GB702072A - Improvements in or relating to the production of hecogenin from plant material - Google Patents
Improvements in or relating to the production of hecogenin from plant materialInfo
- Publication number
- GB702072A GB702072A GB756151A GB756151A GB702072A GB 702072 A GB702072 A GB 702072A GB 756151 A GB756151 A GB 756151A GB 756151 A GB756151 A GB 756151A GB 702072 A GB702072 A GB 702072A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hecogenin
- alcohol
- suitably
- recovered
- ether
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
In the production of hecogenin, a material of the class of steroidal sapogenins and of possible use in the preparation of hormones, leaves or other material of the plant Agave Sisalana or related plants, e.g. sisal waste obtained after the extraction of the fibre, which may first be defatted by percolation with light petroleum, ether &c., is extracted with hot or cold alcohol, e.g. methyl or ethyl alcohol containing 0-50 per cent. water, a mineral acid is added to the extract to give a concentration of 1-2M, the mixture is refluxed, alcohol is removed, suitably by steam distillation, and an aqueous suspension produced, precipitated solids are separated and saponified by heating with alcoholic caustic alkali, alcohol is removed suitably by steam distillation, and hecogenin is recovered from the aqueous suspension. Recovery is suitably effected by treating the suspension with an adsorbent such as charcoal, extracting the latter with ether, carbon tetrachloride, trichlorethylene, benzene, ethyl acetate &c. and crystallizing the hecogenin from the solution. Residual material in the mother liquor is recovered by further fractional crystallization or by chromatography, e.g. on alumina.ALSO:In the production of hecogenin, a material of the class of steroidal sapogenins and of possible use in the preparation of hormones, leaves or other material of the plant Agave Sisalana or related plants, e.g. sisal waste obtained after the extraction of the fibre, which may first be defatted by percolation with light petroleum, ether, &c. is extracted with hot or cold alcohol, e.g. methyl or ethyl alcohol containing 0-50 per cent water, a mineral acid is added to the extract to give a concentration of 1-2M, the mixture is refluxed, alcohol is removed, suitably by steam distillation, and an aqueous suspension produced, precipitated solids are separated and saponified by heating with alcoholic caustic alkali, alcohol is removed suitably by steam distillation, and hecogenin is recovered from the aqueous suspension. Recovery is suitable effected by treating the suspension with an adsorbent such as charcoal, extracting the latter with ether, carbon tetrachloride, trichlorethylene, benzene, ethyl acetate &c. and crystallizing the hecogenin from the solution. Residual material in the mother liquor is recovered by further fractional crystallization or by chromatography, e.g. on alumina.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB756151A GB702072A (en) | 1951-04-02 | 1951-04-02 | Improvements in or relating to the production of hecogenin from plant material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB756151A GB702072A (en) | 1951-04-02 | 1951-04-02 | Improvements in or relating to the production of hecogenin from plant material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB702072A true GB702072A (en) | 1954-01-06 |
Family
ID=9835473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB756151A Expired GB702072A (en) | 1951-04-02 | 1951-04-02 | Improvements in or relating to the production of hecogenin from plant material |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB702072A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1035130B (en) * | 1955-02-21 | 1958-07-31 | Glaxo Lab Ltd | Process for the production of hecogenin and its acyl derivatives from crude hecogenin |
| US2960500A (en) * | 1955-12-07 | 1960-11-15 | Glaxo Lab Ltd | Process for the extraction and purification of sapogenins |
| CN111943991A (en) * | 2019-05-15 | 2020-11-17 | 山东洲星生物技术有限公司 | Extraction process of water-soluble saponin |
-
1951
- 1951-04-02 GB GB756151A patent/GB702072A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1035130B (en) * | 1955-02-21 | 1958-07-31 | Glaxo Lab Ltd | Process for the production of hecogenin and its acyl derivatives from crude hecogenin |
| US2960500A (en) * | 1955-12-07 | 1960-11-15 | Glaxo Lab Ltd | Process for the extraction and purification of sapogenins |
| CN111943991A (en) * | 2019-05-15 | 2020-11-17 | 山东洲星生物技术有限公司 | Extraction process of water-soluble saponin |
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