CY1117067T1 - Η χρηση σωματιδιων στερεων φορεων για τη βελτιωση της επεξεργασιμοτητας φαρμακευτικου παραγοντα - Google Patents

Η χρηση σωματιδιων στερεων φορεων για τη βελτιωση της επεξεργασιμοτητας φαρμακευτικου παραγοντα

Info

Publication number
CY1117067T1
CY1117067T1 CY20151101168T CY151101168T CY1117067T1 CY 1117067 T1 CY1117067 T1 CY 1117067T1 CY 20151101168 T CY20151101168 T CY 20151101168T CY 151101168 T CY151101168 T CY 151101168T CY 1117067 T1 CY1117067 T1 CY 1117067T1
Authority
CY
Cyprus
Prior art keywords
improving
processing
pharmaceutical agent
solid
particulars
Prior art date
Application number
CY20151101168T
Other languages
English (en)
Inventor
Joanna M Koziara
Mark M Menning
Reza Oliyai
Robert G Strickley
Richard Yu
Brian P Kearney
Anita A Mathias
Original Assignee
Gilead Sciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40809930&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1117067(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences, Inc. filed Critical Gilead Sciences, Inc.
Publication of CY1117067T1 publication Critical patent/CY1117067T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

H εφεύρεση παρέχει κάποια σύνθεση που περιλαμβάνει ένωση του χημικού τύπου (I) ή φαρμακευτικά αποδεκτό άλας αυτής και πλήθος σωματιδίων στερεού φορέα, όπως επίσης μεθόδους για τη χρήση της σύνθεσης στην αναστολή της ενεργότητας του κυτοχρώματος Ρ-450.
CY20151101168T 2008-05-02 2015-12-22 Η χρηση σωματιδιων στερεων φορεων για τη βελτιωση της επεξεργασιμοτητας φαρμακευτικου παραγοντα CY1117067T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US4993508P 2008-05-02 2008-05-02
US15065509P 2009-02-06 2009-02-06
US15065209P 2009-02-06 2009-02-06
EP09739981.0A EP2296633B1 (en) 2008-05-02 2009-05-01 The use of solid carrier particles to improve the processability of a pharmaceutical agent

Publications (1)

Publication Number Publication Date
CY1117067T1 true CY1117067T1 (el) 2017-04-05

Family

ID=40809930

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20151101168T CY1117067T1 (el) 2008-05-02 2015-12-22 Η χρηση σωματιδιων στερεων φορεων για τη βελτιωση της επεξεργασιμοτητας φαρμακευτικου παραγοντα

Country Status (27)

