CN102227434B - 选择性胺化酮吗啡喃的方法 - Google Patents
选择性胺化酮吗啡喃的方法 Download PDFInfo
- Publication number
- CN102227434B CN102227434B CN200980147647.4A CN200980147647A CN102227434B CN 102227434 B CN102227434 B CN 102227434B CN 200980147647 A CN200980147647 A CN 200980147647A CN 102227434 B CN102227434 B CN 102227434B
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- CN
- China
- Prior art keywords
- alkyl
- ketone
- hydrogen
- morphinan
- replacement
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *C(C(*)C(C1)=O)C2(*)C11c3c(*)c(*)c(*)c(*)c3CC2*CC1 Chemical compound *C(C(*)C(C1)=O)C2(*)C11c3c(*)c(*)c(*)c(*)c3CC2*CC1 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (14)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19469608P | 2008-09-30 | 2008-09-30 | |
US61/194,696 | 2008-09-30 | ||
PCT/US2009/005377 WO2010039222A2 (en) | 2008-09-30 | 2009-09-29 | Processes for the selective amination of ketomorphinans |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102227434A CN102227434A (zh) | 2011-10-26 |
CN102227434B true CN102227434B (zh) | 2015-02-18 |
Family
ID=41381615
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200980147647.4A Active CN102227434B (zh) | 2008-09-30 | 2009-09-29 | 选择性胺化酮吗啡喃的方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US8269006B2 (zh) |
EP (1) | EP2340253B1 (zh) |
CN (1) | CN102227434B (zh) |
AU (1) | AU2009300392B2 (zh) |
CA (1) | CA2738628C (zh) |
ES (1) | ES2439015T3 (zh) |
NZ (2) | NZ607842A (zh) |
PL (1) | PL2340253T3 (zh) |
WO (1) | WO2010039222A2 (zh) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10221018A1 (de) * | 2002-05-11 | 2003-11-27 | Boehringer Ingelheim Pharma | Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie |
PL2398808T3 (pl) * | 2009-02-17 | 2014-04-30 | Mallinckrodt Llc | Sposób redukcyjnego alkilowania normorfinanów |
EP2440561B1 (en) * | 2009-06-11 | 2014-04-30 | Mallinckrodt LLC | Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer |
CA2764915C (en) * | 2009-06-11 | 2017-07-11 | Mallinckrodt Llc | Preparation of 6-alpha-amino n-substituted morphinans by catalytic hydrogen transfer |
AU2011263416B2 (en) | 2010-06-11 | 2014-04-10 | Rhodes Technologies | Process for N-dealkylation of tertiary amines |
WO2011154827A2 (en) | 2010-06-11 | 2011-12-15 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
PL2718294T3 (pl) | 2011-06-09 | 2019-04-30 | SpecGx LLC | Redukcyjne aminowanie 6-keto morfinanów przez katalityczne przeniesienie wodoru |
KR20140063763A (ko) | 2011-09-08 | 2014-05-27 | 말린크로트 엘엘씨 | 중간체를 단리하지 않는 알칼로이드의 제조 방법 |
WO2015015146A1 (en) * | 2013-08-02 | 2015-02-05 | Johnson Matthey Public Limited Company | Process for the preparation of oxymorphone |
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DE922827C (de) | 1951-02-08 | 1955-01-27 | Knoll Ag | Verfahren zur Herstellung von quartaeren Ammoniumsalzen, die 2 Tetrahydroisochinolinreste enthalten |
US2772270A (en) * | 1954-10-21 | 1956-11-27 | M J Lewenstein | 14-hydroxymorphinone and 8, 14-dihydroxydihydromorphinone |
US3717643A (en) * | 1967-05-04 | 1973-02-20 | Sterling Drug Inc | N-substituted-norapomorphines |
US3763167A (en) * | 1970-06-24 | 1973-10-02 | Us Army | Process of purifying oripavines |
US4089855A (en) * | 1976-04-23 | 1978-05-16 | Cornell Research Foundation, Inc. | Process for the stereoselective reduction of 6- and 8-keto morphine and morphinan derivatives with formamidinesulfinic acid and compounds obtained thereby |
EP0034480A3 (en) | 1980-02-14 | 1982-01-13 | Grigg, Ronald Ernest | Alkylation of amines |
US4521601A (en) * | 1981-05-20 | 1985-06-04 | The United States Of America As Represented By The Department Of Health & Human Services | Practical total synthesis unnatural enantiomers of opium-derived morphinans |
US4795813A (en) * | 1981-08-17 | 1989-01-03 | The Florida Board Of Regents On Behalf Of The Florida State University | Synthesis of derivatives of codeine and other 3-O-alkylmorphines |
US4443605A (en) * | 1982-07-30 | 1984-04-17 | Miles Laboratories, Inc. | 7β-Arylalkyl-6α, 7 α-oxymethylene-3-methoxy or 3-hydroxy-4, 5α-epoxy-17 methyl or 17-cycloalkyl-methyl morphinans |
US4775759A (en) * | 1984-11-27 | 1988-10-04 | The United States Of America As Represented By The Department Of Health And Human Services | Synthesis and utilization of 17-methyl and 17-cyclopropylmethyl-3,14-dihydroxy-4,5α-epoxy 6β-fluoromorphinans (foxy and cyclofoxy) as (18F)-labeled opioid ligands for position emission transaxial tomography (PETT) |
US4673679A (en) * | 1986-05-14 | 1987-06-16 | E. I. Du Pont De Nemours And Company | Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration |
US5668285A (en) * | 1986-10-31 | 1997-09-16 | The United States Of America As Represented By The Department Of Health And Human Services | Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates |
US4912114A (en) * | 1988-03-18 | 1990-03-27 | Sandoz Ltd. | Morphinan derivatives |
US4991391A (en) * | 1989-01-27 | 1991-02-12 | Westinghouse Electric Corp. | System for cooling in a gas turbine |
US5208338A (en) * | 1991-06-14 | 1993-05-04 | The United States Of America As Represented By The Department Of Health & Human Services. | Radiolabeled N-substituted-6-iodo-3,14-dihydroxy-4,5α-epoxymorphinans |
DE4132159A1 (de) * | 1991-09-27 | 1993-04-01 | Boehringer Ingelheim Kg | 14-hydroxy-n-(2-methoxyethyl)-7,8-dihydromorphin und -norisomorphin, verfahren zu deren herstellung und deren verwendung als arzneimittel |
US5633259A (en) * | 1992-09-21 | 1997-05-27 | United Biomedical, Inc. | Method for identification of low/non-addictive opioid analgesics and the use of said analgesics for treatment of opioid addiction |
US5756745A (en) * | 1994-05-31 | 1998-05-26 | Mallinckrodt Medical, Inc. | Preparation of nalbuphine having low levels of β-epimer |
CN1045442C (zh) | 1994-07-20 | 1999-10-06 | 中国科学院上海药物研究所 | 左、右旋氯斯库利啉及它的制备方法和用途 |
EP1300381B1 (en) * | 1995-12-06 | 2006-03-08 | Japan Science and Technology Agency | Process for preparing optically active alcohols |
DE19548399A1 (de) * | 1995-12-22 | 1997-06-26 | Basf Ag | Rutheniumkomplexe mit einem chiralen, zweizähnigen Phosphinoxazolin-Liganden zur enantioselektiven Transferhydrierung von prochiralen Ketonen |
KR100204659B1 (ko) * | 1996-05-28 | 1999-06-15 | 강재헌 | 신규한 부프레노핀계 진통제용 화합물 |
GB9616253D0 (en) | 1996-08-01 | 1996-09-11 | Johnson Matthey Plc | Preparation of narcotic analgesics |
PT102006B (pt) | 1997-05-19 | 2000-06-30 | Hovione Sociedade Quimica S A | Novo processo de preparacao de azitromicina |
GB9821067D0 (en) * | 1998-09-29 | 1998-11-18 | Zeneca Ltd | Transfer hydrogenation process |
