ATE448231T1 - Verfahren zur herstellung von morphinan-6-on- produkten mit geringen konzentrationen von alpha-,beta-ungesättigten ketonverbindungen - Google Patents

Verfahren zur herstellung von morphinan-6-on- produkten mit geringen konzentrationen von alpha-,beta-ungesättigten ketonverbindungen

Info

Publication number
ATE448231T1
ATE448231T1 AT07751984T AT07751984T ATE448231T1 AT E448231 T1 ATE448231 T1 AT E448231T1 AT 07751984 T AT07751984 T AT 07751984T AT 07751984 T AT07751984 T AT 07751984T AT E448231 T1 ATE448231 T1 AT E448231T1
Authority
AT
Austria
Prior art keywords
products
alpha
morphinan
beta
unsaturated ketone
Prior art date
Application number
AT07751984T
Other languages
English (en)
Inventor
Henry Buehler
William Dummitt
Anthony Mannino
Dennis Aubuchon
Hong Gu
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38326629&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE448231(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ATE448231T1 publication Critical patent/ATE448231T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT07751984T 2006-03-02 2007-03-02 Verfahren zur herstellung von morphinan-6-on- produkten mit geringen konzentrationen von alpha-,beta-ungesättigten ketonverbindungen ATE448231T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77825806P 2006-03-02 2006-03-02
PCT/US2007/005256 WO2007103105A2 (en) 2006-03-02 2007-03-02 Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds

Publications (1)

Publication Number Publication Date
ATE448231T1 true ATE448231T1 (de) 2009-11-15

Family

ID=38326629

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07751984T ATE448231T1 (de) 2006-03-02 2007-03-02 Verfahren zur herstellung von morphinan-6-on- produkten mit geringen konzentrationen von alpha-,beta-ungesättigten ketonverbindungen

Country Status (10)

