GB366940A - A process for preparing liquids containing active principles or hormones from parathyroid glands - Google Patents
A process for preparing liquids containing active principles or hormones from parathyroid glandsInfo
- Publication number
- GB366940A GB366940A GB3385830A GB3385830A GB366940A GB 366940 A GB366940 A GB 366940A GB 3385830 A GB3385830 A GB 3385830A GB 3385830 A GB3385830 A GB 3385830A GB 366940 A GB366940 A GB 366940A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- glands
- liquid
- alcohol
- concentrated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A substance having the property of inhibiting the growth of tissues is obtained from parathyroid glands by neutralizing an acid extract of the glands to a pH of 4,6 to 5,0, filtering off the insoluble matters precipitated and treating the filtrate to concentrate or purify the hormone therein. The filtrate may be concentrated under reduced pressure the pH being readjusted if necessary to 4,5 to 5,0. The acid liquid may consist of water, an alcohol, e.g. ethyl alcohol, or a ketone, e.g. acetone, and an acid, e.g. sulphuric or hydrochloric acid. The fat may be extracted by treatment of the glands with a fat solvent prior to or simultaneously with treatment with the acid liquid. Examples: (1) Minced glands are shaken with a mixture of water, sulphuric acid, alcohol, and benzene; strained off and the benzene separated. The acid alcoholic liquid is neutralized with caustic soda to pH 4,8. Alcohol is added to precipitate sodium sulphate and the liquid after filtration is concentrated in vacuo, and the pH adjusted to 4,8. (2) Glands are shaken with strong alcohol containing 5 per cent concentrated sulphuric acid, the liquid is neutralized till slightly acid to litmus, filtered, and concentrated by distillation and adjusted to pH=4,8, (3) Glands are treated on a boiling water bath with dilute sulphuric acid, the liquid is cooled and the fat separated and its pH adjusted to pH=9 by addition of sodium hydroxide, strained and centrifuged. The liquid is then neutralized with sulphuric acid to pH=4,8, allowed to stand in the cold and centrifuged. The precipitate so obtained is dissolved in dilute alkali, the pH adjusted to pH=4,8, centrifuged and the filtrate added to that first obtained. Alcohol is added to precipitate sodium sulphate and the filtrate concentrated. (4) Glands are macerated with acetone, and the solid residue is dried, ground and treated with dilute sulphuric acid. The solution obtained is treated in a similar manner to that of example 3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3385830A GB366940A (en) | 1930-11-10 | 1930-11-10 | A process for preparing liquids containing active principles or hormones from parathyroid glands |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3385830A GB366940A (en) | 1930-11-10 | 1930-11-10 | A process for preparing liquids containing active principles or hormones from parathyroid glands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB366940A true GB366940A (en) | 1932-02-10 |
Family
ID=10358343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3385830A Expired GB366940A (en) | 1930-11-10 | 1930-11-10 | A process for preparing liquids containing active principles or hormones from parathyroid glands |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB366940A (en) |
-
1930
- 1930-11-10 GB GB3385830A patent/GB366940A/en not_active Expired
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