JP2007532524A - フッ素化方法 - Google Patents

フッ素化方法 Download PDF

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Publication number
JP2007532524A
JP2007532524A JP2007506837A JP2007506837A JP2007532524A JP 2007532524 A JP2007532524 A JP 2007532524A JP 2007506837 A JP2007506837 A JP 2007506837A JP 2007506837 A JP2007506837 A JP 2007506837A JP 2007532524 A JP2007532524 A JP 2007532524A
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JP
Japan
Prior art keywords
water
alkyl
solvent
ion
fluoride
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Pending
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JP2007506837A
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Japanese (ja)
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JP2007532524A5 (https=
Inventor
ワズワース，ハリー・ジョン
ディヴェニッシュ，トニー
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GE Healthcare Ltd
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GE Healthcare Ltd
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Publication of JP2007532524A publication Critical patent/JP2007532524A/ja
Publication of JP2007532524A5 publication Critical patent/JP2007532524A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/361—Preparation of halogenated hydrocarbons by reactions involving a decrease in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
JP2007506837A 2004-04-08 2005-04-06 フッ素化方法 Pending JP2007532524A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0407952.1A GB0407952D0 (en) 2004-04-08 2004-04-08 Fluoridation method
PCT/GB2005/001344 WO2005097713A1 (en) 2004-04-08 2005-04-06 Fluoridation method

Publications (2)

Publication Number Publication Date
JP2007532524A true JP2007532524A (ja) 2007-11-15
JP2007532524A5 JP2007532524A5 (https=) 2008-05-15

Family

ID=32320540

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007506837A Pending JP2007532524A (ja) 2004-04-08 2005-04-06 フッ素化方法

Country Status (6)

Country Link
US (2) US7935852B2 (https=)
EP (1) EP1732865A1 (https=)
JP (1) JP2007532524A (https=)
CN (1) CN1938244B (https=)
GB (1) GB0407952D0 (https=)
WO (1) WO2005097713A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012506440A (ja) * 2008-10-21 2012-03-15 ヌテク ベンチャーズ 環系芳香族のフッ素化
JP2013507343A (ja) * 2009-10-08 2013-03-04 ジーイー・ヘルスケア・リミテッド 自動化放射合成
JP2017502971A (ja) * 2014-01-03 2017-01-26 ニューテック・ベンチャーズ 放射性ヨウ素化化合物
JP2018536031A (ja) * 2015-11-24 2018-12-06 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル ジアリールヨードニウム塩を使用してヨード−又はアスタトアレーンを合成するための方法
WO2025115709A1 (ja) * 2023-11-28 2025-06-05 東京応化工業株式会社 レジスト組成物、レジストパターン形成方法、及び化合物

