PT2146944E - Processo para a preparação de folatos marcados com 18f - Google Patents

Processo para a preparação de folatos marcados com 18f Download PDF

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Publication number
PT2146944E
PT2146944E PT87361176T PT08736117T PT2146944E PT 2146944 E PT2146944 E PT 2146944E PT 87361176 T PT87361176 T PT 87361176T PT 08736117 T PT08736117 T PT 08736117T PT 2146944 E PT2146944 E PT 2146944E
Authority
PT
Portugal
Prior art keywords
preparation
folates
labelled
labelled folates
Prior art date
Application number
PT87361176T
Other languages
English (en)
Inventor
Rudolf Moser
Simon Mensah Ametamey
Tobias Ludwig Ross
Phoebe Lam
Viola Groehn
Original Assignee
Merck & Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Cie filed Critical Merck & Cie
Publication of PT2146944E publication Critical patent/PT2146944E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT87361176T 2007-04-11 2008-04-11 Processo para a preparação de folatos marcados com 18f PT2146944E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07105976 2007-04-11

Publications (1)

Publication Number Publication Date
PT2146944E true PT2146944E (pt) 2014-03-11

Family

ID=39620260

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87361176T PT2146944E (pt) 2007-04-11 2008-04-11 Processo para a preparação de folatos marcados com 18f

Country Status (15)

Country Link
US (2) US20100111864A1 (pt)
EP (1) EP2146944B1 (pt)
JP (1) JP2010523624A (pt)
KR (2) KR101781461B1 (pt)
CN (2) CN107573347A (pt)
AU (1) AU2008237930B2 (pt)
CA (1) CA2670363C (pt)
DK (1) DK2146944T3 (pt)
EA (1) EA200901347A1 (pt)
ES (1) ES2449774T3 (pt)
IL (1) IL201248A (pt)
PL (1) PL2146944T3 (pt)
PT (1) PT2146944E (pt)
WO (1) WO2008125613A1 (pt)
ZA (1) ZA200903486B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101756793B1 (ko) 2008-10-10 2017-07-11 메르크 앤드 씨에 Ｐｅｔ 방사성트레이서로서의 18ｆ-표지화된 엽산
CN103608337B (zh) * 2011-05-13 2016-07-06 Futurechem株式会社 Pet放射性医疗用品的18f-标记前体及其制备方法
PL2776382T3 (pl) 2011-08-22 2019-05-31 Merck & Cie 18f-sacharydo-foliany
WO2013167653A1 (en) 2012-05-08 2013-11-14 Merck & Cie 18f-labelled folate/antifolate analogues
US10003388B2 (en) 2012-09-04 2018-06-19 Ntt Docomo, Inc. Method and apparatus for internal relative transceiver calibration
US10300154B2 (en) * 2014-09-17 2019-05-28 David R Elmaleh Anticoagulant derivatives for cardiovascular imaging
WO2018029644A2 (en) 2016-08-12 2018-02-15 Telefonaktiebolaget Lm Ericsson (Publ) Progressive advanced csi feedback
WO2018029646A1 (en) 2016-08-12 2018-02-15 Telefonaktiebolaget Lm Ericsson (Publ) Layer 1 and layer 2 channel state information rich reporting mechanisms
US10939389B2 (en) 2016-08-12 2021-03-02 Telefonaktiebolaget Lm Ericsson (Publ) Configurable codebook for advanced CSI feedback overhead reduction
PT3754863T (pt) 2016-08-12 2022-12-09 Ericsson Telefon Ab L M Livros de códigos de múltiplo feixe com sobrecarga mais otimizada
KR102031652B1 (ko) * 2018-01-19 2019-10-14 서울대학교산학협력단 전이체 단백질 과발현 관련 질환의 양성자방출단층촬영 방사성추적자, 형광영상 진단 및 광역학 치료를 위한 전이체 단백질 표적 리간드 및 이의 제조방법

