GB713689A - A process for the extraction of alkaloids from poppy straw and/or capsules - Google Patents
A process for the extraction of alkaloids from poppy straw and/or capsulesInfo
- Publication number
- GB713689A GB713689A GB333752A GB333752A GB713689A GB 713689 A GB713689 A GB 713689A GB 333752 A GB333752 A GB 333752A GB 333752 A GB333752 A GB 333752A GB 713689 A GB713689 A GB 713689A
- Authority
- GB
- United Kingdom
- Prior art keywords
- morphine
- capsules
- alkaline
- water
- alkaloids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G5/00—Alkaloids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Extraction Or Liquid Replacement (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Morphine is extracted from poppies by mixing dry, finely ground poppy straw and/or capsules with lime and enough water to wet the mass, pressing out the extract, adding sulphuric acid to pH 4-5.5, evaporating under reduced pressure until the mass is firm when cold but fluid when hot, making alkaline (other than with caustic alkali) and extracting the alkaloids with a water-immiscible solvent, preferably at an elevated temperature. When making the mixture alkaline, caustic alkali may be used to bring the pH to 6-7 and another alkali then added for the final step. In preferred operating conditions the straw and/or capsules are mixed with 5 per cent of calcium hydroxide and 4 times their weight of water and allowed to stand for 2 hours. The extract is pressed out, acidified to pH 4.5-5.5, evaporated under reduced pressure, made alkaline with sodium carbonate and the morphine extracted with a mixture of fusel oil and xylene at 100 DEG C. The morphine is recovered by extraction with hydrochloric acid and precipitation with ammonia. An example is given of the process.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB333752A GB713689A (en) | 1952-02-08 | 1952-02-08 | A process for the extraction of alkaloids from poppy straw and/or capsules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB333752A GB713689A (en) | 1952-02-08 | 1952-02-08 | A process for the extraction of alkaloids from poppy straw and/or capsules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB713689A true GB713689A (en) | 1954-08-18 |
Family
ID=9756410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB333752A Expired GB713689A (en) | 1952-02-08 | 1952-02-08 | A process for the extraction of alkaloids from poppy straw and/or capsules |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB713689A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2153876A1 (en) * | 2008-07-22 | 2010-02-17 | Vog Ag | Method for removing alkaloids attached to poppy seeds |
| US8748611B2 (en) | 2006-03-02 | 2014-06-10 | Mallinckrodt Llc | Processes for preparing morphinan-6-one products with low levels of alpha beta-unsaturated compounds |
-
1952
- 1952-02-08 GB GB333752A patent/GB713689A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8748611B2 (en) | 2006-03-02 | 2014-06-10 | Mallinckrodt Llc | Processes for preparing morphinan-6-one products with low levels of alpha beta-unsaturated compounds |
| US8871779B2 (en) | 2006-03-02 | 2014-10-28 | Mallinckrodt Llc | Process for preparing morphinan-6-one products with low levels of α,β-unsaturated ketone compounds |
| EP2153876A1 (en) * | 2008-07-22 | 2010-02-17 | Vog Ag | Method for removing alkaloids attached to poppy seeds |
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