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GB0329716D0 (en) * 2003-12-23 2004-01-28 Amersham Plc Radical trap
GB0407952D0 (en) * 2004-04-08 2004-05-12 Amersham Plc Fluoridation method
GB0524851D0 (en) * 2005-12-06 2006-01-11 Ge Healthcare Ltd Radiolabelling method using polymers
CA2670363C (en) * 2007-04-11 2015-07-21 Merck Eprova Ag 18f-labelled folates
BRPI0813671A2 (pt) * 2007-06-20 2014-12-30 Ge Healthcare Ltd Métodos para radiofluoração, para gerar uma imagem de um corpo humano ou animal, e para formação de imagem, composto, e, formulação radiofarmacêutica
RU2474435C2 (ru) * 2007-11-07 2013-02-10 Джи-И Хелткер БВ Стабилизация радиофармацевтических композиций
EP2238074A2 (en) * 2008-01-03 2010-10-13 GE Healthcare UK Limited Fluoride processing method
GB0808986D0 (en) 2008-05-16 2008-06-25 Univ Newcastle Formation of 18F and 19F fluoroarenes bearing reactive functionalities
WO2009149347A1 (en) * 2008-06-05 2009-12-10 President And Fellows Of Harvard College High-valent palladium fluoride complexes and uses thereof
US8674101B2 (en) 2008-07-14 2014-03-18 The Regents Of The University Of California Nucleophilic fluorination of aromatic compounds
WO2010015340A1 (en) * 2008-08-06 2010-02-11 Bayer Schering Pharma Aktiengesellschaft Daa-pyridine as peripheral benzodiazepine receptor ligand for diagnostic imaging and pharmaceutical treatment
GB0814893D0 (en) * 2008-08-14 2008-09-17 Ge Healthcare Ltd Improved fluoridation of iodonium salts
CN101723850B (zh) * 2008-10-10 2012-11-21 北京师范大学 18f标记芳香氨基酸及其制备方法和肿瘤显像应用
CN101723849B (zh) * 2008-10-10 2012-11-21 北京师范大学 18f标记氨基酸类衍生物、其制备方法及其制备报告肿瘤的正电子发射断层显像分子探针中的应用
JP4358892B1 (ja) * 2008-10-16 2009-11-04 エア・ウォーター株式会社 フッ化処理方法およびフッ化処理装置ならびにフッ化処理装置の使用方法
GB0819293D0 (en) * 2008-10-21 2008-11-26 Hammersmith Imanet Ltd Radiofluorination
US9302990B2 (en) 2008-10-21 2016-04-05 Nutech Ventures Fluorination of aromatic ring systems
AU2009316478A1 (en) 2008-11-20 2010-05-27 President And Fellows Of Harvard College Fluorination of organic compounds
EP2385944A4 (en) * 2009-01-09 2013-06-19 Harvard College FLUORINARY COMPOUNDS AND METHOD OF USE THEREOF
US8377704B2 (en) * 2009-10-20 2013-02-19 Nutech Ventures Detection and quantification of anions
WO2011070905A1 (en) 2009-12-11 2011-06-16 Semiconductor Energy Laboratory Co., Ltd. Nonvolatile latch circuit and logic circuit, and semiconductor device using the same
US8546578B2 (en) 2010-02-04 2013-10-01 Nutech Ventures Iodonium Cyclophanes for SECURE arene functionalization
WO2011127345A1 (en) 2010-04-08 2011-10-13 Siemens Medical Solutions Usa, Inc. Synthesis of 18f-labeled tracers in hydrous organic solvents
WO2011141515A1 (en) 2010-05-14 2011-11-17 Bayer Pharma Aktiengesellschaft Diagnostic agents for amyloid beta imaging
GB201105445D0 (en) * 2011-03-31 2011-05-18 Ge Healthcare Ltd Radiolabelled flumazenil derivatives
WO2012142162A2 (en) 2011-04-12 2012-10-18 President And Fellows Of Harvard College Fluorination of organic compounds
US9273083B2 (en) 2012-09-26 2016-03-01 President And Fellows Of Harvard College Nickel fluorinating complexes and uses thereof
US9266847B2 (en) * 2012-11-09 2016-02-23 Vanderbilt University Compounds, probes, and methods of synthesis and methods of imaging COX-2-associated diseases
ITTO20120996A1 (it) * 2012-11-16 2014-05-17 Consiglio Nazionale Ricerche Procedimento e impianto per la produzione di radiotraccianti pet 18f-fluorurati
WO2015058047A2 (en) 2013-10-18 2015-04-23 President And Fellows Of Harvard College Fluorination of organic compounds
US20150367005A1 (en) * 2014-06-19 2015-12-24 The Regents Of The University Of Michigan Method of synthesizing fluorine-18 labeled radiopharmaceuticals in ethanol and water
US11628229B2 (en) * 2017-03-13 2023-04-18 Arizona Board Of Regents On Behalf Of The University Of Arizona Method of synthesizing 18F radiolabeled biomolecular agents
KR102031652B1 (ko) * 2018-01-19 2019-10-14 서울대학교산학협력단 전이체 단백질 과발현 관련 질환의 양성자방출단층촬영 방사성추적자, 형광영상 진단 및 광역학 치료를 위한 전이체 단백질 표적 리간드 및 이의 제조방법
WO2021243337A1 (en) * 2020-05-29 2021-12-02 Fuzionaire. Inc. Methods for rapid formation of chemicals including positron emission tomography biomarkers

