JP2007532524A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007532524A5 JP2007532524A5 JP2007506837A JP2007506837A JP2007532524A5 JP 2007532524 A5 JP2007532524 A5 JP 2007532524A5 JP 2007506837 A JP2007506837 A JP 2007506837A JP 2007506837 A JP2007506837 A JP 2007506837A JP 2007532524 A5 JP2007532524 A5 JP 2007532524A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- ion
- water
- aromatic
- fluorine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003118 aryl group Chemical group 0.000 claims 12
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- -1 trifluoromethanesulfonate ion Chemical class 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 239000002904 solvent Substances 0.000 claims 6
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 4
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical class I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 3
- 125000004008 6 membered carbocyclic group Chemical group 0.000 claims 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 2
- 230000002950 deficient Effects 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 239000007810 chemical reaction solvent Substances 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 238000004255 ion exchange chromatography Methods 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0407952.1A GB0407952D0 (en) | 2004-04-08 | 2004-04-08 | Fluoridation method |
| PCT/GB2005/001344 WO2005097713A1 (en) | 2004-04-08 | 2005-04-06 | Fluoridation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007532524A JP2007532524A (ja) | 2007-11-15 |
| JP2007532524A5 true JP2007532524A5 (https=) | 2008-05-15 |
Family
ID=32320540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007506837A Pending JP2007532524A (ja) | 2004-04-08 | 2005-04-06 | フッ素化方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7935852B2 (https=) |
| EP (1) | EP1732865A1 (https=) |
| JP (1) | JP2007532524A (https=) |
| CN (1) | CN1938244B (https=) |
| GB (1) | GB0407952D0 (https=) |
| WO (1) | WO2005097713A1 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0329716D0 (en) * | 2003-12-23 | 2004-01-28 | Amersham Plc | Radical trap |
| GB0407952D0 (en) * | 2004-04-08 | 2004-05-12 | Amersham Plc | Fluoridation method |
| GB0524851D0 (en) * | 2005-12-06 | 2006-01-11 | Ge Healthcare Ltd | Radiolabelling method using polymers |
| CA2670363C (en) * | 2007-04-11 | 2015-07-21 | Merck Eprova Ag | 18f-labelled folates |
| BRPI0813671A2 (pt) * | 2007-06-20 | 2014-12-30 | Ge Healthcare Ltd | Métodos para radiofluoração, para gerar uma imagem de um corpo humano ou animal, e para formação de imagem, composto, e, formulação radiofarmacêutica |
| RU2474435C2 (ru) * | 2007-11-07 | 2013-02-10 | Джи-И Хелткер БВ | Стабилизация радиофармацевтических композиций |
| EP2238074A2 (en) * | 2008-01-03 | 2010-10-13 | GE Healthcare UK Limited | Fluoride processing method |
| GB0808986D0 (en) | 2008-05-16 | 2008-06-25 | Univ Newcastle | Formation of 18F and 19F fluoroarenes bearing reactive functionalities |
| WO2009149347A1 (en) * | 2008-06-05 | 2009-12-10 | President And Fellows Of Harvard College | High-valent palladium fluoride complexes and uses thereof |
| US8674101B2 (en) | 2008-07-14 | 2014-03-18 | The Regents Of The University Of California | Nucleophilic fluorination of aromatic compounds |
| WO2010015340A1 (en) * | 2008-08-06 | 2010-02-11 | Bayer Schering Pharma Aktiengesellschaft | Daa-pyridine as peripheral benzodiazepine receptor ligand for diagnostic imaging and pharmaceutical treatment |
