PT835257E - Intermediarios e processo para o fabrico de derivados camptotecina (cpt-11) e compostos relacionados - Google Patents
Intermediarios e processo para o fabrico de derivados camptotecina (cpt-11) e compostos relacionadosInfo
- Publication number
- PT835257E PT835257E PT96912468T PT96912468T PT835257E PT 835257 E PT835257 E PT 835257E PT 96912468 T PT96912468 T PT 96912468T PT 96912468 T PT96912468 T PT 96912468T PT 835257 E PT835257 E PT 835257E
- Authority
- PT
- Portugal
- Prior art keywords
- intermediates
- pct
- cpt
- manufacture
- related compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C07D213/643—2-Phenoxypyridines; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heat Sensitive Colour Forming Recording (AREA)
- Paper (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Lubricants (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41964395A | 1995-04-07 | 1995-04-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT835257E true PT835257E (pt) | 2003-01-31 |
Family
ID=23663114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT96912468T PT835257E (pt) | 1995-04-07 | 1996-04-01 | Intermediarios e processo para o fabrico de derivados camptotecina (cpt-11) e compostos relacionados |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US6121451A (pt) |
| EP (1) | EP0835257B1 (pt) |
| JP (2) | JP4281075B2 (pt) |
| KR (1) | KR100423627B1 (pt) |
| CN (5) | CN1241926C (pt) |
| AT (1) | ATE224899T1 (pt) |
| AU (1) | AU717179B2 (pt) |
| CA (1) | CA2214793C (pt) |
| CZ (1) | CZ297862B6 (pt) |
| DE (1) | DE69623960T2 (pt) |
| DK (1) | DK0835257T3 (pt) |
| ES (1) | ES2183943T3 (pt) |
| HK (5) | HK1009448A1 (pt) |
| HU (1) | HUP9801436A3 (pt) |
| IL (1) | IL117684A (pt) |
| MX (1) | MX9707706A (pt) |
| NO (2) | NO320482B1 (pt) |
| NZ (1) | NZ306664A (pt) |
| PL (2) | PL186446B1 (pt) |
| PT (1) | PT835257E (pt) |
| RU (1) | RU2164917C2 (pt) |
| SI (1) | SI0835257T1 (pt) |
| TW (1) | TW438775B (pt) |
| WO (1) | WO1996031513A1 (pt) |
| ZA (1) | ZA962747B (pt) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW464652B (en) * | 1996-10-30 | 2001-11-21 | Tanabe Seiyaku Co | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof |
| WO2000020405A1 (fr) * | 1998-10-07 | 2000-04-13 | Mitsubishi Chemical Corporation | Melanges d'isomeres optiques de 2,3-epoxypropanes disubstitues en 1,2, leur procede de production, pesticides les contenant sous forme de principe actif et intermediaire de ceux-ci |
| FR2794123B1 (fr) | 1999-05-28 | 2001-07-27 | Aventis Pharma Sa | Preparation de derives de la camptothecine et de la nothapodytine |
| EP1229934B1 (en) | 1999-10-01 | 2014-03-05 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| US6855294B2 (en) * | 2000-11-22 | 2005-02-15 | Resonance, Inc. | Apparatus and methods for efficient generation of chlorine dioxide |
| TWI245768B (en) | 2001-02-21 | 2005-12-21 | Yakult Honsha Kk | Process for synthesizing camptothecin related compound(s) |
| US6723853B2 (en) | 2001-08-27 | 2004-04-20 | University Of Pittsburgh | Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins |
| JP3839813B2 (ja) * | 2002-04-17 | 2006-11-01 | ファルマシア コーポレイション | カンプトテシン誘導体の調製に有用な化合物 |
| CA2523059A1 (en) | 2003-05-12 | 2004-11-25 | Scinopharm Taiwan, Ltd. | Process for the preparation of 7-alkyl-10-hydroxy-20(s)-camptothecin |
| CZ299329B6 (cs) * | 2003-08-26 | 2008-06-18 | Pliva-Lachema A.S. | Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu |
| US8394365B2 (en) | 2003-09-17 | 2013-03-12 | Nektar Therapeutics | Multi-arm polymer prodrugs |
| WO2005028539A2 (en) * | 2003-09-17 | 2005-03-31 | Nektar Therapeutics Al, Corporation | Multi-arm polymer prodrugs |
| CZ299593B6 (cs) | 2003-12-16 | 2008-09-10 | Pliva-Lachema A. S. | Zpusob výroby 7-ethyl-10-hydroxykamptothecinu |
