GB417513A - Method of producing an enzyme for treatment of malignant growths - Google Patents

Method of producing an enzyme for treatment of malignant growths

Info

Publication number
GB417513A
GB417513A GB957333A GB957333A GB417513A GB 417513 A GB417513 A GB 417513A GB 957333 A GB957333 A GB 957333A GB 957333 A GB957333 A GB 957333A GB 417513 A GB417513 A GB 417513A
Authority
GB
United Kingdom
Prior art keywords
enzyme
alcohol
alkali
residue
extracting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB957333A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to GB957333A priority Critical patent/GB417513A/en
Publication of GB417513A publication Critical patent/GB417513A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/0101—Oligo-1,6-glucosidase (3.2.1.10), i.e. sucrase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Enzymes for use as therapeutic agents in treatment of malignant growths are obtained fruits of the prunus family particularly the apricot (prunus armeniaca) by purification of an enzyme complex extracted therefrom. The crude enzyme is dissolved in alkali, agitated with successive additions of chloroform, alcohol and ether and the enzyme is recovered from the chloroform layer in evaporation in the compressed air, dehydrated with alcohol and heating to not above 120 DEG F. For medicinal use the enzyme is dissolved in water dilute alkali or combined with blood serum to form an albumose. The crude enzyme complex may be obtained by the usual method for the extraction of emulsions or by extracting the ground material with ether, drying the residue, extracting with alcohol, treating the residue with dilute alkali and precipitating the enzyme from the alkali solution with alcohol.ALSO:Enzymes for use as therapeutic agents in treatment of malignant growths are obtained from fruits of the prunus family particularly the apricot (prunus armeniaca) by purification of an enzyme complex extracted therefrom. The crude enzyme is dissolved in alkali, agitated with successive additions of chloroform, alcohol and ether and the enzyme is recovered from the chloroform layer by evaporation with compressed air, dehydrated with alcohol and heating to not above 120 DEG F. For medicinal use the enzyme is dissolved in water dilute alkali, or combined with blood serum to form an albumose. The crude enzyme complex may be obtained by the usual method for the extraction of emulsions or by extracting the ground material with ether, drying the residue, extracting with alcohol, treating the residue with dilute alkali and precipitating the enzyme from the alkali solution with alcohol.
GB957333A 1933-03-30 1933-03-30 Method of producing an enzyme for treatment of malignant growths Expired GB417513A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB957333A GB417513A (en) 1933-03-30 1933-03-30 Method of producing an enzyme for treatment of malignant growths

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB957333A GB417513A (en) 1933-03-30 1933-03-30 Method of producing an enzyme for treatment of malignant growths

Publications (1)

Publication Number Publication Date
GB417513A true GB417513A (en) 1934-10-01

Family

ID=9874585

Family Applications (1)

Application Number Title Priority Date Filing Date
GB957333A Expired GB417513A (en) 1933-03-30 1933-03-30 Method of producing an enzyme for treatment of malignant growths

Country Status (1)

Country Link
GB (1) GB417513A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2703778A (en) * 1952-07-10 1955-03-08 Ernst T Krebs Therapeutic emulsin complex
WO2005099727A1 (en) * 2004-04-13 2005-10-27 Peter Greifenstein Drug

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2703778A (en) * 1952-07-10 1955-03-08 Ernst T Krebs Therapeutic emulsin complex
WO2005099727A1 (en) * 2004-04-13 2005-10-27 Peter Greifenstein Drug

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