| GB0814893D0 (en) * | 2008-08-14 | 2008-09-17 | Ge Healthcare Ltd | Improved fluoridation of iodonium salts |
| CN101723850B (zh) * | 2008-10-10 | 2012-11-21 | 北京师范大学 | 18f标记芳香氨基酸及其制备方法和肿瘤显像应用 |
| CN101723849B (zh) * | 2008-10-10 | 2012-11-21 | 北京师范大学 | 18f标记氨基酸类衍生物、其制备方法及其制备报告肿瘤的正电子发射断层显像分子探针中的应用 |
| JP4358892B1 (ja) * | 2008-10-16 | 2009-11-04 | エア・ウォーター株式会社 | フッ化処理方法およびフッ化処理装置ならびにフッ化処理装置の使用方法 |
| GB0819293D0 (en) * | 2008-10-21 | 2008-11-26 | Hammersmith Imanet Ltd | Radiofluorination |
| EP2537826B1 (en) | 2008-10-21 | 2017-03-08 | Nutech Ventures, Inc. | Fluorination of aromatic ring systems |
| US9302990B2 (en) | 2008-10-21 | 2016-04-05 | Nutech Ventures | Fluorination of aromatic ring systems |
| AU2009316478A1 (en) | 2008-11-20 | 2010-05-27 | President And Fellows Of Harvard College | Fluorination of organic compounds |
| EP2385944A4 (en) * | 2009-01-09 | 2013-06-19 | Harvard College | FLUORINARY COMPOUNDS AND METHOD OF USE THEREOF |
| GB0917611D0 (en) | 2009-10-08 | 2009-11-25 | Ge Healthcare Ltd | Automated radiosynthesis |
| US8377704B2 (en) * | 2009-10-20 | 2013-02-19 | Nutech Ventures | Detection and quantification of anions |
| WO2011070905A1 (en) | 2009-12-11 | 2011-06-16 | Semiconductor Energy Laboratory Co., Ltd. | Nonvolatile latch circuit and logic circuit, and semiconductor device using the same |
| US8546578B2 (en) | 2010-02-04 | 2013-10-01 | Nutech Ventures | Iodonium Cyclophanes for SECURE arene functionalization |
| WO2011127345A1 (en) | 2010-04-08 | 2011-10-13 | Siemens Medical Solutions Usa, Inc. | Synthesis of 18f-labeled tracers in hydrous organic solvents |
| WO2011141515A1 (en) | 2010-05-14 | 2011-11-17 | Bayer Pharma Aktiengesellschaft | Diagnostic agents for amyloid beta imaging |
| GB201105445D0 (en) * | 2011-03-31 | 2011-05-18 | Ge Healthcare Ltd | Radiolabelled flumazenil derivatives |
| WO2012142162A2 (en) | 2011-04-12 | 2012-10-18 | President And Fellows Of Harvard College | Fluorination of organic compounds |
| US9273083B2 (en) | 2012-09-26 | 2016-03-01 | President And Fellows Of Harvard College | Nickel fluorinating complexes and uses thereof |
| US9266847B2 (en) * | 2012-11-09 | 2016-02-23 | Vanderbilt University | Compounds, probes, and methods of synthesis and methods of imaging COX-2-associated diseases |
| ITTO20120996A1 (it) * | 2012-11-16 | 2014-05-17 | Consiglio Nazionale Ricerche | Procedimento e impianto per la produzione di radiotraccianti pet 18f-fluorurati |
| WO2015058047A2 (en) | 2013-10-18 | 2015-04-23 | President And Fellows Of Harvard College | Fluorination of organic compounds |
| CA2935856A1 (en) | 2014-01-03 | 2015-10-01 | Nutech Ventures | Radioiodinated compounds |
| US20150367005A1 (en) * | 2014-06-19 | 2015-12-24 | The Regents Of The University Of Michigan | Method of synthesizing fluorine-18 labeled radiopharmaceuticals in ethanol and water |
| US10703708B2 (en) | 2015-11-24 | 2020-07-07 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method for synthesizing iodo- or astatoarenes using diaryliodonium salts |
| US11628229B2 (en) * | 2017-03-13 | 2023-04-18 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Method of synthesizing 18F radiolabeled biomolecular agents |
| KR102031652B1 (ko) * | 2018-01-19 | 2019-10-14 | 서울대학교산학협력단 | 전이체 단백질 과발현 관련 질환의 양성자방출단층촬영 방사성추적자, 형광영상 진단 및 광역학 치료를 위한 전이체 단백질 표적 리간드 및 이의 제조방법 |
| WO2021243337A1 (en) * | 2020-05-29 | 2021-12-02 | Fuzionaire. Inc. | Methods for rapid formation of chemicals including positron emission tomography biomarkers |