DE60106928T2 (de) * | 2000-07-24 | 2005-03-10 | Chirotech Technology Ltd. | Rutheniumkomplexe und ihre verwendung zur asymmetrischen hydrierung |
CN1233645C (zh) | 2001-09-14 | 2005-12-28 | 中国人民解放军军事医学科学院毒物药物研究所 | 新的东罂粟碱衍生物及其医药用途 |
US20030194420A1 (en) * | 2002-04-11 | 2003-10-16 | Richard Holl | Process for loading a drug delivery device |
CA2520030A1 (en) * | 2003-03-26 | 2004-10-07 | Pharmacia & Upjohn Company Llc | Process to produce enantiomerically enriched alcohols and amines |
US20060182692A1 (en) * | 2003-12-16 | 2006-08-17 | Fishburn C S | Chemically modified small molecules |
SK286047B6 (sk) | 2004-04-13 | 2008-01-07 | Zentiva, A. S. | Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu |
US6887999B1 (en) * | 2004-05-21 | 2005-05-03 | Acura Pharmaceuticals, Inc. | Preparation of dihydrocodeine from codeine |
WO2006008562A1 (en) | 2004-07-23 | 2006-01-26 | Pliva-Istrazivanje I Razvoj D.O.O. | Process |
GB0421687D0 (en) * | 2004-09-30 | 2004-11-03 | Johnson Matthey Plc | Preparation of opiate analgesics |
KR101115841B1 (ko) | 2004-11-05 | 2012-03-09 | 렌슬러 폴리테크닉 인스티튜트 | 4-하이드록시벤조모르판 |
CN1939920B (zh) | 2005-09-29 | 2011-08-31 | 中国人民解放军军事医学科学院毒物药物研究所 | 东罂粟碱类化合物及其医药用途 |
EP2032579A2 (en) | 2006-05-25 | 2009-03-11 | Alpharma (Bermuda) Investments Ltd | Process useful in the preparation of morphinan antagonists |
EP2189460B1 (en) * | 2007-05-04 | 2014-04-23 | Mallinckrodt LLC | Improved process for the preparation of 6-alpha-hydroxy-n-alkylated opiates |
-
2009
- 2009-09-29 CN CN200980147647.4A patent/CN102227434B/zh active Active
- 2009-09-29 NZ NZ607842A patent/NZ607842A/en unknown
- 2009-09-29 ES ES09789384.6T patent/ES2439015T3/es active Active
- 2009-09-29 EP EP09789384.6A patent/EP2340253B1/en active Active
- 2009-09-29 WO PCT/US2009/005377 patent/WO2010039222A2/en active Application Filing
- 2009-09-29 CA CA2738628A patent/CA2738628C/en active Active
- 2009-09-29 AU AU2009300392A patent/AU2009300392B2/en active Active
- 2009-09-29 NZ NZ592005A patent/NZ592005A/xx unknown
- 2009-09-29 PL PL09789384T patent/PL2340253T3/pl unknown
- 2009-09-29 US US12/586,844 patent/US8269006B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN102227434A (zh) | 2011-10-26 |
PL2340253T3 (pl) | 2014-04-30 |
US8269006B2 (en) | 2012-09-18 |
CA2738628C (en) | 2017-07-04 |
AU2009300392B2 (en) | 2014-10-23 |
WO2010039222A3 (en) | 2010-11-18 |
WO2010039222A2 (en) | 2010-04-08 |
CA2738628A1 (en) | 2010-04-08 |
AU2009300392A1 (en) | 2010-04-08 |
ES2439015T3 (es) | 2014-01-21 |
EP2340253B1 (en) | 2013-11-13 |
EP2340253A2 (en) | 2011-07-06 |
US20100081817A1 (en) | 2010-04-01 |
NZ592005A (en) | 2013-03-28 |
NZ607842A (en) | 2013-12-20 |
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C53 | Correction of patent of invention or patent application | ||
CB02 | Change of applicant information |
Address after: American Missouri Applicant after: Mallinckrodt Inc. Address before: American Missouri Applicant before: Mallinckrodt Inc. |
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Effective date of registration: 20180104 Address after: The United States of Missouri, 63119 Webster groves No. 385 Marshall Street Patentee after: Thought hundred Gex Co., Ltd. Address before: American Missouri Patentee before: Mallinckrodt Inc. |
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TR01 | Transfer of patent right |