Country Link
US (1) US10039718B2 (el)
EP (2) EP2296633B1 (el)
JP (2) JP5722213B2 (el)
KR (2) KR101784647B1 (el)
CN (3) CN104940937A (el)
AP (1) AP3089A (el)
AU (3) AU2009242451C1 (el)
BR (1) BRPI0911871A8 (el)
CA (1) CA2720856C (el)
CO (1) CO6321225A2 (el)
CY (1) CY1117067T1 (el)
DK (1) DK2296633T3 (el)
EA (2) EA022950B1 (el)
EC (1) ECSP10010636A (el)
ES (1) ES2553897T3 (el)
HK (2) HK1153670A1 (el)
HR (1) HRP20151357T1 (el)
HU (1) HUE026380T2 (el)
IL (2) IL208614A (el)
MX (2) MX342377B (el)
NZ (1) NZ588978A (el)
PL (1) PL2296633T3 (el)
PT (1) PT2296633E (el)
SG (2) SG10201609006WA (el)
SI (1) SI2296633T1 (el)
WO (1) WO2009135179A2 (el)
ZA (1) ZA201008007B (el)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP2985A (en) 2006-07-07 2014-09-30 Gilead Sciences Inc Modulators of pharmacokinetic properties of therapeutics
ES2602784T3 (es) * 2007-02-23 2017-02-22 Gilead Sciences, Inc. Moduladores de las propiedades farmacocinéticas de los agentes terapéuticos
BRPI0813000A2 (pt) * 2007-06-29 2014-12-23 Gilead Sciences Inc Composições terapêuticas e uso das mesmas
CN101743004A (zh) * 2007-06-29 2010-06-16 吉里德科学公司 治疗用组合物及其用途
CN104940937A (zh) 2008-05-02 2015-09-30 吉里德科学公司 固体载体颗粒在改善药物制剂加工性中的应用
UA108738C2 (uk) 2009-04-03 2015-06-10 Спосіб одержання інгібітора цитохром р450 монооксигенази та залучені проміжні сполуки
RS53691B1 (en) 2010-11-19 2015-04-30 Janssen R&D Ireland THERAPEUTIC COMPOSITIONS CONTAINING RILPIVIRINE HCL AND TENOVOFIR DIZOPROXYL FUMARATE
EP2705027B1 (en) * 2011-05-02 2015-06-03 Gilead Sciences, Inc. Amorphous solid salts of Cobicistat (GS-9350)
BR112014000290B1 (pt) 2011-07-07 2022-05-10 Gilead Sciences, Inc. Forma de dosagem oral de combinação de darunavir, processo para preparação de uma forma de dosagem oral e uso de granulado de darunavir
UY34262A (es) 2011-08-16 2013-04-05 Gilead Sciences Inc Hemifumarato de tenofovir alafenamida, sus composiciones, método de preparación, métodos para tratar infecciones virales y su uso para preparar medi camentos
US20150004239A1 (en) * 2012-01-12 2015-01-01 Gilead Sciences, Inc. Pharmaceutical compositions and methods for their preparation
RU2014129937A (ru) 2012-02-03 2016-03-27 Джилид Сайэнс, Инк. Способы и промежуточные соединения для получения фармацевтических агентов
CA2865491A1 (en) 2012-03-01 2013-09-06 Gilead Sciences, Inc. Spray dried formulations
RU2648457C2 (ru) * 2012-10-23 2018-03-26 Сипла Лимитед Фармацевтическая антиретровирусная композиция
WO2014105777A1 (en) 2012-12-26 2014-07-03 Assia Chemical Industries Ltd. Cobicostat dichlohydrate salt
DE102013205347A1 (de) 2013-03-26 2014-10-02 Hilti Aktiengesellschaft Additiv-Zusammensetzung für Amin-Härter, deren Verwendung sowie diese enthaltende Amin-Härterzusammensetzung
CN103230403A (zh) * 2013-04-23 2013-08-07 苏州谷力生物科技有限公司 一种抗艾滋病毒的组合型药物片剂
US20170035911A1 (en) * 2013-11-29 2017-02-09 Mylan Laboratories Ltd. Amorphous Cobicistat Solid Dispersion
WO2015145324A1 (en) * 2014-03-25 2015-10-01 Mylan Laboratories Ltd Process for the preparation of cobicistat
US20160145344A1 (en) * 2014-10-20 2016-05-26 University Of Southern California Murine and human innate lymphoid cells and lung inflammation
WO2016201119A1 (en) * 2015-06-09 2016-12-15 J. Rettenmaier & Söhne Gmbh + Co Kg Excipient and oral solid dosage forms for oily drugs
US10166185B2 (en) * 2015-06-09 2019-01-01 J. Rettenmaier & Söhne Gmbh + Co Kg Excipient and oral solid dosage forms for oily drugs
TW201728582A (zh) 2016-01-28 2017-08-16 基利科學股份有限公司 結晶型
BR112019002120A2 (pt) 2016-08-08 2019-05-14 Hetero Labs Limited composição anti-retroviral de várias classes
EP3496718A4 (en) 2016-08-08 2020-01-22 Hetero Labs Limited ANTIRETROVIRAL COMPOSITIONS
EA202191370A1 (ru) * 2018-12-14 2021-09-16 Фуджифилм Корпорэйшн Фармацевтическая композиция и способ ее получения
CN110251476B (zh) * 2019-08-01 2022-08-09 海思科制药(眉山)有限公司 一种恩曲他滨替诺福韦药物组合物
CN113425702B (zh) * 2021-06-25 2022-08-26 中国药科大学 应用微流控技术制备纳米颗粒、制备方法及装置和用途

