GB682280A - Purification of ortho-methoxyphenylacetone - Google Patents

Purification of ortho-methoxyphenylacetone

Info

Publication number
GB682280A
GB682280A GB17600/50A GB1760050A GB682280A GB 682280 A GB682280 A GB 682280A GB 17600/50 A GB17600/50 A GB 17600/50A GB 1760050 A GB1760050 A GB 1760050A GB 682280 A GB682280 A GB 682280A
Authority
GB
United Kingdom
Prior art keywords
methoxyphenylacetone
bisulphite
solution
methoxybenzaldehyde
crude
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB17600/50A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB682280A publication Critical patent/GB682280A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/80—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/85—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to a chemical modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

In a method for the purification of o-methoxyphenylacetone containing as impurities one or more aldehydes and/or other ketones and/or one or more other organic compounds which form more readily than o-methoxyphenylacetone an addition complex with a bisulphite, crude o-methoxyphenylacetone is brought into contact with an alkali metal bisulphite, and the o-methoxyphenylacetone is separated in purified form from the complex formed between the bisulphite and the impurities present. The bisulphite may be in the form of finely-divided solid, but is preferably used in aqueous solution. The crude o-methoxy phenylacetone may be dissolved in a water-immiscible organic solvent, e.g. benzene, toluene, chloroform dichlorethane, ether, petroleum ether or ethyl acetate. Examples describe the separation of purified o-methoxyphenylacetone from a mixture of (1) a toluene solution of crude o-methoxyphenylacetone obtained by Experiment 2 of Specification 671,240, and aqueous sodium bisulphite solution; (2) the separated product of (1) and further bisulphite solution; (3) 85.5 per cent o-methoxyphenylacetone and 14.5 per cent o-methoxybenzaldehyde with solid sodium bisulphite; (4) as in (3) but with aqueous sodium bisulphite. The bisulphite addition compound is treated with concentrated hydrochloric acid and the liberated o-methoxybenzaldehyde is recovered; (5) a benzene solution of o-methoxyphenylacetone and o-methoxybenzaldehyde with aqueous sodium bisulphite.
GB17600/50A 1949-08-08 1950-07-13 Purification of ortho-methoxyphenylacetone Expired GB682280A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US682280XA 1949-08-08 1949-08-08

Publications (1)

Publication Number Publication Date
GB682280A true GB682280A (en) 1952-11-05

Family

ID=22081219

Family Applications (1)

Application Number Title Priority Date Filing Date
GB17600/50A Expired GB682280A (en) 1949-08-08 1950-07-13 Purification of ortho-methoxyphenylacetone

Country Status (2)

Country Link
DE (1) DE892442C (en)
GB (1) GB682280A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5221992A (en) * 1991-02-20 1993-06-22 Park Ki K Door viewer including inner tube encasing object lenses and ocular lens and including a rubberized flexible hood
CN114858944A (en) * 2022-05-31 2022-08-05 石家庄四药有限公司 Method for detecting p-methoxypropiophenone related substances

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5221992A (en) * 1991-02-20 1993-06-22 Park Ki K Door viewer including inner tube encasing object lenses and ocular lens and including a rubberized flexible hood
CN114858944A (en) * 2022-05-31 2022-08-05 石家庄四药有限公司 Method for detecting p-methoxypropiophenone related substances
CN114858944B (en) * 2022-05-31 2023-02-03 石家庄四药有限公司 Method for detecting p-methoxypropiophenone related substances

Also Published As

Publication number Publication date
DE892442C (en) 1953-10-08

Similar Documents

Publication Publication Date Title
GB1458705A (en) Process for separating acrylic acid from aqueous solutions
GB682280A (en) Purification of ortho-methoxyphenylacetone
US2695313A (en) Oxidation of nonaromatic organic compounds
US2692282A (en) N-cyclohexylcyclopropane carboxamide
US2489200A (en) Separation of vanillin from alkaline solutions
GB1495481A (en) Process for the obtaining of isobutylene of high purity
US2755307A (en) Process for the recovery of 2, 4, 5-trichlorophenol
GB560165A (en) Improvements in or relating to the manufacture of pentaerythritol
KR840004053A (en) Method for preparing phenylalkanoic acid
US3658905A (en) Process for the purification of p-aminophenol
GB1118013A (en) Process for the preparation of very pure trioxane
US2400934A (en) Amines and purification thereof
GB1071309A (en) Production of 2-silamorpholine derivatives
GB848287A (en) Purification of pseudo-ionone
GB670445A (en) Recovery of by-products in the manufacture of phenol
GB649286A (en) Manufacture of phenol
US3024276A (en) Process for the preparation of aminoacids from organic peroxides and nitrogen oxide
GB676370A (en) Recovery of procaine
GB967080A (en) Novel steroid compounds and process for the preparation thereof
US2304563A (en) Process for the production of racemic menthol
SU115827A1 (en) The method of obtaining O-benzoyl-N-phenyl-N-beta-nafgilgidroksilamin
JPS5210214A (en) Process for recovery of methylmethacrylate dimer
US3423460A (en) Process for extraction of oximes from mineral acid solutions
US2302294A (en) Process for the separation of phenol from phenylphenols
McKay et al. New Compounds. 1, 5-Endomethylene-3, 7-di-p-toluenesulfonyl-1, 3, 5, 7-tetrazacycloöctane