GB913059A - New oestrogenic substance - Google Patents
New oestrogenic substanceInfo
- Publication number
- GB913059A GB913059A GB1022259A GB1022259A GB913059A GB 913059 A GB913059 A GB 913059A GB 1022259 A GB1022259 A GB 1022259A GB 1022259 A GB1022259 A GB 1022259A GB 913059 A GB913059 A GB 913059A
- Authority
- GB
- United Kingdom
- Prior art keywords
- solution
- acid
- acidifying
- dissolving
- new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises oestra-1,3,5(10)-triene-17b -ol-3-yl-a -oxyisobutryric acid of the formula <FORM:0913059/IV (b)/1> and the preparation thereof by refluxing a solution of oestradiol-17b in a mixture of acetone and chloroform containing sodium hydroxide for 6 to 10 hours, removing the solvent by distillation, dissolving the residue in water, acidifying the aqueous solution to a pH of about 4 with a mineral acid such as hydrochloric acid, dissolving the precipitate formed in a saturated aqueous sodium bicarbonate solution, acidifying the resulting alkaline solution to a pH below 4.5 with a mineral acid, and collecting the precipitate of the desired product. In the above process the aqueous solution and/or the alkaline solution may be extracted with ether before the acidification step.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1022259A GB913059A (en) | 1959-03-24 | 1959-03-24 | New oestrogenic substance |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1022259A GB913059A (en) | 1959-03-24 | 1959-03-24 | New oestrogenic substance |
Publications (1)
Publication Number | Publication Date |
---|---|
GB913059A true GB913059A (en) | 1962-12-19 |
Family
ID=9963858
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1022259A Expired GB913059A (en) | 1959-03-24 | 1959-03-24 | New oestrogenic substance |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB913059A (en) |
-
1959
- 1959-03-24 GB GB1022259A patent/GB913059A/en not_active Expired
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