| US20050197355A1 (en) * | 2004-03-02 | 2005-09-08 | Henegar Kevin E. | Compounds useful in preparing camptothecin derivatives |
| US20050267141A1 (en) * | 2004-05-28 | 2005-12-01 | Phytogen Life Sciences Inc. | Process to prepare camptothecin derivatives |
| US20050272757A1 (en) * | 2004-06-04 | 2005-12-08 | Phytogen Life Sciences Inc. | Process to prepare camptothecin derivatives and novel intermediate and compounds thereof |
| EP1791846A1 (en) * | 2004-08-09 | 2007-06-06 | Shilpa Medicare Limited | An improved process for the preparation of irinotecan hydrochloride trihydrate |
| US20060046993A1 (en) * | 2004-09-01 | 2006-03-02 | Pharmacia Italia S.P.A. | Crystalline polymorphic form of irinotecan hydrochloride |
| JP5133705B2 (ja) * | 2005-02-07 | 2013-01-30 | フェルミオン オサケ ユキチュア | ７−エチル−１０−ヒドロキシカンプトテシンの製造方法 |
| US7662964B2 (en) * | 2005-02-08 | 2010-02-16 | Fermion Oy | Process for producing [1,4′] bipiperidinyl-1′-carbonyl chloride or hydrochloride thereof |
| JP5133704B2 (ja) * | 2005-02-08 | 2013-01-30 | フェルミオン オサケ ユキチュア | 製造方法 |
| TWI375678B (en) * | 2005-06-09 | 2012-11-01 | Yakult Honsha Kk | A method of preparation of a tricyclic ketone |
| EP1803725A1 (en) * | 2005-12-13 | 2007-07-04 | W.C. Heraeus GmbH | Methods for preparing irinotecan |
| US7462627B2 (en) * | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
| US7671067B2 (en) * | 2006-02-09 | 2010-03-02 | Enzon Pharmaceuticals, Inc. | Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin |
| WO2008066902A2 (en) | 2006-11-30 | 2008-06-05 | Nektar Therapeutics Al, Corporation | Method for preparing a polymer conjugate |
| KR20090108082A (ko) * | 2007-02-09 | 2009-10-14 | 엔존 파마슈티컬즈, 인코포레이티드 | 7-에틸-10-하이드록시캄토테신 다분지형 고분자 접합체를 이용한 내성 또는 불응성 암의 치료방법 |
| EP2664632A1 (en) * | 2008-07-31 | 2013-11-20 | The Lubrizol Corporation | Novel copolymers and lubricating compositions thereof |
| WO2010019233A1 (en) | 2008-08-11 | 2010-02-18 | Nektar Therapeutics | Multi-arm polymeric alkanoate conjugates |
| WO2010025337A1 (en) * | 2008-08-29 | 2010-03-04 | Enzon Pharmaceuticals, Inc. | Method of treating ras associated cancer |
| HUE047352T2 (hu) | 2008-09-23 | 2020-04-28 | Nektar Therapeutics | Eljárás ütemezett beadásra kamptotecin elõgyógyszerekkel (például PEG-ironotekánnal) |
| EP2341774B1 (en) * | 2008-10-21 | 2013-12-04 | Belrose Pharma Inc. | Treatment of neuroblastoma with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
| WO2012032531A1 (en) * | 2010-09-06 | 2012-03-15 | Avra Laboratories Pvt. Ltd. | Process for the manufacture of irinotecan hydrochloride by total synthesis |
| US20130331443A1 (en) | 2010-12-22 | 2013-12-12 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
| WO2012088445A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
| JO3283B1 (ar) | 2011-04-26 | 2018-09-16 | Sanofi Sa | تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI) |
| LT3170005T (lt) | 2014-07-18 | 2019-07-10 | Sanofi | Paciento, įtariamo, kad serga vėžiu, gydymo afliberceptu rezultato prognozavimo būdas |
| WO2017074325A1 (en) | 2015-10-27 | 2017-05-04 | California Pacific Medical Center | Podophyllotoxin derivatives and their use |
| US10087194B2 (en) * | 2015-10-27 | 2018-10-02 | California Pacific Medical Center | Podophyllotoxin derivatives and their use |
| JP7158023B2 (ja) | 2016-03-15 | 2022-10-21 | オリソン ヘノミクス エセ． アー． | 固形腫瘍の治療における使用のための、ｌｓｄ１阻害剤の組合せ |
| CN105965710B (zh) * | 2016-06-28 | 2019-03-22 | 常州大学 | 一种硅棒金钢线切割树脂板的制备方法及应用 |
| EP3911660B1 (en) | 2019-01-15 | 2023-05-10 | Laurus Labs Limited | Process for preparation of 2-amino-5-hydroxy propiophenone |
| CN112300184B (zh) * | 2019-08-02 | 2022-12-06 | 华东师范大学 | 一种三元环化合物的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5217499A (en) * | 1975-07-31 | 1977-02-09 | Nippon Chemiphar Co Ltd | Preparation of mappicine |
