AR048957A1 - Derivados ciclopeptidos dotados de actividad anti-integrina. - Google Patents
Derivados ciclopeptidos dotados de actividad anti-integrina.Info
- Publication number
- AR048957A1 AR048957A1 ARP050101955A ARP050101955A AR048957A1 AR 048957 A1 AR048957 A1 AR 048957A1 AR P050101955 A ARP050101955 A AR P050101955A AR P050101955 A ARP050101955 A AR P050101955A AR 048957 A1 AR048957 A1 AR 048957A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- benzyl
- coow
- ch2ch2o
- nhr
- Prior art date
Links
- 102000001189 Cyclic Peptides Human genes 0.000 title abstract 2
- 108010069514 Cyclic Peptides Proteins 0.000 title abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 102000006495 integrins Human genes 0.000 abstract 2
- 108010044426 integrins Proteins 0.000 abstract 2
- CSJZKSXYLTYFPU-LLVKDONJSA-N (2r)-2-azaniumyl-3-(4-tert-butylphenyl)propanoate Chemical compound CC(C)(C)C1=CC=C(C[C@@H]([NH3+])C([O-])=O)C=C1 CSJZKSXYLTYFPU-LLVKDONJSA-N 0.000 abstract 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000009304 Acute Kidney Injury Diseases 0.000 abstract 1
- 208000031104 Arterial Occlusive disease Diseases 0.000 abstract 1
- -1 D-2-naphthyl-Ala Chemical compound 0.000 abstract 1
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 abstract 1
- OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical compound OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000033626 Renal failure acute Diseases 0.000 abstract 1
- 208000017442 Retinal disease Diseases 0.000 abstract 1
- 206010038923 Retinopathy Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 201000011040 acute kidney failure Diseases 0.000 abstract 1
- 208000012998 acute renal failure Diseases 0.000 abstract 1
- 235000015107 ale Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 208000021328 arterial occlusion Diseases 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000239A ITRM20040239A1 (it) | 2004-05-13 | 2004-05-13 | Derivati ciclopeptidici ad attivita' antintegrine. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR048957A1 true AR048957A1 (es) | 2006-06-14 |
Family
ID=34968013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050101955A AR048957A1 (es) | 2004-05-13 | 2005-05-13 | Derivados ciclopeptidos dotados de actividad anti-integrina. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20070178045A1 (enExample) |
| EP (1) | EP1751176B1 (enExample) |
| JP (1) | JP2008500971A (enExample) |
| KR (1) | KR20070012524A (enExample) |
| CN (1) | CN1953990A (enExample) |
| AR (1) | AR048957A1 (enExample) |
| AT (1) | ATE460426T1 (enExample) |
| AU (1) | AU2005243418A1 (enExample) |
| BR (1) | BRPI0510985A (enExample) |
| CA (1) | CA2562576A1 (enExample) |
| CY (1) | CY1110039T1 (enExample) |
| DE (1) | DE602005019876D1 (enExample) |
| DK (1) | DK1751176T3 (enExample) |
| ES (1) | ES2340862T3 (enExample) |
| HR (1) | HRP20100301T1 (enExample) |
| IT (1) | ITRM20040239A1 (enExample) |
| MX (1) | MXPA06012887A (enExample) |
| PL (1) | PL1751176T3 (enExample) |
| PT (1) | PT1751176E (enExample) |
| RS (1) | RS51300B (enExample) |
| SI (1) | SI1751176T1 (enExample) |
| TW (1) | TW200606178A (enExample) |
| WO (1) | WO2005111064A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2436109T3 (es) * | 2006-02-09 | 2013-12-27 | Belrose Pharma Inc. | Conjugados poliméricos de múltiples brazos de 7-etil-10-hidroxicamptotecina para el tratamiento del cáncer de mama, del cáncer colorrectal, del cáncer de páncreas, de ovario y de pulmón |
| EP1961759A1 (en) * | 2007-02-21 | 2008-08-27 | Universita'degli Studi Di Milano | Integrin targeted cyclopeptide ligands, their preparation and use |
| TWI474819B (zh) | 2012-05-15 | 2015-03-01 | 國立成功大學 | 調控物及含有該調控物之醫藥組合物 |
