kada T je dušik, tada R6 ili R7 nisu vezani na T, i
pod uvjetom da kada Q je dušik, tada R6 ili R7 nisu vezani na Q, i pod uvjetom da kada X je dušik, tada R6 ili R7 nisu vezani na X;
R8 i R9 se neovisno na svakom pojavljivanju izabire od
- vodika, -halogena, -(C1-C7)alkila (izborno supstituiranog s 1 do 3 halogena), -(C1-C7)alkoksi, -(C3-C7) cikloalkila, -C(O)R12, -C(O)OR12, -OC(O)R12, -OS(O)2R12, -SR12, -S(O)R12, -S(O)2R12 i -O(C2-C7) atkenila;
R10 je -H;
R11 se neovisno na svakom pojavljivanju izabire od
- H, -halogena, i
[image]
,
gdje cik-cak oznaka pokazuje točku vezanja na matičnu molekulu, pri čemu A, G i E neovisno predstavlja ugljik (supstituiran s vodikom ili izbornim supstituentima kako je naznačeno ovdje);
R12 se neovisno na svakom pojavljivanju izabire od
- vodika i -{C1-C7) alkila (izborno supstituiranog s 1 do 3 halogena); i
R14 je neovisno na svakom pojavljivanju -H, halogen, ili -(C1-C7)alkil (izborno supstituiran s 1 do 3 halogena).
4. Spoj prema bilo kojem od patentnih zahtjeva 1, 2, ili 3, ili njegova farmaceutski prihvatljiva sol, naznačen time što Y je -O- ili -S-; R1 je vodik ili -OH; R2 je vodik; R3 i R4 su neovisno vodik ili halogen; R5 je metil, etil, propil, izopropil, butil, pentil, heksil, oktil, 3,3-dimetilbutil, 2-metilpropil, 4-metilpentil, 2,2-dimetilpropil, 3-triflorpropil, 4-triflorbutil, cikloheksil ili 4-brom-fenil; R6 i R7 su neovisno vodik, metil, etil, 1,1,3,3-tetrametilbutil, terc-butil, cikloheksil, pentil, izopropoksi, klor, flor, brom, hidroksi, triflormetil, -CN, methoksi, terc-butoksiiminmetil, 1,3-dioksan-2-il, hidroksimetil, formil, hidroksi-iminmetil, morfolin-4-il-metil, 4-metilpentiloksi ili pentiloksi, a pri čemu R6 i R7 su spojeni tako da bi formirali, s fenilom na koji su vezani, stopljeni benzodioksinski ostatak; R8 i R9 su neovisno vodik, flor, klor, metil, etil, pentil, izopropil, terc-butil, triflormetil, acetil, 2-metilpropil, methoksi, cikloheksil, aliloksi ili ortriflormethoksi; R10 je vodik; R11 je vodik, halogen, fenil (supstituiran, neovisno na svakom pojavljivanju, jednom s R8, jednom s R9, i dvaput s R14), piridinil (supstituiran, neovisno na svakom pojavljivanju, jednom s R8, jednom s R9, i dvaput s R14), ili benzoksi (supstituiran dvaput s R13); R13 je vodik, triflormetil, terc-butil, izopropil, klor, flor, brom, metil, etil ili fenil, T je -CH-, -CR6- ili N; X je -CH- ili -CR11-; D je -CH-, -CR6-, -CR11- ili N; Q je -CH-, -CR6- ili N; i R14 je vodik, brom, flor, metil, terc-butil ili izopropil.
5. Spoj prema bilo kojem od patentnih zahtjeva 1, 2, 3, ili 4 ili njegova farmaceutski prihvatljiva sol, naznačen time što Y je -O-.
6. Spoj prema bilo kojem od patentnih zahtjeva 1, 2, 3, ili 4 ili njegova farmaceutski prihvatljiva sol, naznačen time što Y je -S-.
7. Spoj iz patentnih zahtjeva 5 ili 6 ili njegova farmaceutski prihvatljiva sol, naznačen time što R1, R2, R3, R4 i R10 su -H.
8. Spoj prema bilo kojem od patentnih zahtjeva 1, 2, 3, 4, 5, 6, ili 7 ili njegova farmaceutski prihvatljiva sol, naznačen time što D, X, Q i T su ugljici (supstituiran s vodikom ili izbornim supstituentima kako je naznačeno ovdje).
9. Spoj prema bilo kojem od patentnih zahtjeva 1, 2, 3, 4, 5, 6, ili 7 ili njegova farmaceutski prihvatljiva sol, naznačen time što D je dušik, a T, Q i X su ugljici (supstituiran s vodikom ili izbornim supstituentima kako je naznačeno ovdje).
10. Spoj prema bilo kojem od patentnih zahtjeva 1, 2, 3, 4, 5, 6, ili 7 ili njegova farmaceutski prihvatljiva sol, naznačen time što R6 i R7 su neovisno vodik ili metil; X je ugljik supstituiran s R11; A, G i E su ugljici (supstituiran s vodikom ili izbornim supstituentima kako je naznačeno ovdje); i R5 je -(C1-C12) alkil (izborno supstituiran s 1 do 3 halogena), ili -(C3-C12)cikloalkil.