Country Link
US (8) US8871779B2 (de)
EP (1) EP1994034B1 (de)
JP (2) JP5695296B2 (de)
CN (1) CN101395159A (de)
AT (1) ATE448231T1 (de)
AU (1) AU2007224221B2 (de)
CA (1) CA2644095A1 (de)
DE (1) DE602007003197D1 (de)
MX (1) MX2008010921A (de)
WO (1) WO2007103105A2 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
TWI365880B (en) 2004-03-30 2012-06-11 Euro Celtique Sa Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
CN101346384B (zh) * 2005-11-22 2012-07-04 控制化学品公司 用于降低羟考酮和其它组分中杂质迈克尔受体水平的方法
US8871779B2 (en) * 2006-03-02 2014-10-28 Mallinckrodt Llc Process for preparing morphinan-6-one products with low levels of α,β-unsaturated ketone compounds
CA2674915C (en) * 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US20080125592A1 (en) * 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
DK2073636T3 (da) * 2006-10-17 2012-11-19 Penick Corp Fremgangsmåde til fremstilling af oxymorphon
US7906647B2 (en) 2006-12-04 2011-03-15 Noramco, Inc. Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone
US7875719B2 (en) 2006-12-04 2011-01-25 Cox D Phillip Process for reducing impurities in oxycodone base
GB0624880D0 (en) * 2006-12-14 2007-01-24 Johnson Matthey Plc Improved method for making analgesics
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
FR2923484B1 (fr) * 2007-11-09 2012-11-09 Sanofi Aventis Procede de preparation de composes morphiniques
CA2713128C (en) 2008-01-25 2016-04-05 Gruenenthal Gmbh Pharmaceutical dosage form
PT2273983T (pt) 2008-05-09 2016-10-28 Gruenenthal Gmbh Processo para a preparação de uma formulação em pó intermediária e uma forma de dosagem sólida final sob utilização de uma etapa de congelamento por atomização
PE20120572A1 (es) 2009-07-22 2012-06-06 Gruenenthal Chemie Forma de dosificacion de oxidacion estabilizada resistente a la manipulacion
BR112012001547A2 (pt) 2009-07-22 2016-03-08 Gruenenthal Gmbh forma de dosagem farmacêutica extrusada por fusão a quente
CA2804101C (en) * 2010-07-02 2021-01-19 Johnson Matthey Public Limited Company Process for the synthesis and purification of oxycodone
AU2011297892B2 (en) 2010-09-02 2014-05-29 Grunenthal Gmbh Tamper resistant dosage form comprising an anionic polymer
MX2013002377A (es) 2010-09-02 2013-04-29 Gruenenthal Gmbh Forma de dosificacion resistente a manipulacion que comprende una sal inorganica.
MX348054B (es) 2011-07-29 2017-05-25 Gruenenthal Gmbh Tableta a prueba de alteracion que proporciona liberacion inmediata del farmaco.
NO2736495T3 (de) 2011-07-29 2018-01-20
TWI560170B (en) * 2011-12-06 2016-12-01 Lundbeck & Co As H Process for recovery of nalmefene hydrochloride
CA2864949A1 (en) 2012-02-28 2013-09-06 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
PT2838512T (pt) 2012-04-18 2018-11-09 Gruenenthal Gmbh Forma farmacêutica resistente à adulteração e resistente à libertação inesperada de alta quantidade (dose-dumping)
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
KR101946104B1 (ko) 2012-07-16 2019-02-08 로드스 테크놀로지즈 개선된 오피오이드 합성을 위한 방법
WO2014191397A1 (en) 2013-05-29 2014-12-04 Grünenthal GmbH Tamper-resistant dosage form containing one or more particles
JP6466417B2 (ja) 2013-05-29 2019-02-06 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 二峰性放出プロファイルを有する改変防止（ｔａｍｐｅｒ−ｒｅｓｉｓｔａｎｔ）剤形
BR112016000194A8 (pt) 2013-07-12 2019-12-31 Gruenenthal Gmbh forma de dosagem resistente à violação contendo o polímero de acetato de etileno-vinila
GB201313211D0 (en) * 2013-07-24 2013-09-04 Cambrex Karlskoga Ab New process
GB201313915D0 (en) * 2013-08-02 2013-09-18 Johnson Matthey Plc Process
BR112016002079A2 (pt) 2013-08-02 2017-09-05 Johnson Matthey Plc Processo para preparação de um aditivo ácido de oximorfona, solução aquosa de aditivo ácido de oximorfona, aditivo ácido de oximorfona sólido, e, alcaloide de oximorfona sólido
MX371372B (es) 2013-11-26 2020-01-28 Gruenenthal Gmbh Preparacion de una composicion farmaceutica en polvo por medio de criomolienda.
US9932348B2 (en) 2014-01-15 2018-04-03 Rhodes Technologies Process for improved oxycodone synthesis
CN106572980A (zh) 2014-05-12 2017-04-19 格吕伦塔尔有限公司 包含他喷他多的防篡改即释胶囊制剂
MX2016015417A (es) 2014-05-26 2017-02-22 Gruenenthal Gmbh Multiparticulas protegidas contra vertido de dosis etanolico.
EP3166948A1 (de) * 2014-07-09 2017-05-17 Rhodes Technologies Inc. Reduktion der anteile von alpha-, beta-ungesättigten ketonen in morphinanderivatzusammensetzungen
