DE521106C - Process for the production of physiologically active substances - Google Patents

Process for the production of physiologically active substances

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Publication number
DE521106C
DE521106C DEG74422D DEG0074422D DE521106C DE 521106 C DE521106 C DE 521106C DE G74422 D DEG74422 D DE G74422D DE G0074422 D DEG0074422 D DE G0074422D DE 521106 C DE521106 C DE 521106C
Authority
DE
Germany
Prior art keywords
active substances
physiologically active
production
parts
soaps
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEG74422D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemische Ind Ges
GESELLSCHAFT fur CHEMISCHE INDUSTRIE
BASF Schweiz AG
Original Assignee
Chemische Ind Ges
GESELLSCHAFT fur CHEMISCHE INDUSTRIE
Gesellschaft fuer Chemische Industrie in Basel CIBA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemische Ind Ges, GESELLSCHAFT fur CHEMISCHE INDUSTRIE, Gesellschaft fuer Chemische Industrie in Basel CIBA filed Critical Chemische Ind Ges
Application granted granted Critical
Publication of DE521106C publication Critical patent/DE521106C/en
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

Verfahren zur Gewinnung von physiologisch wirksamen Stoffen Inder Patentschriftd.7933a ist einverfahren beschrieben zur Gewinnung von physiologisch wirksamen Stoffen in hochgereinigter Form aus den Extrakten von weiblichen innersekretorischen Organen durch Behandeln der Extrakte mit verseifenden Mitteln und _@btrennung der gebildeten Seifen, dadurch gekennzeichnet, daß die Verseifung mit Alkalien oder Erdalkalien in solchen organischen Lösungsmitteln erfolgt, die Alkali- bzw. Erdalkaliseifen nicht auflösen, wobei man das zu verwendende Alkali oder Erdalkali gegebenenfalls auf indifferenten Trägern verteilt.Process for the extraction of physiologically active substances Indian Patentschriftd.7933a describes a process for obtaining physiologically effective substances in highly purified form from the extracts of female internal secretory Organs by treating the extracts with saponifying agents and separating the formed soaps, characterized in that the saponification with alkalis or Alkaline earths are made in organic solvents such as alkali or alkaline earth soaps do not dissolve, the alkali or alkaline earth to be used if necessary distributed on indifferent carriers.

Es wurde nun gefunden, daß dieses Verfahren sich ebensogut zur Gewinnung von physiologisch wirksamen Stoffen in hochgereinigter Form aus den Extrakten von Hoden eignet. Beispiel i Man löst i Teil Extrakt aus Hoden (erhalten z. B. durch Extraktion von getrocknetem Hodenpulver mit Äther und Entfernung des Lösungsmittels) in 25 Teilen Alkohol und trägt so lange gepulvertes Calciumhvdroxyd ein, bis eine herausgenommene Probe - mit Wasser verdünnt - alkalischeReaktion zeigt. 'Zach einstündigem Rühren filtriert man von den Kalkseifen ab und verdampft den Alkohol im Vakuum.It has now been found that this process works just as well for extraction of physiologically active substances in a highly purified form from the extracts of Testicles. Example i Dissolve i part extract from testes (obtained e.g. through Extraction of dried testicle powder with ether and removal of the solvent) in 25 parts of alcohol and adds powdered calcium hydroxide until one removed sample - diluted with water - shows an alkaline reaction. 'Zach an hour Stirring, the lime soaps are filtered off and the alcohol is evaporated off in vacuo.

Durch Aufnehmen des Rückstandes in Petroläther entfernt man in Lösung gebliebene Spuren von Seifen, Calciumhydroxyd und andern Verunreinigungen und erhält nach dem Abdampfen des P,etroläthers das gereinigte Produkt als helles 01, löslich in fetten Ölen und in den gebräuchlichen organischen Lösungsmitteln.By absorbing the residue in petroleum ether, traces of soaps, calcium hydroxide and other impurities that have remained in solution are removed and, after evaporation of the petroleum ether, the purified product is obtained as a light oil, soluble in fatty oils and common organic solvents.