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4914430A (https=) * 1972-06-10 1974-02-07
JPS635039A (ja) * 1986-06-26 1988-01-11 Sagami Chem Res Center 芳香族フツ素化合物の製造方法
JPS6445321A (en) * 1987-08-14 1989-02-17 Asahi Glass Co Ltd Fluorination of halogenated organic compound
JPH02218630A (ja) * 1988-11-28 1990-08-31 Dow Chem Co:The ハロフルオロベンゼンの製造法
JPH02218629A (ja) * 1988-11-28 1990-08-31 Dow Chem Co:The 電子吸引置換基を含むジフルオロベンゼンの製造法
JPH0867657A (ja) * 1994-08-31 1996-03-12 Nkk Corp フッ素放射性同位元素標識ｌ−ドーパの製造方法
JPH08325168A (ja) * 1995-03-29 1996-12-10 Nkk Corp フッ素放射性同位元素標識有機化合物の製造方法
JP2005512952A (ja) * 2001-06-29 2005-05-12 アメルシャム・パブリック・リミテッド・カンパニー 固相求核フッ素化
JP2006510707A (ja) * 2002-12-20 2006-03-30 ハマースミス・イメイネット・リミテッド ウラシル及びシトシンの固相フッ素化
JP2007515465A (ja) * 2003-12-23 2007-06-14 ジーイー・ヘルスケア・リミテッド ヨードニウム塩のフッ素化におけるラジカル捕捉剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0407952D0 (en) * 2004-04-08 2004-05-12 Amersham Plc Fluoridation method

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4914430A (https=) * 1972-06-10 1974-02-07
JPS635039A (ja) * 1986-06-26 1988-01-11 Sagami Chem Res Center 芳香族フツ素化合物の製造方法
JPS6445321A (en) * 1987-08-14 1989-02-17 Asahi Glass Co Ltd Fluorination of halogenated organic compound
JPH02218630A (ja) * 1988-11-28 1990-08-31 Dow Chem Co:The ハロフルオロベンゼンの製造法
JPH02218629A (ja) * 1988-11-28 1990-08-31 Dow Chem Co:The 電子吸引置換基を含むジフルオロベンゼンの製造法
JPH0867657A (ja) * 1994-08-31 1996-03-12 Nkk Corp フッ素放射性同位元素標識ｌ−ドーパの製造方法
JPH08325168A (ja) * 1995-03-29 1996-12-10 Nkk Corp フッ素放射性同位元素標識有機化合物の製造方法
JP2005512952A (ja) * 2001-06-29 2005-05-12 アメルシャム・パブリック・リミテッド・カンパニー 固相求核フッ素化
JP2006510707A (ja) * 2002-12-20 2006-03-30 ハマースミス・イメイネット・リミテッド ウラシル及びシトシンの固相フッ素化
JP2007515465A (ja) * 2003-12-23 2007-06-14 ジーイー・ヘルスケア・リミテッド ヨードニウム塩のフッ素化におけるラジカル捕捉剤

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012506440A (ja) * 2008-10-21 2012-03-15 ヌテク ベンチャーズ 環系芳香族のフッ素化
JP2015180668A (ja) * 2008-10-21 2015-10-15 ヌテク ベンチャーズ 環系芳香族のフッ素化
JP2013507343A (ja) * 2009-10-08 2013-03-04 ジーイー・ヘルスケア・リミテッド 自動化放射合成
JP2017502971A (ja) * 2014-01-03 2017-01-26 ニューテック・ベンチャーズ 放射性ヨウ素化化合物
JP2018536031A (ja) * 2015-11-24 2018-12-06 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル ジアリールヨードニウム塩を使用してヨード−又はアスタトアレーンを合成するための方法
WO2025115709A1 (ja) * 2023-11-28 2025-06-05 東京応化工業株式会社 レジスト組成物、レジストパターン形成方法、及び化合物

Also Published As

Publication number Publication date
CN1938244A (zh) 2007-03-28
EP1732865A1 (en) 2006-12-20
US20070092441A1 (en) 2007-04-26
US7935852B2 (en) 2011-05-03
US20110196149A1 (en) 2011-08-11
CN1938244B (zh) 2013-03-13
WO2005097713A1 (en) 2005-10-20
GB0407952D0 (en) 2004-05-12

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