US9918979B2 (en) 2015-01-29 2018-03-20 Johnson Matthey Public Limited Company Process of preparing low ABUK oxymorphone hydrochloride
AU2016251854A1 (en) 2015-04-24 2017-10-19 Grunenthal Gmbh Tamper-resistant dosage form with immediate release and resistance against solvent extraction
WO2016187522A1 (en) * 2015-05-20 2016-11-24 Noramco, Inc. Process for the preparation of oxymorphone freebase
JP2018526414A (ja) 2015-09-10 2018-09-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護
US20230399334A1 (en) * 2020-11-02 2023-12-14 Rhodes Technologies Process for purifying noroxymorphone
CN114634514B (zh) * 2022-04-14 2024-04-09 甘肃农垦药物碱厂有限公司 一种去甲羟吗啡酮中杂质的去除方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1479293A (en) 1924-01-01 Hiabtor fbettlid
US2009181A (en) 1935-07-23 Process for obtaining opium alka
FR1000543A (fr) 1946-02-26 1952-02-13 Roussel Uclaf Procédé d'extraction des alcaloïdes de l'opium
GB713689A (en) 1952-02-08 1954-08-18 T And H Smith Ltd A process for the extraction of alkaloids from poppy straw and/or capsules
US4435572A (en) 1978-04-26 1984-03-06 The United States Of America As Represented By The Department Of Health And Human Services Synthesis of ethyl-4(3'-methoxyphenyl)-1-methyl piperidine-3-carboxylate
NO793297L (no) 1978-10-19 1980-04-22 Mallinckrodt Inc Fremgangsmaate til fremstilling av oksymorfon
JPS55102538A (en) 1979-01-30 1980-08-05 Kawasaki Kasei Chem Ltd Preparation of p-n-alkyl benzoate
IT1129758B (it) 1980-01-23 1986-06-11 Montedison Spa Processo per la riduzione catalitica di chetoni insaturi
US4368326A (en) 1980-07-03 1983-01-11 Rice Kenner C Short total synthesis of dihydrothebainone, dihydrocodeinone, and nordihydroccodeinone
US4410700A (en) 1980-07-03 1983-10-18 The United States Of America As Represented By The Department Of Health And Human Services Preparation of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines by optical resolution
US4556712A (en) 1981-05-20 1985-12-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Preparation and racemization of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines
US4727146A (en) 1980-07-03 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Synthesis of chiral 1-benzyl-1,2,3,4-tetra-hydroisoquinolines by asymmetric reduction
US4521601A (en) 1981-05-20 1985-06-04 The United States Of America As Represented By The Department Of Health & Human Services Practical total synthesis unnatural enantiomers of opium-derived morphinans
US4613668A (en) 1983-12-22 1986-09-23 The United States Of America As Represented By The Department Of Health And Human Services Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
JPS60193902A (ja) 1984-03-16 1985-10-02 Mitsui Toatsu Chem Inc 害虫防除用組成物
CA2111820C (en) 1992-12-21 1999-05-18 Mitsuru Imuta Method for reducing an .alpha.,.beta.-unsaturated ketone
HU223345B1 (hu) 1995-12-20 2004-08-30 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Eljárás alfa, béta-telítetlen ketonok sztereoszelektív redukciójára
US6046185A (en) 1996-07-11 2000-04-04 Inflazyme Pharmaceuticals Ltd. 6,7-oxygenated steroids and uses related thereto
US5869669A (en) 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
US6312662B1 (en) 1998-03-06 2001-11-06 Metabasis Therapeutics, Inc. Prodrugs phosphorus-containing compounds
US6177567B1 (en) * 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
TWI365880B (en) 2004-03-30 2012-06-11 Euro Celtique Sa Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp
WO2006084389A1 (de) 2005-02-11 2006-08-17 Cilag Ltd. Verfahren zur reinigung von noroxymorphon-verbindungen
SI2112153T1 (sl) 2005-03-04 2011-02-28 Euro Celtique Sa Postopek za zmanjšanje alfa, beta-nenasičenih ketonov v opioidnih sestavkih
CN101346384B (zh) * 2005-11-22 2012-07-04 控制化学品公司 用于降低羟考酮和其它组分中杂质迈克尔受体水平的方法
US8871779B2 (en) * 2006-03-02 2014-10-28 Mallinckrodt Llc Process for preparing morphinan-6-one products with low levels of α,β-unsaturated ketone compounds
DK2073636T3 (da) 2006-10-17 2012-11-19 Penick Corp Fremgangsmåde til fremstilling af oxymorphon
GB0624880D0 (en) 2006-12-14 2007-01-24 Johnson Matthey Plc Improved method for making analgesics
US8217175B2 (en) 2007-03-23 2012-07-10 Mallinckrodt Llc Preparation of oxymorphone from oripavine

