|
US6897220B2
(en)
|
2001-09-14 |
2005-05-24 |
Methylgene, Inc. |
Inhibitors of histone deacetylase
|
|
MXPA04002397A
(es)
|
2001-09-14 |
2004-12-02 |
Methylgene Inc |
Inhibidores de histona deacetilasa.
|
|
WO2003076400A1
(en)
|
2002-03-13 |
2003-09-18 |
Janssen Pharmaceutica N.V. |
New inhibitors of histone deacetylase
|
|
HRP20040804A2
(en)
|
2002-03-13 |
2005-02-28 |
Janssen Pharmaceutica N.V. |
Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase
|
|
KR20040094672A
(ko)
|
2002-03-13 |
2004-11-10 |
얀센 파마슈티카 엔.브이. |
히스톤 디아세틸라제의 신규한 저해제로서의설포닐아미노-유도체
|
|
CN100503599C
(zh)
|
2002-03-13 |
2009-06-24 |
詹森药业有限公司 |
作为组蛋白脱乙酰酶的新颖抑制剂的羰基氨基衍生物
|
|
EP1663953A1
(en)
|
2003-09-24 |
2006-06-07 |
Methylgene, Inc. |
Inhibitors of histone deacetylase
|
|
US7253204B2
(en)
|
2004-03-26 |
2007-08-07 |
Methylgene Inc. |
Inhibitors of histone deacetylase
|
|
US8193205B2
(en)
|
2004-07-28 |
2012-06-05 |
Janssen Pharmaceutica N.V. |
Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
|
|
CN101048406B
(zh)
|
2004-08-31 |
2010-12-22 |
万有制药株式会社 |
新型取代的咪唑衍生物
|
|
HN2005000795A
(es)
*
|
2004-10-15 |
2010-08-19 |
Aventis Pharma Inc |
Pirimidinas como antagonistas del receptor de prostaglandina d2
|
|
WO2006066133A2
(en)
|
2004-12-16 |
2006-06-22 |
Takeda San Diego, Inc. |
Histone deacetylase inhibitors
|
|
JP2008536925A
(ja)
|
2005-04-20 |
2008-09-11 |
メルク エンド カムパニー インコーポレーテッド |
ベンゾチオフェンヒドロキサム酸誘導体
|
|
WO2006115833A1
(en)
|
2005-04-20 |
2006-11-02 |
Merck & Co., Inc. |
Benzothiophene hydroxamic acid derivatives with carbamate, urea, amide and sulfonamide substitutions
|
|
WO2006115845A1
(en)
*
|
2005-04-20 |
2006-11-02 |
Merck & Co., Inc. |
Benzothiophene derivatives
|
|
JP2008540574A
(ja)
|
2005-05-11 |
2008-11-20 |
タケダ サン ディエゴ インコーポレイテッド |
ヒストンデアセチラーゼ阻害剤
|
|
EP1885710B1
(en)
|
2005-05-18 |
2015-08-19 |
Janssen Pharmaceutica N.V. |
Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase
|
|
BRPI0610322B8
(pt)
|
2005-05-20 |
2021-05-25 |
Methylgene Inc |
inibidores de sinalização de receptor de vegf e de receptor de hgf e composição farmacêutica
|
|
DE102005027274A1
(de)
*
|
2005-06-08 |
2006-12-14 |
Schering Ag |
Inhibitoren der löslichen Adenylatzyklase
|
|
US7417066B2
(en)
|
2005-06-08 |
2008-08-26 |
Schering Ag |
Inhibitors of soluble adenylate cyclase
|
|
EP1896395B1
(en)
|
2005-06-24 |
2015-07-15 |
Merck Sharp & Dohme Corp. |
Modified malonate derivatives
|
|
US7732475B2
(en)
|
2005-07-14 |
2010-06-08 |
Takeda San Diego, Inc. |
Histone deacetylase inhibitors
|
|
GB0521244D0
(en)
|
2005-10-19 |
2005-11-30 |
Astrazeneca Ab |
Benzamide compounds
|
|
AR057579A1
(es)
|
2005-11-23 |
2007-12-05 |
Merck & Co Inc |
Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac)
|
|
CA2635210A1
(en)
*
|
2006-01-12 |
2007-08-02 |
Merck & Co., Inc. |
Hydroxyalkylarylamide derivatives
|
|
WO2007084390A2
(en)
*
|
2006-01-13 |
2007-07-26 |
Takeda San Diego, Inc. |
Histone deacetylase inhibitors
|
|
EP1979328B1
(en)
|
2006-01-19 |
2012-12-26 |
Janssen Pharmaceutica N.V. |
Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
|
|
ES2396986T3
(es)
|
2006-01-19 |
2013-03-01 |
Janssen Pharmaceutica N.V. |
Derivados de piridina y pirimidina como inhibidores de histona desacetilasa
|
|
CA2635015C
(en)
|
2006-01-19 |
2014-06-03 |
Janssen Pharmaceutica N.V. |
Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase
|
|
ES2376121T3
(es)
|
2006-01-19 |
2012-03-09 |
Janssen Pharmaceutica, N.V. |
Derivados de heterociclilalquilo como nuevos inhibidores de histona deacetilasa.
|
|
PT1981874E
(pt)
|
2006-01-19 |
2009-09-02 |
Janssen Pharmactuica N V |
Derivados de aminofenil como novos inibidores de histonadesacetilase
|
|
US8101616B2
(en)
|
2006-01-19 |
2012-01-24 |
Janssen Pharmaceutica N.V. |
Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
|
|
WO2007100657A2
(en)
|
2006-02-28 |
2007-09-07 |
Merck & Co., Inc. |
Inhibitors of histone deacetylase
|
|
EP2013196B1
(en)
|
2006-04-26 |
2015-09-16 |
Merck Sharp & Dohme Corp. |
Disubstituted aniline compounds
|
|
US8119652B2
(en)
|
2006-05-18 |
2012-02-21 |
Merck Sharp & Dohme Corp. |
Aryl-fused spirocyclic compounds
|
|
JP2009544611A
(ja)
|
2006-07-20 |
2009-12-17 |
メルク エンド カムパニー インコーポレーテッド |
ヒストン脱アセチル化酵素阻害剤としてのリン誘導体
|
|
WO2008029152A2
(en)
*
|
2006-09-08 |
2008-03-13 |
Summit Corporation Plc |
Treatment of duchenne muscular dystrophy
|
|
US7977336B2
(en)
|
2006-12-28 |
2011-07-12 |
Banyu Pharmaceutical Co. Ltd |
Aminopyrimidine derivatives as PLK1 inhibitors
|
|
WO2008089436A2
(en)
*
|
2007-01-18 |
2008-07-24 |
Takeda San Diego, Inc. |
Crystalline forms of histone deacetylase inhibitors
|
|
US8030344B2
(en)
*
|
2007-03-13 |
2011-10-04 |
Methylgene Inc. |
Inhibitors of histone deacetylase
|
|
CN103087043A
(zh)
*
|
2007-03-16 |
2013-05-08 |
中国人民解放军军事医学科学院放射与辐射医学研究所 |
具有抗增殖活性的苯甲酰胺类衍生物及其药用制剂
|
|
US20090005374A1
(en)
*
|
2007-06-26 |
2009-01-01 |
Melvin Jr Lawrence S |
Imidazopyridinyl thiazolyl histone deacetylase inhibitors
|
|
WO2009005638A2
(en)
|
2007-06-27 |
2009-01-08 |
Merck & Co., Inc. |
Pyridyl and pyrimidinyl derivatives as histone deacetylase inhibitors
|
|
EP2170076B1
(en)
|
2007-06-27 |
2016-05-18 |
Merck Sharp & Dohme Corp. |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
|
|
TW200924777A
(en)
*
|
2007-09-14 |
2009-06-16 |
Methylgene Inc |
Combination therapy
