DE69507697T2 - Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthält - Google Patents

Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthält

Info

Publication number
DE69507697T2
DE69507697T2 DE69507697T DE69507697T DE69507697T2 DE 69507697 T2 DE69507697 T2 DE 69507697T2 DE 69507697 T DE69507697 T DE 69507697T DE 69507697 T DE69507697 T DE 69507697T DE 69507697 T2 DE69507697 T2 DE 69507697T2
Authority
DE
Germany
Prior art keywords
pct
nalbuphin
producing
contains little
epimer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69507697T
Other languages
English (en)
Other versions
DE69507697D1 (de
Inventor
Frank Kavka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Chemical Inc
Original Assignee
Mallinckrodt Chemical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Chemical Inc filed Critical Mallinckrodt Chemical Inc
Publication of DE69507697D1 publication Critical patent/DE69507697D1/de
Application granted granted Critical
Publication of DE69507697T2 publication Critical patent/DE69507697T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
DE69507697T 1994-05-31 1995-05-16 Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthält Expired - Lifetime DE69507697T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25146094A 1994-05-31 1994-05-31
PCT/US1995/006097 WO1995032973A1 (en) 1994-05-31 1995-05-16 The preparation of nalbuphine having low levels of beta-epimer

Publications (2)

Publication Number Publication Date
DE69507697D1 DE69507697D1 (de) 1999-03-18
DE69507697T2 true DE69507697T2 (de) 1999-06-10

Family

ID=22952064

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69507697T Expired - Lifetime DE69507697T2 (de) 1994-05-31 1995-05-16 Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthält

Country Status (11)

Country Link
US (1) US5756745A (de)
EP (1) EP0763038B1 (de)
JP (1) JP4040673B2 (de)
AT (1) ATE176472T1 (de)
AU (1) AU699114B2 (de)
CA (1) CA2191843C (de)
DE (1) DE69507697T2 (de)
ES (1) ES2127532T3 (de)
HU (1) HU224914B1 (de)
NZ (1) NZ287243A (de)
WO (1) WO1995032973A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19622866C2 (de) * 1996-06-07 1998-12-24 Viva Diagnostika Diagnostische Verwendung von Opiat-Antagonisten und -Agonisten enthaltende Präparationen zur Prophylaxe und therapeutischen Behandlung von Migräne und Migräne-verwandten Erkrankungen
GB9717629D0 (en) * 1997-08-21 1997-10-22 Johnson Matthey Plc Removal of residual organic solvents
US6114370A (en) * 1998-09-28 2000-09-05 Wall, Jr.; William H. Amnesic sedation composition and method of administering same
WO2006084389A1 (de) * 2005-02-11 2006-08-17 Cilag Ltd. Verfahren zur reinigung von noroxymorphon-verbindungen
EP1893616B1 (de) * 2005-06-16 2010-12-29 Mallinckrodt, Inc. Synthetische route zu 14-hydroxylopiaten über 1-halogenthebain oder analoga
NZ572252A (en) * 2006-04-21 2011-09-30 Nektar Therapeutics Stereoselective reduction of a morphinone
CA2637610A1 (en) * 2007-05-04 2008-11-04 Mallinckrodt Inc. Improved process for the preparation of 6-alpha-hydroxy-n-alkylated opiates
CA2693436A1 (en) * 2007-07-17 2009-01-22 Christopher W. Grote Preparation of n-alkylated opiates by reductive amination
EP2328900B1 (de) * 2008-08-11 2013-08-28 Tasmanian Alkaloids Pty. Ltd. VERFAHREN ZUR HERSTELLUNG VON MORPHINAN-6 alpha-OLS
ES2439015T3 (es) 2008-09-30 2014-01-21 Mallinckrodt Llc Procedimientos de aminación selectiva de cetomorfinanos
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
AU2010239059B2 (en) 2009-04-24 2016-06-09 Brock University Processes for the preparation of morphinane and morphinone compounds
EP2440562B1 (de) * 2009-06-11 2016-08-10 Mallinckrodt LLC Herstellung von 6-alpha-amino-n-substituierten morphinanen durch katalytischen wasserstofftransfer
PL2440561T3 (pl) * 2009-06-11 2014-09-30 SpecGx LLC Redukcyjne aminowanie 6-keto-normorfinanow przez katalityczne przeniesienie wodoru
GB0914338D0 (en) 2009-08-17 2009-09-30 Johnson Matthey Plc Improved process
MY173491A (en) * 2010-01-29 2020-01-29 Toray Industries Therapeutic or prophylactic agent for biliary tract diseases
JP2014516085A (ja) 2011-06-09 2014-07-07 マリンクロッド エルエルシー 触媒的水素移動による６−ケトモルフィナンの還元的アミノ化
EP2753622B1 (de) 2011-09-08 2016-01-20 Mallinckrodt LLC Herstellung von alkaloiden ohne isolierung von zwischenprodukten
WO2015066443A1 (en) 2013-11-01 2015-05-07 Mallinckrodt Llc Convenient preparation of n-substituted morphinan-6-ols from morphinan-6-ones
MX2016005187A (es) * 2013-11-07 2016-08-08 Mallinckrodt Llc Produccion de 6-hidroxi morfinanos sin el aislamiento de intermediarios.
CN110305142B (zh) * 2019-07-12 2021-11-16 宜昌人福药业有限责任公司 一种6β-羟基吗啡衍生物的立体选择性合成方法
CN110330500B (zh) * 2019-07-12 2021-11-23 宜昌人福药业有限责任公司 一种6β-羟基-7,8-二氢-吗啡衍生物的立体选择性合成方法
CN113845526B (zh) * 2021-01-18 2022-11-08 四川大学 一种蒂巴因衍生物及其制备方法和应用
CN112759596B (zh) * 2021-01-05 2022-03-15 宜昌人福药业有限责任公司 一种纳布啡的制备方法及其中间体
US20230255956A1 (en) * 2022-02-01 2023-08-17 HUMANWELL PHARMACEUTICAL US, Inc. Pharmaceutical formulations containing nalbuphine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3332950A (en) * 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
IL26896A (en) * 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine

Also Published As

Publication number Publication date
HUT77409A (hu) 1998-04-28
HU224914B1 (en) 2006-04-28
DE69507697D1 (de) 1999-03-18
NZ287243A (en) 1997-12-19
EP0763038A1 (de) 1997-03-19
CA2191843C (en) 2006-05-02
AU699114B2 (en) 1998-11-19
ES2127532T3 (es) 1999-04-16
EP0763038B1 (de) 1999-02-03
JPH10501223A (ja) 1998-02-03
CA2191843A1 (en) 1995-12-07
WO1995032973A1 (en) 1995-12-07
JP4040673B2 (ja) 2008-01-30
US5756745A (en) 1998-05-26
ATE176472T1 (de) 1999-02-15
HU9603289D0 (en) 1997-01-28
AU2590295A (en) 1995-12-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: VONNEMANN, KLOIBER & KOLLEGEN, 80796 MUENCHEN