TW200606160A - Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid - Google Patents
Process for preparation of mycophenolate mofetil and other esters of mycophenolic acidInfo
- Publication number
- TW200606160A TW200606160A TW094113507A TW94113507A TW200606160A TW 200606160 A TW200606160 A TW 200606160A TW 094113507 A TW094113507 A TW 094113507A TW 94113507 A TW94113507 A TW 94113507A TW 200606160 A TW200606160 A TW 200606160A
- Authority
- TW
- Taiwan
- Prior art keywords
- esters
- preparation
- mycophenolic acid
- mycophenolate mofetil
- mofetil
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/141111—Diverse hetero atoms in same or different rings [e.g., alkaloids, opiates, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Saccharide Compounds (AREA)
- External Artificial Organs (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56605604P | 2004-04-27 | 2004-04-27 | |
US57298504P | 2004-05-20 | 2004-05-20 | |
US58940004P | 2004-07-19 | 2004-07-19 | |
US63915104P | 2004-12-22 | 2004-12-22 | |
US63847804P | 2004-12-23 | 2004-12-23 | |
US64286705P | 2005-01-10 | 2005-01-10 | |
US66148505P | 2005-03-15 | 2005-03-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200606160A true TW200606160A (en) | 2006-02-16 |
Family
ID=34981904
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW094113530A TWI338006B (en) | 2004-04-27 | 2005-04-27 | Mycophenolate mofetil impurity |
TW094113507A TW200606160A (en) | 2004-04-27 | 2005-04-27 | Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW094113530A TWI338006B (en) | 2004-04-27 | 2005-04-27 | Mycophenolate mofetil impurity |
Country Status (8)
Country | Link |
---|---|
US (3) | US20050250773A1 (zh) |
EP (2) | EP1740563A2 (zh) |
JP (2) | JP2007522117A (zh) |
CA (2) | CA2555461A1 (zh) |
IL (2) | IL175516A0 (zh) |
MX (2) | MXPA06005660A (zh) |
TW (2) | TWI338006B (zh) |
WO (2) | WO2005105771A1 (zh) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200613294A (en) | 2004-04-26 | 2006-05-01 | Teva Gyogyszergyar Reszvenytarsasag | Process for preparation of mycophenolic acid and ester derivatives thereof |
US20050250773A1 (en) * | 2004-04-27 | 2005-11-10 | Sandor Molnar | Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid |
US20080300404A1 (en) * | 2005-01-20 | 2008-12-04 | Apotex Fermentation Inc. | Process for the Preparation of Mycophenolate Mofetil |
KR20080015861A (ko) * | 2005-06-14 | 2008-02-20 | 쉐링 코포레이션 | 아스파르틸 프로테아제 억제제로서의 화합물의 제조방법 및용도 |
SI2032712T1 (sl) * | 2006-06-29 | 2010-06-30 | Ivax Pharmaceuticals Sro | Regulacija proizvodnje kislinskega metabolita |
CN1974564B (zh) * | 2006-12-15 | 2010-05-12 | 丽珠集团新北江制药股份有限公司 | 一种霉酚酸莫啡酯的制备方法 |
US20080188653A1 (en) | 2007-02-04 | 2008-08-07 | Formosa Laboratories, Inc. | Process for Preparation of Mycophenolate Mofetil |
EP2024506A1 (en) * | 2007-04-11 | 2009-02-18 | Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság | Method for reducing impurity level in mycophenolic acid fermentation |
WO2008125616A2 (en) * | 2007-04-12 | 2008-10-23 | Dsm Ip Assets B.V. | Method for the purification of bio-molecules |
WO2009010503A1 (en) * | 2007-07-18 | 2009-01-22 | Dsm Ip Assets B.V. | Mycophenolic acid recycling in a method for the preparation of mycophenolate mofetil |
CN105510496B (zh) * | 2015-11-25 | 2017-06-16 | 宜昌东阳光长江药业股份有限公司 | 一种富马酸卢帕他定原料药合成工艺中dmf残留的测定方法 |
CN107727605A (zh) * | 2016-08-11 | 2018-02-23 | 立邦涂料(中国)有限公司 | 一种分析矿物油类消泡剂的新方法 |
CN112710752A (zh) * | 2020-12-18 | 2021-04-27 | 卓和药业集团有限公司 | 麦考酚钠残留溶剂的检测方法 |
CN116500172B (zh) * | 2023-06-29 | 2023-09-05 | 成都普康唯新生物科技有限公司 | 一种酸性底物中胺类溶剂的检测方法 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1157099A (en) | 1966-09-27 | 1969-07-02 | Ici Ltd | Fermentation Process |
GB1158387A (en) | 1967-06-13 | 1969-07-16 | Ici Ltd | Procedure for Isolation of Mycophenolic Acid |
ZA684959B (en) | 1967-11-22 | 1969-05-22 | Lilly Co Eli | Agents and methods for inhibiting the growth of malignant tumor cells in warm-blooded mammals |
US4452891A (en) * | 1980-09-08 | 1984-06-05 | Ajinomoto Company Incorporated | Method for production of mycophenolic acid by fermentation |
US4748173A (en) * | 1987-01-30 | 1988-05-31 | Syntex (U.S.A.) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof and pharmaceutical compositions |
