ES2127532T3 - Preparacion de nalbufina con niveles bajos del epimero beta. - Google Patents
Preparacion de nalbufina con niveles bajos del epimero beta.Info
- Publication number
- ES2127532T3 ES2127532T3 ES95920456T ES95920456T ES2127532T3 ES 2127532 T3 ES2127532 T3 ES 2127532T3 ES 95920456 T ES95920456 T ES 95920456T ES 95920456 T ES95920456 T ES 95920456T ES 2127532 T3 ES2127532 T3 ES 2127532T3
- Authority
- ES
- Spain
- Prior art keywords
- nalbuphine
- low levels
- epimeral
- beta
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
SE DESCRIBE UN PROCESO PARA LA SINTESIS DE NALBUFINA. EL PROCESO DA COMO RESULTADO UN PRODUCTO QUE TIENE NIVELES MUY BAJOS DEL {BE}-EPIMERO NO DESEABLE. EL PROCESO ES UNA SINTESIS DE CINCO PASOS QUE COMIENZA CON UN COMPUESTO COMO UN N,0{SUP,3}BIS(ALCOXICARBONILO)-14-HIDROXINORMORFINONA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25146094A | 1994-05-31 | 1994-05-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2127532T3 true ES2127532T3 (es) | 1999-04-16 |
Family
ID=22952064
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95920456T Expired - Lifetime ES2127532T3 (es) | 1994-05-31 | 1995-05-16 | Preparacion de nalbufina con niveles bajos del epimero beta. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5756745A (es) |
EP (1) | EP0763038B1 (es) |
JP (1) | JP4040673B2 (es) |
AT (1) | ATE176472T1 (es) |
AU (1) | AU699114B2 (es) |
CA (1) | CA2191843C (es) |
DE (1) | DE69507697T2 (es) |
ES (1) | ES2127532T3 (es) |
HU (1) | HU224914B1 (es) |
NZ (1) | NZ287243A (es) |
WO (1) | WO1995032973A1 (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19622866C2 (de) * | 1996-06-07 | 1998-12-24 | Viva Diagnostika Diagnostische | Verwendung von Opiat-Antagonisten und -Agonisten enthaltende Präparationen zur Prophylaxe und therapeutischen Behandlung von Migräne und Migräne-verwandten Erkrankungen |
GB9717629D0 (en) * | 1997-08-21 | 1997-10-22 | Johnson Matthey Plc | Removal of residual organic solvents |
US6114370A (en) * | 1998-09-28 | 2000-09-05 | Wall, Jr.; William H. | Amnesic sedation composition and method of administering same |
WO2006084389A1 (de) * | 2005-02-11 | 2006-08-17 | Cilag Ltd. | Verfahren zur reinigung von noroxymorphon-verbindungen |
JP2008546688A (ja) * | 2005-06-16 | 2008-12-25 | マリンクロッド・インコーポレイテッド | 1−ハロ−テバインまたは類似体を介する14−ヒドロキシルオピエート類への合成経路 |
EP2010539B1 (en) * | 2006-04-21 | 2017-06-14 | Nektar Therapeutics | Stereoselective reduction of a morphinone |
DE602008004245D1 (de) * | 2007-05-04 | 2011-02-10 | Mallinckrodt Inc | Verbessertes verfahren zur herstellung von 6-alpha-hydroxy-n-alkylierten opiaten |
EP2167505B1 (en) * | 2007-07-17 | 2012-11-28 | Mallinckrodt LLC | Preparation of n-alkylated opiates by reductive amination |
WO2010017573A1 (en) * | 2008-08-11 | 2010-02-18 | Tasmanian Alkaloids Pty Limited | PROCESS FOR MAKING MORPHINAN-6α-OLS |
CN102227434B (zh) * | 2008-09-30 | 2015-02-18 | 马林克罗特有限公司 | 选择性胺化酮吗啡喃的方法 |
US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
US8853401B2 (en) | 2009-04-24 | 2014-10-07 | Brock University | Processes for the preparation of morphinane and morphinone compounds |
