GB682280A - Purification of ortho-methoxyphenylacetone - Google Patents
Purification of ortho-methoxyphenylacetoneInfo
- Publication number
- GB682280A GB682280A GB17600/50A GB1760050A GB682280A GB 682280 A GB682280 A GB 682280A GB 17600/50 A GB17600/50 A GB 17600/50A GB 1760050 A GB1760050 A GB 1760050A GB 682280 A GB682280 A GB 682280A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methoxyphenylacetone
- bisulphite
- solution
- methoxybenzaldehyde
- crude
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/80—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/85—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to a chemical modification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
In a method for the purification of o-methoxyphenylacetone containing as impurities one or more aldehydes and/or other ketones and/or one or more other organic compounds which form more readily than o-methoxyphenylacetone an addition complex with a bisulphite, crude o-methoxyphenylacetone is brought into contact with an alkali metal bisulphite, and the o-methoxyphenylacetone is separated in purified form from the complex formed between the bisulphite and the impurities present. The bisulphite may be in the form of finely-divided solid, but is preferably used in aqueous solution. The crude o-methoxy phenylacetone may be dissolved in a water-immiscible organic solvent, e.g. benzene, toluene, chloroform dichlorethane, ether, petroleum ether or ethyl acetate. Examples describe the separation of purified o-methoxyphenylacetone from a mixture of (1) a toluene solution of crude o-methoxyphenylacetone obtained by Experiment 2 of Specification 671,240, and aqueous sodium bisulphite solution; (2) the separated product of (1) and further bisulphite solution; (3) 85.5 per cent o-methoxyphenylacetone and 14.5 per cent o-methoxybenzaldehyde with solid sodium bisulphite; (4) as in (3) but with aqueous sodium bisulphite. The bisulphite addition compound is treated with concentrated hydrochloric acid and the liberated o-methoxybenzaldehyde is recovered; (5) a benzene solution of o-methoxyphenylacetone and o-methoxybenzaldehyde with aqueous sodium bisulphite.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US682280XA | 1949-08-08 | 1949-08-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB682280A true GB682280A (en) | 1952-11-05 |
Family
ID=22081219
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB17600/50A Expired GB682280A (en) | 1949-08-08 | 1950-07-13 | Purification of ortho-methoxyphenylacetone |
Country Status (2)
Country | Link |
---|---|
DE (1) | DE892442C (en) |
GB (1) | GB682280A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5221992A (en) * | 1991-02-20 | 1993-06-22 | Park Ki K | Door viewer including inner tube encasing object lenses and ocular lens and including a rubberized flexible hood |
CN114858944A (en) * | 2022-05-31 | 2022-08-05 | 石家庄四药有限公司 | Method for detecting p-methoxypropiophenone related substances |
-
1950
- 1950-07-13 GB GB17600/50A patent/GB682280A/en not_active Expired
- 1950-08-02 DE DEU479A patent/DE892442C/en not_active Expired
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5221992A (en) * | 1991-02-20 | 1993-06-22 | Park Ki K | Door viewer including inner tube encasing object lenses and ocular lens and including a rubberized flexible hood |
CN114858944A (en) * | 2022-05-31 | 2022-08-05 | 石家庄四药有限公司 | Method for detecting p-methoxypropiophenone related substances |
CN114858944B (en) * | 2022-05-31 | 2023-02-03 | 石家庄四药有限公司 | Method for detecting p-methoxypropiophenone related substances |
Also Published As
Publication number | Publication date |
---|---|
DE892442C (en) | 1953-10-08 |
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