11. Spoj iz patentnog zahtjeva 1, naznačen time što se izabire od:
racemična 3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-propil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[3-metil-1-(4'-triflormetil-bifenil-4-iloksi)-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4-terc-butil-fenoksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-4,4,4-triflor-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[4,4,4-triflor-1-(4'-triflormetil-bifenil-4-iloksi)-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[(4-brom-fenil)-(4'-terc-butil-bifenil-4-iloksi)-metil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[2-metil-1-(4'-triflormetil-bifenil-4-iloksi)-propil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-propil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4-cikloheksil-fenoksi)-heksil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4-benziloksi-fenoksi)-heksil]-benzoilamino}-propionska kiselina;
racemična 3-[4-(1-fenoksi-heksil)-benzoilamino]-propionska kiselina;
racemična 3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-triflormetil-bifenil-4-ilsulfanil)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-pentil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-pentil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[3-metil-1-(4'-triflormetil-bifenil-4-ilsulfanil)-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-nonil]-benzoilamino}-propionska kiselina;
racemična 3-(4-{3-metil-1-[4-(6-triflormetil-piridin-3-il)-fenoksi]-butil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{2-metil-1-[4-(6-triflormetil-piridin-3-il)-fenoksi]-propil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{1-[4'-triflormethoksi-bifenil-4-ilsulfanil]-3-metil-butil}-benzoilamino)-propionska kiselina;
racemična 3-{4-[1-(3',4'-dimetil-bifenil-4-ilsulfanil)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-ciano-bifenil-4-ilsulfanil)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-izobutil-bifenil-4-ilsulfanil)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-(4-{1-[4-(6-methoksi-piridin-3-il)-fenilsulfanil]-3-metil-butil}-benzoilamino)-propionska kiselina;
racemična 3-{4-[1-(4'-etil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
3-{4-[1-(4-benziloksi-fenoksi)-heksil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4-benziloksi-fenoksi)-heksil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[3-metil-1-(4'-triflormetil-bifenil-4-iloksi)-butil]-benzoilamino-propionska kiselina, Izomer 1;
3-{4-[3-metil-1-(4'-triflormetil-bifenil-4-iloksi)-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-propil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-propil]-benzoilamino}-propionska kiselina, Izomer 2;
3-(4-[1-(4'-terc-butil-bifenil-4-iloksi)-propil]-benzoilamino)-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-propil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-triflormetil-bifenil-4-ilsulfanil)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-triflormetil-bifenil-4-ilsulfanil)-heptil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-pentil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-pentil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[2-metil-1-(4'-triflormetil-bifenil-4-iloksi)-propil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[2-metil-1-(4'-triflormetil-bifenil-4-iloksi)-propil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-pentil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-pentil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-(4-{1-[4'-(1-flor-1-metil-etil)-bifenil-4-ilsulfanil]-3-metil-butil}-benzoilamino)-propionska kiselina, Izomer 1;
3-(4-{1-[4'-(1-flor-1-metil-etil)-bifenil-4-ilsulfanil]-3-metil-butil}-benzoilamino)-propionska kiselina, Izomer 2;
3-(4-{3-metil-1-[4-(6-triflormetil-piridin-3-il)-fenoksi]-butil}-benzoilamino)-propionska kiselina, Izomer 1;
3-(4-{3-metil-1-[4-(6-triflormetil-piridin-3-il)-fenoksi]-butil}-benzoilamino)-propionska kiselina, Izomer 2;
3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-nonil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-nonil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-etil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-etil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 2;
3-(4-{1-[6-(4-terc-butil-fenil)-piridin-3-iloksi]-4,4-dimetil-pentil}-benzoilamino)-propionska kiselina, Izomer 1;
racemična 3-(4-{1-[6-(4-triflormetil-fenil)-piridin-3-iloksi]-heptil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{4,4,4-triflor-1-[6-(4-triflormetil-fenil)-piridin-3-iloksi]-butil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{3-metil-1-[6-(4-triflormetil-fenil)-piridin-3-iloksi]-butil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{4,4-dimetil-1-[6-(4-triflormetil-fenil)-piridin-3-iloksi]-pentil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{1-[6-(4-triflormetil-fenil)-piridin-3-il]-butoksi}-benzoilamino)-propionska kiselina;
racemična 3-(4-{1-[6-(4-terc-butil-fenil)-piridin-3-iloksi]-4,4,4-triflor-butil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{1-[6-(4-terc-butil-fenil)-piridin-3-iloksi]-3-metil-butil}-benzoilamino)-propionska kiselina;
3-(4-{1-[6-(4-terc-butil-fenil)-piridin-3-iloksi]-4,4-dimetil-pentil}-benzoilamino)-propionska kiselina, Izomer 2;
3-(4-{1-[6-(4-triflormetil-fenil)-piridin-3-iloksi]-heptil}-benzoilamino)-propionska kiselina, Izomer 1;
3-(4-{1-[6-(4-triflormetil-fenil)-piridin-3-iloksi]-heptil}-benzoilamino)-propionska kiselina, Izomer 2;
3-(4-{4,4,4-triflor-1-[6-(4-triflormetil-fenil)-piridin-3-iloksi]-butil}-benzoilamino)-propionska kiselina, Izomer 1;
3-(4-{4,4,4-triflor-1-[6-(4-triflormetil-fenil)-piridin-3-iloksi]-butil}-benzoilamino)-propionska kiselina, Izomer 2;
3-(4-{1-[6-(4-terc-butil-fenil)-piridin-3-iloksi]-butil}-benzoilamino)-propionska kiselina, Izomer 1;
3-(4-{1-[6-(4-terc-butil-fenil)-piridin-3-iloksi]-butil}-benzoilamino)-propionska kiselina, Izomer 2;
racemična 3-(4-{1-[6-(4-izobutil-fenil)-piridin-3-iloksi]-butil}-benzoilamino)-propionska kiselina;
