DE69507697T2 - Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthält - Google Patents
Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthältInfo
- Publication number
- DE69507697T2 DE69507697T2 DE69507697T DE69507697T DE69507697T2 DE 69507697 T2 DE69507697 T2 DE 69507697T2 DE 69507697 T DE69507697 T DE 69507697T DE 69507697 T DE69507697 T DE 69507697T DE 69507697 T2 DE69507697 T2 DE 69507697T2
- Authority
- DE
- Germany
- Prior art keywords
- pct
- nalbuphin
- producing
- contains little
- epimer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25146094A | 1994-05-31 | 1994-05-31 | |
PCT/US1995/006097 WO1995032973A1 (en) | 1994-05-31 | 1995-05-16 | The preparation of nalbuphine having low levels of beta-epimer |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69507697D1 DE69507697D1 (de) | 1999-03-18 |
DE69507697T2 true DE69507697T2 (de) | 1999-06-10 |
Family
ID=22952064
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69507697T Expired - Lifetime DE69507697T2 (de) | 1994-05-31 | 1995-05-16 | Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthält |
Country Status (11)
Country | Link |
---|---|
US (1) | US5756745A (de) |
EP (1) | EP0763038B1 (de) |
JP (1) | JP4040673B2 (de) |
AT (1) | ATE176472T1 (de) |
AU (1) | AU699114B2 (de) |
CA (1) | CA2191843C (de) |
DE (1) | DE69507697T2 (de) |
ES (1) | ES2127532T3 (de) |
HU (1) | HU224914B1 (de) |
NZ (1) | NZ287243A (de) |
WO (1) | WO1995032973A1 (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19622866C2 (de) * | 1996-06-07 | 1998-12-24 | Viva Diagnostika Diagnostische | Verwendung von Opiat-Antagonisten und -Agonisten enthaltende Präparationen zur Prophylaxe und therapeutischen Behandlung von Migräne und Migräne-verwandten Erkrankungen |
GB9717629D0 (en) * | 1997-08-21 | 1997-10-22 | Johnson Matthey Plc | Removal of residual organic solvents |
US6114370A (en) * | 1998-09-28 | 2000-09-05 | Wall, Jr.; William H. | Amnesic sedation composition and method of administering same |
WO2006084389A1 (de) * | 2005-02-11 | 2006-08-17 | Cilag Ltd. | Verfahren zur reinigung von noroxymorphon-verbindungen |
DE602006019246D1 (de) * | 2005-06-16 | 2011-02-10 | Mallinckrodt Inc | Synthetische route zu 14-hydroxylopiaten über 1-halogenthebain oder analoga |
CN101466381B (zh) | 2006-04-21 | 2012-11-14 | 尼克塔治疗公司 | 吗啡酮的立体选择性还原 |
EP2152715B1 (de) * | 2007-05-04 | 2010-12-29 | Mallinckrodt Inc. | Verbessertes verfahren zur herstellung von 6-alpha-hydroxy-n-alkylierten opiaten |
NZ582668A (en) * | 2007-07-17 | 2012-02-24 | Mallinckrodt Llc | Preparation of n-alkylated opiates by reductive amination |
EP2328900B1 (de) * | 2008-08-11 | 2013-08-28 | Tasmanian Alkaloids Pty. Ltd. | VERFAHREN ZUR HERSTELLUNG VON MORPHINAN-6 alpha-OLS |
US8269006B2 (en) | 2008-09-30 | 2012-09-18 | Mallinckrodt Llc | Processes for the selective amination of ketomorphinans |
US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
NZ595591A (en) | 2009-04-24 | 2013-11-29 | Univ Brock | Processes for the preparation of morphinane and morphinone compounds |
