GB382047A - Process for the manufacture of female sexual hormone - Google Patents
Process for the manufacture of female sexual hormoneInfo
- Publication number
- GB382047A GB382047A GB27753/31A GB2775331A GB382047A GB 382047 A GB382047 A GB 382047A GB 27753/31 A GB27753/31 A GB 27753/31A GB 2775331 A GB2775331 A GB 2775331A GB 382047 A GB382047 A GB 382047A
- Authority
- GB
- United Kingdom
- Prior art keywords
- precipitate
- water
- urine
- extracted
- organic solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Extraction Or Liquid Replacement (AREA)
Abstract
Female sexual hormones are extracted from the urine of mares by precipitation with heavy metal salts, such as mercury, silver or lead acetate, or by adsorption on substances such as animal charcoal or by extraction with an organic solvent. When the urine is extracted with organic solvent, it is preferably acidified and heated to boiling-point. A preliminary extraction with ether may be followed by extraction with an organic solvent soluble in water. When a heavy metal salt is used as precipitant the precipitate may be decomposed, e.g. by hydrogen sulphide, the hormone remaining in the solution, or it may be extracted with an organic solvent. According to examples: 1. Urine is acidified, mixed with lead acetate and the precipitate formed filtered off, suspended in water and decomposed by hydrogen sulphide. 2. Mercury acetate is used as precipitant, and the precipitate is extracted with alcohol which is eliminated and the residue dissolved in water. 3. A precipitate obtained as in example 1 is digested with alcohol, which is then evaporated. The residue is dissolved in a small quantity of alcohol, poured into an excess of acetone and the precipitate produced is filtered off. The filtrate is concentrated, a solvent such as ethyl acetate, acetoacetic ester or ether and water is added and the mixture shaken in a funnel, the hormone remaining in the non-aqueous layer. 4. Silver acetate is added to the acidified urine and the precipitate filtered off, suspended in water and decomposed by hydrogen sulphide which is removed from the filtrate by passing air or carbon dioxide therethrough. Reference has been directed by the Comptroller to Specifications 295,680, 298,610, and 310,056, [all in Class 81 (i), Disinfecting &c.].
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE382047X | 1930-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB382047A true GB382047A (en) | 1932-10-20 |
Family
ID=6356650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB27753/31A Expired GB382047A (en) | 1930-10-13 | 1931-10-06 | Process for the manufacture of female sexual hormone |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB382047A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2461921A (en) * | 1945-06-15 | 1949-02-15 | Harold M Rabinowitz | Antispasmodic composition |
-
1931
- 1931-10-06 GB GB27753/31A patent/GB382047A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2461921A (en) * | 1945-06-15 | 1949-02-15 | Harold M Rabinowitz | Antispasmodic composition |
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