racemična 3-{4-[1-(3'-triflormetil-bifenil-4-ilsulfanil)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-acetil-bifenil-4-ilsulfanil)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(3',4'-dimetil-bifenil-4-ilsulfanil)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-metilsulfonil-bifenil-4-ilsulfanil)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2',3'-dimetil-bifenil-4-ilsulfanil)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2',6'-dimetil-bifenil-4-ilsulfanil)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(3'-izopropil-bifenil-4-ilsulfanil)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(3'-acetil-bifenil-4-ilsulfanil)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-pentil-bifenil-4-ilsulfanil)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-cikloheksil-bifenil-4-ilsulfanil)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4-aliloksi-fenoksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2,2,3,3-tetraflor-2,3-dihidro-benzo[1,4]dioksin-6-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-(4-{1-[4-(4-triflormetil-fenoksi)-fenoksi]-heptil}-benzoilamino)-propionska kiselina;
racemična 3-{4-[1-(4-pentil-fenoksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-(4-{1-[4-(4-terc-butil-benziloksi)-fenoksi]-heptil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{1-[4-(3,5-bistriflormetil-benziloksi)-fenoksi]-heptil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{1-[4-(4-izopropil-benziloksi)-fenoksi]-heptil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{1-[4-(4-klor-benziloksi)-fenoksi]-heptil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{1-[4-(4-etil-benziloksi)-fenoksi]-heptil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{1-[4-(4-brom-benziloksi)-fenoksi]-heptil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{1-[4-(4-flor-benziloksi)-fenoksi]-heptil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{1-[4-(4-triflormetil-benziloksi)-fenoksi]-heptil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{1-[4-(4-fenil-benziloksi)-fenoksi]-heptil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{1-[4-(3-klor-benziloksi)-fenoksi]-heptil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{1-[4-(3,4-dimetil-benziloksi)-fenoksi]-heptil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{1-[4-(4-izopropoksifenoksi]-heptil}-benzoilamino)-propionska kiselina;
racemična 3-{4-[1-(3',5'-bistriflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-4,4-dimetil-pentil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-4,4-dimetil-pentil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-heksil]-benzoilamino}-propionska kiselina;
3-{4-[1-(3',5'-bistriflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(3',5'-bistriflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4-terc-butil-fenoksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4-terc-butil-fenoksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[-(4'-triflormetil-bifenil-4-iloksi)-4,4-dimetil-pentil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-4,4-dimetil-pentil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-triflormethoksi-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-triflormethoksi-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(2,2,3,3-tetraflor-2,3-dihidro-benzo[1,4]dioksin-6-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(2,2,3,3-tetraflor-2,3-dihidro-benzo[1,4]dioksin-6-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 2;
3-(4-{1-[4-(4-triflormetil-fenoksi)-fenoksi]-heptil}-benzoilamino)-propionska kiselina, Izomer 1;
3-(4-{1-[4-(4-triflormetil-fenoksi)-fenoksi]-heptil}-benzoilamino)-propionska kiselina, Izomer 2;
3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-heksil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-heksil]-benzoilamino}-propionska kiselina, Izomer 2;
3-(4-{1-[4'-izopropil-bifenil-4-ilsulfanil]-butil}-benzoilamino)-propionska kiselina, Izomer 1;
racemična 3-{4-[1-(2,6-dimetil-4'-triflormethoksi-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2,6-dimetil-4'-terc-butil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-2(R)-hidroksi-propionska kiselina;
3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-2(S)-hidroksi-propionska kiselina;
3-{4-[1-(4'-pentil-bifenil-4-iloksi)-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-izobutil-bifenil-4-iloksi)-butil]-benzoilamino}-propionska kiselina, Izomer 1;
racemična 3-{4-[1-(6-klor-piridin-3-iloksi)-4,4,4-triflor-butil]-benzoilamino}-propionska kiselina;
3-{4-[1-(4'-acetil-bifenil-4-iloksi)-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(3',5'-diklor-bifenil-4-iloksi)-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(3', 5'-diklor-bifenil-4-iloksi)-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(2', 3', 4'-triflor-bifenil-4-iloksi)-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(2', 4'-dimethoksi-bifenil-4-iloksi)-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-t-butil-bifenil-4-iloksi)-heksil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-t-butil-bifenil-4-iloksi)-heksil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-pentilfenil-4-iloksi)-heksil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-pentilfenil-4-iloksi)-heksil]-benzoilamino}-propionska kiselina, Izomer 2;
3-(4-{1-[4-(1-metil-1-fenil-etil)-fenoksi]-heptil}-benzoilamino)-propionska kiselina, Izomer 1;
3-(4-{1-[4-(1-metil-1-fenil-etil)-fenoksi]-heptil}-benzoilamino)-propionska kiselina, Izomer 2;
3-{4-[1-(2', 4', 6'-trimetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-flor-2'-metil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-triflormethoksi-bifenil-4-iloksi)-heksil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-flor-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[ciklopropil-(4'-triflormetil-bifenil-4-iloksi)-metil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[ciklopropil-(4'-triflormetil-bifenil-4-iloksi)-metil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-4,4,4-triflor-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-4,4,4-triflor-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-klor-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-2-metil-bifenil-4-iloksi)-3-metil-butil]-3-flor-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-2-metil-bifenil-4-iloksi)-3-metil-butil]-3-flor-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-heptil]-3-flor-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-heptil]-3-flor-benzoilamino}-propionska kiselina, Izomer 2;
3-{3-flor-4-[1-(2-metil-4'-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{3-flor-4-[1-(2-metil-4'-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-3-metil-butil]-3-flor-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-3-metil-butil]-3-flor-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-terc-butil-2-metil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-2-metil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(2-metil-4'-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(2-metil-4'-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-izopropil-2-metil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-izopropil-2-metil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-flor-2-metil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
