ATE448231T1 - Verfahren zur herstellung von morphinan-6-on- produkten mit geringen konzentrationen von alpha-,beta-ungesättigten ketonverbindungen - Google Patents
Verfahren zur herstellung von morphinan-6-on- produkten mit geringen konzentrationen von alpha-,beta-ungesättigten ketonverbindungenInfo
- Publication number
- ATE448231T1 ATE448231T1 AT07751984T AT07751984T ATE448231T1 AT E448231 T1 ATE448231 T1 AT E448231T1 AT 07751984 T AT07751984 T AT 07751984T AT 07751984 T AT07751984 T AT 07751984T AT E448231 T1 ATE448231 T1 AT E448231T1
- Authority
- AT
- Austria
- Prior art keywords
- products
- alpha
- morphinan
- beta
- unsaturated ketone
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77825806P | 2006-03-02 | 2006-03-02 | |
PCT/US2007/005256 WO2007103105A2 (en) | 2006-03-02 | 2007-03-02 | Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE448231T1 true ATE448231T1 (de) | 2009-11-15 |
Family
ID=38326629
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07751984T ATE448231T1 (de) | 2006-03-02 | 2007-03-02 | Verfahren zur herstellung von morphinan-6-on- produkten mit geringen konzentrationen von alpha-,beta-ungesättigten ketonverbindungen |
Country Status (10)
Country | Link |
---|---|
US (8) | US8871779B2 (de) |
EP (1) | EP1994034B1 (de) |
JP (2) | JP5695296B2 (de) |
CN (1) | CN101395159A (de) |
AT (1) | ATE448231T1 (de) |
AU (1) | AU2007224221B2 (de) |
CA (1) | CA2644095A1 (de) |
DE (1) | DE602007003197D1 (de) |
MX (1) | MX2008010921A (de) |
WO (1) | WO2007103105A2 (de) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
TW201509943A (zh) | 2004-03-30 | 2015-03-16 | Euro Celtique Sa | 含有小於25ppm14-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝 |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
WO2007062184A2 (en) * | 2005-11-22 | 2007-05-31 | Controlled Chemicals, Inc. | Processes for reducing contaminating michael acceptor levels in oxycodone and other compositions |
WO2007103105A2 (en) * | 2006-03-02 | 2007-09-13 | Mallinckrodt Inc. | Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds |
CA2674915C (en) | 2006-10-17 | 2015-06-30 | Penick Corporation | Process for preparing oxymorphone |
US20080125592A1 (en) * | 2006-10-17 | 2008-05-29 | Penick Corporation | Process for preparing oxymorphone, naltrexone, and buprenorphine |
DK2073636T3 (da) * | 2006-10-17 | 2012-11-19 | Penick Corp | Fremgangsmåde til fremstilling af oxymorphon |
JP2010511725A (ja) | 2006-12-04 | 2010-04-15 | ノランコ・インコーポレーテツド | オキシコドン塩基中の不純物を減少させる方法 |
CA2671518C (en) | 2006-12-04 | 2016-06-07 | Noramco, Inc. | Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone |
GB0624880D0 (en) * | 2006-12-14 | 2007-01-24 | Johnson Matthey Plc | Improved method for making analgesics |
DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
FR2923484B1 (fr) * | 2007-11-09 | 2012-11-09 | Sanofi Aventis | Procede de preparation de composes morphiniques |
TWI454288B (zh) | 2008-01-25 | 2014-10-01 | Gruenenthal Chemie | 藥物劑型 |
PT2273983T (pt) | 2008-05-09 | 2016-10-28 | Gruenenthal Gmbh | Processo para a preparação de uma formulação em pó intermediária e uma forma de dosagem sólida final sob utilização de uma etapa de congelamento por atomização |