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1458978A (en) * 1973-12-11 1976-12-22 Radiochemical Centre Ltd Saturation analysis
US4202976A (en) * 1973-09-11 1980-05-13 Bayly Russell J Selenium-75 labelled derivatives of folates
US3989812A (en) * 1974-08-09 1976-11-02 Smithkline Instruments, Inc. Folic acid derivatives and use in radio-assay
GB1501119A (en) 1974-12-20 1978-02-15 Radiochemical Centre Ltd Folate compounds
US4276280A (en) * 1976-09-29 1981-06-30 Becton, Dickinson And Company Radiolabeled derivatives of folic acid
US4298735A (en) * 1979-04-30 1981-11-03 Union Carbide Corporation Folic acid derivatives
US4337339A (en) * 1979-04-30 1982-06-29 Baker Instruments Corp. Process for preparation of folic acid derivatives
US4314988A (en) * 1979-10-31 1982-02-09 Baker Instruments Corp. Folic acid derivatives and process for preparation
JPS6144890A (ja) 1984-08-08 1986-03-04 Shionogi & Co Ltd 含フツ素メトトレキサ−ト誘導体
US4628090A (en) * 1984-08-21 1986-12-09 Rensselaer Polytechnic Institute Fluorine-containing antifolates incapable of polyglutanayte formation related compounds
US4584375A (en) * 1984-08-21 1986-04-22 Rensselaer Polytechnic Institute Fluorine-containing antifolates incapable of polyglutamate formation
US5066828A (en) 1990-04-12 1991-11-19 Merrell Dow Pharmaceuticals Inc. Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
US5286726A (en) * 1990-04-12 1994-02-15 The Regents Of The University Of Michigan Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
CA2156657C (en) 1994-11-02 1999-06-15 Richard G. Beauclerc Gravity wedge for a slackless railcar connector assembly
US6291673B1 (en) 1997-10-17 2001-09-18 Purdue Research Foundation Folic acid derivatives
US6093382A (en) * 1998-05-16 2000-07-25 Bracco Research Usa Inc. Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
ATE427948T1 (de) 2001-04-24 2009-04-15 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
CN100528241C (zh) 2002-05-06 2009-08-19 恩多塞特公司 维生素-定向的显象剂
GB0407952D0 (en) * 2004-04-08 2004-05-12 Amersham Plc Fluoridation method
JP2008525485A (ja) 2004-12-23 2008-07-17 パーデュー・リサーチ・ファウンデーション ポジトロン放射断層画像法
EP1863816B1 (en) 2005-03-16 2014-06-25 Endocyte, Inc. Synthesis and purification of pteroic acid and conjugates thereof
EP1875240A2 (en) * 2005-04-27 2008-01-09 Siemens Medical Solutions USA, Inc. The preparation of molecular imaging probes using click chemistry
EP1904183B1 (en) 2005-07-05 2014-10-15 Purdue Research Foundation Pharmaceutical composition for the treatment of osteoarthritis
WO2007022493A2 (en) 2005-08-19 2007-02-22 Endocyte, Inc. Ligand conjugates of vinca alkaloids, analogs, and derivatives
EP1948241B1 (en) 2005-08-19 2014-03-05 Endocyte, Inc. Multi-drug ligand conjugates
EP1940473A2 (en) 2005-09-23 2008-07-09 Purdue Research Foundation Multiphoton in vivo flow cytometry method and device
WO2008054404A2 (en) 2005-11-15 2008-05-08 California Institute Of Technology Resonant vibratory device having high quality factor and methods of fabricating same
WO2007139815A2 (en) 2006-05-23 2007-12-06 Purdue Research Foundation Imaging and therapeutic method using progenitor cells
US8586595B2 (en) * 2007-02-07 2013-11-19 Purdue Research Foundation Positron emission tomography imaging method
PT2144912E (pt) * 2007-04-11 2013-02-01 Merck & Cie Folatos marcados com 18f
CA2670379C (en) * 2007-04-11 2015-06-23 Merck Eprova Ag 18f-labelled folates
KR101756793B1 (ko) * 2008-10-10 2017-07-11 메르크 앤드 씨에 Ｐｅｔ 방사성트레이서로서의 18ｆ-표지화된 엽산

Also Published As

Publication number Publication date
IL201248A (en) 2016-02-29
AU2008237930B2 (en) 2014-03-27
ES2449774T3 (es) 2014-03-21
CA2670363C (en) 2015-07-21
AU2008237930A1 (en) 2008-10-23
CA2670363A1 (en) 2008-10-23
JP2010523624A (ja) 2010-07-15
DK2146944T3 (da) 2014-02-03
KR20090130111A (ko) 2009-12-17
WO2008125613A1 (en) 2008-10-23
US10377756B2 (en) 2019-08-13
EA200901347A1 (ru) 2010-04-30
KR101781461B1 (ko) 2017-10-23
EP2146944B1 (en) 2014-01-22
KR20160074683A (ko) 2016-06-28
US20100111864A1 (en) 2010-05-06
CN107573347A (zh) 2018-01-12
US20150315189A1 (en) 2015-11-05
ZA200903486B (en) 2010-01-27
PL2146944T3 (pl) 2014-05-30
EP2146944A1 (en) 2010-01-27
CN101646639A (zh) 2010-02-10
IL201248A0 (en) 2010-05-31

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