|
|
CN101925573A
(zh)
*
|
2008-01-29 |
2010-12-22 |
霍夫曼-拉罗奇有限公司 |
新型的n-(2-氨基-苯基)-酰胺衍生物
|
|
ES2395347T3
(es)
|
2008-03-27 |
2013-02-12 |
Janssen Pharmaceutica, N.V. |
Derivados de indolilalquilamino sustituidos con aza-biciclohexilo como inhibidores novedosos de histona desacetilasa
|
|
PT2268635E
(pt)
*
|
2008-04-21 |
2015-10-06 |
Taigen Biotechnology Co Ltd |
Compostos heterocíclicos
|
|
EP2303841A1
(en)
*
|
2008-07-14 |
2011-04-06 |
Gilead Sciences, Inc. |
Oxindolyl inhibitor compounds
|
|
AU2009271019A1
(en)
|
2008-07-14 |
2010-01-21 |
Gilead Sciences, Inc. |
Fused heterocyclyc inhibitors of histone deacetylase and/or cyclin-dependent kinases
|
|
NZ590283A
(en)
|
2008-07-14 |
2012-11-30 |
Gilead Sciences Inc |
Imidazolylpyrimidine compounds as hdac and / or cdk inhibitors
|
|
CA2731323A1
(en)
*
|
2008-07-28 |
2010-02-04 |
Gilead Sciences, Inc. |
Cycloalkylidene and heterocycloalkylidene histone deacetylase inhibitor compounds
|
|
AU2009289649B2
(en)
|
2008-09-03 |
2016-05-05 |
Biomarin Pharmaceutical Inc. |
Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
|
|
WO2010045095A1
(en)
|
2008-10-14 |
2010-04-22 |
Ning Xi |
Compounds and methods of use
|
|
JP2010111702A
(ja)
*
|
2009-02-16 |
2010-05-20 |
Tetsuya Nishio |
複素環化合物、その製造法および用途
|
|
KR20110117194A
(ko)
*
|
2009-02-23 |
2011-10-26 |
에프. 호프만-라 로슈 아게 |
암 치료를 위한 신규한 오르토-아미노아미드
|
|
EP2414346B1
(en)
*
|
2009-04-02 |
2015-06-24 |
Merck Patent GmbH |
Autotaxin inhibitors
|
|
CA2763167A1
(en)
|
2009-06-08 |
2010-12-16 |
Gilead Sciences, Inc. |
Cycloalkylcarbamate benzamide aniline hdac inhibitor compounds
|
|
EP2440519A1
(en)
|
2009-06-08 |
2012-04-18 |
Gilead Sciences, Inc. |
Alkanoylamino benzamide aniline hdac inihibitor compounds
|
|
CA2779497A1
(en)
|
2009-10-30 |
2011-05-05 |
Massachusetts Institute Of Technology |
The use of ci-994 and dinaline for the treatment of memory/cognition and anxiety disorders
|
|
BR112012024815A2
(pt)
|
2010-03-29 |
2017-04-11 |
Basf Se |
imunoderivados fungicidas
|
|
TWI429628B
(zh)
*
|
2010-03-29 |
2014-03-11 |
Univ Taipei Medical |
吲哚基或吲哚啉基羥肟酸化合物
|
|
CA2829790C
(en)
|
2010-03-30 |
2018-06-05 |
Verseon Corporation |
Multisubstituted aromatic compounds as inhibitors of thrombin
|
|
US9133123B2
(en)
|
2010-04-23 |
2015-09-15 |
Cytokinetics, Inc. |
Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
|
|
AR081331A1
(es)
*
|
2010-04-23 |
2012-08-08 |
Cytokinetics Inc |
Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
|
|
AR081626A1
(es)
|
2010-04-23 |
2012-10-10 |
Cytokinetics Inc |
Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
|
|
US8957066B2
(en)
*
|
2011-02-28 |
2015-02-17 |
