EP3065743A4 - Production of 6-hydroxy morphinans without the isolation of intermediates - Google Patents

Production of 6-hydroxy morphinans without the isolation of intermediates Download PDF

Info

Publication number
EP3065743A4
EP3065743A4 EP14860961.3A EP14860961A EP3065743A4 EP 3065743 A4 EP3065743 A4 EP 3065743A4 EP 14860961 A EP14860961 A EP 14860961A EP 3065743 A4 EP3065743 A4 EP 3065743A4
Authority
EP
European Patent Office
Prior art keywords
intermediates
isolation
production
hydroxy morphinans
morphinans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP14860961.3A
Other languages
German (de)
French (fr)
Other versions
EP3065743B1 (en
EP3065743A1 (en
Inventor
Peter X. Wang
Tao Jiang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Specgx LLC
Original Assignee
Mallinckrodt LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt LLC filed Critical Mallinckrodt LLC
Priority to PL14860961T priority Critical patent/PL3065743T3/en
Publication of EP3065743A1 publication Critical patent/EP3065743A1/en
Publication of EP3065743A4 publication Critical patent/EP3065743A4/en
Application granted granted Critical
Publication of EP3065743B1 publication Critical patent/EP3065743B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
EP14860961.3A 2013-11-07 2014-11-05 Production of 6-hydroxy morphinans without the isolation of intermediates Active EP3065743B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL14860961T PL3065743T3 (en) 2013-11-07 2014-11-05 Production of 6-hydroxy morphinans without the isolation of intermediates

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361901032P 2013-11-07 2013-11-07
PCT/US2014/064054 WO2015069717A1 (en) 2013-11-07 2014-11-05 Production of 6-hydroxy morphinans without the isolation of intermediates

Publications (3)

Publication Number Publication Date
EP3065743A1 EP3065743A1 (en) 2016-09-14
EP3065743A4 true EP3065743A4 (en) 2017-04-05
EP3065743B1 EP3065743B1 (en) 2019-05-29

Family

ID=53007506

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14860961.3A Active EP3065743B1 (en) 2013-11-07 2014-11-05 Production of 6-hydroxy morphinans without the isolation of intermediates

Country Status (10)

Country Link
US (1) US9193737B2 (en)
EP (1) EP3065743B1 (en)
JP (1) JP6484618B2 (en)
AU (1) AU2014346883B2 (en)
BR (1) BR112016008459B1 (en)
CA (1) CA2927800C (en)
ES (1) ES2741810T3 (en)
MX (1) MX2016005187A (en)
PL (1) PL3065743T3 (en)
WO (1) WO2015069717A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3065743B1 (en) 2013-11-07 2019-05-29 SpecGx LLC Production of 6-hydroxy morphinans without the isolation of intermediates
CN110305142B (en) * 2019-07-12 2021-11-16 宜昌人福药业有限责任公司 Stereoselective synthesis method of 6 beta-hydroxymorphine derivative
JP2023113976A (en) * 2020-06-30 2023-08-17 日本ケミファ株式会社 Method for producing morphinan derivative

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009003271A1 (en) * 2007-06-29 2009-01-08 Brock University Conversion of thebaine to morphine derivatives

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756745A (en) * 1994-05-31 1998-05-26 Mallinckrodt Medical, Inc. Preparation of nalbuphine having low levels of β-epimer
TWI365880B (en) 2004-03-30 2012-06-11 Euro Celtique Sa Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp
US20070172958A1 (en) 2004-03-30 2007-07-26 Euro-Celtique S.A. Methods for detecting 14-hydroxy codeinone and codeinone
US7885858B2 (en) 2006-01-24 2011-02-08 Dell Products L.P. System and method for managing information handling system wireless network provisioning
CA2684458A1 (en) 2007-04-16 2008-10-30 Mallinckrodt Inc. Novel opiate reduction utilizing catalytic hydrogen transfer reaction
EP2152715B1 (en) 2007-05-04 2010-12-29 Mallinckrodt Inc. Improved process for the preparation of 6-alpha-hydroxy-n-alkylated opiates
DE102007044499A1 (en) 2007-09-18 2009-03-19 Robert Bosch Gmbh Fuel pump, in particular for a fuel system of a piston internal combustion engine
EP2896614B1 (en) * 2008-05-27 2017-07-12 Mallinckrodt LLC Processes and compounds for the preparation of normorphinans
CA2728083A1 (en) 2008-06-17 2009-12-23 Mallinckrodt Inc. Processes for the preparation of 6- beta-hydroxy morphinan compounds
EP2328900B1 (en) 2008-08-11 2013-08-28 Tasmanian Alkaloids Pty. Ltd. PROCESS FOR MAKING MORPHINAN-6 alpha-OLS
GB0914338D0 (en) 2009-08-17 2009-09-30 Johnson Matthey Plc Improved process
WO2012003468A1 (en) 2010-07-02 2012-01-05 Johnson Matthey Public Limited Company Process for the synthesis and purification of oxycodone
PL2812336T3 (en) 2012-02-08 2017-07-31 Mallinckrodt Llc One pot process for producing 6-hydroxyl nal-opiate
EP3065743B1 (en) 2013-11-07 2019-05-29 SpecGx LLC Production of 6-hydroxy morphinans without the isolation of intermediates

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009003271A1 (en) * 2007-06-29 2009-01-08 Brock University Conversion of thebaine to morphine derivatives

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LEISCH ET AL: "Studies on regioselective hydrogenation of thebaine and its conversion to hydrocodone", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 48, no. 23, 4 June 2007 (2007-06-04), pages 3979 - 3981, XP022069428, ISSN: 0040-4039, DOI: 10.1016/J.TETLET.2007.04.051 *
MICHAEL P. KOTICK ET AL: "Analgesic narcotic antagonists. 1. 8.beta.-Alkyl-, 8.beta.-acyl-, and 8.beta.-(tertiary alcohol)dihydrocodeinones and -dihydromorphinones", JOURNAL OF MEDICINAL CHEMISTRY, vol. 23, no. 2, 1 February 1980 (1980-02-01), US, pages 166 - 174, XP055350372, ISSN: 0022-2623, DOI: 10.1021/jm00176a012 *
See also references of WO2015069717A1 *

Also Published As

Publication number Publication date
BR112016008459A2 (en) 2017-08-01
AU2014346883A1 (en) 2016-05-05
US20150126742A1 (en) 2015-05-07
EP3065743B1 (en) 2019-05-29
JP6484618B2 (en) 2019-03-13
CA2927800A1 (en) 2015-05-14
WO2015069717A1 (en) 2015-05-14
EP3065743A1 (en) 2016-09-14
AU2014346883B2 (en) 2018-07-19
PL3065743T3 (en) 2019-12-31
US9193737B2 (en) 2015-11-24
MX2016005187A (en) 2016-08-08
BR112016008459B1 (en) 2023-02-07
ES2741810T3 (en) 2020-02-12
JP2016534999A (en) 2016-11-10
CA2927800C (en) 2019-06-18

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