GB482125A - Process for the preparation of new hormones from the male sex apparatus and the new hormones obtained by such process - Google Patents
Process for the preparation of new hormones from the male sex apparatus and the new hormones obtained by such processInfo
- Publication number
- GB482125A GB482125A GB1706536A GB1706536A GB482125A GB 482125 A GB482125 A GB 482125A GB 1706536 A GB1706536 A GB 1706536A GB 1706536 A GB1706536 A GB 1706536A GB 482125 A GB482125 A GB 482125A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- precipitation
- glands
- acetone
- picrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/52—Sperm; Prostate; Seminal fluid; Leydig cells of testes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Reproductive Health (AREA)
- Zoology (AREA)
- Peptides Or Proteins (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Biotechnology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
Abstract
A sex hormone of polypeptide type may be obtained from an extract of male sex glands by precipitation by means of picric acid, and decomposition of the precipitated picrate with alcoholic hydrochloric acid to yield the hydrochloride which is then precipitated in crystalline form by addition of acetone.ALSO:Hormones of polypeptide type which are synergistic to the action of the male hormones of the sterol group are prepared from testicles, seminal vesicles and prostate glands by extraction in known manner followed by precipitation at the iso-electric point. p Fresh, or acetone dried, glands may be extracted with aqueous alcohol or acetone containing sodium hydroxide or ammonia and the extract acidified to pH 5,9 to 6,2, according to the particular glands treated, and allowed to stand in an ice box to throw down the active substance as a precipitate which is then taken up in N/10 NaOH and reprecipitated. A crystalline hydrochloride may be obtained by cooling a solution of the product in acid alcohol or by decomposing a picric of the active substance. Active substance remaining in the initial extract after iso-electric precipitation may be precipitated with picrate acid, the picrate decomposed with alcoholic hydrochloric acid and the solution obtained treated with acetone to precipitate a crystalline hydrochloride. Substances obtained by picric acid precipitation are further purified by iso-electric precipitation. The initial extraction may be done under acid or neutral conditions and water may, less favourably, be employed in place of the aqueous organic solvent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1706536A GB482125A (en) | 1936-06-19 | 1936-06-19 | Process for the preparation of new hormones from the male sex apparatus and the new hormones obtained by such process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1706536A GB482125A (en) | 1936-06-19 | 1936-06-19 | Process for the preparation of new hormones from the male sex apparatus and the new hormones obtained by such process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB482125A true GB482125A (en) | 1938-03-21 |
Family
ID=10088627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1706536A Expired GB482125A (en) | 1936-06-19 | 1936-06-19 | Process for the preparation of new hormones from the male sex apparatus and the new hormones obtained by such process |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB482125A (en) |
-
1936
- 1936-06-19 GB GB1706536A patent/GB482125A/en not_active Expired
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB482125A (en) | Process for the preparation of new hormones from the male sex apparatus and the new hormones obtained by such process | |
| GB756130A (en) | Cardio-active substances, processes for preparing same, stabilized solutions of cardio-active substances and a process for preparing same | |
| GB366940A (en) | A process for preparing liquids containing active principles or hormones from parathyroid glands | |
| GB479487A (en) | Manufacture of stable therapeutic products from intestinal mucous membrane | |
| US1924073A (en) | Stable ammonium salt of primula saponine | |
| GB785987A (en) | Improvements in or relating to oestrogenic substances | |
| GB487352A (en) | A process for the production and purification of sexual hormone derivatives | |
| US3538103A (en) | Method of producing the alkaloid securinine | |
| GB334898A (en) | Process for extracting and separating the active substances from the posterior lobe of the hypophysis | |
| GB446703A (en) | Process for the manufacture of phenyl mercury nitrates | |
| GB555450A (en) | Process for the preparation of active glucosides of senna | |
| DE1667884C3 (en) | Process for the production of pure Ae | |
| GB316359A (en) | Process for the manufacture of sexual hormones | |
| AT159196B (en) | Process for obtaining the lactation-promoting substance from the anterior pituitary gland. | |
| US1987743A (en) | Compounds of primula saponine | |
| GB382047A (en) | Process for the manufacture of female sexual hormone | |
| GB255689A (en) | Process for the manufacture of the pure glucoside of bulbus scillae | |
| GB161341A (en) | Process for the detoxication of the tubercle bacillus and other germs, for the preparation of vaccines | |
| GB291018A (en) | Manufacture of physiologically active substances from the anterior lobes of the hypophysis | |
| GB199400A (en) | Process for the manufacture of the cardiac glucoside of bulbus scillae | |
| GB430280A (en) | Method of extracting cardio-active principles of squill | |
| Speziale et al. | Tautomerism in solid secobarbital sodium | |
| GB740299A (en) | Improved process for the preparation of enzyme extracts from liver and extracts so produced | |
| GB298610A (en) | The manufacture of sexual hormones | |
| GB457433A (en) | Process for obtaining morphine and codeine |