GB161341A - Process for the detoxication of the tubercle bacillus and other germs, for the preparation of vaccines - Google Patents

Process for the detoxication of the tubercle bacillus and other germs, for the preparation of vaccines

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Publication number
GB161341A
GB161341A GB219620A GB219620A GB161341A GB 161341 A GB161341 A GB 161341A GB 219620 A GB219620 A GB 219620A GB 219620 A GB219620 A GB 219620A GB 161341 A GB161341 A GB 161341A
Authority
GB
United Kingdom
Prior art keywords
treated
alcohol
solution
precipitate
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB219620A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to GB219620A priority Critical patent/GB161341A/en
Publication of GB161341A publication Critical patent/GB161341A/en
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

161,341. Thomson, D. Jan. 23, 1920. Vaccines.-Non-toxic vaccines are prepared from germs by separating the alkali-, acid-, and alcohol-soluble portions by successive precipitations. Tubercle bacilli, gonococci, or Pfeiffer bacilli are treated with an alkaline solution and the solid residue removed. The solution is treated with acid, and the resulting precipitate is neutralized and then treated with alcohol to form a precipitate A. The acid solution is treated with alcohol to yield a precipitate B. The residue of the germ substance not soluble in alkali is treated with acid, and the solution obtained is rendered alkaline to give a precipitate C, and then treated with alcohol to give a precipitate D. The residue of germ substance not dissolved by the alkali or bv the acid is treated with alcohol to give a solution from which a precipitate E is obtained by the addition of salt solution, and the final residue of germ substance is treated with chloroform to obtain an extract which is evaporated to dryness and washed with alcohol to yield a residue F. The substances A, C, E, and F, with or without Band D, are emulsified with normal saline solution and standardized for use as vaccines. Specification 136,036 is referred to.
GB219620A 1920-01-23 1920-01-23 Process for the detoxication of the tubercle bacillus and other germs, for the preparation of vaccines Expired GB161341A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB219620A GB161341A (en) 1920-01-23 1920-01-23 Process for the detoxication of the tubercle bacillus and other germs, for the preparation of vaccines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB219620A GB161341A (en) 1920-01-23 1920-01-23 Process for the detoxication of the tubercle bacillus and other germs, for the preparation of vaccines

Publications (1)

Publication Number Publication Date
GB161341A true GB161341A (en) 1921-04-14

Family

ID=9735268

Family Applications (1)

Application Number Title Priority Date Filing Date
GB219620A Expired GB161341A (en) 1920-01-23 1920-01-23 Process for the detoxication of the tubercle bacillus and other germs, for the preparation of vaccines

Country Status (1)

Country Link
GB (1) GB161341A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1979000823A1 (en) * 1978-03-23 1979-10-18 Us Commerce Neisseria gonorrhoeae vaccine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1979000823A1 (en) * 1978-03-23 1979-10-18 Us Commerce Neisseria gonorrhoeae vaccine

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