GB435535A - Process for the mutual separation of the gonadotrop hormons of the pituitary anterior lobe, or of the hormons having the same effects - Google Patents

Process for the mutual separation of the gonadotrop hormons of the pituitary anterior lobe, or of the hormons having the same effects

Info

Publication number
GB435535A
GB435535A GB3599833A GB3599833A GB435535A GB 435535 A GB435535 A GB 435535A GB 3599833 A GB3599833 A GB 3599833A GB 3599833 A GB3599833 A GB 3599833A GB 435535 A GB435535 A GB 435535A
Authority
GB
United Kingdom
Prior art keywords
hormone
picric acid
hormons
precipitate
influencing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3599833A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Priority to GB3599833A priority Critical patent/GB435535A/en
Publication of GB435535A publication Critical patent/GB435535A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Hormones of the anterior lobe of the pituitary, obtained from the gland itself or from urine, blood or placenta, are separated into a hormone A influencing the ripening of the follicles and a hormone B influencing the development of the corpora lutea, by adding picric acid to an aqueous solution of the preparation to precipitate hormone B, leaving hormone A in solution. The precipitate is separated and dissolved in acetic or hydrochloric acid, free picric acid is removed by means of ether or a similar solvent, and the aqueous solution of hormone B so obtained is evaporated to dryness.ALSO:Hormones of the anterior lobe of the pituitary obtained from the gland itself or from urine, blood, or placenta, are separated into a hormone A influencing the ripening of the follicles and a hormone B influencing the development of the corpora lutea, by adding picric acid to an aqueous solution of the preparation to precipitate hormone B, leaving hormone A in solution. The precipitate is separated and dissolved in acetic or hydrochloric acid, free picric acid is removed by means of ether or a similar solvent, and the aqueous solution so obtained is evaporated to dryness. The filtrate from the picric acid precipitate is either treated with solvents to remove picric acid and evaporated in vacuo to yield hormone A, or the hormone may be precipitated by addition of alcohol without previous removal of the picric acid. It is stated that precipitants other than picric acid may be employed, but no other substance is specified.
GB3599833A 1933-12-21 1933-12-21 Process for the mutual separation of the gonadotrop hormons of the pituitary anterior lobe, or of the hormons having the same effects Expired GB435535A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3599833A GB435535A (en) 1933-12-21 1933-12-21 Process for the mutual separation of the gonadotrop hormons of the pituitary anterior lobe, or of the hormons having the same effects

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3599833A GB435535A (en) 1933-12-21 1933-12-21 Process for the mutual separation of the gonadotrop hormons of the pituitary anterior lobe, or of the hormons having the same effects

Publications (1)

Publication Number Publication Date
GB435535A true GB435535A (en) 1935-09-23

Family

ID=10383842

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3599833A Expired GB435535A (en) 1933-12-21 1933-12-21 Process for the mutual separation of the gonadotrop hormons of the pituitary anterior lobe, or of the hormons having the same effects

Country Status (1)

Country Link
GB (1) GB435535A (en)

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