CA2764915C (en) * | 2009-06-11 | 2017-07-11 | Mallinckrodt Llc | Preparation of 6-alpha-amino n-substituted morphinans by catalytic hydrogen transfer |
EP2440561B1 (de) * | 2009-06-11 | 2014-04-30 | Mallinckrodt LLC | Reduktive aminierung von 6-keto-normorphinanen durch katalytischen wasserstofftransfer |
GB0914338D0 (en) | 2009-08-17 | 2009-09-30 | Johnson Matthey Plc | Improved process |
CA2787323C (en) * | 2010-01-29 | 2017-08-29 | Toray Industries, Inc. | Therapeutic or prophylactic agent for biliary tract diseases |
CN103717601A (zh) | 2011-06-09 | 2014-04-09 | 马林克罗特有限公司 | 通过催化氢转移对6-酮基吗啡喃的还原胺化 |
KR20140063763A (ko) | 2011-09-08 | 2014-05-27 | 말린크로트 엘엘씨 | 중간체를 단리하지 않는 알칼로이드의 제조 방법 |
US9499556B2 (en) | 2013-11-01 | 2016-11-22 | Mallinckrodt Llc | Convenient preparation of N-substituted morphinan-6-ols from morphinan-6-ones |
EP3065743B1 (de) | 2013-11-07 | 2019-05-29 | SpecGx LLC | Herstellung von 6-hydroxymorphinanen ohne isolierung von zwischenprodukten |
CN110330500B (zh) * | 2019-07-12 | 2021-11-23 | 宜昌人福药业有限责任公司 | 一种6β-羟基-7,8-二氢-吗啡衍生物的立体选择性合成方法 |
CN110305142B (zh) * | 2019-07-12 | 2021-11-16 | 宜昌人福药业有限责任公司 | 一种6β-羟基吗啡衍生物的立体选择性合成方法 |
CN113845526B (zh) * | 2021-01-18 | 2022-11-08 | 四川大学 | 一种蒂巴因衍生物及其制备方法和应用 |
CN112759596B (zh) * | 2021-01-05 | 2022-03-15 | 宜昌人福药业有限责任公司 | 一种纳布啡的制备方法及其中间体 |
US20230255956A1 (en) * | 2022-02-01 | 2023-08-17 | HUMANWELL PHARMACEUTICAL US, Inc. | Pharmaceutical formulations containing nalbuphine |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3332950A (en) * | 1963-03-23 | 1967-07-25 | Endo Lab | 14-hydroxydihydronormorphinone derivatives |
IL26896A (en) * | 1966-01-19 | 1970-11-30 | Endo Lab | 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones |
US4795813A (en) * | 1981-08-17 | 1989-01-03 | The Florida Board Of Regents On Behalf Of The Florida State University | Synthesis of derivatives of codeine and other 3-O-alkylmorphines |
US5112975A (en) * | 1984-03-27 | 1992-05-12 | Mallinckrodt Specialty Chemicals Company | Preparation of noroxymorphone from morphine |
-
1995
- 1995-05-16 US US08/737,887 patent/US5756745A/en not_active Expired - Lifetime
- 1995-05-16 CA CA002191843A patent/CA2191843C/en not_active Expired - Fee Related
- 1995-05-16 NZ NZ287243A patent/NZ287243A/en not_active IP Right Cessation
- 1995-05-16 HU HU9603289A patent/HU224914B1/hu not_active IP Right Cessation
- 1995-05-16 ES ES95920456T patent/ES2127532T3/es not_active Expired - Lifetime
- 1995-05-16 DE DE69507697T patent/DE69507697T2/de not_active Expired - Lifetime
- 1995-05-16 AT AT95920456T patent/ATE176472T1/de not_active IP Right Cessation
- 1995-05-16 JP JP50091596A patent/JP4040673B2/ja not_active Expired - Fee Related
- 1995-05-16 AU AU25902/95A patent/AU699114B2/en not_active Ceased
- 1995-05-16 EP EP95920456A patent/EP0763038B1/de not_active Expired - Lifetime
- 1995-05-16 WO PCT/US1995/006097 patent/WO1995032973A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
US5756745A (en) | 1998-05-26 |
JP4040673B2 (ja) | 2008-01-30 |
JPH10501223A (ja) | 1998-02-03 |
CA2191843A1 (en) | 1995-12-07 |
NZ287243A (en) | 1997-12-19 |
AU699114B2 (en) | 1998-11-19 |