| DE3682874D1 (de) * | 1985-10-21 | 1992-01-23 | Daiichi Seiyaku Co | Pyranoindolizinderivate und verfahren zu ihrer herstellung. |
| US4894456A (en) * | 1987-03-31 | 1990-01-16 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
| US4981968A (en) * | 1987-03-31 | 1991-01-01 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
| US5053512A (en) * | 1987-04-14 | 1991-10-01 | Research Triangle Institute | Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives |
| US5883255A (en) * | 1990-10-31 | 1999-03-16 | Smithkline Beecham Corporation | Substituted indolizino 1,2-b!quinolinones |
| US5405963A (en) * | 1993-06-10 | 1995-04-11 | Smithkline Beecham Corporation | Process for asymmetric total synthesis of camptothecin analogues |
-
1996
- 1996-03-27 TW TW085103680A patent/TW438775B/zh not_active IP Right Cessation
- 1996-03-27 IL IL11768496A patent/IL117684A/en not_active IP Right Cessation
- 1996-04-01 CA CA002214793A patent/CA2214793C/en not_active Expired - Fee Related
- 1996-04-01 JP JP53035696A patent/JP4281075B2/ja not_active Expired - Fee Related
- 1996-04-01 WO PCT/US1996/004163 patent/WO1996031513A1/en active IP Right Grant
- 1996-04-01 PL PL96322651A patent/PL186446B1/pl not_active IP Right Cessation
- 1996-04-01 KR KR1019970707091A patent/KR100423627B1/ko not_active IP Right Cessation
- 1996-04-01 MX MX9707706A patent/MX9707706A/es not_active IP Right Cessation
- 1996-04-01 SI SI9630551T patent/SI0835257T1/xx unknown
- 1996-04-01 CZ CZ0311097A patent/CZ297862B6/cs not_active IP Right Cessation
- 1996-04-01 CN CNB031030998A patent/CN1241926C/zh not_active Expired - Fee Related
- 1996-04-01 DK DK96912468T patent/DK0835257T3/da active
- 1996-04-01 PL PL96355318A patent/PL186564B1/pl not_active IP Right Cessation
- 1996-04-01 AU AU55278/96A patent/AU717179B2/en not_active Ceased
- 1996-04-01 AT AT96912468T patent/ATE224899T1/de active
- 1996-04-01 DE DE69623960T patent/DE69623960T2/de not_active Expired - Lifetime
- 1996-04-01 US US09/230,245 patent/US6121451A/en not_active Expired - Fee Related
- 1996-04-01 RU RU97118673/04A patent/RU2164917C2/ru not_active IP Right Cessation
- 1996-04-01 CN CN96193138A patent/CN1100058C/zh not_active Expired - Fee Related
- 1996-04-01 HU HU9801436A patent/HUP9801436A3/hu unknown
- 1996-04-01 PT PT96912468T patent/PT835257E/pt unknown
- 1996-04-01 CN CNB031030971A patent/CN100396682C/zh not_active Expired - Fee Related
- 1996-04-01 CN CNB031031005A patent/CN100537538C/zh not_active Expired - Fee Related
- 1996-04-01 EP EP96912468A patent/EP0835257B1/en not_active Expired - Lifetime
- 1996-04-01 NZ NZ306664A patent/NZ306664A/xx not_active IP Right Cessation
- 1996-04-01 ES ES96912468T patent/ES2183943T3/es not_active Expired - Lifetime
- 1996-04-01 CN CN03103098XA patent/CN1434043B/zh not_active Expired - Fee Related
- 1996-04-04 ZA ZA9602747A patent/ZA962747B/xx unknown
-
1997
- 1997-10-06 NO NO19974608A patent/NO320482B1/no not_active IP Right Cessation
-
1998
- 1998-09-04 HK HK98110439A patent/HK1009448A1/xx not_active IP Right Cessation
-
2000
- 2000-02-22 US US09/511,006 patent/US6235907B1/en not_active Expired - Fee Related
- 2000-10-13 US US09/687,227 patent/US6444820B1/en not_active Expired - Fee Related
-
2003
- 2003-09-11 HK HK03106488.3A patent/HK1054234B/zh not_active IP Right Cessation
- 2003-09-11 HK HK03106509.8A patent/HK1054236B/zh not_active IP Right Cessation
- 2003-10-15 HK HK03107416.8A patent/HK1055118A1/xx not_active IP Right Cessation
- 2003-10-15 HK HK03107420A patent/HK1055119A1/xx not_active IP Right Cessation
-
2005
- 2005-01-25 NO NO20050408A patent/NO329776B1/no not_active IP Right Cessation
-
2007
- 2007-10-25 JP JP2007277903A patent/JP2008069170A/ja active Pending
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