RU2547555C2 (ru) | 2009-07-22 | 2015-04-10 | Грюненталь Гмбх | Экструдированная из горячего расплава фармацевтическая лекарственная форма |
KR101747156B1 (ko) | 2009-07-22 | 2017-06-27 | 그뤼넨탈 게엠베하 | 산화-안정화된 탬퍼-내성 용량형 |
US8703950B2 (en) | 2010-07-02 | 2014-04-22 | Johnson Matthey Public Limited Co. | Low ABUK oxycodone, its salts and methods of making same |
EP2611426B1 (de) | 2010-09-02 | 2014-06-25 | Grünenthal GmbH | Manipulationssichere darreichungsform mit einem anorganischen salz |
EP2611425B1 (de) | 2010-09-02 | 2014-07-02 | Grünenthal GmbH | Manipulationssichere darreichungsform mit einem anionischen polymer |
DK2736495T3 (da) | 2011-07-29 | 2017-11-13 | Gruenenthal Gmbh | Misbrugsbestandig tablet som tilvejebringer øjeblikkelig frigivelse af lægemiddel |
US20130028972A1 (en) | 2011-07-29 | 2013-01-31 | Grunenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
TWI560170B (en) * | 2011-12-06 | 2016-12-01 | Lundbeck & Co As H | Process for recovery of nalmefene hydrochloride |
CA2864949A1 (en) | 2012-02-28 | 2013-09-06 | Grunenthal Gmbh | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
EA201401139A1 (ru) | 2012-04-18 | 2015-03-31 | Грюненталь Гмбх | Устойчивая к разрушению и к сбросу дозы фармацевтическая лекарственная форма |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
US20150259355A1 (en) | 2012-07-16 | 2015-09-17 | Rhodes Technologies | Process for improved opioid synthesis |
MX371432B (es) | 2013-05-29 | 2020-01-30 | Gruenenthal Gmbh | Forma de dosificacion resistente al uso indebido que contiene una o mas particulas. |
JP6466417B2 (ja) | 2013-05-29 | 2019-02-06 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 二峰性放出プロファイルを有する改変防止(tamper−resistant)剤形 |
KR20160031526A (ko) | 2013-07-12 | 2016-03-22 | 그뤼넨탈 게엠베하 | 에틸렌-비닐 아세테이트 중합체를 함유하는 템퍼 내성 투여형 |
GB201313211D0 (en) * | 2013-07-24 | 2013-09-04 | Cambrex Karlskoga Ab | New process |
GB2517000B (en) | 2013-08-02 | 2018-05-09 | Johnson Matthey Plc | Process for the synthesis of oxymorphone alkaloid and oxymorphone salts |
GB201313915D0 (en) * | 2013-08-02 | 2013-09-18 | Johnson Matthey Plc | Process |
CN105934241B (zh) | 2013-11-26 | 2020-06-05 | 格吕伦塔尔有限公司 | 通过低温研磨制备粉末状药物组合物 |
AU2015207733A1 (en) | 2014-01-15 | 2016-07-14 | Rhodes Technologies | Process for improved oxycodone synthesis |
EP3142646A1 (de) | 2014-05-12 | 2017-03-22 | Grünenthal GmbH | Manipulationssichere kapselformulierung mit tapentadol mit unmittelbarer freisetzung |
MX2016015417A (es) | 2014-05-26 | 2017-02-22 | Gruenenthal Gmbh | Multiparticulas protegidas contra vertido de dosis etanolico. |
CA2954600A1 (en) * | 2014-07-09 | 2016-01-14 | Rhodes Technologies | Reduction of alpha, beta-unsaturated ketone levels in morphinan derivative compositions |
US9918979B2 (en) * | 2015-01-29 | 2018-03-20 | Johnson Matthey Public Limited Company | Process of preparing low ABUK oxymorphone hydrochloride |
EP3285745A1 (de) | 2015-04-24 | 2018-02-28 | Grünenthal GmbH | Manipulationssichere darreichungsform mit sofortiger freisetzung und widerstand gegen lösungsmittelextraktion |
WO2016187522A1 (en) * | 2015-05-20 | 2016-11-24 | Noramco, Inc. | Process for the preparation of oxymorphone freebase |