3-4-[-(4'-flor-2-metil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-etil-2-metil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-etil-2-metil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(2,6-dimetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(2,6-dimetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-etil-2,6-dimetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-etil-2,6-dimetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-terc-butil-2-triflormetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-2-triflormetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-terc-butil-2-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-2-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-terc-butil-2-triflormetil-bifenil-4-iloksi)-pentil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-2-triflormetil-bifenil-4-iloksi)-pentil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-terc-butil-2-triflormetil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-2-triflormetil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-4,4-dimetil-pentil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-4,4-dimetil-pentil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-izopropil-2,6-dimetil-bifenil-4-iloksi)-4,4-dimetil-pentil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-izopropil-2,6-dimetil-bifenil-4-iloksi)-4,4-dimetil-pentil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(2-Ciano-4'-izopropil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(2-Ciano-4'-izopropil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-izopropil-2,6-dimetil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-izopropil-2,6-dimetil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(2-etil-4'-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(2-etil-4'-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-klor-2,6-dimetil-bifenil-4-iloksi)-4,4-dimetil-pentil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-klor-2,6-dimetil-bifenil-4-iloksi)-4,4-dimetil-pentil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[2-metil-1-(2-metil-4'-triflormethoksi-bifenil-4-iloksi)-propil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[2-metil-1-(2-metil-4'-triflormethoksi-bifenil-4-iloksi)-propil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(2-klor-4'-izopropil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(2-klor-4'-izopropil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(2-klor-4'-triflormetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(2-klor-4'-triflormetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[2-metil-1-(2-metil-4'-triflormetil-bifenil-4-iloksi)-propil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[2-metil-1-(2-metil-4'-triflormetil-bifenil-4-iloksi)-propil]-benzoilamino}-propionska kiselina, Izomer 2;
3-(4-{3-metil-1-[5-metil-6-(4-triflormetil-fenil)-piridin-3-iloksi]-butil}-benzoilamino)-propionska kiselina, Izomer 1;
3-(4-{3-metil-1-[5-metil-6-(4-triflormetil-fenil)-piridin-3-iloksi]-butil}-benzoilamino)-propionska kiselina, Izomer 2;
3-(4-{1-[6-(4-izopropil-fenil)-5-metil-piridin-3-iloksi]-3-metil-butil}-benzoilamino)-propionska kiselina, Izomer 1;
3-(4-{1-[6-(4-izopropil-fenil)-5-metil-piridin-3-iloksi]-3-metil-butil}-benzoilamino)-propionska kiselina, Izomer 2;
3-(3-flor-4-{3-metil-1-[6-(4-triflormetil-fenil)-piridin-3-iloksi]-butil}-benzoilamino)-propionska kiselina, Izomer 1;
3-(3-flor-4-{3-metil-1-[6-(4-triflormetil-fenil)-piridin-3-iloksi]-butil}-benzoilamino)-propionska kiselina, Izomer 2;
3-(4-{3-metil-1-[4-(5-triflormetil-piridin-2-il)-fenoksi]-butil}-benzoilamino)-propionska kiselina, Izomer 1;
3-(4-{3-metil-1-[4-(5-triflormetil-piridin-2-il)-fenoksi]-butil}-benzoilamino)-propionska kiselina, Izomer 2;
3-{4-[1-(4-terc-butil-fenoksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4-terc-butil-fenoksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 2;
2-hidroksi-3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
2-hidroksi-3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 2;
2-hidroksi-3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
2-hidroksi-3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 2;
3-(4-{1-[4-(1,1,3,3-tetrametil-butil)-fenoksi]-heptil}-benzoilamino)-propionska kiselina, Izomer 1;
3-(4-{1-[4-(1,1,3,3-tetrametil-butil)-pherioksi]-heptil}-benzoilamino)-propionska kiselina, Izomer 2;
3-{4-[1-(2,2,3,3-tetraflor-2,3-dihidro-benzo[1,4]dioksin-6-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(2,2,3,3-tetraflor-2,3-dihidro-benzo[1,4]dioksin-6-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-3,3-dimetil-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-3,3-dimetil-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-3,3-dimetil-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-3,3-dimetil-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-izopropil-2,6-dimetil-bifenil-4-iloksi)-3,3-dimetil-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-izopropil-2,6-dimetil-bifenil-4-iloksi)-3,3-dimetil-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-(4-{3,3-dimetil-1-[5-metil-6-(4-triflormetil-fenil)-piridin-3-iloksi]-butil}-benzoilamino)-propionska kiselina, Izomer 1;
3-(4-{3,3-dimetil-1-[5-metil-6-(4-triflormetil-fenil)-piridin-3-iloksi]-butil}-benzoilamino)-propionska kiselina, Izomer 2;
3-{4-[1-(4'-izopropil-2-methoksi-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-izopropil-2-methoksi-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-izopropil-2-metil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-izopropil-2-metil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(2,6-dimetil-4'-triflormethoksi-bifenil-4-iloksi)-3,3-dimetil-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(2,6-dimetil-4'-triflormethoksi-bifenil-4-iloksi)-3,3-dimetil-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-(4-{1-[2-(terc-butoksiimin-metil)-4'-triflormetil-bifenil-4-iloksi]-3-metil-butil}-benzoilamino)-propionska kiselina, Izomer 1;
3-(4-{1-[2-(terc-butoksiimin-metil)-4'-triflormetil-bifenil-4-iloksi]-3-metil-butil}-benzoilamino)-propionska kiselina, Izomer 2;
3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-3,3-dimetil-butil]-benzoilamino}-2-hidroksi-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-3,3-dimetil-butil]-benzoilamino}-2-hidroksi-propionska kiselina, Izomer 2;
3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-3,3-dimetil-butil]-benzoilamino}-2-hidroksi-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-3,3-dimetil-butil]-benzoilamino}-2-hidroksi-propionska kiselina, Izomer 2;