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3400197A (en) 1965-01-26 1968-09-03 Robins Co Inc A H Compressible sustained release pharmaceutical tablet lipid-colloidal silica gel matrix fragment granules
GB1241024A (en) 1968-10-29 1971-07-28 Boehringer Sohn Ingelheim Pharmaceutical tablet base and a process for its manufacture
CA926708A (en) 1970-06-15 1973-05-22 Oushima Yoshitaka Process for producing spherical pellets
CH586568A5 (el) 1972-04-10 1977-04-15 Hoffmann La Roche
DE2845326C2 (de) 1978-10-18 1985-05-23 Beiersdorf Ag, 2000 Hamburg Verwendung einer spezifischen mikrodispersen, amorphen, porösen Kieselsäure zur Herstellung von Digoxin enthaltenden Tabletten mit stark beschleunigter Wirkstoff-Freisetzung
US4603143A (en) 1983-05-02 1986-07-29 Basf Corporation Free-flowing, high density, fat soluble vitamin powders with improved stability
GB8413191D0 (en) 1984-05-23 1984-06-27 Beecham Group Plc Pharmaceutical composition
FR2609958B1 (fr) 1987-01-27 1995-03-10 Honda Motor Co Ltd Dispositif de support pour roues arriere de motocyclettes
FR2631620B1 (fr) 1988-05-19 1990-07-27 Rhone Poulenc Chimie Nouvelle silice precipitee absorbante et composition a base de cette s ilice
US5354866A (en) 1989-05-23 1994-10-11 Abbott Laboratories Retroviral protease inhibiting compounds
US5552558A (en) 1989-05-23 1996-09-03 Abbott Laboratories Retroviral protease inhibiting compounds
IE913840A1 (en) 1990-11-20 1992-05-20 Abbott Lab Retroviral protease inhibiting compounds
GB9109862D0 (en) 1991-05-08 1991-07-03 Beecham Lab Sa Pharmaceutical formulations
ZA923640B (en) 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
DE69332616T2 (de) 1992-12-29 2003-11-06 Abbott Lab Hemmer der retroviralen Protease
GB9301192D0 (en) 1993-06-09 1993-06-09 Trott Francis W Flower shaped mechanised table
WO1995005808A1 (en) 1993-08-24 1995-03-02 Abbott Laboratories Oil-based tableting method
US5559158A (en) * 1993-10-01 1996-09-24 Abbott Laboratories Pharmaceutical composition
US5585115A (en) 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
US5948438A (en) 1995-01-09 1999-09-07 Edward Mendell Co., Inc. Pharmaceutical formulations having improved disintegration and/or absorptivity
GB9514464D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Medicaments
JP4064476B2 (ja) 1996-03-29 2008-03-19 エラワン ファーマスーティカル リサーチ アンドラボラトリー カンパニー リミテッド 二酸化珪素を有する球状凝集した澱粉
US6348216B1 (en) 1996-06-10 2002-02-19 Knoll Pharmaceutical Company Ibuprofen and narcotic analgesic compositions
US6361794B1 (en) 1996-06-12 2002-03-26 Basf Corporation Method of making ibuprofen and narcotic analgesic composition
US5922695A (en) 1996-07-26 1999-07-13 Gilead Sciences, Inc. Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
US5939090A (en) 1996-12-03 1999-08-17 3M Innovative Properties Company Gel formulations for topical drug delivery
JP4494539B2 (ja) 1997-02-28 2010-06-30 ディーエスエム アイピー アセッツ ビー．ブイ． 流動自由な乾燥粒子
FR2767071B1 (fr) 1997-08-06 1999-09-10 Rhodia Chimie Sa Composition comprenant un liquide absorbe sur un support a base de silice precipitee
JP4027535B2 (ja) 1998-05-26 2007-12-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 脂溶性薬物を含有した粉末
US6342249B1 (en) 1998-12-23 2002-01-29 Alza Corporation Controlled release liquid active agent formulation dosage forms
WO2003030868A1 (en) 2001-10-09 2003-04-17 Bristol-Myers Squibb Company Flashmelt oral dosage formulation
CA2311734C (en) 2000-04-12 2011-03-08 Bristol-Myers Squibb Company Flash-melt oral dosage formulation
US20030035834A1 (en) 2000-05-26 2003-02-20 Pawan Seth Sustained release verapamil pharmaceutical composition free of food effect and a method for alleviating food effect in drug release
