PL3065743T3 - Sposób wytwarzania 6-hydroksymorfinanów bez izolowania związków pośrednich - Google Patents

Sposób wytwarzania 6-hydroksymorfinanów bez izolowania związków pośrednich

Info

Publication number
PL3065743T3
PL3065743T3 PL14860961T PL14860961T PL3065743T3 PL 3065743 T3 PL3065743 T3 PL 3065743T3 PL 14860961 T PL14860961 T PL 14860961T PL 14860961 T PL14860961 T PL 14860961T PL 3065743 T3 PL3065743 T3 PL 3065743T3
Authority
PL
Poland
Prior art keywords
intermediates
isolation
production
hydroxy morphinans
morphinans
Prior art date
Application number
PL14860961T
Other languages
English (en)
Inventor
Peter X. Wang
Tao Jiang
Original Assignee
SpecGx LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SpecGx LLC filed Critical SpecGx LLC
Publication of PL3065743T3 publication Critical patent/PL3065743T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
PL14860961T 2013-11-07 2014-11-05 Sposób wytwarzania 6-hydroksymorfinanów bez izolowania związków pośrednich PL3065743T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361901032P 2013-11-07 2013-11-07
PCT/US2014/064054 WO2015069717A1 (en) 2013-11-07 2014-11-05 Production of 6-hydroxy morphinans without the isolation of intermediates
EP14860961.3A EP3065743B1 (en) 2013-11-07 2014-11-05 Production of 6-hydroxy morphinans without the isolation of intermediates

Publications (1)

Publication Number Publication Date
PL3065743T3 true PL3065743T3 (pl) 2019-12-31

Family

ID=53007506

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14860961T PL3065743T3 (pl) 2013-11-07 2014-11-05 Sposób wytwarzania 6-hydroksymorfinanów bez izolowania związków pośrednich

Country Status (10)

Country Link
US (1) US9193737B2 (pl)
EP (1) EP3065743B1 (pl)
JP (1) JP6484618B2 (pl)
AU (1) AU2014346883B2 (pl)
BR (1) BR112016008459B1 (pl)
CA (1) CA2927800C (pl)
ES (1) ES2741810T3 (pl)
MX (1) MX2016005187A (pl)
PL (1) PL3065743T3 (pl)
WO (1) WO2015069717A1 (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2016005187A (es) 2013-11-07 2016-08-08 Mallinckrodt Llc Produccion de 6-hidroxi morfinanos sin el aislamiento de intermediarios.
CN110305142B (zh) * 2019-07-12 2021-11-16 宜昌人福药业有限责任公司 一种6β-羟基吗啡衍生物的立体选择性合成方法
JP2023113976A (ja) * 2020-06-30 2023-08-17 日本ケミファ株式会社 モルヒナン誘導体の製造方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69507697T2 (de) * 1994-05-31 1999-06-10 Mallinckrodt Chemical Inc Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthält
WO2005098414A1 (en) 2004-03-30 2005-10-20 Euro-Celtique S.A Methods for detecting 14-hydroxycodeinone and codeinone
TWI483944B (zh) 2004-03-30 2015-05-11 Euro Celtique Sa 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
US7885858B2 (en) 2006-01-24 2011-02-08 Dell Products L.P. System and method for managing information handling system wireless network provisioning
CA2684458A1 (en) * 2007-04-16 2008-10-30 Mallinckrodt Inc. Novel opiate reduction utilizing catalytic hydrogen transfer reaction
MX2008013842A (es) 2007-05-04 2009-03-06 Mallinckrodt Inc Proceso mejorado para la preparacion de opiatos 6-alfa-hidroxi-n-alquilados.
US7928234B2 (en) 2007-06-29 2011-04-19 Brock University Conversion of thebaine to morphine derivatives
DE102007044499A1 (de) 2007-09-18 2009-03-19 Robert Bosch Gmbh Kraftstoffpumpe, insbesondere für ein Kraftstoffsystem einer Kolben-Brennkraftmaschine
US8148528B2 (en) * 2008-05-27 2012-04-03 Mallinckrodt Llc Processes and compounds for the preparation of normorphinans
NZ589963A (en) 2008-06-17 2011-08-26 Mallinckrodt Inc Processes for the preparation of 6- beta-hydroxy morphinan compounds
EP2328900B1 (en) 2008-08-11 2013-08-28 Tasmanian Alkaloids Pty. Ltd. PROCESS FOR MAKING MORPHINAN-6 alpha-OLS
GB0914338D0 (en) 2009-08-17 2009-09-30 Johnson Matthey Plc Improved process
ES2659168T3 (es) * 2010-07-02 2018-03-14 Johnson Matthey Public Limited Company Proceso para la síntesis y purificación de oxicodona
WO2013119886A1 (en) 2012-02-08 2013-08-15 Mallinckrodt Llc One pot process for producing 6-hydroxyl nal-opiate
MX2016005187A (es) 2013-11-07 2016-08-08 Mallinckrodt Llc Produccion de 6-hidroxi morfinanos sin el aislamiento de intermediarios.

Also Published As

Publication number Publication date
EP3065743A4 (en) 2017-04-05
BR112016008459B1 (pt) 2023-02-07
EP3065743B1 (en) 2019-05-29
WO2015069717A1 (en) 2015-05-14
AU2014346883B2 (en) 2018-07-19
US9193737B2 (en) 2015-11-24
CA2927800C (en) 2019-06-18
JP2016534999A (ja) 2016-11-10
AU2014346883A1 (en) 2016-05-05
ES2741810T3 (es) 2020-02-12
EP3065743A1 (en) 2016-09-14
BR112016008459A2 (pl) 2017-08-01
US20150126742A1 (en) 2015-05-07
CA2927800A1 (en) 2015-05-14
JP6484618B2 (ja) 2019-03-13
MX2016005187A (es) 2016-08-08

Similar Documents

Publication Publication Date Title
GB2514894B (en) Superhard constructions & methods of making same
GB201423357D0 (en) Superhard Constructions & Methods of making same
SG11201504608SA (en) Production of para-xylene
GB2516359B (en) Superhard constructions & methods of making same
GB2512500B (en) Superhard constructions & methods of making same
IL241758B (en) Preparation of pyrimidine intermediates useful for the manufacture of macitentan
WO2014147640A3 (en) Process for the preparation of anagliptin
IL245474A0 (en) Process for the preparation of 5-fluoro-1h-pyrazoles
IL243211A0 (en) Production of dimethyl ether
GB201418779D0 (en) Superhard constructions & methods of making same
IL245476B (en) Process for the preparation of 5-fluoro-1h-pyrazoles
GB2525950B (en) Process for the production of dialkyl succinate
GB2525949B (en) Process for the production of dialkyl succinate
EP3016935A4 (en) Process for the preparation of intermediate of dolutegravir
PL3065743T3 (pl) Sposób wytwarzania 6-hydroksymorfinanów bez izolowania związków pośrednich
SG11201405355WA (en) Process for the isolation of carotenoids
IL229326A (en) Process for making n-iodine-affluent
GB201311714D0 (en) Superhard constructions & methods of making same
GB2520695B (en) Scheme for identification of MTMF signals
GB201707235D0 (en) Production of butanol
IL231292A0 (en) Production of alkaloids without the isolation of intermediates
EP3043646A4 (en) Methods of making 2-halonicotinonitriles
PL2964659T3 (pl) Sposób wytwarzania deferazyroksu
IL246188B (en) A process for the preparation of tiacomycin
HUP1300722A2 (en) Norsteroid intermediates and process for their preparation