JP2007531756A5 - - Google Patents

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Publication number
JP2007531756A5
JP2007531756A5 JP2007506507A JP2007506507A JP2007531756A5 JP 2007531756 A5 JP2007531756 A5 JP 2007531756A5 JP 2007506507 A JP2007506507 A JP 2007506507A JP 2007506507 A JP2007506507 A JP 2007506507A JP 2007531756 A5 JP2007531756 A5 JP 2007531756A5
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hydroxycodeinone
free base
oxycodone
dihydrocodeinone
dihydroxy
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JP2007506507A
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JP2007531756A (ja
JP4912294B2 (ja
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Priority claimed from PCT/US2005/010666 external-priority patent/WO2005097801A1/en
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１４−ヒドロキシコデイノンを生じるためのテバインの酸化の間、８，１４−ジヒドロキシ−７，８−ジヒドロコデイノンを包含するいくつかの過酸化生成物が形成される。１４−ヒドロキシコデイノンからのオキシコドン遊離塩基の生成において、８，１４−ジヒドロキシ−７，８−ジヒドロコデイノンが、このプロセスを通って運ばれる。オキシコドン遊離塩基のオキシコドンハイドロクロライドへの転化の間、その不純物が、酸触媒された脱水を受け、１４−ヒドロキシコデイノンに転化される。このようにして、１４−ヒドロキシコデイノンが、最終オキシコドンハイドロクロライド組成物中に存在する。
実施例３において、２７．８３ｇのオキシコドン遊離塩基のウォーターウェット（２４．５７ｇ乾燥ベース、０．０７７９モル、約３０００ｐｐｍ １４−ヒドロキシコデイノン）、３９．８ｇの脱イオン水、８１．９ｇのイソプロパノール、０．４９ｇ ５％Ｐｄ／Ｃ触媒の５０％ウォーターウェット（ジョンソン・マッセイ８７Ｌ型）、および濃ＨＣｌ（１１．３ｇ、０．１１７モル、３７．７％ＨＣｌアッセイを基準にして１．５０当量）が、５００ｍＬパーシェイカービンにおいて組合わされた。
JP2007506507A 2004-03-30 2005-03-30 ２５ｐｐｍ未満の１４−ヒドロキシコデイノンを有するオキシコドンハイドロクロライドの調製方法 Active JP4912294B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US55749204P 2004-03-30 2004-03-30
US60/557,492 2004-03-30
US60153404P 2004-08-13 2004-08-13
US60/601,534 2004-08-13
US62007204P 2004-10-18 2004-10-18
US60/620,072 2004-10-18
US64862505P 2005-01-31 2005-01-31
US60/648,625 2005-01-31
US65177805P 2005-02-10 2005-02-10
US60/651,778 2005-02-10
PCT/US2005/010666 WO2005097801A1 (en) 2004-03-30 2005-03-30 Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone

Related Child Applications (2)

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JP2011058728A Division JP5118223B2 (ja) 2004-03-30 2011-03-17 ２５ｐｐｍ未満の１４−ヒドロキシコデイノンを有するオキシコドンハイドロクロライドの調製方法
JP2011251260A Division JP5378486B2 (ja) 2004-03-30 2011-11-17 ２５ｐｐｍ未満の１４−ヒドロキシコデイノンを有するオキシコドンハイドロクロライドの調製方法

Publications (3)

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JP2007531756A JP2007531756A (ja) 2007-11-08
JP2007531756A5 true JP2007531756A5 (ja) 2012-01-12
JP4912294B2 JP4912294B2 (ja) 2012-04-11