US4861776A (en) * | 1987-01-30 | 1989-08-29 | Syntex (U.S.A) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof, compositions and use |
US4753935A (en) * | 1987-01-30 | 1988-06-28 | Syntex (U.S.A.) Inc. | Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions |
US5247083A (en) | 1992-07-10 | 1993-09-21 | Syntex (U.S.A.) Inc. | Direct esterification of mycophenolic acid |
US5455045A (en) * | 1993-05-13 | 1995-10-03 | Syntex (U.S.A.) Inc. | High dose formulations |
HU217300B (hu) * | 1993-09-15 | 1999-12-28 | Syntex (U.S.A.) Inc. | Kristályos, vízmentes mikofenolát-mofetil sók, a vegyületet tartalmazó intravénás gyógyászati készítmények és előállításuk |
SG55007A1 (en) * | 1993-10-01 | 1998-12-21 | Syntrex U S A Inc | Mycophenolate mofetil high dose oral suspensions |
ID18663A (id) | 1996-04-12 | 1998-04-30 | Novartis Ag | Komposisi farmasi berlapis enterik |
GB9812413D0 (en) | 1998-06-10 | 1998-08-05 | Glaxo Group Ltd | Compound and its use |
IN188985B (zh) | 1998-12-09 | 2002-11-30 | Biocon Ltd | |
HUP9903226A2 (en) | 1999-09-23 | 2002-08-28 | Gyogyszerki | Process for producing mycophenolic acid and derivatives thereof |
WO2001064931A1 (en) | 2000-02-29 | 2001-09-07 | Biocon India Limited | Manufacture and purification of mycophenolic acid |
CZ292123B6 (cs) | 2001-06-08 | 2003-08-13 | Ivax Pharmaceuticals S.R.O. | Způsob přípravy mykofenolátu mofetilu |
US6706846B2 (en) * | 2001-10-10 | 2004-03-16 | General Electric Company | Method for end-capping polycarbonate resins and composition for use in same |
WO2004020426A1 (en) | 2002-08-29 | 2004-03-11 | Biocon Limited | Process for the production of an immunosuppressant |
GB0301259D0 (en) | 2003-01-20 | 2003-02-19 | Novartis Ag | Organic compounds |
TWI221414B (en) * | 2003-02-21 | 2004-10-01 | Chunghwa Chemical Synthesis & | Method of making mycophenolate mofetil using transesterification |
GB0307553D0 (en) | 2003-04-01 | 2003-05-07 | Novartis Ag | Organic compounds |
US20050250773A1 (en) * | 2004-04-27 | 2005-11-10 | Sandor Molnar | Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid |
US20080280977A1 (en) * | 2005-04-26 | 2008-11-13 | Sandor Molnar | Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid |
-
2005
- 2005-04-26 US US11/115,820 patent/US20050250773A1/en not_active Abandoned
- 2005-04-26 EP EP05739984A patent/EP1740563A2/en not_active Withdrawn
- 2005-04-26 CA CA002555461A patent/CA2555461A1/en not_active Abandoned
- 2005-04-26 JP JP2006549718A patent/JP2007522117A/ja active Pending
- 2005-04-26 EP EP05744402A patent/EP1675841A1/en not_active Withdrawn
- 2005-04-26 MX MXPA06005660A patent/MXPA06005660A/es active IP Right Grant
- 2005-04-26 JP JP2007509732A patent/JP2007534697A/ja active Pending
- 2005-04-26 CA CA002555454A patent/CA2555454C/en not_active Expired - Fee Related
- 2005-04-26 US US11/115,593 patent/US7358247B2/en not_active Expired - Fee Related
- 2005-04-26 WO PCT/US2005/014238 patent/WO2005105771A1/en not_active Application Discontinuation
- 2005-04-26 MX MXPA06005658A patent/MXPA06005658A/es unknown
- 2005-04-26 WO PCT/US2005/014354 patent/WO2005105769A2/en not_active Application Discontinuation
- 2005-04-27 TW TW094113530A patent/TWI338006B/zh not_active IP Right Cessation
- 2005-04-27 TW TW094113507A patent/TW200606160A/zh unknown
-
2006
- 2006-05-09 IL IL175516A patent/IL175516A0/en unknown
- 2006-05-09 IL IL175517A patent/IL175517A0/en unknown
-
2008
- 2008-03-31 US US12/012,343 patent/US20080241948A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1675841A1 (en) | 2006-07-05 |
WO2005105769A3 (en) | 2006-03-30 |
WO2005105771A1 (en) | 2005-11-10 |
JP2007534697A (ja) | 2007-11-29 |
TW200614994A (en) | 2006-05-16 |
US20050282806A1 (en) | 2005-12-22 |
US7358247B2 (en) | 2008-04-15 |
WO2005105769A2 (en) | 2005-11-10 |
MXPA06005660A (es) | 2007-04-10 |
CA2555454A1 (en) | 2005-11-10 |
IL175517A0 (en) | 2006-09-05 |
EP1740563A2 (en) | 2007-01-10 |
US20050250773A1 (en) | 2005-11-10 |
JP2007522117A (ja) | 2007-08-09 |
MXPA06005658A (es) | 2007-04-10 |
US20080241948A1 (en) | 2008-10-02 |
IL175516A0 (en) | 2006-09-05 |
TWI338006B (en) | 2011-03-01 |
CA2555461A1 (en) | 2005-11-10 |
CA2555454C (en) | 2009-12-15 |
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