Beispiele Man imprägniert io Teile Tierkohle mit i Teil Ätznatron in wässerig-alkoholischer Lösung und' verdampft den wässerigen Alkohol wieder. Das alkalische Kohlepulver wird mit einer konzentrierten benzolischen Lösung Von 2 Teilen Hodenextrakt. welches durch Extraktion von getrocknetem Hodenpulver mit Benzol oder einem andern wasserunlöslichen Lösungsmittel gewonnen wurde, gekocht. Nach dem Vertreiben des Benzols wird mit Aceton bei gewöhnlicher Teml_,eratur völlig extrahiert und das Aceton aus dem erhaltenen Extrakt abdestiiliert. Man erhält ein helles- Q1, _ das- einer dyeiteren Reinigung unterworfen oder in dieseriZustand verwendet werden @ kanp.Examples 10 parts of animal charcoal are impregnated with 1 part of caustic soda in aqueous-alcoholic solution and 'evaporates the aqueous alcohol again. That alkaline carbon powder is mixed with a concentrated benzene solution of 2 parts Testicular extract. which by extraction of dried testicle powder with benzene or another water-insoluble solvent was obtained, boiled. After the eviction of the benzene is completely extracted with acetone at an ordinary temperature and the acetone from the obtained extract distilled off. You get a light- Q1, _that- subjected to a further purification or in this state can be used @ kanp.

Statt Ätznatron können in diesem Beispiel auch andere geeignete Alkaliverbindungen, wie z. B. 1i atriumcarbonat, verwendet werden. Beispiel 3 to Teile Kohle werden mit 2 Teilen Kalkmilch verrührt. Der entstandene Brei wird im Vakuum soweit eingetrocknet, bis er nur noch wenig Wasser enthält. Man trägt ihn unter Rühren in eine ätherische Lösung von 2 Teilen Extrakt aus Hoden ein und rührt mehrere Stunden. Hierbei entzieht ..das Kohlekalkpulv er der Lösung die Fettsäuren und ai,dern Verunreinigungen unter gleichzeitiger Entfärbung und adsorbiert erstere als Kalkseifen. Die hellgewordene ätherische Lösung wird nach Filtration eingeengt und der Rückstand zur völligen Abscheidung geringer Mengen von Kalkseifen noch aus Alkohol umgelöst. Man erhält nach Verdampfung des Alkohols ein helles Öl, leicht löslich in den gebräuchlichen organischen Lösungsmitteln und in fetten ölen.Instead of caustic soda, other suitable alkali compounds can also be used in this example, such as B. 1i atrium carbonate can be used. Example 3 to parts are coal mixed with 2 parts milk of lime. The resulting pulp is dried in a vacuum to the point that until it contains little water. One carries it into an ethereal while stirring Solution of 2 parts of extract from testes and stir for several hours. Here withdraws ..the coal-lime powder subverts the fatty acids and ai, impurities into the solution simultaneous discoloration and adsorbs the former as lime soaps. The one that has become bright ethereal solution is concentrated after filtration and the residue to complete Separation of small amounts of lime soaps still dissolved from alcohol. You get after evaporation of the alcohol a light-colored oil, easily soluble in the common ones organic solvents and fatty oils.

Claims (1)

PATEN TAKTSPRUCH Abänderung des Verfahrens gemäß Patent ¢79 332, dadurch gekennzeichnet, d@aß man hierbei als Ausgangsstoffe Extrakte von Hoden verwendet. PATEN CERTIFICATE Modification of the process according to patent [79 332], characterized in that extracts from testes are used as starting materials.
DEG74422D 1927-09-30 1928-09-29 Process for the production of physiologically active substances Expired DE521106C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH521106X 1927-09-30

Publications (1)

Publication Number Publication Date
DE521106C true DE521106C (en) 1931-03-20

Family

ID=4517964

Family Applications (1)

Application Number Title Priority Date Filing Date
DEG74422D Expired DE521106C (en) 1927-09-30 1928-09-29 Process for the production of physiologically active substances

Country Status (1)

Country Link
DE (1) DE521106C (en)

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