3-{4-[1-(4'-flor-2,6-dimetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-flor-2,6,2'-trimetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-klor-2,6-dimetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-izopropil-2,6-dimetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 2;
racemična 3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-heksil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-heptil]-3-flor-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-3-metil-butil]-3-flor-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2-Ciano-4'-izopropil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-izopropil-2-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2-etil-4'-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
3-[4-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksimetil)-benzoilamino]-propionska kiselina;
3-[4-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksimetil)-benzoilamino]-propionska kiselina;
racemična 3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-etil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-etil]-benzoilamino}-propionska kiselina;
racemična 3-(3-flor-4-{3-metil-1-[6-(4-triflormetil-fenil)-piridin-3-iloksi]-butil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{1-[4-(1,1,3,3-tetrametil-butil)-fenoksi]-heptil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{3-metil-1-[4-(5-triflormetil-piridin-2-il)-fenoksi]-butil}-benzoilamino)-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-3,3-dimetil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-3,3-dimetil-butil]-benzoilamino}-2-hidroksi-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-3,3-dimetil-butil]-benzoilamino}-2-hidroksi-propionska kiselina;
kiralna 3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-2-hidroksi-propionska kiselina, Izomer 1;
kiralna 3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-2-hidroksi-propionska kiselina, Izomer 1;
racemična 3-{4-[1-(4-brom-3-[1,3]dioksan-2-il-fenoksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4-terc-butil-fenoksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-2-hidroksi-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-2-hidroksi-propionska kiselina;
racemična 3-{4-[1-(4-pentil-fenoksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-(4-{1-[4-(1-metil-1-fenil-etil)-fenoksi]-heptil}-benzoilamino)-propionska kiselina;
racemična 2-hidroksi-3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 2-hidroksi-3-{4-[1-(4'-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-izopropil-2-metil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4-klor-3-triflormetil-fenoksi)-heptil]-benzoilamino}-2-hidroksi-propionska kiselina;
racemična 3-{4-[1-(3-klor-4-metil-fenoksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2,2,3,3-tetraflor-2,3-dihidro-benzo[1,4]dioksin-6-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[ciklopropil-(4'-triflormetil-bifenil-4-iloksi)-metil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-izopropil-2,6-dimetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-acetil-2,6-dimetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-2-metil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2-metil-4'-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-(4-{1-[6-(4-izopropil-fenil)-5-metil-piridin-3-iloksi]-4,4-dimetilpentil}-benzoilamino)-propionska kiselina;
racemična (4-{4,4-dimetil-1-[5-metil-6-(4-triflormetil-fenil)-piridin-3-iloksi]-pentil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{4,4-dimetil-1-[5-metil-6-(4-triflormethoksi-fenil)-piridin-3-iloksi]-pentil}-benzoilamino)-propionska kiselina;
racemična 3-{4-[1-(2,6-dimetil-4'-triflormethoksi-bifenil-4-iloksi)-3,3-dimetil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-3,3-dimetil-butil]-benzoilamino}-2-hidroksi-propionska kiselina;
racemična 3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-3,3-dimetil-butil]-benzoilamino}-2-hidroksi-propionska kiselina;
racemična 2-hidroksi-3-{4-[1-(4'-izopropil-2,6-dimetil-bifenil-4-iloksi)-3,3-dimetil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-izopropil-2-methoksi-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{3-flor-4-[1-(2-metil-4'-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-2-klor-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-triflormetil-2-klor-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2',4'-bistriflormetil-2-klor-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2-hidroksi-4'-izopropil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2-[1,3]dioksan-2-il-4'-izopropil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-(4-{1-[2-(terc-butoksiimin-metil)-4'-izopropil-bifenil-4-iloksi]-3-metil-butil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{1-[2-(terc-butoksiimin-metil)-4'-triflormetil-bifenil-4-iloksi]-3-metil-butil}-benzoilamino)-propionska kiselina;
racemična 3-{4-[1-(2,6-dimetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-etil-2,6-dimetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2-metil-4'-triflormethoksi-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-izopropil-2-metil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2,6-dimetil-4'-triflormethoksi-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-'(4'-etil-2-metil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-acetil-2-metil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-flor-2-metil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-2-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-2-triflormetil-bifenil-4-iloksi)-pentil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-2-triflormetil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-2-tritluorometil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(3,5-dimetil-4'-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-klor-3,5-dimetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-klor-3-metil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-3,3-dimetil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-4,4-dimetil-pentil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2,6-dimetil-4'-izopropil-bifenil-4-iloksi)-4,4-dimetil-pentil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-izopropil-2,6-dimetil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[2-metil-1-(2-metil-4'-triflormetil-bifenil-4-iloksi)-propil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2,6-dimetil-4'-klor-bifenil-4-iloksi)-4,4-dimetil-pentil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