Also Published As

Publication number Publication date
US20080312442A1 (en) 2008-12-18
CN101395159A (zh) 2009-03-25
US20150148365A1 (en) 2015-05-28
EP1994034B1 (de) 2009-11-11
US20190381033A1 (en) 2019-12-19
US20200338068A1 (en) 2020-10-29
MX2008010921A (es) 2008-09-03
US8748611B2 (en) 2014-06-10
JP5695296B2 (ja) 2015-04-01
EP1994034A2 (de) 2008-11-26
US20180008596A1 (en) 2018-01-11
CA2644095A1 (en) 2007-09-13
US8871779B2 (en) 2014-10-28
WO2007103105A2 (en) 2007-09-13
US20120059167A1 (en) 2012-03-08
US20220079938A1 (en) 2022-03-17
WO2007103105A3 (en) 2007-11-22
DE602007003197D1 (de) 2009-12-24
JP2013173765A (ja) 2013-09-05
US20160243113A1 (en) 2016-08-25
JP2009528366A (ja) 2009-08-06
AU2007224221B2 (en) 2013-02-14
AU2007224221A1 (en) 2007-09-13

Similar Documents

Publication Publication Date Title
ATE448231T1 (de) Verfahren zur herstellung von morphinan-6-on- produkten mit geringen konzentrationen von alpha-,beta-ungesättigten ketonverbindungen
ATE487722T1 (de) Verfahren zur verminderung von alpha, beta- ungesättigten ketonen in opioidzusammensetzungen
ATE473224T1 (de) Verfahren zur herstellung von nebivolol
ATE475655T1 (de) Verfahren zur herstellung von (s)-4- fluormethyldihydrofuran-2-on
MY148483A (en) 4,5-diphenyl-pyrimidinyl-oxy or-mercapto substituted carboxylic acids, method for the production and use thereof as medicaments
ATE489354T1 (de) Verfahren zur herstellung von metallorganischen gerüstmaterialien hauptgruppen metallionen enthaltend
DE602004030239D1 (de) Verfahren und zwischenprodukte zur herstellung von (1r,2s,5s)-6,6-dimethyl-3-azabicycloä3,1,0 ühexan-2-carboxylaten oder salzen davon
ATE542803T1 (de) Verfahren zur herstellung von dihydrochinazolinen
ATE458535T1 (de) Verfahren zur herstellung von konzentrierten tensidzusammensetzungen
ATE417107T1 (de) Verfahren zur herstellung von l-aminosäuren durch enterobacteriaceae-stämmen mit verstärkter expression des pts-g
AT507172A3 (de) Verfahren zur herstellung von dibenz (c,e) (1,2)- oxaphosphorin-derivaten, amino-dibenz (c,e) (1,2)-oxaphosphorin sowie deren verwendung
ATE544566T1 (de) Verfahren zur herstellung von dünne metallnanodrähte durch biotemplating
UA107325C2 (uk) Спосіб обробки декоративних рослин
ATE452117T1 (de) Verfahren zur herstellung von cyclischen ketonen
ATE510812T1 (de) Verfahren zur reinigung von cyclischen ketonen
DE602005020185D1 (de) Verfahren zur herstellung von 17-hydroxy-6 beta, 7 beta, 15 beta,16 beta-bismethylen-17alpha-pregn-4henprodukte für dieses verfahren
DE602007003198D1 (de) Verfahren zur herstellung einer zusammensetzung auf 4-hydroxyprolin-basis sowie verwendungen davon auf landwirtschaftlichem gebiet
DE602006019870D1 (de) Verfahren zur synthese von triazolen
ATE466010T1 (de) Verfahren zur herstellung von candesartan
DK2038341T3 (da) Sammensætning med en polymer og en oxidationskatalysator
DE602005013007D1 (de) Verfahren zur herstellung von lactonen
ATE515502T1 (de) Verfahren zur herstellung von tetranorlabdanderivaten
ATE501115T1 (de) Verfahren zur herstellung von entacapon
ATE487730T1 (de) Verfahren zur herstellung eines oxaliplatins
ATE341558T1 (de) Verfahren zur herstellung von topiramate

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties