JP2007522117A5 - - Google Patents

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Publication number
JP2007522117A5
JP2007522117A5 JP2006549718A JP2006549718A JP2007522117A5 JP 2007522117 A5 JP2007522117 A5 JP 2007522117A5 JP 2006549718 A JP2006549718 A JP 2006549718A JP 2006549718 A JP2006549718 A JP 2006549718A JP 2007522117 A5 JP2007522117 A5 JP 2007522117A5
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JP
Japan
Prior art keywords
compound
mycophenolate mofetil
sample
mixture
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006549718A
Other languages
English (en)
Japanese (ja)
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JP2007522117A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2005/014354 external-priority patent/WO2005105769A2/en
Publication of JP2007522117A publication Critical patent/JP2007522117A/ja
Publication of JP2007522117A5 publication Critical patent/JP2007522117A5/ja
Pending legal-status Critical Current

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JP2006549718A 2004-04-27 2005-04-26 ミコフェノール酸モフェチル不純物 Pending JP2007522117A (ja)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US56605604P 2004-04-27 2004-04-27
US57298504P 2004-05-20 2004-05-20
US58940004P 2004-07-19 2004-07-19
US63915104P 2004-12-22 2004-12-22
US63847804P 2004-12-23 2004-12-23
US64286705P 2005-01-10 2005-01-10
US66148505P 2005-03-15 2005-03-15
PCT/US2005/014354 WO2005105769A2 (en) 2004-04-27 2005-04-26 Mycophenolate mofetil impurity

Publications (2)

Publication Number Publication Date
JP2007522117A JP2007522117A (ja) 2007-08-09
JP2007522117A5 true JP2007522117A5 (https=) 2008-07-17

Family

ID=34981904

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2006549718A Pending JP2007522117A (ja) 2004-04-27 2005-04-26 ミコフェノール酸モフェチル不純物
JP2007509732A Pending JP2007534697A (ja) 2004-04-27 2005-04-26 ミコフェノール酸モフェチルおよび他のミコフェノール酸エステルの調製方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2007509732A Pending JP2007534697A (ja) 2004-04-27 2005-04-26 ミコフェノール酸モフェチルおよび他のミコフェノール酸エステルの調製方法

Country Status (8)

Country Link
US (3) US20050250773A1 (https=)
EP (2) EP1675841A1 (https=)
JP (2) JP2007522117A (https=)
CA (2) CA2555461A1 (https=)
IL (2) IL175517A0 (https=)
MX (2) MXPA06005658A (https=)
TW (2) TW200606160A (https=)
WO (2) WO2005105771A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06005659A (es) 2004-04-26 2007-04-10 Teva Gyogyszergyar Zartkoruen Proceso para preparacion de acido micofenolico y derivados de ester del mismo.
WO2005105771A1 (en) * 2004-04-27 2005-11-10 Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid
CA2533326C (en) * 2005-01-20 2012-01-03 Apotex Fermentation Inc. An improved process for the preparation of mycophenolate mofetil
CN101198597B (zh) * 2005-06-14 2011-11-16 先灵公司 作为天冬氨酰基蛋白酶抑制剂的化合物的制备和用途
KR20080069571A (ko) * 2006-06-29 2008-07-28 테바 파마슈티컬 인더스트리즈 리미티드 산 대사산물 생성의 조절
CN1974564B (zh) * 2006-12-15 2010-05-12 丽珠集团新北江制药股份有限公司 一种霉酚酸莫啡酯的制备方法
US20080188653A1 (en) * 2007-02-04 2008-08-07 Formosa Laboratories, Inc. Process for Preparation of Mycophenolate Mofetil
US20080254520A1 (en) * 2007-04-11 2008-10-16 Eva Gulyas Method for reducing impurity level in mycophenolic acid fermentation
WO2008125616A2 (en) * 2007-04-12 2008-10-23 Dsm Ip Assets B.V. Method for the purification of bio-molecules
WO2009010503A1 (en) * 2007-07-18 2009-01-22 Dsm Ip Assets B.V. Mycophenolic acid recycling in a method for the preparation of mycophenolate mofetil
CN105510496B (zh) * 2015-11-25 2017-06-16 宜昌东阳光长江药业股份有限公司 一种富马酸卢帕他定原料药合成工艺中dmf残留的测定方法
CN107727605A (zh) * 2016-08-11 2018-02-23 立邦涂料（中国）有限公司 一种分析矿物油类消泡剂的新方法
CN113549040B (zh) * 2020-04-23 2024-08-06 鲁南制药集团股份有限公司 一种吗替麦考酚酯杂质d的制备方法
CN112710752A (zh) * 2020-12-18 2021-04-27 卓和药业集团有限公司 麦考酚钠残留溶剂的检测方法
CN116500172B (zh) * 2023-06-29 2023-09-05 成都普康唯新生物科技有限公司 一种酸性底物中胺类溶剂的检测方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1157099A (en) 1966-09-27 1969-07-02 Ici Ltd Fermentation Process
GB1158387A (en) 1967-06-13 1969-07-16 Ici Ltd Procedure for Isolation of Mycophenolic Acid
ZA684959B (en) 1967-11-22 1969-05-22 Lilly Co Eli Agents and methods for inhibiting the growth of malignant tumor cells in warm-blooded mammals
US4452891A (en) * 1980-09-08 1984-06-05 Ajinomoto Company Incorporated Method for production of mycophenolic acid by fermentation
US4861776A (en) * 1987-01-30 1989-08-29 Syntex (U.S.A) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof, compositions and use
US4753935A (en) * 1987-01-30 1988-06-28 Syntex (U.S.A.) Inc. Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
US4748173A (en) * 1987-01-30 1988-05-31 Syntex (U.S.A.) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof and pharmaceutical compositions
US5247083A (en) 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid
US5455045A (en) * 1993-05-13 1995-10-03 Syntex (U.S.A.) Inc. High dose formulations
PL178522B1 (pl) * 1993-09-15 2000-05-31 Syntex Inc Krystaliczny, bezwodny związek, mykofenolan mofetylu, kompozycja odpowiednia do sporządzania wodnego preparatu dożylnego, sposób wytwarzania kompozycji odpowiedniej do sporządzania preparatu dożylnego i zestaw użyteczny do sporządzania dożylnego preparatu
CZ301771B6 (cs) * 1993-10-01 2010-06-16 Syntex (U.S.A.) Llc. Farmaceutický prostredek ve forme suchého granulátu obsahující mofetil mykofenolát nebo kyselinu mykofenolovou a zpusob jeho prípravy
ID18663A (id) 1996-04-12 1998-04-30 Novartis Ag Komposisi farmasi berlapis enterik
GB9812413D0 (en) * 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
IN188985B (https=) 1998-12-09 2002-11-30 Biocon Ltd
HUP9903226A2 (en) 1999-09-23 2002-08-28 Gyogyszerki Process for producing mycophenolic acid and derivatives thereof
WO2001064931A1 (en) 2000-02-29 2001-09-07 Biocon India Limited Manufacture and purification of mycophenolic acid
CZ292123B6 (cs) 2001-06-08 2003-08-13 Ivax Pharmaceuticals S.R.O. Způsob přípravy mykofenolátu mofetilu
US6706846B2 (en) * 2001-10-10 2004-03-16 General Electric Company Method for end-capping polycarbonate resins and composition for use in same
US7122687B2 (en) 2002-08-29 2006-10-17 Sunesis Pharmaceuticals, Inc. Process for the production of an immunosuppressant
GB0301259D0 (en) 2003-01-20 2003-02-19 Novartis Ag Organic compounds
TWI221414B (en) * 2003-02-21 2004-10-01 Chunghwa Chemical Synthesis & Method of making mycophenolate mofetil using transesterification
GB0307553D0 (en) 2003-04-01 2003-05-07 Novartis Ag Organic compounds
WO2005105771A1 (en) * 2004-04-27 2005-11-10 Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid
US20080280977A1 (en) * 2005-04-26 2008-11-13 Sandor Molnar Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid

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