-izopropil-2-metil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2,6-diflor-4'-triflormetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2,6-diflor-4'-izopropil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2-klor-4'-izopropil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2-klor-4'-triflormetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-(4-{3-metil-1-[5-metil-6-(4-triflormetil-fenil)-piridin-3-iloksi]-butil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{1-[6-(4-izopropil-fenil)-5-metil-piridin-3-iloksi]-3-metil-butil}-benzoilamino)-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-bifenil-3-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[3-metil-1-(4'-triflormetil-bifenil-3-iloksi)-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-izopropil-bifenil-3-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[3-metil-1-(4'-triflormethoksi-bifenil-3-iloksi)-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[3-metil-1-(6-metil-4'-triflormetil-bifenil-3-iloksi)-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-6-metil-bifenil-3-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2-hidroksimetil-4'-izopropil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2-formil-4'-izopropil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-(4-{1-[2-(hidroksi-imin-metil)-4'-izopropil-bifenil-4-iloksi]-3-metil-butil}-benzoilamino)-propionska kiselina;
racemična 3-{4-[1-(4'-izopropil-2-morfolin-4-ilmetil-bifenil-4-iloksi)-3-metil-butil]-benzoilamino}-propionska kiselina;
3-(4-{3,3-dimetil-1-[5-metil-1-oksi-6-(4-triflormethoksi-fenil)-piridin-3-iloksi]-butil}-benzoilamino)-propionska kiselina;
2-hidroksi-3-{4-[1-(4'-izopropil-2,6-dimetil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-propionska kiselina, Izomer 1;
2-hidroksi-3-{4-[1-(4'-izopropil-2,6-dimetil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-propionska kiselina, Izomer 2;
2-hidroksi-3-{4-[1-(4'-izopropil-2,6-dimetil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-propionska kiselina, Izomer 1;
2-hidroksi-3-{4-[1-(4'-izopropil-2,6-dimetil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-2-hidroksi-propionska kiselina, Izomer 1;
3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-2-hidroksi-propionska kiselina, Izomer 2;
3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-2-hidroksi-propionska kiselina, Izomer 1;
3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-2-hidroksi-propionska kiselina, Izomer 2;
racemična 3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-ilsulfanil)-5,5,5-triflor-pentil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2,4,6-tri-t-butil-fenoksi)-5,5,5-triflor-pentil]-benzoilamino}-propionska kiselina;
3-(4-{5,5,5-triflor-1-[5-metil-6-(4-triflormetil-fenil)-piridin-3-iloksi]-pentil}-benzoilamino)-propionska kiselina, Izomer 1;
3-(4-{5,5,5-triflor-1-[5-metil-6-(4-triflormetil-fenil)-piridin-3-iloksi]-pentil}-benzoilamino)-propionska kiselina, Izomer 2;
racemična 3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-ilsulfanil)-5,5,5-triflor-pentil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-ilsulfanil)-5,5,5-triflor-pentil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(-4-brom-3,5-dimetil-fenilsulfanil)-5,5,5-triflor-pentil] benzoilamino}-propionska kiselina;
racemična 3-(4-{5,5,5-triflor-1-[5-metil-6-(4-triflormetil-fenil)-piridin-3-iloksi]-pentil}-benzoilamino)-propionska kiselina;
Racemi3-(4-{4,4,4-triflor-1-[5-metil-6-(4-triflormetil-fenil)-piridin-3-iloksi]-butil}-benzoilamino)-propionska kiselina;
3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-ilsulfanil)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-ilsulfanil)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-ilsulfanil)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-ilsulfanil)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-ilsulfanil)-4,4,4-triflor-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-ilsulfanil)-4,4,4-triflor-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4-brom-3,5-dimetil-fenilsulfanil)-4,4,4-triflor-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4-brom-3,5-dimetil-fenilsulfanil)-4,4,4-triflor-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4-brom-3,5-dimetil-fenilsulfanil)-3-metil-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4-brom-3,5-dimetil-fenilsulfanil)-3-metil-butil]-benzoilamino-propionska kiselina, Izomer 2;
3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-5,5,5-triflor-pentil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-5,5,5-triflor-pentil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[4,4,4-triflor-1-(4'-izopropil-2,6-dimetil-bifenil-4-iloksi)-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[4,4,4-triflor-1-(4'-izopropil-2,6-dimetil-bifenil-4-iloksi)-butil]-benzoilamino}-propionska kiselina, Izomer 2;
racemična 3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-ilsulfanil)-4,4,4-triflor-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-ilsulfanil)-4,4,4-triflor-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-ilsulfanil)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-ilsulfanil)-3-metil-butil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4-brom-3,5-dimetil-fenilsulfanil)-4,4,4-triflor-butil-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4-brom-3,5-dimetil-fenilsulfanil)-3-metil-butil]-benzoilamino}-propionska kiselina;
3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[3-metil-1-(2,2',4'-triklor-bifenil-4-iloksi)-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[3-metil-1-(2,2',4'-triklor-bifenil-4-iloksi)-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-4,4,4-triflor-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-4,4,4-triflor-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-4,4,4-triflor-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-4,4,4-triflor-butil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[5,5,5-triflor-1-(4'-izopropil-2,6-dimetil-bifenil-4-iloksi)-pentil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[5,5,5-triflor-1-(4'-izopropil-2,6-dimetil-bifenil-4-iloksi)-pentil]-benzoilamino}-propionska kiselina, Izomer 2;
racemična 3-{4-[5,5,5-triflor-1-(4'-izopropil-2,6-dimetil-bifenil-4-iloksi)-pentil]-benzoilamino}-propionska kiselina;
3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-5-metil-heksil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-5-metil-heksil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[5-metil-1-(4'-triflormetil-bifenil-4-iloksi)-heksil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[5-metil-1-(4'-triflormetil-bifenil-4-iloksi)-heksil]-benzoilamino}-propionska kiselina, Izomer 2;
