CY1110039T1 - Παραγωγα κυκλοπεπτιδιων με δραση κατα της ιντεγκρινης - Google Patents

Παραγωγα κυκλοπεπτιδιων με δραση κατα της ιντεγκρινης

Info

Publication number
CY1110039T1
CY1110039T1 CY20101100440T CY101100440T CY1110039T1 CY 1110039 T1 CY1110039 T1 CY 1110039T1 CY 20101100440 T CY20101100440 T CY 20101100440T CY 101100440 T CY101100440 T CY 101100440T CY 1110039 T1 CY1110039 T1 CY 1110039T1
Authority
CY
Cyprus
Prior art keywords
useful
compounds
integrin activity
integrin inhibitors
drugs
Prior art date
Application number
CY20101100440T
Other languages
English (en)
Inventor
Alma Dal Pozzo
Sergio Penco
Giuseppe Giannini
Maria Ornella Tinti
Claudio Pisano
Loredana Vesci
Ming Hong Ni
Original Assignee
Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. filed Critical Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Publication of CY1110039T1 publication Critical patent/CY1110039T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Περιγράφονται ενώσεις του χημικού τύπου (I) c(R1-Arg- Gly-Asp-R2) όπου η σημασία των διαφόρων ομάδων είναι όπως περιγράφεται στο παρόν, οι οποίες είναι αναστολείς ιντεγκρίνης, και ιδίως αναστολείς ιντεγκρίνης της οικογένειας ανβ3 και ανβ5, και συνεπώς είναι χρήσιμες ως φάρμακα, ιδίως για την θεραπευτική αγωγή νόσων υποκείμενων της μη φυσιολογικής αγγειογένεσης, όπως η αμφιβληστροειδοπάθεια, η οξεία νεφρική ανεπάρκεια, η οστεοπόρωση και οι μεταστάσεις. Οι ενώσεις που περιγράφονται στο παρόν, όταν σημανθούν καταλλήλως, είναι επίσης χρήσιμες ως διαγνωστικοί παράγοντες, ιδίως για την ανίχνευση μικρών όγκων και συμβαμάτων αρτηριακής απόφραξης, καθώς και ως φορείς στοχευμένων φαρμάκων.
CY20101100440T 2004-05-13 2010-05-19 Παραγωγα κυκλοπεπτιδιων με δραση κατα της ιντεγκρινης CY1110039T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000239A ITRM20040239A1 (it) 2004-05-13 2004-05-13 Derivati ciclopeptidici ad attivita' antintegrine.
PCT/IT2005/000262 WO2005111064A1 (en) 2004-05-13 2005-05-04 Cyclopeptide derivatives with anti-integrin activity

Publications (1)

Publication Number Publication Date
CY1110039T1 true CY1110039T1 (el) 2012-05-23

Family

ID=34968013

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100440T CY1110039T1 (el) 2004-05-13 2010-05-19 Παραγωγα κυκλοπεπτιδιων με δραση κατα της ιντεγκρινης

Country Status (23)

Country Link
US (1) US20070178045A1 (el)
EP (1) EP1751176B1 (el)
JP (1) JP2008500971A (el)
KR (1) KR20070012524A (el)
CN (1) CN1953990A (el)
AR (1) AR048957A1 (el)
AT (1) ATE460426T1 (el)
AU (1) AU2005243418A1 (el)
BR (1) BRPI0510985A (el)
CA (1) CA2562576A1 (el)
CY (1) CY1110039T1 (el)
DE (1) DE602005019876D1 (el)
DK (1) DK1751176T3 (el)
ES (1) ES2340862T3 (el)
HR (1) HRP20100301T1 (el)
IT (1) ITRM20040239A1 (el)
MX (1) MXPA06012887A (el)
PL (1) PL1751176T3 (el)
PT (1) PT1751176E (el)
RS (1) RS51300B (el)
SI (1) SI1751176T1 (el)
TW (1) TW200606178A (el)
WO (1) WO2005111064A1 (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007092646A2 (en) * 2006-02-09 2007-08-16 Enzon Pharmaceuticals, Inc. Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
EP1961759A1 (en) * 2007-02-21 2008-08-27 Universita'degli Studi Di Milano Integrin targeted cyclopeptide ligands, their preparation and use
TWI474819B (zh) * 2012-05-15 2015-03-01 Univ Nat Cheng Kung 調控物及含有該調控物之醫藥組合物
WO2014151680A1 (en) * 2013-03-15 2014-09-25 Biogen Idec Ma Inc. Treatment and prevention of acute kidney injury using anti-alpha v beta 5 antibodies
CN103588863B (zh) * 2013-11-15 2016-08-17 苏州强耀生物科技有限公司 Rgd环肽合成制备工艺
WO2022183360A1 (en) * 2021-03-02 2022-09-09 Tsao Yeou Ping Short synthetic peptide and their uses for treating dry eye disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4310643A1 (de) * 1993-04-01 1994-10-06 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren
US5449761A (en) * 1993-09-28 1995-09-12 Cytogen Corporation Metal-binding targeted polypeptide constructs
US6027711A (en) * 1995-06-07 2000-02-22 Rhomed Incorporated Structurally determined metallo-constructs and applications
DE19725368A1 (de) * 1997-06-16 1998-12-17 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren und deren Verwendung für bildgebende Verfahren
ITRM20040242A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine.
ITRM20040240A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 7 con antagonisti delle integrine.

Also Published As

Publication number Publication date
US20070178045A1 (en) 2007-08-02
EP1751176B1 (en) 2010-03-10
JP2008500971A (ja) 2008-01-17
PT1751176E (pt) 2010-05-12
ES2340862T3 (es) 2010-06-10
TW200606178A (en) 2006-02-16
ATE460426T1 (de) 2010-03-15
ITRM20040239A1 (it) 2004-08-13
KR20070012524A (ko) 2007-01-25
DE602005019876D1 (de) 2010-04-22
WO2005111064A1 (en) 2005-11-24
MXPA06012887A (es) 2007-02-15
SI1751176T1 (sl) 2010-06-30
AU2005243418A1 (en) 2005-11-24
RS51300B (sr) 2010-12-31
DK1751176T3 (da) 2010-06-14
CN1953990A (zh) 2007-04-25
PL1751176T3 (pl) 2010-08-31
WO2005111064A8 (en) 2006-02-09
CA2562576A1 (en) 2005-11-24
BRPI0510985A (pt) 2007-12-04
AR048957A1 (es) 2006-06-14
EP1751176A1 (en) 2007-02-14
HRP20100301T1 (hr) 2010-06-30

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