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JP2007506507A Active JP4912294B2 (ja) 2004-03-30 2005-03-30 ２５ｐｐｍ未満の１４−ヒドロキシコデイノンを有するオキシコドンハイドロクロライドの調製方法
JP2011058728A Active JP5118223B2 (ja) 2004-03-30 2011-03-17 ２５ｐｐｍ未満の１４−ヒドロキシコデイノンを有するオキシコドンハイドロクロライドの調製方法
JP2011251260A Active JP5378486B2 (ja) 2004-03-30 2011-11-17 ２５ｐｐｍ未満の１４−ヒドロキシコデイノンを有するオキシコドンハイドロクロライドの調製方法
JP2012123160A Active JP5543991B2 (ja) 2004-03-30 2012-05-30 ２５ｐｐｍ未満の１４−ヒドロキシコデイノンを有するオキシコドンハイドロクロライドの調製方法
JP2014045713A Pending JP2014139205A (ja) 2004-03-30 2014-03-07 ２５ｐｐｍ未満の１４−ヒドロキシコデイノンを有するオキシコドンハイドロクロライドの調製方法
JP2015108759A Pending JP2015187134A (ja) 2004-03-30 2015-05-28 ２５ｐｐｍ未満の１４−ヒドロキシコデイノンを有するオキシコドンハイドロクロライドの調製方法
JP2017043530A Active JP6503392B2 (ja) 2004-03-30 2017-03-08 ２５ｐｐｍ未満の１４−ヒドロキシコデイノンを有するオキシコドンハイドロクロライドの調製方法
JP2018144003A Pending JP2018184462A (ja) 2004-03-30 2018-07-31 ２５ｐｐｍ未満の１４−ヒドロキシコデイノンを有するオキシコドンハイドロクロライドの調製方法

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JP2011058728A Active JP5118223B2 (ja) 2004-03-30 2011-03-17 ２５ｐｐｍ未満の１４−ヒドロキシコデイノンを有するオキシコドンハイドロクロライドの調製方法
JP2011251260A Active JP5378486B2 (ja) 2004-03-30 2011-11-17 ２５ｐｐｍ未満の１４−ヒドロキシコデイノンを有するオキシコドンハイドロクロライドの調製方法
JP2012123160A Active JP5543991B2 (ja) 2004-03-30 2012-05-30 ２５ｐｐｍ未満の１４−ヒドロキシコデイノンを有するオキシコドンハイドロクロライドの調製方法
JP2014045713A Pending JP2014139205A (ja) 2004-03-30 2014-03-07 ２５ｐｐｍ未満の１４−ヒドロキシコデイノンを有するオキシコドンハイドロクロライドの調製方法
JP2015108759A Pending JP2015187134A (ja) 2004-03-30 2015-05-28 ２５ｐｐｍ未満の１４−ヒドロキシコデイノンを有するオキシコドンハイドロクロライドの調製方法
JP2017043530A Active JP6503392B2 (ja) 2004-03-30 2017-03-08 ２５ｐｐｍ未満の１４−ヒドロキシコデイノンを有するオキシコドンハイドロクロライドの調製方法
JP2018144003A Pending JP2018184462A (ja) 2004-03-30 2018-07-31 ２５ｐｐｍ未満の１４−ヒドロキシコデイノンを有するオキシコドンハイドロクロライドの調製方法

Country Status (39)

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US (35) US7129248B2 (ja)
EP (7) EP2314589B1 (ja)
JP (8) JP4912294B2 (ja)
KR (12) KR20140021716A (ja)
CN (5) CN102838607B (ja)
AP (1) AP2232A (ja)
AR (1) AR049012A1 (ja)
AT (2) ATE501150T1 (ja)
AU (2) AU2005230826C1 (ja)
BR (1) BRPI0508758B8 (ja)
CA (3) CA2774121C (ja)
CR (2) CR8593A (ja)
CY (5) CY1111487T1 (ja)
DE (2) DE602005026786D1 (ja)
DK (6) DK2316837T3 (ja)
EA (1) EA013208B1 (ja)
EC (1) ECSP066953A (ja)
ES (6) ES2585576T3 (ja)
FI (1) FI7843U1 (ja)
HK (3) HK1098745A1 (ja)
HR (5) HRP20110425T4 (ja)
HU (3) HUE036451T2 (ja)
IL (8) IL178038A (ja)
LT (2) LT2316837T (ja)
MA (1) MA28492B1 (ja)
ME (4) ME01299B (ja)
MX (2) MX363228B (ja)
MY (3) MY143205A (ja)
NO (1) NO337669B1 (ja)
NZ (3) NZ602862A (ja)
PE (1) PE20050880A1 (ja)
PL (5) PL2305683T3 (ja)
PT (5) PT2316837T (ja)
RS (5) RS54941B1 (ja)
SG (3) SG170735A1 (ja)
SI (5) SI2426132T1 (ja)
TW (3) TWI365880B (ja)
WO (1) WO2005097801A1 (ja)
ZA (1) ZA200607181B (ja)

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