JP2007516189A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007516189A5 JP2007516189A5 JP2006518300A JP2006518300A JP2007516189A5 JP 2007516189 A5 JP2007516189 A5 JP 2007516189A5 JP 2006518300 A JP2006518300 A JP 2006518300A JP 2006518300 A JP2006518300 A JP 2006518300A JP 2007516189 A5 JP2007516189 A5 JP 2007516189A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- formula
- substituted
- process according
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 5
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- DQFBYFPFKXHELB-VAWYXSNFSA-N trans-chalcone Chemical group C=1C=CC=CC=1C(=O)\C=C\C1=CC=CC=C1 DQFBYFPFKXHELB-VAWYXSNFSA-N 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000006244 carboxylic acid protecting group Chemical group 0.000 claims 3
- 239000003054 catalyst Substances 0.000 claims 3
- 238000005903 acid hydrolysis reaction Methods 0.000 claims 2
- 150000001732 carboxylic acid derivatives Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
- -1 thionitroso group Chemical group 0.000 claims 2
- ZWVHTXAYIKBMEE-UHFFFAOYSA-N 2-hydroxyacetophenone Chemical class OCC(=O)C1=CC=CC=C1 ZWVHTXAYIKBMEE-UHFFFAOYSA-N 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- 150000008062 acetophenones Chemical class 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 238000005882 aldol condensation reaction Methods 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000005130 alkyl carbonyl thio group Chemical group 0.000 claims 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 150000003935 benzaldehydes Chemical class 0.000 claims 1
- FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 claims 1
- 229910000024 caesium carbonate Inorganic materials 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229910000027 potassium carbonate Inorganic materials 0.000 claims 1
- SMQUZDBALVYZAC-UHFFFAOYSA-N salicylaldehyde Chemical class OC1=CC=CC=C1C=O SMQUZDBALVYZAC-UHFFFAOYSA-N 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- ACOOSTZBTYEGER-UHFFFAOYSA-N thiobenzaldehyde Chemical compound S=CC1=CC=CC=C1 ACOOSTZBTYEGER-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0308354A FR2857361B1 (fr) | 2003-07-08 | 2003-07-08 | PREPARATION DE DERIVES DE 1,3-DIPHENYPROP-2-¼n-1-one |
| PCT/FR2004/001797 WO2005005369A1 (fr) | 2003-07-08 | 2004-07-08 | Preparation de derives de 1,3-diphenylprop-2-en-1-one |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007516189A JP2007516189A (ja) | 2007-06-21 |
| JP2007516189A5 true JP2007516189A5 (enExample) | 2007-08-02 |
Family
ID=33522868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006518300A Pending JP2007516189A (ja) | 2003-07-08 | 2004-07-08 | １，３−ジフェニルプロパ−２−エン−１−オン誘導体の製造 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7385082B2 (enExample) |
| EP (1) | EP1644312B1 (enExample) |
| JP (1) | JP2007516189A (enExample) |
| KR (1) | KR20060030110A (enExample) |
| CN (1) | CN1819986B (enExample) |
| AT (1) | ATE468317T1 (enExample) |
| AU (1) | AU2004255905B2 (enExample) |
| BR (1) | BRPI0412370A (enExample) |
| CA (1) | CA2531443C (enExample) |
| DE (1) | DE602004027251D1 (enExample) |
| DK (1) | DK1644312T3 (enExample) |
| EA (1) | EA010410B1 (enExample) |
| ES (1) | ES2343803T3 (enExample) |
| FR (1) | FR2857361B1 (enExample) |
| IL (1) | IL172825A (enExample) |
| MX (1) | MXPA06000159A (enExample) |
| NO (1) | NO332411B1 (enExample) |
| NZ (1) | NZ544792A (enExample) |
| PL (1) | PL213226B1 (enExample) |
| SG (1) | SG129448A1 (enExample) |
| WO (1) | WO2005005369A1 (enExample) |
| ZA (1) | ZA200601040B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2841784B1 (fr) * | 2002-07-08 | 2007-03-02 | Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations | |
| FR2841900B1 (fr) * | 2002-07-08 | 2007-03-02 | Genfit S A | Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations |
| ES2441665T3 (es) | 2009-11-26 | 2014-02-05 | Genfit | Utilización de derivados de 1,3-difenilprop-2-en-1-ona para tratar trastornos hepáticos |
| WO2011080276A1 (en) | 2009-12-29 | 2011-07-07 | Genfit | Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative |
| PH12012502213A1 (en) | 2010-05-17 | 2015-10-09 | Genfit | Improved preparation of chalcone derivatives |
| SI2948137T1 (sl) * | 2013-01-18 | 2019-01-31 | Genfit | Metode zdravljenja fibroz in rakov |