HUT77409A (hu) | 1998-04-28 |
DE69507697D1 (de) | 1999-03-18 |
CA2191843C (en) | 2006-05-02 |
ES2127532T3 (es) | 1999-04-16 |
HU9603289D0 (en) | 1997-01-28 |
EP0763038A1 (de) | 1997-03-19 |
EP0763038B1 (de) | 1999-02-03 |
WO1995032973A1 (en) | 1995-12-07 |
HU224914B1 (en) | 2006-04-28 |
ATE176472T1 (de) | 1999-02-15 |
AU2590295A (en) | 1995-12-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69507697T2 (de) | Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthält | |
ATE190222T1 (de) | Verfahren zur herstellung von umhüllten tabletten | |
AU6124696A (en) | Control method for processes of synthesis of chemical products | |
ATE149196T1 (de) | Verfahren zur herstellung von olefinen | |
DE68910083D1 (de) | Verfahren zur Herstellung von harten Konfektprodukten, die hauptsächlich Xylitol enthalten. | |
DE69206226D1 (de) | Verfahren zur Herstellung von mit Gas versetzten Süsswaren. | |
DE59606782D1 (de) | Fachwerk und gefacheelement und verfarhren zur herstellung eines gefacheelements | |
DE69111534T2 (de) | Verfahren zur Herstellung von Alpha-Olefin durch Ethenolyse. | |
DE69418581D1 (de) | Verfahren zur herstellung dünner bleche, geeignet für die anfertigung von dosenteilen | |
HUP9601321A3 (en) | Substituted (benzyloxy)-carbonyl-guanidine derivatives, process for producing them, pharmaceutical compositions containing them their use as pharmaceutical compositions or diagnostica, and the use of the said compds. | |
ATE152722T1 (de) | Verfahren zur herstellung von 9-(2-hydroxy)- ethoxy-guanin | |
DE58900821D1 (de) | Verfahren zur herstellung von phosphororganischen derivaten des 2,4-di-t-butylphenols, der 4,4'-dihalogenmagnesium-verbindungen des biphenyls und die verwendung der phosphororganischen derivate zur stabilisierung von kunststoffen, insbesondere in polyolefinformmassen. | |
DE69514122T2 (de) | Lösungsmittelfreies verfahren zur herstellung von 2,6 difluorbenzonitril | |
DE69414586T2 (de) | Verfahren zur herstellung von indolizinderivaten | |
ATE101846T1 (de) | Verfahren zur herstellung von 1,1dichlorotetrafluorethan. | |
ATE192437T1 (de) | Verfahren zur herstellung von 3-amino-2-chlor-4- alkyl- bzw. 4-cycloalkyl-pyridine | |
DE59007022D1 (de) | Verfahren zur kontinuierlichen Herstellung von Nylon 4,6. | |
DE68917284D1 (de) | Verfahren zur Herstellung von Laminaten. | |
DE59407666D1 (de) | VERFAHREN ZUR HERSTELLUNG VON 8-g(a),12-OXIDO-13,14,15,16-TETRANORLABDAN | |
ATE215071T1 (de) | Verfahren zur herstellung von prostaglandin e1 | |
DE69108319D1 (de) | Verfahren zur herstellung von vitamin-d2-verbindungen und ihrer 1-alpha hydrogenierten derivate. | |
ATE183736T1 (de) | Cycloalkanediole und ihre verwendung zur herstellung von chiralen verbindungen | |
DE59106957D1 (de) | Verfahren zur herstellung von trans-3,3,5-trimethylcyclohexylethylether. | |
DE68913299D1 (de) | Verfahren zur Herstellung von 1,1,3,3-Tetramethylbutylhydroperoxid. | |
ATA269083A (de) | Verfahren zur herstellung des neuen 1-chlor-3,5,7-trimethyl-2,6-octadiens |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: VONNEMANN, KLOIBER & KOLLEGEN, 80796 MUENCHEN |