Biomarin Pharmaceutical Inc. |
Histone deacetylase inhibitors
|
|
WO2012118632A1
(en)
|
2011-02-28 |
2012-09-07 |
Ning Xi |
Substituted quinoline compounds and methods of use
|
|
JP6250403B2
(ja)
*
|
2011-02-28 |
2017-12-20 |
バイオマリン ファーマシューティカル インク |
ヒストン脱アセチル化酵素阻害剤
|
|
US10059723B2
(en)
|
2011-02-28 |
2018-08-28 |
Biomarin Pharmaceutical Inc. |
Histone deacetylase inhibitors
|
|
WO2013004332A1
(en)
*
|
2011-07-07 |
2013-01-10 |
Merck Patent Gmbh |
Substituted azaheterocycles for the treatment of cancer
|
|
BR112014000371A2
(pt)
|
2011-07-08 |
2017-01-10 |
Novartis Ag |
derivados de trifluormetil-oxadiazol e uso dos mesmos no tratamento de doença
|
|
US8916555B2
(en)
|
2012-03-16 |
2014-12-23 |
Axikin Pharmaceuticals, Inc. |
3,5-diaminopyrazole kinase inhibitors
|
|
UA112897C2
(uk)
|
2012-05-09 |
2016-11-10 |
Байєр Фарма Акцієнгезелльшафт |
Біциклічно заміщені урацили та їх застосування для лікування і/або профілактики захворювань
|
|
AU2013296897B2
(en)
|
2012-07-28 |
2015-09-17 |
Beijing Findcure Biosciences Ltd. |
Substituted pyrazolone compounds and methods of use
|
|
TWI574962B
(zh)
|
2012-11-14 |
2017-03-21 |
加拓科學公司 |
作爲ｐｉ３激酶調節劑的芳雜環化合物及其使用方法和用途
|
|
KR102194646B1
(ko)
|
2012-11-27 |
2020-12-23 |
토마스 헬데이스 스티프텔스 퓌어 메디신스크 포르스닝 |
암 치료를 위한 피리미딘-2,4-다이아민 유도체
|
|
JP2016511237A
(ja)
|
2013-02-01 |
2016-04-14 |
アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． |
選択的ｈｄａｃ３阻害剤
|
|
BR112015018318A2
(pt)
|
2013-02-21 |
2017-08-22 |
Sunshine Lake Pharma Co Ltd |
Composto, composição farmacêutica, uso de um composto ou de uma composição farmacêutica, e, métodos para prevenir, gerenciar, tratar ou diminuir a severidade de um distúrbio proliferativo em um paciente e para inibir ou modular a atividade de uma proteína quinase em uma amostra biológica
|
|
EP3421036B8
(en)
|
2013-03-15 |
2020-12-30 |
Verseon International Corporation |
Multisubstituted aromatic compounds as serine protease inhibitors
|
|
CA2902431A1
(en)
*
|
2013-03-15 |
2014-09-25 |
Kevin Michael Short |
Halogenopyrazoles as inhibitors of thrombin
|
|
JP6503338B2
(ja)
|
2013-03-15 |
2019-04-17 |
バイオマリン ファーマシューティカル インコーポレイテッド |
Ｈｄａｃ阻害剤
|
|
EP2991982B1
(en)
|
2013-04-29 |
2018-08-15 |
Chong Kun Dang Pharmaceutical Corp. |
Novel compounds for selective histone deacetylase inhibitors, and pharmaceutical composition comprising the same
|
|
WO2015006875A1
(en)
*
|
2013-07-18 |
2015-01-22 |
Methylgene Inc. |
Process for the preparation of substituted pyrimidines
|
|
NZ631142A
(en)
|
2013-09-18 |
2016-03-31 |
Axikin Pharmaceuticals Inc |
Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors
|
|
EP3769757A3
(en)
*
|
2013-10-18 |
2021-10-06 |