3-(4-{1-[6-(4-terc-butil-fenil)-piridin-3-iloksi]-5-metil-heksil}-benzoilamino)-propionska kiselina, Izomer 1;
3-(4-{1-[6-(4-terc-butil-fenil)-piridin-3-iloksi]-5-metil-heksil}-benzoilamino)-propionska kiselina, Izomer 2;
racemična 3-(4-{5-metil-1-[6-(4-triflormetil-fenil)-piridin-3-iloksi]-heksil}-benzoilamino)-propionska kiselina;
racemična 3-{4-[1-(6-klor-piridin-3-iloksi)-5-metil-heksil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-5-metil-heksil]-benzoilamino}-propionska kiselina;
racemična 3-(4-{1-[6-(4-terc-butil-fenil)-piridin-3-iloksi]-5-metil-heksil}-benzoilamino)-propionska kiselina;
racemična 3-{4-[5-metil-1-(4'-triflormetil-bifenil-4-iloksi)-heksil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-5-metil-heksil]-benzoilamino}-propionska kiselina;
3-(4-{1-[6-(4-terc-butil-fenil)-piridin-3-iloksi]-5,5,5-triflor-pentil}-benzoilamino)-propionska kiselina, Izomer 1;
3-(4-{1-[6-(4-terc-butil-fenil)-piridin-3-iloksi]-5,5,5-triflor-pentil}-benzoilamino)-propionska kiselina, Izomer 2;
3-(4-{1-[6-(4-terc-butil-fenil)-piridin-3-iloksi]-4,4,4-triflor-butil}-benzoilamino)-propionska kiselina, Izomer 1;
3-(4-{1-[6-(4-terc-butil-fenil)-piridin-3-iloksi]-4,4,4-triflor-butil}-benzoilamino)-propionska kiselina, Izomer 2;
racemična 3-{4-[(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-cikloheksil-metil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-4,4,4-triflor-butil]-benzoilamino}-propionska kiselina;
3-{4-[4,4,4-triflor-1-(4'-triflormetil-bifenil-4-iloksi)-butil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[4,4,4-triflor-1-(4'-triflormetil-bifenil-4-iloksi)-butil]-benzoilamino}-propionska kiselina, Izomer 2;
racemična 3-(4-{4,4,4-triflor-1-[6-(4-izopropil-fenil)-piridin-3-iloksi]-butil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{5,5,5-triflor-1-[6-(4-triflormetil-fenil)-piridin-3-iloksi]-pentil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{[6-(4-terc-butil-fenil)-piridin-3-iloksi]-cikloheksil-metil}-benzoilamino)-propionska kiselina;
racemična 3-(4-{5,5,5-triflor-1-[6-(4-izopropil-fenil)-piridin-3-iloksi]-pentil}-benzoilamino)-propionska kiselina;
racemična 3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-4,4,4-triflor-butil]-benzoilamino}-propionska kiselina;
racemična 3-(4-{cikloheksil-[6-(4-izopropil-fenil)-piridin-3-iloksi]-metil}-benzoilamino)-propionska kiselina;
racemična 3-{4-[cikloheksil-(4'-izopropil-2,6-dimetil-bifenil-4-iloksi)-metil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[4,4,4-triflor-1-(4'-izopropil-2,6-dimetil-bifenil-4-iloksi)-butil]-benzoilamino}-propionska kiselina;
3-{4-[cikloheksil-(4'-triflormetil-bifenil-4-iloksi)-metil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[cikloheksil-(4'-triflormetil-bifenil-4-iloksi)-metil]-benzoilamino}-propionska kiselina, Izomer 2;
3-{4-[5,5,5-triflor-1-(4'-izopropil-bifenil-4-iloksi)-pentil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[5,5,5-triflor-1-(4'-izopropil-bifenil-4-iloksi)-pentil]-benzoilamino}-propionska kiselina, Izomer 2;
racemična 3-{4-[(4'-terc-butil-bifenil-4-iloksi)-cikloheksil-metil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[5,5,5-triflor-1-(2'-3'-flor-4'-triflormetil-bifenil-4-iloksi)-pentil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[cikloheksil-(4'-triflormetil-bifenil-4-iloksi)-metil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[5,5,5-triflor-1-(4'-izopropil-bifenil-4-iloksi)-pentil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-etil-bifenil-4-iloksi)-5,5,5-triflor-pentil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[5,5,5-triflor-1-(3'-flor-4'-triflormetil-bifenil-4-iloksi)-pentil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2,4,6-triizopropil-fenoksi)-5,5,5-triflor-pentil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2,3,4,5,6-pentametil-fenoksi)-5,5,5-triflor-pentil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2,4,6-tri-t-butil-fenoksi)-5,5,5-triflor-pentil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(3,5-dimetil-fenoksi)-5,5,5-triflor-pentil]-benzoilamino}-propionska kiselina;
3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-5,5,5-triflor-pentil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-5,5,5-triflor-pentil]-benzoilamino}-propionska kiselina, Izomer 2;
racemična 3-{4-[1-(4-etil-3,5-dimetil-fenoksi)-5,5,5-triflor-pentil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-5,5,5-triflor-pentil]-benzoilamino}-propionska kiselina;
racemična 3-(4-{1-[4-(4-metil-pentiloksi)-fenoksi]-heptil}-benzoilamino)-propionska kiselina;
racemična 3-{4-[1-(4-pentiloksi-fenoksi)-heptil]-benzoilamino}-propionska kiselina;
3-{4-[5,5,5-triflor-1-(4'-trif-luorometil-bifenil-4-iloksi)-pentil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[5,5,5-triflor-1-(4'-triflormetil-bifenil-4-iloksi)-pentil]-benzoilamino}-propionska kiselina, Izomer 2;
racemična 3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-5,5,5-triflor-pentil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4-brom-3,5-dimetil-fenoksi)-5,5,5-triflor-pentil]-benzoilamino}-propionska kiselina;
3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-5,5,5-triflor-pentil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-5,5,5-triflor-pentil]-benzoilamino}-propionska kiselina, Izomer 2;
3-(4-{1-[6-(4-triflormetil-fenil)-piridin-3-iloksi]-heksil}-benzoilamino)-propionska kiselina, Izomer 1;
3-(4-{1-[6-(4-triflormetil-fenil)-piridin-3-iloksi]-heksil}-benzoilamino)-propionska kiselina, Izomer 2;
3-(4-{1-[6-(4-triflormetil-fenil)-piridin-3-iloksi]-pentil}-benzoilamino)-propionska kiselina, Izomer 1;
3-(4-{1-[6-(4-triflormetil-fenil)-piridin-3-iloksi]-pentil}-benzoilamino)-propionska kiselina, Izomer 2;
racemična 3-{4-[5,5,5-triflor-1-(4'-triflormetil-bifenil-4-iloksi)-pentil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4'-terc-butil-bifenil-4-iloksi)-5,5,5-triflor-pentil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4-brom-fenoksi)-5,5,5-triflor-pentil]-benzoilamino}-propionska kiselina;
racemična 3-{4-[1-(4-hidroksi-fenoksi)-heptil]-benzoilamino}-propionska kiselina;
racemična 3-(4-{1-[6-(4-triflormetil-fenil)-piridin-3-iloksi]-pentil}-benzoilamino)-propionska kiselina;
3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-propionska kiselina, Izomer 1;
3-{4-[1-(2,6-dimetil-4'-triflormethoksi-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1; i
3-{4-[1-(2,6-dimetil-4'-triflormethoksi-bifenil-4-iloksi)-heptil]-benzoilamino}-propionska kiselina, Izomer 1,
ili njegova farmaceutski prihvatljiva sol.