JP5697215B2 (ja) * | 2009-06-11 | 2015-04-08 | マリンクロッド エルエルシー | 触媒的水素移動による6−α−アミノN−置換モルフィナンの合成 |
WO2010144640A2 (en) * | 2009-06-11 | 2010-12-16 | Mallinckrodt Inc. | Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer |
GB0914338D0 (en) | 2009-08-17 | 2009-09-30 | Johnson Matthey Plc | Improved process |
EP2529739B1 (en) * | 2010-01-29 | 2016-07-13 | Toray Industries, Inc. | Therapeutic or prophylactic agent for biliary diseases |
ES2698408T3 (es) | 2011-06-09 | 2019-02-04 | SpecGx LLC | Aminación reductora de 6-ceto morfinanos por transferencia de hidrógeno catalítico |
AU2012304484B2 (en) | 2011-09-08 | 2016-07-28 | SpecGx LLC | Production of alkaloids without the isolation of intermediates |
CA2926726C (en) * | 2013-11-01 | 2020-09-22 | Mallinckrodt Llc | Convenient preparation of n-substituted morphinan-6-ols from morphinan-6-ones |
MX2016005187A (es) | 2013-11-07 | 2016-08-08 | Mallinckrodt Llc | Produccion de 6-hidroxi morfinanos sin el aislamiento de intermediarios. |
CN110330500B (zh) * | 2019-07-12 | 2021-11-23 | 宜昌人福药业有限责任公司 | 一种6β-羟基-7,8-二氢-吗啡衍生物的立体选择性合成方法 |
CN110305142B (zh) * | 2019-07-12 | 2021-11-16 | 宜昌人福药业有限责任公司 | 一种6β-羟基吗啡衍生物的立体选择性合成方法 |
CN113845526B (zh) * | 2021-01-18 | 2022-11-08 | 四川大学 | 一种蒂巴因衍生物及其制备方法和应用 |
CN112759596B (zh) * | 2021-01-05 | 2022-03-15 | 宜昌人福药业有限责任公司 | 一种纳布啡的制备方法及其中间体 |
WO2023150579A2 (en) * | 2022-02-01 | 2023-08-10 | HUMANWELL PHARMACEUTICAL US, Inc. | Pharmaceutical formulations containing nalbuphine |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3332950A (en) * | 1963-03-23 | 1967-07-25 | Endo Lab | 14-hydroxydihydronormorphinone derivatives |
IL26896A (en) * | 1966-01-19 | 1970-11-30 | Endo Lab | 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones |
US4795813A (en) * | 1981-08-17 | 1989-01-03 | The Florida Board Of Regents On Behalf Of The Florida State University | Synthesis of derivatives of codeine and other 3-O-alkylmorphines |
US5112975A (en) * | 1984-03-27 | 1992-05-12 | Mallinckrodt Specialty Chemicals Company | Preparation of noroxymorphone from morphine |
-
1995
- 1995-05-16 US US08/737,887 patent/US5756745A/en not_active Expired - Lifetime
- 1995-05-16 EP EP95920456A patent/EP0763038B1/en not_active Expired - Lifetime
- 1995-05-16 AU AU25902/95A patent/AU699114B2/en not_active Ceased
- 1995-05-16 ES ES95920456T patent/ES2127532T3/es not_active Expired - Lifetime
- 1995-05-16 HU HU9603289A patent/HU224914B1/hu not_active IP Right Cessation
- 1995-05-16 WO PCT/US1995/006097 patent/WO1995032973A1/en active IP Right Grant
- 1995-05-16 DE DE69507697T patent/DE69507697T2/de not_active Expired - Lifetime
- 1995-05-16 CA CA002191843A patent/CA2191843C/en not_active Expired - Fee Related
- 1995-05-16 NZ NZ287243A patent/NZ287243A/en not_active IP Right Cessation
- 1995-05-16 AT AT95920456T patent/ATE176472T1/de not_active IP Right Cessation
- 1995-05-16 JP JP50091596A patent/JP4040673B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69507697D1 (de) | 1999-03-18 |
HU9603289D0 (en) | 1997-01-28 |
CA2191843C (en) | 2006-05-02 |
EP0763038B1 (en) | 1999-02-03 |
NZ287243A (en) | 1997-12-19 |
AU699114B2 (en) | 1998-11-19 |
DE69507697T2 (de) | 1999-06-10 |