KR20030040389A (ko) 2000-09-19 2003-05-22 다이이찌 세이야꾸 가부시기가이샤 의약 조성물
US7056951B2 (en) 2000-09-26 2006-06-06 Mutual Pharmaceutical Co., Inc. Stable solid dosage forms of amino acids and processes for producing same
US6524615B2 (en) 2001-02-21 2003-02-25 Kos Pharmaceuticals, Incorporated Controlled release pharmaceutical composition
DE10112651A1 (de) 2001-03-16 2002-09-19 Degussa Inhomogene Kieselsäuren als Trägermaterial
PT1383482E (pt) 2001-05-01 2007-09-20 Pfizer Prod Inc Método para o fabrico de uma composição farmacêutica de baixa dosagem tendo distribuição e potência de fármaco uniforme
JP4166580B2 (ja) 2001-05-18 2008-10-15 ロンザ ア−ゲ− ３−ヒドロキシ−３−メチル酪酸ナトリウムの固体組成物の製造方法
DE10126163A1 (de) 2001-05-30 2002-12-05 Degussa Pharmazeutische Zubereitungen
ES2739023T3 (es) 2001-07-06 2020-01-28 Veloxis Pharmaceuticals As Aglomeración controlada
GB0123400D0 (en) 2001-09-28 2001-11-21 Novartis Ag Organic compounds
US7815936B2 (en) 2001-10-30 2010-10-19 Evonik Degussa Gmbh Use of granular materials based on pyrogenically produced silicon dioxide in pharmaceutical compositions
DE10153078A1 (de) * 2001-10-30 2003-05-22 Degussa Verwendung von Granulaten auf Basis von pyrogen hergestelltem Siliciumdioxid in pharmazeutischen Zusammensetzungen
WO2003047551A1 (en) 2001-11-29 2003-06-12 Penwest Pharmaceutical Company Agglomerated particles including an active agent coprocessed with silicified microcrystalline cellulose
US20030206978A1 (en) 2001-11-29 2003-11-06 Bob Sherwood Agglomerated particles including an active agent coprocessed with silicified microcrystalline cellulose
US6926906B2 (en) 2002-02-20 2005-08-09 M./S. Strides, Inc. Orally administrable pharmaceutical formulation
PA8576201A1 (es) 2002-07-10 2004-05-26 Pfizer Prod Inc Composicion farmaceutica que tiene una distribucion y potencia uniforme de farmaco
DE10250711A1 (de) 2002-10-31 2004-05-19 Degussa Ag Pharmazeutische und kosmetische Zubereitungen
MY136173A (en) 2002-11-20 2008-08-29 Japan Tobacco Inc 4-oxoquinoline compound and use thereof as hiv integrase inhibitor
JP3567162B1 (ja) 2002-11-20 2004-09-22 日本たばこ産業株式会社 ４−オキソキノリン化合物及びそのｈｉｖインテグラーゼ阻害剤としての利用
US7189416B2 (en) 2002-11-23 2007-03-13 Glykon Technologies Group, Llc Method for stable and controlled delivery of (-)-hydroxycitric acid
ATE398455T1 (de) 2003-01-14 2008-07-15 Gilead Sciences Inc Zusammensetzungen und verfahren zur antiviralen kombinationstherapie
US20060115524A1 (en) 2003-02-19 2006-06-01 H. Lundbeck A/S Method for preparation of an agglomerate using melt agglomeration
CA2516096A1 (en) 2003-02-19 2004-09-02 Lifecycle Pharma A/S Use of a silica or silica derivative as a sorption material
FR2851918B1 (fr) 2003-03-06 2006-06-16 Poudre impregnee ameliorant la biodisponibilite et/ou la solubilite et procede de fabrication
JP4018664B2 (ja) 2003-04-30 2007-12-05 第一三共株式会社 安定化固形製剤
DE10337198A1 (de) 2003-08-13 2005-03-17 Degussa Ag Träger auf Basis von Granulaten, die aus pyrogen hergestelltem Siliciumdioxiden hergestellt sind
US8025899B2 (en) * 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
JP2005075826A (ja) 2003-08-29 2005-03-24 Boehringer Ingelheim Internatl Gmbh 多孔質シリカ担体を含有する徐放性製剤
WO2005032525A1 (en) 2003-10-03 2005-04-14 Lifecycle Pharma A/S A method for preparing modified release pharmaceutical compositions
US9173847B2 (en) 2003-10-10 2015-11-03 Veloxis Pharmaceuticals A/S Tablet comprising a fibrate
US20050096390A1 (en) 2003-10-10 2005-05-05 Per Holm Compositions comprising fenofibrate and pravastatin
EP1680091B1 (en) 2003-10-10 2017-05-31 Veloxis Pharmaceuticals A/S A solid dosage form comprising a fibrate