12. Spoj iz patentnog zahtjeva 1, naznačen time što je to spoj formule
[image]
,
ili njegova farmaceutski prihvatljiva sol.
13. Spoj iz patentnog zahtjeva 12, naznačen time što taj spoj je 3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-4,4,4-triflor-butil]-benzoilamino}-propionska kiselina, Izomer 1, ili njegova farmaceutski prihvatljiva sol.
14. Spoj iz patentnog zahtjeva 1, naznačen time što je to spoj formule
[image]
,
ili njegova farmaceutski prihvatljiva sol.
15. Spoj iz patentnog zahtjeva 14, naznačen time što taj spoj je 3-{4-[1-(2,6-dimetil-4'-triflormetil-bifenil-4-iloksi)-4,4-dimetil-pentil]-benzoilamino}-propionska kiselina, Izomer 1, ili njegova farmaceutski prihvatljiva sol.
16. Spoj iz patentnog zahtjeva 1, naznačen time što taj spoj je 3-{4-[1-(4'-terc-butil-2,6-dimetil-bifenil-4-iloksi)-2-metil-propil]-benzoilamino}-propionska kiselina, Izomer 1, ili njegova farmaceutski prihvatljiva sol.
17. Farmaceutski pripravak, naznačen time što sadržava spoj prema bilo kojem od patentnih zahtjeva 1 - 16 ili njegovu farmaceutski prihvatljivu sol, i farmaceutski prihvatljiv nosač.
18. Spoj prema bilo kojem od patentnih zahtjeva 1 - 16 ili njegova farmaceutski prihvatljiva sol, naznačen time što se koristi u liječenju dijabetesa ili drugog metaboličkog poremećaja povezanog s glukagonom.
19. Spoj prema bilo kojem od patentnih zahtjeva 1 - 16 ili njegova farmaceutski prihvatljiva sol, naznačen time što se koristi u liječenju dijabetesa tipa II.
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US57936204P | 2004-06-14 | 2004-06-14 | |
PCT/US2005/019901 WO2005123668A1 (en) | 2004-06-14 | 2005-06-08 | Glucagon receptor antagonists, preparation and therapeutic uses |
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CN101146762A (zh) | 2005-03-21 | 2008-03-19 | 默克公司 | 取代的芳基和杂芳基衍生物 |
CA2629172C (en) * | 2005-11-22 | 2014-05-06 | Eli Lilly And Company | Glucagon receptor antagonists, preparation and therapeutic uses |
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CN105566265A (zh) | 2007-02-09 | 2016-05-11 | 症变治疗公司 | 新颖的胰高血糖素受体拮抗剂 |
ES2714207T3 (es) | 2008-08-13 | 2019-05-27 | Metabasis Therapeutics Inc | Antagonistas de glucagón |
WO2010098948A1 (en) * | 2009-02-13 | 2010-09-02 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions containin such compounds and methods of use |
US8039495B2 (en) * | 2009-11-16 | 2011-10-18 | Hoffman-La Roche Inc. | Biphenyl carboxylic acids and bioisosteres as glycogen synthase activators |
AU2011346670B2 (en) * | 2010-12-23 | 2015-05-07 | Pfizer Inc. | Glucagon receptor modulators |
DK2673260T3 (en) | 2011-02-08 | 2016-10-10 | Pfizer | Glucagonreceptormodulator |
BR112014000288A2 (pt) | 2011-07-22 | 2017-01-10 | Pfizer | moduladores do receptor de glucagon de quinolinila |
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EP3065736B1 (en) | 2013-11-04 | 2018-11-14 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions thereof, and methods of use |
JP2017519000A (ja) | 2014-06-12 | 2017-07-13 | リガンド・ファーマシューティカルズ・インコーポレイテッド | グルカゴンアンタゴニスト |
BR112018010140A8 (pt) | 2015-12-01 | 2019-02-26 | Basf Se | compostos de fórmula, composição, utilização de um composto de fórmula, método para o combate de fungos fitopatogênicos e semente |
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KR102606541B1 (ko) * | 2021-04-23 | 2023-11-29 | 가천대학교 산학협력단 | 바이페닐설폰아마이드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 글루카곤 수용체 활성 관련 질환의 예방 또는 치료용 약학적 조성물 |
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