GB913059A - New oestrogenic substance - Google Patents

New oestrogenic substance

Info

Publication number
GB913059A
GB913059A GB1022259A GB1022259A GB913059A GB 913059 A GB913059 A GB 913059A GB 1022259 A GB1022259 A GB 1022259A GB 1022259 A GB1022259 A GB 1022259A GB 913059 A GB913059 A GB 913059A
Authority
GB
United Kingdom
Prior art keywords
solution
acid
acidifying
dissolving
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1022259A
Inventor
Paolo Galimberti
Vittorina Gerosa
Max Marcello Melandri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IT PRODOTTI SCHERING SOC
Original Assignee
IT PRODOTTI SCHERING SOC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IT PRODOTTI SCHERING SOC filed Critical IT PRODOTTI SCHERING SOC
Priority to GB1022259A priority Critical patent/GB913059A/en
Publication of GB913059A publication Critical patent/GB913059A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises oestra-1,3,5(10)-triene-17b -ol-3-yl-a -oxyisobutryric acid of the formula <FORM:0913059/IV (b)/1> and the preparation thereof by refluxing a solution of oestradiol-17b in a mixture of acetone and chloroform containing sodium hydroxide for 6 to 10 hours, removing the solvent by distillation, dissolving the residue in water, acidifying the aqueous solution to a pH of about 4 with a mineral acid such as hydrochloric acid, dissolving the precipitate formed in a saturated aqueous sodium bicarbonate solution, acidifying the resulting alkaline solution to a pH below 4.5 with a mineral acid, and collecting the precipitate of the desired product. In the above process the aqueous solution and/or the alkaline solution may be extracted with ether before the acidification step.
GB1022259A 1959-03-24 1959-03-24 New oestrogenic substance Expired GB913059A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1022259A GB913059A (en) 1959-03-24 1959-03-24 New oestrogenic substance

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1022259A GB913059A (en) 1959-03-24 1959-03-24 New oestrogenic substance

Publications (1)

Publication Number Publication Date
GB913059A true GB913059A (en) 1962-12-19

Family

ID=9963858

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1022259A Expired GB913059A (en) 1959-03-24 1959-03-24 New oestrogenic substance

Country Status (1)

Country Link
GB (1) GB913059A (en)

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