WO1995032973A1 (en) | 1995-12-07 |
HUT77409A (hu) | 1998-04-28 |
AU2590295A (en) | 1995-12-21 |
JP4040673B2 (ja) | 2008-01-30 |
CA2191843A1 (en) | 1995-12-07 |
JPH10501223A (ja) | 1998-02-03 |
US5756745A (en) | 1998-05-26 |
HU224914B1 (en) | 2006-04-28 |
EP0763038A1 (en) | 1997-03-19 |
ATE176472T1 (de) | 1999-02-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2127532T3 (es) | Preparacion de nalbufina con niveles bajos del epimero beta. | |
SV1995000042A (es) | Heteroaril-oxazolidinonas de 5 eslabones ref. le a 30523-sv | |
DE69526756T2 (de) | Pentapeptid-Amide und -Ester, die menslichen Krebs hemmen | |
MX9301787A (es) | Producto nutricional liquido para alimentacion enteral. | |
MX9206450A (es) | Proceso para la produccion de isoleucina-l. | |
HU901325D0 (en) | Process for preparation of 4-phenyl-1,2,3,4-tetrahydro-1-naphthaleneamine derivatives | |
BG102999A (en) | New 2,3-diasubstituted-4-(3h)-quinazolinons | |
ES2144239T3 (es) | Derivados de vitamina d con sustituyentes en c-25, procedimiento para su preparacion, productos intermedios y la utilizacion para la preparacion de medicamentos. | |
MX9400341A (es) | Derivados de los acidos quinolon- y naftiridon-carboxilicos, procedimiento para su obtencion y agentes antibacterianos y aditivos para piensos que los contienen. | |
ES2192680T3 (es) | Nuevos derivados de vitamina d con sustituyentes carbo- o heterociclicos en c-25, procedimiento para su preparacion, productos intermedios y la utilizacion para la preparacion de medicamentos. | |
MX9602806A (es) | Derivados del 1,2,4-oxadiazol y su uso como parasiticidas para animales. | |
ES2054746T3 (es) | Aditivo para piensos estabilizado y procedimiento para su preparacion. | |
ES2193246T3 (es) | Cefalosporinas antibacterianas. | |
MX9207062A (es) | Procedimiento para la obtencion de compuestos que presentan grupos hidroxilo, adecuadas como material de partida para el procedimiento de poliadicion de isocianato. | |
ES2170785T3 (es) | Procedimiento para la fabricacion de arilpirroles insecticidas a traves de productos intermedios de oxazolamina. | |
AU8471491A (en) | Oligosaccharide derivatives | |
ES538579A0 (es) | Un procedimiento para la produccion de 3,3",4"-tri-o-acilespiramicina i"-. | |
ES2174396T3 (es) | Vela odorifera y su procedimiento de fabricacion. | |
ES2167721T3 (es) | Utilizacion de 1-hidroxi-2-piridonas para el tratamiento de la dermatitis seborreica. | |
ES2177877T3 (es) | Procedimiento para la fabricacion de 1,4-bis(aminometil)ciclohexano. | |
HUT58094A (en) | Process for producing 20,21-dinoreburnamenin derivatives and pharmaceutical compositions comprising such compounds, as well as their intermediates | |
AR059965A2 (es) | Uso de 8,9-dehidroestrona para la preparacion de un medicamento antioxidante | |
MX9302313A (es) | Procedimiento para la obtencion de hexafluorclorobutenos. | |
ES2141948T3 (es) | Derivados de ciclohexanona, procedimiento para su preparacion y productos intermedios del procedimiento. | |
MX9201219A (es) | Procedimiento para la produccion de 2-cloro-1,1,1-trifluoro etano. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 763038 Country of ref document: ES |