| WO2025115709A1 (ja) * | 2023-11-28 | 2025-06-05 | 東京応化工業株式会社 | レジスト組成物、レジストパターン形成方法、及び化合物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4914430A (https=) * | 1972-06-10 | 1974-02-07 | ||
| JPH0611718B2 (ja) * | 1986-06-26 | 1994-02-16 | 財団法人相模中央化学研究所 | 芳香族フツ素化合物の製造方法 |
| JPS6445321A (en) * | 1987-08-14 | 1989-02-17 | Asahi Glass Co Ltd | Fluorination of halogenated organic compound |
| US4937397A (en) * | 1988-11-28 | 1990-06-26 | The Dow Chemical Company | Preparation of halofluorobenzenes |
| DE68917567T2 (de) * | 1988-11-28 | 1994-12-22 | Dowelanco | Verfahren zur Herstellung von Difluorbenzolen mit elektronenabziehenden Substituenten. |
| JP3165775B2 (ja) * | 1994-08-31 | 2001-05-14 | 日本鋼管株式会社 | フッ素放射性同位元素標識ｌ−ドーパの製造方法 |
| JPH08325168A (ja) * | 1995-03-29 | 1996-12-10 | Nkk Corp | フッ素放射性同位元素標識有機化合物の製造方法 |
| GB0115927D0 (en) * | 2001-06-29 | 2001-08-22 | Nycomed Amersham Plc | Solid-phase nucleophilic fluorination |
| GB0229683D0 (en) * | 2002-12-20 | 2003-01-29 | Imaging Res Solutions Ltd | Preparation of radiopharmaceuticals |
| GB0329716D0 (en) * | 2003-12-23 | 2004-01-28 | Amersham Plc | Radical trap |
| GB0407952D0 (en) * | 2004-04-08 | 2004-05-12 | Amersham Plc | Fluoridation method |
-
2004
- 2004-04-08 GB GBGB0407952.1A patent/GB0407952D0/en not_active Ceased
-
2005
- 2005-04-06 CN CN200580010361.3A patent/CN1938244B/zh not_active Expired - Fee Related
- 2005-04-06 US US10/559,878 patent/US7935852B2/en not_active Expired - Fee Related
- 2005-04-06 EP EP05732929A patent/EP1732865A1/en not_active Withdrawn
- 2005-04-06 JP JP2007506837A patent/JP2007532524A/ja active Pending
- 2005-04-06 WO PCT/GB2005/001344 patent/WO2005097713A1/en not_active Ceased
-
2011
- 2011-04-18 US US13/088,461 patent/US20110196149A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007532524A5 (https=) | ||
| JP2007515465A5 (https=) | ||
| Wiehn et al. | Electrophilic trifluoromethylation of arenes and N-heteroarenes using hypervalent iodine reagents | |
| Gung et al. | Quantitative study of interactions between oxygen lone pair and aromatic rings: Substituent effect and the importance of closeness of contact | |
| ES2602972T3 (es) | Derivados de indazol para su uso en el tratamiento de infección por virus de la gripe | |
| CN1938244B (zh) | 氟化方法 | |
| EP3284736B1 (en) | Fluorination of aromatic ring systems | |
| WO2017069834A2 (en) | Organic synthesis applications of non-aqueous fluoride salt solutions | |
| CA2840608C (en) | Fluorination of aromatic ring systems | |
| JP2010513494A5 (https=) | ||
| EP3715342B1 (en) | Fluorosulfonyl-containing compound, intermediate thereof, preparation method therefor and use thereof | |
| ES2901984T3 (es) | Procedimiento para fluorar compuestos | |
| BR112015019268B1 (pt) | Processo de fabricação de vortioxetina ou seus sais farmaceuticamente aceitáveis | |
| JP2017533203A5 (https=) | ||
| Karabiyikoglu et al. | Enantiomerically enriched tetrahydropyridine allyl chlorides | |
| RU2014111249A (ru) | Способ синтеза 18f-меченных биомолекул | |
| JP2011530572A5 (https=) | ||
| CN112778190B (zh) | 一种丁二酰亚胺型三氟甲硫化试剂的合成方法 | |
| ES2720234T3 (es) | Procedimiento de fluoración de compuestos | |
| CN110621658B (zh) | 五氟硫烷基芳香族化合物的制造方法 | |
| JP6240364B2 (ja) | 均一系触媒作用によりフルオロ、クロロおよびフルオロクロロアルキル化化合物を調製するための方法 | |
| CN106188046B (zh) | 一种碘促进的3-芳硫基咪唑并[1,5-a]N-杂环化合物的合成方法 | |
| CN109134316B (zh) | 一种氟烷基磺酰氟类化合物及其中间体、制备方法和应用 | |
| JP2012522051A (ja) | 放射性標識方法 | |
| JP2006169158A (ja) | 光学活性アミノ酸類の製造方法 |