| EP3416629A4 (en) | 2016-02-16 | 2019-08-07 | CoNCERT Pharmaceuticals, Inc. | DEUTERATED GFT-505 |
| CN106674069B (zh) * | 2016-12-06 | 2018-05-11 | 上海博志研新药物技术有限公司 | Gft505及其中间体的制备方法 |
| WO2018133705A1 (zh) * | 2017-01-22 | 2018-07-26 | 苏州科睿思制药有限公司 | Gft-505的晶型及其制备方法和用途 |
| SG11201906987RA (en) | 2017-02-21 | 2019-09-27 | Genfit | Combination of a ppar agonist with a fxr agonist |
| WO2019025017A1 (en) | 2017-08-04 | 2019-02-07 | Advitech Advisory And Technologies Sa | PROCESS FOR THE PREPARATION OF ELAFIBRANOR AND NEW SYNTHETIC INTERMEDIATES |
| EP3710425A1 (en) | 2017-11-16 | 2020-09-23 | Teva Pharmaceuticals International GmbH | Solid state forms of elafibranor |
| CN109608318A (zh) * | 2019-01-31 | 2019-04-12 | 上海生农生化制品股份有限公司 | 一种戊唑醇中间体α的工业合成方法 |
| CN110156648A (zh) * | 2019-05-30 | 2019-08-23 | 河北科技大学 | 一种Elafibranor中间体的制备方法 |
| CN110143890B (zh) * | 2019-06-12 | 2020-12-22 | 天津科技大学 | 一种查尔酮衍生物和合成方法及其在制备抗非酒精性脂肪肝炎药物中的应用 |
| CN110143902B (zh) * | 2019-06-12 | 2021-06-04 | 天津科技大学 | 含硒查尔酮衍生物Compound 1和合成方法及在抗非酒精性脂肪肝炎药物中的应用 |
| US20230008367A1 (en) | 2019-09-26 | 2023-01-12 | Abionyx Pharma Sa | Compounds useful for treating liver diseases |
| CN113121394B (zh) * | 2019-12-30 | 2022-11-08 | 中国药科大学 | 一种苯氧乙酸类衍生物的制备方法 |
| KR20230011958A (ko) | 2020-05-18 | 2023-01-25 | 장피트 | 원발성 경화성 담관염의 치료를 위한 엘라피브라노 |
| WO2022043367A1 (en) | 2020-08-26 | 2022-03-03 | Genfit | Compositions and methods for the treatment of primary biliary cholangitis |
| WO2022189856A1 (en) | 2021-03-08 | 2022-09-15 | Abionyx Pharma Sa | Compounds useful for treating liver diseases |
| CN113230240B (zh) * | 2021-03-22 | 2022-12-27 | 广州医科大学 | 1,3-二苯基丙-2-烯-1-酮衍生物及其应用 |
| WO2022238448A1 (en) | 2021-05-11 | 2022-11-17 | Genfit | Elafibranor derivatives agonists of ppar for use in the treatment of sepsis |
| WO2022238445A1 (en) | 2021-05-11 | 2022-11-17 | Genfit | Ppar-agonists for use in the treatment of liver failure |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2359621C2 (de) * | 1973-11-30 | 1982-11-18 | Hoechst Ag, 6000 Frankfurt | Antiviral wirksame Alkalimetall- oder Ammoniumsalze der Polyacrylsäure |
| GB8426424D0 (en) * | 1984-10-19 | 1984-11-28 | Biorex Laboratories Ltd | Chalcone derivatives |
| JPH023670A (ja) * | 1988-06-22 | 1990-01-09 | Nippon Oil & Fats Co Ltd | アルキルチオカルコン誘導体 |
| JPH05255655A (ja) * | 1992-03-12 | 1993-10-05 | Kanebo Ltd | 紫外線吸収剤 |
| US5523302A (en) * | 1993-11-24 | 1996-06-04 | The Du Pont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
| EP0947511A1 (en) * | 1998-03-30 | 1999-10-06 | F. Hoffmann-La Roche Ag | Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity |
| JPH11302243A (ja) * | 1998-04-24 | 1999-11-02 | Mitsubishi Chemical Corp | ジエチレントリアミン５酢酸誘導体 |
-
2003
- 2003-07-08 FR FR0308354A patent/FR2857361B1/fr not_active Expired - Fee Related
-
2004
- 2004-07-08 PL PL379543A patent/PL213226B1/pl unknown
- 2004-07-08 EP EP04767629A patent/EP1644312B1/fr not_active Expired - Lifetime
- 2004-07-08 CA CA2531443A patent/CA2531443C/fr not_active Expired - Fee Related
- 2004-07-08 NZ NZ544792A patent/NZ544792A/en not_active IP Right Cessation
- 2004-07-08 CN CN2004800195644A patent/CN1819986B/zh not_active Expired - Lifetime
- 2004-07-08 SG SG200700644A patent/SG129448A1/en unknown
- 2004-07-08 EA EA200600197A patent/EA010410B1/ru not_active IP Right Cessation
- 2004-07-08 US US10/563,057 patent/US7385082B2/en not_active Expired - Lifetime
- 2004-07-08 AT AT04767629T patent/ATE468317T1/de active
- 2004-07-08 JP JP2006518300A patent/JP2007516189A/ja active Pending
- 2004-07-08 MX MXPA06000159A patent/MXPA06000159A/es active IP Right Grant
- 2004-07-08 KR KR1020067000562A patent/KR20060030110A/ko not_active Ceased
- 2004-07-08 WO PCT/FR2004/001797 patent/WO2005005369A1/fr not_active Ceased
- 2004-07-08 DE DE602004027251T patent/DE602004027251D1/de not_active Expired - Lifetime
- 2004-07-08 ES ES04767629T patent/ES2343803T3/es not_active Expired - Lifetime
- 2004-07-08 AU AU2004255905A patent/AU2004255905B2/en not_active Ceased
- 2004-07-08 BR BRPI0412370-0A patent/BRPI0412370A/pt not_active Application Discontinuation
- 2004-07-08 DK DK04767629.1T patent/DK1644312T3/da active
-
2005
- 2005-12-26 IL IL172825A patent/IL172825A/en unknown
-
2006
- 2006-01-06 NO NO20060087A patent/NO332411B1/no not_active IP Right Cessation
- 2006-02-06 ZA ZA200601040A patent/ZA200601040B/en unknown