RU2343905C2 (ru) 2003-10-10 2009-01-20 Лайфсайкл Фарма А/С Твердые дозированные формы, включающие фибрат и статин
US20070014846A1 (en) 2003-10-10 2007-01-18 Lifecycle Pharma A/S Pharmaceutical compositions comprising fenofibrate and atorvastatin
US20050096391A1 (en) 2003-10-10 2005-05-05 Per Holm Compositions comprising fenofibrate and rosuvastatin
US20050095287A1 (en) 2003-10-29 2005-05-05 Matharu Amol S. Fosinopril composition
WO2005084670A1 (en) 2004-03-01 2005-09-15 Lek Pharmaceuticals D.D. Pharmaceutical formulation
MY142989A (en) 2004-03-10 2011-02-14 Bayer Schering Pharma Ag Stabilised supersaturated solids of lipophilic drugs
WO2005105040A2 (en) 2004-04-26 2005-11-10 Micelle Products, Inc. Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications
MY134672A (en) 2004-05-20 2007-12-31 Japan Tobacco Inc Stable crystal of 4-oxoquinoline compound
EP1765297A2 (en) 2004-06-28 2007-03-28 LifeCycle Pharma A/S Porous tablets as carriers for liquid formulations
US20060009603A1 (en) * 2004-07-09 2006-01-12 David Young Fibrillation-resistant polypropylene tape
AR045841A1 (es) * 2004-09-28 2005-11-16 Richmond Sa Com Ind Y Financie Una composicion farmaceutica solida que comprende al tiazolil metil ester del acido [5s-(5r*, 8r*, 10r*,11r*)] -10- hidroxi-2- metil-5-(1-metiletil)-1-[2-(1-metiletil)-4-tiazolil]-3,6-dioxo-8,11-bis(fenilmetil)-2,4,7,12- tetraazatridecan-13-oico y un procedimiento para prepararla.
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
US20070014854A1 (en) 2005-07-15 2007-01-18 Ilan Zalit Novel granulation process
JP2007039338A (ja) 2005-07-29 2007-02-15 Hirofumi Takeuchi シリカ系複合顆粒
NZ569349A (en) 2005-12-14 2012-01-12 Cipla Ltd Pharmaceutical combination comprising nucleotide and nucleoside reverse transcriptase inhibitors (such as tenofovir and lamivudine) in different parts of the dosage unit
EP1978939A2 (en) 2005-12-27 2008-10-15 Jubilant Organosys Limited Mouth dissolving pharmaceutical composition and process for preparing the same using a high amount of silicon dioxine
AU2007203715B2 (en) 2006-01-05 2012-08-02 Veloxis Pharmaceuticals A/S Disintegrating loadable tablets
WO2007097333A1 (ja) 2006-02-20 2007-08-30 Asahi Breweries, Ltd. 顆粒、錠剤およびそれらの製造方法
US20070287664A1 (en) * 2006-03-23 2007-12-13 Schering Corporation Combinations of HCV protease inhibitor(s) and CYP3A4 inhibitor(s), and methods of treatment related thereto
AP2985A (en) * 2006-07-07 2014-09-30 Gilead Sciences Inc Modulators of pharmacokinetic properties of therapeutics
WO2008017867A2 (en) * 2006-08-10 2008-02-14 Cipla Limited Antiretroviral solid oral composition with at least one water insoluble polymer
EP2063862A2 (en) * 2006-09-04 2009-06-03 Matrix Laboratories Ltd Pharmaceutical formulation for use in hiv therapy
US7749537B2 (en) 2006-12-04 2010-07-06 Scolr Pharma, Inc. Method of forming a tablet
ES2602784T3 (es) 2007-02-23 2017-02-22 Gilead Sciences, Inc. Moduladores de las propiedades farmacocinéticas de los agentes terapéuticos
BRPI0813000A2 (pt) 2007-06-29 2014-12-23 Gilead Sciences Inc Composições terapêuticas e uso das mesmas
CN101743004A (zh) 2007-06-29 2010-06-16 吉里德科学公司 治疗用组合物及其用途
WO2009037449A1 (en) 2007-09-18 2009-03-26 Cipla Limited Solid pharmaceutical compositions comprising one or more herpes virus inhibitors and one or more reverse transcriptase inhibitors
CN104940937A (zh) 2008-05-02 2015-09-30 吉里德科学公司 固体载体颗粒在改善药物制剂加工性中的应用
US20100285122A1 (en) 2009-02-06 2010-11-11 Gilead Sciences, Inc. Tablets for combination therapy
EP2238979A1 (en) 2009-04-06 2010-10-13 LEK Pharmaceuticals d.d. Active pharmaceutical ingredient adsorbed on solid support
TW201728582A (zh) 2016-01-28 2017-08-16 基利科學股份有限公司 結晶型

