WO2008013995A3 - Tridesmethylvenlafaxine and processes for the synthesis of o-desmethylvenlafaxine - Google Patents

Tridesmethylvenlafaxine and processes for the synthesis of o-desmethylvenlafaxine Download PDF

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Publication number
WO2008013995A3
WO2008013995A3 PCT/US2007/017011 US2007017011W WO2008013995A3 WO 2008013995 A3 WO2008013995 A3 WO 2008013995A3 US 2007017011 W US2007017011 W US 2007017011W WO 2008013995 A3 WO2008013995 A3 WO 2008013995A3
Authority
WO
WIPO (PCT)
Prior art keywords
desmethylvenlafaxine
tridesmethylvenlafaxine
processes
synthesis
preparing
Prior art date
Application number
PCT/US2007/017011
Other languages
French (fr)
Other versions
WO2008013995A2 (en
Inventor
Valerie Niddam-Hildesheim
Natalia Shenkar
Sharona Shachan-Tov
Original Assignee
Teva Pharma
Valerie Niddam-Hildesheim
Natalia Shenkar
Sharona Shachan-Tov
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma, Valerie Niddam-Hildesheim, Natalia Shenkar, Sharona Shachan-Tov filed Critical Teva Pharma
Priority to EP07836330A priority Critical patent/EP1934168A2/en
Priority to PCT/US2007/017011 priority patent/WO2008013995A2/en
Priority to BRPI0702914-4A priority patent/BRPI0702914A2/en
Priority to CA002656285A priority patent/CA2656285A1/en
Publication of WO2008013995A2 publication Critical patent/WO2008013995A2/en
Publication of WO2008013995A3 publication Critical patent/WO2008013995A3/en
Priority to IL196269A priority patent/IL196269A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

The present invention describes processes for the preparation of O-desmethylvenlafaxine and tridesmethylvenlafaxine, which may be used as an intermediate in preparing O-desmethylvenlafaxine.
PCT/US2007/017011 2006-07-26 2007-07-26 Tridesmethylvenlafaxine and processes for the synthesis of o-desmethylvenlafaxine WO2008013995A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP07836330A EP1934168A2 (en) 2006-07-26 2007-07-26 Tridesmethylvenlafaxine and processes for the synthesis of o-desmethylvenlafaxine
PCT/US2007/017011 WO2008013995A2 (en) 2006-07-26 2007-07-26 Tridesmethylvenlafaxine and processes for the synthesis of o-desmethylvenlafaxine
BRPI0702914-4A BRPI0702914A2 (en) 2006-07-26 2007-07-26 o-desmethylvenlafaxine synthesis processes
CA002656285A CA2656285A1 (en) 2006-07-26 2007-07-26 Processes for the synthesis of o-desmethylvenlafaxine
IL196269A IL196269A0 (en) 2006-07-26 2008-12-30 Tridesmethylvenlafaxine and processes for the synthesis of o-desmethylvenlafaxine

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US83361606P 2006-07-26 2006-07-26
US60/833,616 2006-07-26
US83787906P 2006-08-14 2006-08-14
US60/837,879 2006-08-14
US84399806P 2006-09-11 2006-09-11
US60/843,998 2006-09-11
US84921606P 2006-10-03 2006-10-03
US84925506P 2006-10-03 2006-10-03
US60/849,255 2006-10-03
US60/849,216 2006-10-03
US90663907P 2007-03-12 2007-03-12
US60/906,639 2007-03-12
US90687907P 2007-03-13 2007-03-13
US60/906,879 2007-03-13
PCT/US2007/017011 WO2008013995A2 (en) 2006-07-26 2007-07-26 Tridesmethylvenlafaxine and processes for the synthesis of o-desmethylvenlafaxine

Publications (2)

Publication Number Publication Date
WO2008013995A2 WO2008013995A2 (en) 2008-01-31
WO2008013995A3 true WO2008013995A3 (en) 2008-03-20

Family

ID=39750813

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/017011 WO2008013995A2 (en) 2006-07-26 2007-07-26 Tridesmethylvenlafaxine and processes for the synthesis of o-desmethylvenlafaxine

Country Status (3)

Country Link
CA (1) CA2656285A1 (en)
IL (1) IL196269A0 (en)
WO (1) WO2008013995A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007016179A (en) 2006-04-17 2008-03-11 Teva Pharma Polymorphic forms of tegaserod maleate.
US20090069601A1 (en) * 2006-07-26 2009-03-12 Valerie Niddam-Hildesheim Processes for the synthesis of O-desmethylvenlafaxine
US8569371B2 (en) 2010-03-29 2013-10-29 Pliva Hrvatska D.O.O. Crystal forms of O-desmethylvenlafaxine fumarate
CZ303249B6 (en) 2010-04-06 2012-06-20 Zentiva, K.S. Process for preparing 4-(2-(substituted)-1-(1-hydroxycyclohexyl)ethyl)phenols by O-demethylation of their methyl ethers using odor free aromatic thiols
US8933123B2 (en) 2010-10-08 2015-01-13 Cadila Healthcare Limited Polymorphic forms of O-desmethyl-venlafaxine succinate
CN108752235B (en) * 2018-06-19 2020-11-10 武汉普元药业有限责任公司 Method for preparing drug intermediate by hydrotalcite material catalysis

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032555A1 (en) * 1998-12-01 2000-06-08 Sepracor Inc. Derivatives of (+)-venlafaxine and methods of preparing and using the same
US6689912B2 (en) * 2001-12-04 2004-02-10 Wyeth Methods for preparing O-desmethylvenlafaxine
US20040181093A1 (en) * 2003-03-11 2004-09-16 Wyeth Process for preparation of phenethylamine derivatives
US20050197392A1 (en) * 1999-04-06 2005-09-08 Sepracor Inc. O-desmethylvenlafaxine and methods of preparing and using the same
WO2007120923A1 (en) * 2006-04-17 2007-10-25 Teva Pharmaceutical Industries Ltd. Substantially pure o-desmethylvenlafaxine and processes for preparing it

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032555A1 (en) * 1998-12-01 2000-06-08 Sepracor Inc. Derivatives of (+)-venlafaxine and methods of preparing and using the same
US20050197392A1 (en) * 1999-04-06 2005-09-08 Sepracor Inc. O-desmethylvenlafaxine and methods of preparing and using the same
US6689912B2 (en) * 2001-12-04 2004-02-10 Wyeth Methods for preparing O-desmethylvenlafaxine
US20040181093A1 (en) * 2003-03-11 2004-09-16 Wyeth Process for preparation of phenethylamine derivatives
WO2007120923A1 (en) * 2006-04-17 2007-10-25 Teva Pharmaceutical Industries Ltd. Substantially pure o-desmethylvenlafaxine and processes for preparing it

Also Published As

Publication number Publication date
CA2656285A1 (en) 2008-01-31
WO2008013995A2 (en) 2008-01-31
IL196269A0 (en) 2009-11-18

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