JP2018526414A (ja) | 2015-09-10 | 2018-09-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護 |
AU2021368196A1 (en) * | 2020-11-02 | 2023-06-22 | Rhodes Technologies | Process for purifying noroxymorphone |
CN114634514B (zh) * | 2022-04-14 | 2024-04-09 | 甘肃农垦药物碱厂有限公司 | 一种去甲羟吗啡酮中杂质的去除方法 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2009181A (en) | 1935-07-23 | Process for obtaining opium alka | ||
US1479293A (en) | 1924-01-01 | Hiabtor fbettlid | ||
FR1000543A (fr) | 1946-02-26 | 1952-02-13 | Roussel Uclaf | Procédé d'extraction des alcaloïdes de l'opium |
GB713689A (en) | 1952-02-08 | 1954-08-18 | T And H Smith Ltd | A process for the extraction of alkaloids from poppy straw and/or capsules |
US4435572A (en) | 1978-04-26 | 1984-03-06 | The United States Of America As Represented By The Department Of Health And Human Services | Synthesis of ethyl-4(3'-methoxyphenyl)-1-methyl piperidine-3-carboxylate |
NO793297L (no) | 1978-10-19 | 1980-04-22 | Mallinckrodt Inc | Fremgangsmaate til fremstilling av oksymorfon |
JPS55102538A (en) | 1979-01-30 | 1980-08-05 | Kawasaki Kasei Chem Ltd | Preparation of p-n-alkyl benzoate |
IT1129758B (it) | 1980-01-23 | 1986-06-11 | Montedison Spa | Processo per la riduzione catalitica di chetoni insaturi |
US4727146A (en) | 1980-07-03 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Synthesis of chiral 1-benzyl-1,2,3,4-tetra-hydroisoquinolines by asymmetric reduction |
US4368326A (en) | 1980-07-03 | 1983-01-11 | Rice Kenner C | Short total synthesis of dihydrothebainone, dihydrocodeinone, and nordihydroccodeinone |
US4556712A (en) | 1981-05-20 | 1985-12-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Preparation and racemization of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines |
US4410700A (en) | 1980-07-03 | 1983-10-18 | The United States Of America As Represented By The Department Of Health And Human Services | Preparation of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines by optical resolution |
US4521601A (en) | 1981-05-20 | 1985-06-04 | The United States Of America As Represented By The Department Of Health & Human Services | Practical total synthesis unnatural enantiomers of opium-derived morphinans |
US4613668A (en) | 1983-12-22 | 1986-09-23 | The United States Of America As Represented By The Department Of Health And Human Services | Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl |
JPS60193902A (ja) | 1984-03-16 | 1985-10-02 | Mitsui Toatsu Chem Inc | 害虫防除用組成物 |
CA2111820C (en) | 1992-12-21 | 1999-05-18 | Mitsuru Imuta | Method for reducing an .alpha.,.beta.-unsaturated ketone |
HU223345B1 (hu) | 1995-12-20 | 2004-08-30 | Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. | Eljárás alfa, béta-telítetlen ketonok sztereoszelektív redukciójára |
US6046185A (en) | 1996-07-11 | 2000-04-04 | Inflazyme Pharmaceuticals Ltd. | 6,7-oxygenated steroids and uses related thereto |
US5869669A (en) | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
US6312662B1 (en) | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
US6177567B1 (en) | 1999-10-15 | 2001-01-23 | Boehringer Ingelheim Chemicals, Inc. | Method for preparing oxycodone |
