CY1110039T1 - Παραγωγα κυκλοπεπτιδιων με δραση κατα της ιντεγκρινης - Google Patents
Παραγωγα κυκλοπεπτιδιων με δραση κατα της ιντεγκρινηςInfo
- Publication number
- CY1110039T1 CY1110039T1 CY20101100440T CY101100440T CY1110039T1 CY 1110039 T1 CY1110039 T1 CY 1110039T1 CY 20101100440 T CY20101100440 T CY 20101100440T CY 101100440 T CY101100440 T CY 101100440T CY 1110039 T1 CY1110039 T1 CY 1110039T1
- Authority
- CY
- Cyprus
- Prior art keywords
- useful
- compounds
- integrin activity
- integrin inhibitors
- drugs
- Prior art date
Links
- 102000001189 Cyclic Peptides Human genes 0.000 title 1
- 108010069514 Cyclic Peptides Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 102000006495 integrins Human genes 0.000 abstract 2
- 108010044426 integrins Proteins 0.000 abstract 2
- 208000009304 Acute Kidney Injury Diseases 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000033626 Renal failure acute Diseases 0.000 abstract 1
- 208000017442 Retinal disease Diseases 0.000 abstract 1
- 206010038923 Retinopathy Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 201000011040 acute kidney failure Diseases 0.000 abstract 1
- 208000012998 acute renal failure Diseases 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Virology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Περιγράφονται ενώσεις του χημικού τύπου (I) c(R1-Arg- Gly-Asp-R2) όπου η σημασία των διαφόρων ομάδων είναι όπως περιγράφεται στο παρόν, οι οποίες είναι αναστολείς ιντεγκρίνης, και ιδίως αναστολείς ιντεγκρίνης της οικογένειας ανβ3 και ανβ5, και συνεπώς είναι χρήσιμες ως φάρμακα, ιδίως για την θεραπευτική αγωγή νόσων υποκείμενων της μη φυσιολογικής αγγειογένεσης, όπως η αμφιβληστροειδοπάθεια, η οξεία νεφρική ανεπάρκεια, η οστεοπόρωση και οι μεταστάσεις. Οι ενώσεις που περιγράφονται στο παρόν, όταν σημανθούν καταλλήλως, είναι επίσης χρήσιμες ως διαγνωστικοί παράγοντες, ιδίως για την ανίχνευση μικρών όγκων και συμβαμάτων αρτηριακής απόφραξης, καθώς και ως φορείς στοχευμένων φαρμάκων.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT000239A ITRM20040239A1 (it) | 2004-05-13 | 2004-05-13 | Derivati ciclopeptidici ad attivita' antintegrine. |
PCT/IT2005/000262 WO2005111064A1 (en) | 2004-05-13 | 2005-05-04 | Cyclopeptide derivatives with anti-integrin activity |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1110039T1 true CY1110039T1 (el) | 2012-05-23 |
Family
ID=34968013
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101100440T CY1110039T1 (el) | 2004-05-13 | 2010-05-19 | Παραγωγα κυκλοπεπτιδιων με δραση κατα της ιντεγκρινης |
Country Status (23)
Country | Link |
---|---|
US (1) | US20070178045A1 (el) |
EP (1) | EP1751176B1 (el) |
JP (1) | JP2008500971A (el) |
KR (1) | KR20070012524A (el) |
CN (1) | CN1953990A (el) |
AR (1) | AR048957A1 (el) |
AT (1) | ATE460426T1 (el) |
AU (1) | AU2005243418A1 (el) |
BR (1) | BRPI0510985A (el) |
CA (1) | CA2562576A1 (el) |
CY (1) | CY1110039T1 (el) |
DE (1) | DE602005019876D1 (el) |
DK (1) | DK1751176T3 (el) |
ES (1) | ES2340862T3 (el) |
HR (1) | HRP20100301T1 (el) |
IT (1) | ITRM20040239A1 (el) |
MX (1) | MXPA06012887A (el) |
PL (1) | PL1751176T3 (el) |
PT (1) | PT1751176E (el) |
RS (1) | RS51300B (el) |
SI (1) | SI1751176T1 (el) |
TW (1) | TW200606178A (el) |
WO (1) | WO2005111064A1 (el) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101420963B (zh) * | 2006-02-09 | 2012-09-05 | 安佐制药股份有限公司 | 用于治疗乳腺癌、结肠直肠癌、胰腺癌、卵巢癌和肺癌的7-乙基-10-羟基喜树碱的多臂聚合轭合物 |
EP1961759A1 (en) * | 2007-02-21 | 2008-08-27 | Universita'degli Studi Di Milano | Integrin targeted cyclopeptide ligands, their preparation and use |
TWI474819B (zh) * | 2012-05-15 | 2015-03-01 | Univ Nat Cheng Kung | 調控物及含有該調控物之醫藥組合物 |
CN105392801A (zh) * | 2013-03-15 | 2016-03-09 | 比奥根Ma公司 | 使用抗αvβ5抗体治疗和预防急性肾损伤 |
CN103588863B (zh) * | 2013-11-15 | 2016-08-17 | 苏州强耀生物科技有限公司 | Rgd环肽合成制备工艺 |
WO2022183360A1 (en) * | 2021-03-02 | 2022-09-09 | Tsao Yeou Ping | Short synthetic peptide and their uses for treating dry eye disease |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4310643A1 (de) * | 1993-04-01 | 1994-10-06 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
US5449761A (en) * | 1993-09-28 | 1995-09-12 | Cytogen Corporation | Metal-binding targeted polypeptide constructs |
US6027711A (en) * | 1995-06-07 | 2000-02-22 | Rhomed Incorporated | Structurally determined metallo-constructs and applications |
DE19725368A1 (de) * | 1997-06-16 | 1998-12-17 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren und deren Verwendung für bildgebende Verfahren |
ITRM20040240A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | Camptotecine coniugate in posizione 7 con antagonisti delle integrine. |
ITRM20040242A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine. |
-
2004
- 2004-05-13 IT IT000239A patent/ITRM20040239A1/it unknown
-
2005
- 2005-05-04 BR BRPI0510985-0A patent/BRPI0510985A/pt not_active IP Right Cessation
- 2005-05-04 AT AT05742999T patent/ATE460426T1/de not_active IP Right Cessation
- 2005-05-04 MX MXPA06012887A patent/MXPA06012887A/es active IP Right Grant
- 2005-05-04 US US11/596,190 patent/US20070178045A1/en not_active Abandoned
- 2005-05-04 AU AU2005243418A patent/AU2005243418A1/en not_active Abandoned
- 2005-05-04 DE DE602005019876T patent/DE602005019876D1/de active Active
- 2005-05-04 ES ES05742999T patent/ES2340862T3/es active Active
- 2005-05-04 PT PT05742999T patent/PT1751176E/pt unknown
- 2005-05-04 SI SI200530986T patent/SI1751176T1/sl unknown
- 2005-05-04 CA CA002562576A patent/CA2562576A1/en not_active Abandoned
- 2005-05-04 TW TW094114404A patent/TW200606178A/zh unknown
- 2005-05-04 KR KR1020067025228A patent/KR20070012524A/ko not_active Application Discontinuation
- 2005-05-04 RS RSP-2010/0231A patent/RS51300B/sr unknown
- 2005-05-04 WO PCT/IT2005/000262 patent/WO2005111064A1/en active Application Filing
- 2005-05-04 JP JP2007512736A patent/JP2008500971A/ja not_active Withdrawn
- 2005-05-04 PL PL05742999T patent/PL1751176T3/pl unknown
- 2005-05-04 CN CNA2005800152380A patent/CN1953990A/zh active Pending
- 2005-05-04 EP EP05742999A patent/EP1751176B1/en active Active
- 2005-05-04 DK DK05742999.5T patent/DK1751176T3/da active
- 2005-05-13 AR ARP050101955A patent/AR048957A1/es unknown
-
2010
- 2010-05-19 CY CY20101100440T patent/CY1110039T1/el unknown
- 2010-05-27 HR HR20100301T patent/HRP20100301T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
DE602005019876D1 (de) | 2010-04-22 |
ITRM20040239A1 (it) | 2004-08-13 |
WO2005111064A8 (en) | 2006-02-09 |
PL1751176T3 (pl) | 2010-08-31 |
EP1751176A1 (en) | 2007-02-14 |
MXPA06012887A (es) | 2007-02-15 |
US20070178045A1 (en) | 2007-08-02 |
KR20070012524A (ko) | 2007-01-25 |
ES2340862T3 (es) | 2010-06-10 |
CA2562576A1 (en) | 2005-11-24 |
AR048957A1 (es) | 2006-06-14 |
CN1953990A (zh) | 2007-04-25 |
RS51300B (sr) | 2010-12-31 |
AU2005243418A1 (en) | 2005-11-24 |
SI1751176T1 (sl) | 2010-06-30 |
DK1751176T3 (da) | 2010-06-14 |
EP1751176B1 (en) | 2010-03-10 |
HRP20100301T1 (hr) | 2010-06-30 |
PT1751176E (pt) | 2010-05-12 |
WO2005111064A1 (en) | 2005-11-24 |
JP2008500971A (ja) | 2008-01-17 |
BRPI0510985A (pt) | 2007-12-04 |
ATE460426T1 (de) | 2010-03-15 |
TW200606178A (en) | 2006-02-16 |
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