Also Published As

Publication number Publication date
CN103479584A (zh) 2014-01-01
ZA201008007B (en) 2011-10-26
US10039718B2 (en) 2018-08-07
PL2296633T3 (pl) 2016-03-31
NZ588978A (en) 2013-01-25
MX2010011963A (es) 2010-12-06
PT2296633E (pt) 2015-12-04
IL208614A (en) 2016-09-29
HUE026380T2 (en) 2016-06-28
EA201071173A1 (ru) 2011-08-30
IL208614A0 (en) 2010-12-30
SG10201609006WA (en) 2016-12-29
EA022950B1 (ru) 2016-03-31
KR101659971B1 (ko) 2016-09-26
JP2014012741A (ja) 2014-01-23
WO2009135179A3 (en) 2011-05-19
EA201591353A1 (ru) 2016-01-29
MX342377B (es) 2016-09-27
BRPI0911871A8 (pt) 2018-03-06
AU2009242451C1 (en) 2017-05-18
KR20160114728A (ko) 2016-10-05
KR101784647B1 (ko) 2017-10-11
ECSP10010636A (es) 2011-03-31
DK2296633T3 (en) 2016-01-11
EP2296633B1 (en) 2015-09-30
AU2016250470A1 (en) 2016-11-17
EP3006032A1 (en) 2016-04-13
JP5925171B2 (ja) 2016-05-25
SG190618A1 (en) 2013-06-28
AP3089A (en) 2015-01-31
CN102123700A (zh) 2011-07-13
AU2014221210C1 (en) 2017-06-01
SI2296633T1 (sl) 2015-11-30
HK1153670A1 (zh) 2012-04-05
CN104940937A (zh) 2015-09-30
AU2009242451A1 (en) 2009-11-05
CA2720856A1 (en) 2009-11-05
AU2014221210B2 (en) 2016-08-18
BRPI0911871A2 (pt) 2015-11-17
JP5722213B2 (ja) 2015-05-20
KR20110015581A (ko) 2011-02-16
HRP20151357T1 (hr) 2016-01-29
CO6321225A2 (es) 2011-09-20
ES2553897T3 (es) 2015-12-14
HK1215679A1 (zh) 2016-09-09
US20090324729A1 (en) 2009-12-31
AP2010005429A0 (en) 2010-10-31
IL247417A0 (en) 2016-11-30
EP2296633A2 (en) 2011-03-23
WO2009135179A2 (en) 2009-11-05
JP2011522790A (ja) 2011-08-04
CA2720856C (en) 2016-02-02