TW201509943A (zh) | 2004-03-30 | 2015-03-16 | Euro Celtique Sa | 含有小於25ppm14-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝 |
WO2006084389A1 (de) | 2005-02-11 | 2006-08-17 | Cilag Ltd. | Verfahren zur reinigung von noroxymorphon-verbindungen |
JP5314894B2 (ja) * | 2005-03-04 | 2013-10-16 | ユーロ−セルティーク エス.エイ. | オピオイド組成物中のアルファ,ベータ不飽和ケトンの減少方法 |
WO2007062184A2 (en) * | 2005-11-22 | 2007-05-31 | Controlled Chemicals, Inc. | Processes for reducing contaminating michael acceptor levels in oxycodone and other compositions |
WO2007103105A2 (en) * | 2006-03-02 | 2007-09-13 | Mallinckrodt Inc. | Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds |
DK2073636T3 (da) | 2006-10-17 | 2012-11-19 | Penick Corp | Fremgangsmåde til fremstilling af oxymorphon |
GB0624880D0 (en) | 2006-12-14 | 2007-01-24 | Johnson Matthey Plc | Improved method for making analgesics |
AU2008231127B2 (en) | 2007-03-23 | 2013-05-02 | SpecGx LLC | Improved preparation of oxymorphone from oripavine |
-
2007
- 2007-03-02 WO PCT/US2007/005256 patent/WO2007103105A2/en active Application Filing
- 2007-03-02 CA CA002644095A patent/CA2644095A1/en not_active Abandoned
- 2007-03-02 DE DE602007003197T patent/DE602007003197D1/de active Active
- 2007-03-02 JP JP2008557368A patent/JP5695296B2/ja active Active
- 2007-03-02 CN CNA2007800075203A patent/CN101395159A/zh active Pending
- 2007-03-02 EP EP07751984A patent/EP1994034B1/de not_active Revoked
- 2007-03-02 US US11/915,606 patent/US8871779B2/en active Active
- 2007-03-02 AU AU2007224221A patent/AU2007224221B2/en active Active
- 2007-03-02 MX MX2008010921A patent/MX2008010921A/es active IP Right Grant
- 2007-03-02 AT AT07751984T patent/ATE448231T1/de not_active IP Right Cessation
-
2011
- 2011-11-11 US US13/294,546 patent/US8748611B2/en active Active
-
2013
- 2013-04-16 JP JP2013085948A patent/JP2013173765A/ja active Pending
-
2014
- 2014-10-02 US US14/504,750 patent/US20150148365A1/en not_active Abandoned
-
2016
- 2016-05-02 US US15/144,010 patent/US20160243113A1/en not_active Abandoned
-
2017
- 2017-09-21 US US15/710,990 patent/US20180008596A1/en not_active Abandoned
-
2019
- 2019-08-23 US US16/549,718 patent/US20190381033A1/en not_active Abandoned
-
2020
- 2020-07-13 US US16/927,497 patent/US20200338068A1/en not_active Abandoned
-
2021
- 2021-11-29 US US17/536,892 patent/US20220079938A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20120059167A1 (en) | 2012-03-08 |
US20150148365A1 (en) | 2015-05-28 |
JP5695296B2 (ja) | 2015-04-01 |
AU2007224221A1 (en) | 2007-09-13 |
US8871779B2 (en) | 2014-10-28 |
WO2007103105A3 (en) | 2007-11-22 |
US20160243113A1 (en) | 2016-08-25 |
US20220079938A1 (en) | 2022-03-17 |
JP2013173765A (ja) | 2013-09-05 |
US8748611B2 (en) | 2014-06-10 |
EP1994034A2 (de) | 2008-11-26 |
MX2008010921A (es) | 2008-09-03 |
CN101395159A (zh) | 2009-03-25 |
DE602007003197D1 (de) | 2009-12-24 |
US20180008596A1 (en) | 2018-01-11 |
US20080312442A1 (en) | 2008-12-18 |
AU2007224221B2 (en) | 2013-02-14 |
CA2644095A1 (en) | 2007-09-13 |
US20200338068A1 (en) | 2020-10-29 |
JP2009528366A (ja) | 2009-08-06 |
WO2007103105A2 (en) | 2007-09-13 |
US20190381033A1 (en) | 2019-12-19 |
EP1994034B1 (de) | 2009-11-11 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |