JP2008500971A5 - - Google Patents
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- Publication number
- JP2008500971A5 JP2008500971A5 JP2007512736A JP2007512736A JP2008500971A5 JP 2008500971 A5 JP2008500971 A5 JP 2008500971A5 JP 2007512736 A JP2007512736 A JP 2007512736A JP 2007512736 A JP2007512736 A JP 2007512736A JP 2008500971 A5 JP2008500971 A5 JP 2008500971A5
- Authority
- JP
- Japan
- Prior art keywords
- phe
- gly
- asp
- arg
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 5
- 102000006495 integrins Human genes 0.000 claims 3
- 108010044426 integrins Proteins 0.000 claims 3
- -1 D-2-naphthyl-Ala Chemical compound 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- CSJZKSXYLTYFPU-LLVKDONJSA-N (2r)-2-azaniumyl-3-(4-tert-butylphenyl)propanoate Chemical compound CC(C)(C)C1=CC=C(C[C@@H]([NH3+])C([O-])=O)C=C1 CSJZKSXYLTYFPU-LLVKDONJSA-N 0.000 claims 1
- 208000009304 Acute Kidney Injury Diseases 0.000 claims 1
- 208000031104 Arterial Occlusive disease Diseases 0.000 claims 1
- 208000020446 Cardiac disease Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 108010069514 Cyclic Peptides Proteins 0.000 claims 1
- 102000001189 Cyclic Peptides Human genes 0.000 claims 1
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 claims 1
- OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical compound OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 208000033626 Renal failure acute Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 201000011040 acute kidney failure Diseases 0.000 claims 1
- 208000012998 acute renal failure Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 230000002141 anti-parasite Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229940041181 antineoplastic drug Drugs 0.000 claims 1
- 239000003096 antiparasitic agent Substances 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 208000021328 arterial occlusion Diseases 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 238000006798 ring closing metathesis reaction Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- 208000023516 stroke disease Diseases 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000239A ITRM20040239A1 (it) | 2004-05-13 | 2004-05-13 | Derivati ciclopeptidici ad attivita' antintegrine. |
| PCT/IT2005/000262 WO2005111064A1 (en) | 2004-05-13 | 2005-05-04 | Cyclopeptide derivatives with anti-integrin activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008500971A JP2008500971A (ja) | 2008-01-17 |
| JP2008500971A5 true JP2008500971A5 (enExample) | 2008-06-26 |
Family
ID=34968013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007512736A Withdrawn JP2008500971A (ja) | 2004-05-13 | 2005-05-04 | 抗−インテグリン活性を有するシクロペプチド誘導体 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20070178045A1 (enExample) |
| EP (1) | EP1751176B1 (enExample) |
| JP (1) | JP2008500971A (enExample) |
| KR (1) | KR20070012524A (enExample) |
| CN (1) | CN1953990A (enExample) |
| AR (1) | AR048957A1 (enExample) |
| AT (1) | ATE460426T1 (enExample) |
| AU (1) | AU2005243418A1 (enExample) |
| BR (1) | BRPI0510985A (enExample) |
| CA (1) | CA2562576A1 (enExample) |
| CY (1) | CY1110039T1 (enExample) |
| DE (1) | DE602005019876D1 (enExample) |
| DK (1) | DK1751176T3 (enExample) |
| ES (1) | ES2340862T3 (enExample) |
| HR (1) | HRP20100301T1 (enExample) |
| IT (1) | ITRM20040239A1 (enExample) |
| MX (1) | MXPA06012887A (enExample) |
| PL (1) | PL1751176T3 (enExample) |
| PT (1) | PT1751176E (enExample) |
| RS (1) | RS51300B (enExample) |
| SI (1) | SI1751176T1 (enExample) |
| TW (1) | TW200606178A (enExample) |
| WO (1) | WO2005111064A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2640013A1 (en) * | 2006-02-09 | 2007-08-16 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
| EP1961759A1 (en) * | 2007-02-21 | 2008-08-27 | Universita'degli Studi Di Milano | Integrin targeted cyclopeptide ligands, their preparation and use |
| TWI474819B (zh) * | 2012-05-15 | 2015-03-01 | Univ Nat Cheng Kung | 調控物及含有該調控物之醫藥組合物 |
| MX2015011670A (es) * | 2013-03-15 | 2016-03-31 | Biogen Ma Inc | Tratamiento y prevencion de lesion renal aguda usando anticuerpos anti-alfa v beta 5. |
| CN103588863B (zh) * | 2013-11-15 | 2016-08-17 | 苏州强耀生物科技有限公司 | Rgd环肽合成制备工艺 |
| WO2022183360A1 (en) * | 2021-03-02 | 2022-09-09 | Tsao Yeou Ping | Short synthetic peptide and their uses for treating dry eye disease |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4310643A1 (de) * | 1993-04-01 | 1994-10-06 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
| US5449761A (en) * | 1993-09-28 | 1995-09-12 | Cytogen Corporation | Metal-binding targeted polypeptide constructs |
| US6027711A (en) * | 1995-06-07 | 2000-02-22 | Rhomed Incorporated | Structurally determined metallo-constructs and applications |
| DE19725368A1 (de) * | 1997-06-16 | 1998-12-17 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren und deren Verwendung für bildgebende Verfahren |
| ITRM20040242A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine. |
| ITRM20040240A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | Camptotecine coniugate in posizione 7 con antagonisti delle integrine. |
-
2004
- 2004-05-13 IT IT000239A patent/ITRM20040239A1/it unknown
-
2005
- 2005-05-04 EP EP05742999A patent/EP1751176B1/en not_active Expired - Lifetime
- 2005-05-04 RS RSP-2010/0231A patent/RS51300B/sr unknown
- 2005-05-04 DK DK05742999.5T patent/DK1751176T3/da active
- 2005-05-04 MX MXPA06012887A patent/MXPA06012887A/es active IP Right Grant
- 2005-05-04 PL PL05742999T patent/PL1751176T3/pl unknown
- 2005-05-04 SI SI200530986T patent/SI1751176T1/sl unknown
- 2005-05-04 HR HR20100301T patent/HRP20100301T1/hr unknown
- 2005-05-04 JP JP2007512736A patent/JP2008500971A/ja not_active Withdrawn
- 2005-05-04 AU AU2005243418A patent/AU2005243418A1/en not_active Abandoned
- 2005-05-04 CA CA002562576A patent/CA2562576A1/en not_active Abandoned
- 2005-05-04 TW TW094114404A patent/TW200606178A/zh unknown
- 2005-05-04 WO PCT/IT2005/000262 patent/WO2005111064A1/en not_active Ceased
- 2005-05-04 US US11/596,190 patent/US20070178045A1/en not_active Abandoned
- 2005-05-04 PT PT05742999T patent/PT1751176E/pt unknown
- 2005-05-04 CN CNA2005800152380A patent/CN1953990A/zh active Pending
- 2005-05-04 AT AT05742999T patent/ATE460426T1/de not_active IP Right Cessation
- 2005-05-04 KR KR1020067025228A patent/KR20070012524A/ko not_active Ceased
- 2005-05-04 BR BRPI0510985-0A patent/BRPI0510985A/pt not_active IP Right Cessation
- 2005-05-04 DE DE602005019876T patent/DE602005019876D1/de not_active Expired - Lifetime
- 2005-05-04 ES ES05742999T patent/ES2340862T3/es not_active Expired - Lifetime
- 2005-05-13 AR ARP050101955A patent/AR048957A1/es unknown
-
2010
- 2010-05-19 CY CY20101100440T patent/CY1110039T1/el unknown
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