Similar Documents

Publication Publication Date Title
CY1117067T1 (el) Η χρηση σωματιδιων στερεων φορεων για τη βελτιωση της επεξεργασιμοτητας φαρμακευτικου παραγοντα
NO2023022I1 (no) cobimetinib, optionally in any form protected by the basic patent, including harmaceutically acceptable salts and sovates thereof, particularly cobimetinib hemifumarate
CY1120796T1 (el) Συνδυασμος φαινοξυβενζαμινης και πολυμυξινης ε για την θεραπευτικη αντιμετωπιση των μικροβιακων λοιμωξεων
PH12015500719A1 (en) Gdf-8-inhibitors
MY160110A (en) Composition comprising tetracyclic compound
BR112015000704A2 (pt) imidazotriazinacarbonitrilas úteis como inibidores de quinase
CY1116645T1 (el) Ενωση-αναστολεας σηματοδοτικου μονοπατιου notch
MX345928B (es) Composiciones terapeuticamente activas y metodos de uso de las mismas.
CY1119007T1 (el) Συνθεσεις και μεθοδοι αγωγης πνευμονικης υπερτασης
MX336381B (es) Boronatos como inhibidores de arginasa.
EA200802390A1 (ru) Конъюгаты аналогов азиридилэпотилона и фармацевтические композиции, содержащие их
EP2613782A4 (en) INDAZOLE DERIVATIVES AS INHIBITORS OF THE ERK PATHWAY
CL2011000589A1 (es) Compuestos derivados de pirrolidin-2-carboxamida, inhibidores de la interaccion p53-mdm2; composicion farmaceutica que los comprende; y su uso en la preparacion de medicamentos utiles para el tratamiento del cancer.
MX354476B (es) Inhibidores de neprilisina.
EA201201263A1 (ru) Фармацевтическая композиция, содержащая этексилат дабигатрана
PT2310356E (pt) Derivados de adamantildiamida e a sua utilização
UA109417C2 (uk) ЗАМІЩЕНІ ПІПЕРИДИНИ, ЯКІ ПІДВИЩУЮТЬ АКТИВНІСТЬ p53, І ЇХ ЗАСТОСУВАННЯ
MY170935A (en) Neprilysin inhibitors
TW200740776A (en) N-phenylbenzotriazolyl c-kit inhibitors
UY30310A1 (es) Derivados 2-azetidinona, sales, solvatos, composiciones farmacéuticas conteniéndolos, procesos de preparacion y aplicaciones
EA201001196A1 (ru) Соединения 4-пиридинона и их применение для лечения рака
MX2015000362A (es) Benzo(b)-azepin-2-onas antiproliferativas.
GB201209587D0 (en) Therapeutic compounds
CY1121655T1 (el) Φαρμακευτικη συνθεση για αναστολεις της αποακετυλασης ιστονης
WO2012168885A3 (en) Bisacodyl and its analogues as drugs for use in the treatment of cancer