GB756130A - Cardio-active substances, processes for preparing same, stabilized solutions of cardio-active substances and a process for preparing same - Google Patents
Cardio-active substances, processes for preparing same, stabilized solutions of cardio-active substances and a process for preparing sameInfo
- Publication number
- GB756130A GB756130A GB29337/54A GB2933754A GB756130A GB 756130 A GB756130 A GB 756130A GB 29337/54 A GB29337/54 A GB 29337/54A GB 2933754 A GB2933754 A GB 2933754A GB 756130 A GB756130 A GB 756130A
- Authority
- GB
- United Kingdom
- Prior art keywords
- extract
- cardio
- acid
- bovoside
- bovosidal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G99/00—Subject matter not provided for in other groups of this subclass
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention comprises Bovogenin A represented by the empirical formula C24H32O5 and having a m.p. of 247-262 DEG C. and a specific rotation [a ]D22=0 DEG \sB4 DEG (C=0.550 in methanol), Bovogenol A represented by an empirical formula C24H34O5 and having a m.p. of 260-270 DEG C. and a specific rotation [a ]D2-=15.4 DEG \sB4 DEG (C=0.585 in methanol), Bovosidal A i.e. 3b -[1 - thevetoxy] - 14b - hydroxy - 19 - oxo - 5a -bufadienolide having a m.p. of 220 DEG to 238 DEG C. and a specific rotation [a ]D22= - 86.6 DEG \sB2 DEG (C=1.046 in methanol) and Bovosidal D represented by the empirical formula C31H46O10 and having a m.p. 268-286 DEG C. and a specific rotation [a ]D23= - 89 DEG \sB2 DEG (C=0.971 in methanol and the process of recovering Bovogenin A from the plant Bowica volubilis Harvey by preparing a water-containing extract thereof, treating the obtained extract with lead hydroxide, preparing an organic solvent extract from the solution after separation of the precipitate and isolating the cardio-active compound in a crystalline form from the obtained extract. After removal of the tannic acids &c. from the initial extract by means of lead hydroxide the solution is extracted with chloroform/ethanol mixture, the residue treated with water, the aqueous extract treated with ether and the cardio-active substance crystallized from the ethereal extract. Alternatively the ethereal extract is purified by chromatography. Bovosidal A, Bovosidal D and Bovogenol A are obtained by reducing Bovoside A, Bovoside D or Bogovenin A, e.g. with sodium boron hydride, lithium boron hydride, in a solvent. Bovoside A, Bovoside D and Bovogenin A are stabilized against autooxidation an antioxidant, e.g. n-propyl gallate, ethyl gallate, gallic acid, nordihydroguairetic acid, dihydroguairetic acid, guairetic acid, d, l-tocopherol, sodium d, l-a -tocopherol phosphate, caffeic acid or ascorbic acid palmitate. Examples describe the various aspects of the invention.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH756130X | 1953-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB756130A true GB756130A (en) | 1956-08-29 |
Family
ID=4534291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB29337/54A Expired GB756130A (en) | 1953-10-13 | 1954-10-12 | Cardio-active substances, processes for preparing same, stabilized solutions of cardio-active substances and a process for preparing same |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB756130A (en) |
-
1954
- 1954-10-12 GB GB29337/54A patent/GB756130A/en not_active Expired
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