The General Hospital Corporation |
Imaging histone deacetylases with a radiotracer using positron emission tomography
|
|
AU2014369031A1
(en)
|
2013-12-20 |
2016-07-07 |
Signal Pharmaceuticals, Llc |
Substituted Diaminopyrimidyl Compounds, compositions thereof, and methods of treatment therewith
|
|
AU2015268962A1
(en)
|
2014-06-04 |
2017-01-12 |
Thomas Helledays Stiftelse For Medicinsk Forskning |
MTH1 inhibitors for treatment of inflammatory and autoimmune conditions
|
|
CA2949785A1
(en)
|
2014-06-04 |
2015-12-10 |
Thomas Helledays Stiftelse For Medicinsk Forskning |
Mth1 inhibitors for treatment of cancer
|
|
AU2015295248B2
(en)
*
|
2014-07-31 |
2019-05-16 |
Institut Pasteur Korea |
2-amino-benzimidazole derivatives and their use as 5-lipoxygenase and/or prostaglandin e synthase inhibitors
|
|
RU2017112739A
(ru)
|
2014-09-17 |
2018-10-17 |
Версеон Корпорейшн |
Пиразолил-замещенные пиридоновые соединения как ингибиторы сериновых протеаз
|
|
JP6450010B2
(ja)
|
2014-12-23 |
2019-01-09 |
アクシキン ファーマシューティカルズ インコーポレーテッド |
３，５−ジアミノピラゾールキナーゼ阻害剤
|
|
SG11201706411YA
(en)
|
2015-02-27 |
2017-09-28 |
Verseon Corp |
Substituted pyrazole compounds as serine protease inhibitors
|
|
KR20180022840A
(ko)
*
|
2015-07-02 |
2018-03-06 |
바이오마린 파머수티컬 인크. |
히스톤 데아세틸라제 저해제
|
|
EP3365344B1
(en)
|
2015-10-19 |
2020-12-09 |
Sunshine Lake Pharma Co., Ltd. |
(3-chloro-4-fluoro-phenyl)-(6-((4ar,7as)-3-(hexahydro-(1,4)dioxino(2,3-c)pyrrol-6-yl)-propoxy)-7-methoxy-quinazolin-4-yl)-amine di(methanesulfonic acid) salt and crystalline form of the monohydrate (a egfr inhibitor)
|
|
KR101838615B1
(ko)
*
|
2016-09-30 |
2018-03-15 |
숙명여자대학교산학협력단 |
신규한 벤조옥사졸 또는 벤조티아졸 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
|
|
WO2018165520A1
(en)
|
2017-03-10 |
2018-09-13 |
Vps-3, Inc. |
Metalloenzyme inhibitor compounds
|
|
CN111108105B
(zh)
|
2017-09-22 |
2023-03-31 |
朱比兰特埃皮帕德有限公司 |
作为pad抑制剂的杂环化合物
|
|
KR102782563B1
(ko)
|
2017-10-18 |
2025-03-14 |
주빌런트 에피파드 엘엘씨 |
Pad 억제제로서의 이미다조-피리딘 화합물
|
|
AU2018362046B2
(en)
|
2017-11-06 |
2023-04-13 |
Jubilant Prodel LLC |
Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
|
|
HUE067265T2
(hu)
|
2017-11-24 |
2024-10-28 |
Jubilant Episcribe Llc |
Heterociklusos vegyületek mint PRMT5 inhibitorok
|
|
EP3765453A1
(en)
|
2018-03-13 |
2021-01-20 |
Jubilant Prodel LLC |
Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation
|
|
GB201820450D0
(en)
|
2018-12-14 |
2019-01-30 |
Z Factor Ltd |
Compound and its use for the treatment of alpha1-antitryspin deficiency
|
|
GB201918404D0
(en)
*
|
2019-12-13 |
2020-01-29 |
Z Factor Ltd |
Compounds and their use for the treatment of aplha1-antitrypsin deficiency
|