| JP2016515120A (ja) * | 2013-03-15 | 2016-05-26 | バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． | 抗アルファｖベータ５抗体を用いた急性腎損傷の治療及び予防 |
| CN103588863B (zh) * | 2013-11-15 | 2016-08-17 | 苏州强耀生物科技有限公司 | Rgd环肽合成制备工艺 |
| WO2022183360A1 (en) * | 2021-03-02 | 2022-09-09 | Tsao Yeou Ping | Short synthetic peptide and their uses for treating dry eye disease |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4310643A1 (de) * | 1993-04-01 | 1994-10-06 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
| US5449761A (en) * | 1993-09-28 | 1995-09-12 | Cytogen Corporation | Metal-binding targeted polypeptide constructs |
| US6027711A (en) * | 1995-06-07 | 2000-02-22 | Rhomed Incorporated | Structurally determined metallo-constructs and applications |
| DE19725368A1 (de) * | 1997-06-16 | 1998-12-17 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren und deren Verwendung für bildgebende Verfahren |
| ITRM20040240A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | Camptotecine coniugate in posizione 7 con antagonisti delle integrine. |
| ITRM20040242A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine. |
-
2004
- 2004-05-13 IT IT000239A patent/ITRM20040239A1/it unknown
-
2005
- 2005-05-04 SI SI200530986T patent/SI1751176T1/sl unknown
- 2005-05-04 WO PCT/IT2005/000262 patent/WO2005111064A1/en not_active Ceased
- 2005-05-04 DE DE602005019876T patent/DE602005019876D1/de not_active Expired - Lifetime
- 2005-05-04 PL PL05742999T patent/PL1751176T3/pl unknown
- 2005-05-04 CN CNA2005800152380A patent/CN1953990A/zh active Pending
- 2005-05-04 DK DK05742999.5T patent/DK1751176T3/da active
- 2005-05-04 MX MXPA06012887A patent/MXPA06012887A/es active IP Right Grant
- 2005-05-04 CA CA002562576A patent/CA2562576A1/en not_active Abandoned
- 2005-05-04 TW TW094114404A patent/TW200606178A/zh unknown
- 2005-05-04 AU AU2005243418A patent/AU2005243418A1/en not_active Abandoned
- 2005-05-04 KR KR1020067025228A patent/KR20070012524A/ko not_active Ceased
- 2005-05-04 PT PT05742999T patent/PT1751176E/pt unknown
- 2005-05-04 HR HR20100301T patent/HRP20100301T1/hr unknown
- 2005-05-04 JP JP2007512736A patent/JP2008500971A/ja not_active Withdrawn
- 2005-05-04 RS RSP-2010/0231A patent/RS51300B/sr unknown
- 2005-05-04 BR BRPI0510985-0A patent/BRPI0510985A/pt not_active IP Right Cessation
- 2005-05-04 AT AT05742999T patent/ATE460426T1/de not_active IP Right Cessation
- 2005-05-04 US US11/596,190 patent/US20070178045A1/en not_active Abandoned
- 2005-05-04 EP EP05742999A patent/EP1751176B1/en not_active Expired - Lifetime
- 2005-05-04 ES ES05742999T patent/ES2340862T3/es not_active Expired - Lifetime
- 2005-05-13 AR ARP050101955A patent/AR048957A1/es unknown
-
2010
- 2010-05-19 CY CY20101100440T patent/CY1110039T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RS51300B (sr) | 2010-12-31 |
| HRP20100301T1 (hr) | 2010-06-30 |
| ES2340862T3 (es) | 2010-06-10 |
| WO2005111064A8 (en) | 2006-02-09 |
| PT1751176E (pt) | 2010-05-12 |
| JP2008500971A (ja) | 2008-01-17 |
| SI1751176T1 (sl) | 2010-06-30 |
| PL1751176T3 (pl) | 2010-08-31 |
| KR20070012524A (ko) | 2007-01-25 |
| EP1751176A1 (en) | 2007-02-14 |
| CY1110039T1 (el) | 2012-05-23 |
| TW200606178A (en) | 2006-02-16 |
| ATE460426T1 (de) | 2010-03-15 |
| CN1953990A (zh) | 2007-04-25 |
| US20070178045A1 (en) | 2007-08-02 |
| EP1751176B1 (en) | 2010-03-10 |
| DK1751176T3 (da) | 2010-06-14 |
| ITRM20040239A1 (it) | 2004-08-13 |
| MXPA06012887A (es) | 2007-02-15 |
| BRPI0510985A (pt) | 2007-12-04 |
| CA2562576A1 (en) | 2005-11-24 |
| DE602005019876D1 (de) | 2010-04-22 |
| WO2005111064A1 (en) | 2005-11-24 |
| AU2005243418A1 (en) | 2005-11-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |